The Multifaceted Clinical Characteristics of Congenital Cytomegalovirus Infection: From Pregnancy to Long-Term Outcomes

Kim Yejin,Kim Yoo-min,Kim Doo Ri,Kim Han Gyeol,Sung Ji-Hee,Choi Suk-Joo,Oh Soo-young,Kim Yae-Jean,Chang Yun Sil,Kim Dongsub,Kim Jung-Sun,Moon Il Joon,Roh Cheong-Rae 대한의학회 2023 Journal of Korean medical science Vol.38 No.32

Background: The aim of this study was to capture multifaceted clinical characteristics of congenital cytomegalovirus (CMV) infection from diagnosis to treatment using a multidisciplinary approach including obstetrics, pediatrics, pathology, and otorhinolaryngology-head and neck surgery. Methods: This is a retrospective study including 30 consecutive cases of congenital CMV infection that were diagnosed at a single tertiary hospital located in Seoul, Korea from January 2009 to December 2020. Congenital CMV infection was defined as a positive result by polymerase chain reaction from urine, saliva or cerebrospinal fluid or positive CMV IgM from neonatal blood sampled within 3 weeks after birth. All cases were analyzed with respect to whole clinical characteristics from diagnosis to treatment of congenital CMV by a multidisciplinary approach including prenatal sonographic findings, maternal immune status regarding CMV infection, detailed placental pathology, neonatal clinical manifestation, auditory brainstem response test, and antiviral treatment (ganciclovir or valganciclovir). Long-term outcomes including developmental delay and hearing loss were also investigated. Results: The total number of births during the study period in our institution was 19,385, with the prevalence of congenital infection estimated to be 0.15%. Among 30 cases of congenital CMV, the median gestational age at delivery was 32.2 weeks [range, 22.6–40.0] and 66.7% of these infants were delivered preterm at less than 37 weeks. Suspected fetal growth restriction was the most common prenatal ultrasound finding (50%) followed by ventriculomegaly (17.9%) and abnormal placenta (17.9%), defined as thick placenta with calcification. No abnormal findings on ultrasound examination were observed in one-third of births. Maternal CMV serology tests were conducted in only 8 cases, and one case each of positive and equivocal IgM were found. The most common placental pathologic findings were chronic villitis (66.7%) and calcification (63.0%), whereas viral inclusions were identified in only 22.2%. The most common neonatal manifestations were jaundice (58.6%) followed by elevation of aspartate aminotransferase (55.2%) and thrombocytopenia (51.7%). After excluding cases for which long-term outcomes were unavailable due to death (n = 4) or subsequent follow up loss (n = 3), developmental delay was confirmed in 43.5% of infants (10/23), and hearing loss was confirmed in 42.9% (9/21) during the follow-up period. In our cohort, 56.7% (17/30) of neonates were treated for congenital CMV with ganciclovir or valganciclovir. Conclusion: Our data show that prenatal findings including maternal serologic tests and ultrasound have limited ability to detect congenital CMV in Korea. Given that CMV is associated with high rates of developmental delay and hearing loss in infants, there is an urgent need to develop specific strategies for the definite diagnosis of congenital CMV infection during the perinatal period by a multidisciplinary approach to decrease the risks of neurologic impairment and hearing loss through early antiviral treatment.

일제강점기 과학담론을 통한 전쟁양상 연구 - 최초의 대체역사소설 안전민의 「태평양의 독수리」(1941)와 김동진의 『(세계대전) 비행전쟁』(1934)을 중심으로

김예진 ( Kim Yejin ),모희준 ( Mo Hee-june ) 심훈학회 2023 심훈학보 Vol.2 No.0

이 연구는 한국 최초의 대체역사소설인 안전민의 「태평양의 독수리」와 김동진의 『(세계대전) 비행전쟁』을 통해 당대의 전쟁에 대한 인식을 살펴보고자 시도했다. 일제강점기의 과학소설은 창작소설보다는 번역·번안 작품이 주를 이루고 있는데, 김동인의 「K박사의 연구」처럼 몇 안 되지만 순수 창작과학소설 또한 존재한다. 특히 안전민의 「태평양의 독수리」의 경우 대체역사소설의 서사 구조를 충실히 따르고 있다는 점에서 한국 최초의 대체역사소설이라고 볼 수 있다. 일제강점기 과학담론을 통해 당대의 전쟁에 대한 인식을 살펴보고자 한 시도는 현재까지도 찾아보기 어려우며, 특히 「태평양의 독수리」와 『(세계대전) 비행전쟁』을 살핀 연구는 전무하다는 점에서 두 작품을 통해 당대의 전쟁 인식을 살피고자 하는 시도는 의미가 있을 것으로 보인다. 안전민의 「태평양의 독수리」는 미국의 선전포고로 전쟁이 시작되어 전쟁 중의 태평양을 배경으로 하는 소설이다. 소설의 주인공 하나다는 전투기의 엘리트 파일럿으로, 홀로 미군 전투기 53기를 격추시킨 영웅이다. 미군은 일제에 비해 우월한 물자를 가지고 있지만 하나다를 비롯한 일본군의 활약으로 미군은 연패를 거듭한다. 이 과정에서 강조되는 지점이 바로 ‘대동아공영권’과 일본군의 공격 지점인 ‘산호해’이다. 일제의 대동아공영권을 염려하며 선전포고를 한 미군과 일본군이 산호해라는 명확한 공격 목표를 지니고 이를 공격한다는 소설의 내용은 「태평양의 독수리」가 대동아공영권의 선전과 전쟁에 대한 정당성 부여, 그리고 일본군의 사기 고양을 위해 창작되었음을 시사한다. 김동진의 『(세계대전) 비행전쟁』은 「태평양의 독수리」보다 이전의 작품이지만 소설의 형식을 하고 있을 뿐 전쟁 무기를 소개하는 일종의 교양서적과도 같은 내용을 담고 있다. 특히 미래의 무기를 언급하며 비행기가 미래 전쟁에서 중요한 무기가 될 것임을 강력히 주장한다. 김동진은 작품 내에서 제1차 세계대전 이후 급변하는 환경속에서 필연적으로 전쟁이 발생할 것임을 예견하고 있으며, ‘전쟁이 사라지지 않는 한 전쟁에 대한 지식이 필요’함을 말하고 있다. 이러한 사항들을 종합해보았을 때, 김동진은 미래에 발발할 전쟁에 대한 당위성을 제시하기 위해 『(세계대전) 비행전쟁』을 쓴 것으로 추측된다. This study attempted to examine Korea's first alternative historical novels, An Jeon-min's 「Eagle of the Pacific Ocean」 and Kim Dong-jin's 『(World War) Flight War』, to examine the perception of the war of the time. Japanese colonial era's scientific novels are mainly translated and translated works rather than creative novels, and few like Kim Dong-in's 「Doctor K's Research」 but pure creative science novels also exist. In particular, An Jeon-min's 「Eagle of the Pacific Ocean」 can be seen as Korea's first alternative historical novel in that it faithfully follows the narrative structure of alternative historical novels. Attempts to examine the perceptions of the war of the time through Japanese colonial era scientific discourse are still difficult to find, and there is no research on the 「Eagle of the Pacific Ocean」 and the 『(World War) Flight War』, so attempts to examine the perceptions of the war of the time through the two works are likely to be meaningful. An Jeon-min's 「Eagle of the Pacific Ocean」 is a novel set in the Pacific Ocean during the war as the war began with the declaration of war by the United States. Hanada, the protagonist of the novel, is an elite pilot of fighter jets and is a hero who shot down 53 U.S. fighters alone. The U.S. military has superior supplies compared to the Japanese, but the U.S. military continues to lose consecutive games due to the performance of the Japanese military, including Hanada. The points emphasized in this process are the “Greater East Asia Co-Prosperity Sphere” and the “Coral Sea” the Japanese military's attack point. The novel suggests that the U.S. and Japanese forces, who declared war on the Japanese colonial rule, attack it with a clear attack goal of the Coral Sea, suggests that 「Eagle of the Pacific Ocean」 was created to justify the propaganda, war, and boost the morale of the Japanese military. Kim Dong-jin's 『(World War) Flight War』 is a work earlier than 「Eagle of the Pacific Ocean」, but it only takes the form of a novel and contains a kind of liberal arts book that introduces war weapons. In particular, referring to future weapons, he strongly argues that airplanes will become important weapons in future wars. In the work, Kim Dong-jin predicts that war will inevitably occur in a rapidly changing environment after World War I, and says, “Unless war disappears, knowledge of war is necessary.” Taking these points together, it is presumed that Kim Dong-jin wrote 『(World War) Flight War』 to present the justification for the war that will break out in the future.

국내 주요 외식 및 가공식품의 비타민 K 함량 분석

김예진(Yejin Kim),김건오(Keono Kim),김급래(Keup-rae Kim),김준호(Jun Ho Kim),이동희(Donghui Lee),권시용(Siyong Kwon),이준수(Junsoo Lee),장금일(Keum-ll Jang),김병희(Byung Hee Kim),성지혜(Jeehye Sung) 한국식품영양과학회 2022 한국식품영양과학회지 Vol.51 No.1

에폭시/그래핀 옥사이드 복합재료의 전기전도도 특성

김성호(Sungho Kim),김래원(Raewon Kim),김경일(Kyeongil Kim),김세진(Sejin Kim),김수경(Sukyeong Kim),김예진(Yejin Kim),김종호(Jongho Kim),허윤강(Yungang Heo),이재영(Jaeyoung Lee),박재준(Jaejun Park) 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.11

Vitamin K Analysis in Commonly Consumed Foods in Korea

Yejin Kim,Keono Kim,Geub rae Kim,Donghui Lee,Siyong Kwon,Jeehye Sung 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

Association between body shape misperception and unhealthy eating behaviors among Korean adolescents

Kim Yejin,Kim Bomgyeol,Rajaguru Vasuki,Lee Sang Gyu,Kim Tae Hyun 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.6

BACKGROUND/OBJECTIVES: Body shape misperception (BSM) is the disagreement between the subjectively perceived body size and body mass index. This study investigated the association between BSM and unhealthy eating behaviors (UEB) among Korean adolescents. SUBJECTS/METHODS: This cross-sectional study used data from the 2019 Korea Youth Risk Behavior Web-based Survey with 55,748 participants. UEB were measured according to the weekly consumption frequency of caffeinated energy drinks, fast food, carbonated beverages, and sugar-sweetened beverages. The covariates included demographic and socioeconomic characteristics and health-related factors. Multiple logistic regression analysis determined the association between BSM and UEB. RESULTS: Among the participants, 37,607 (67.5%) reported UEB. The gap between UEB among those with BSM was the largest between the underestimated and accurately estimated groups. Participants who underestimated their body shape were likelier to engage in UEB (adjusted odds ratio [AOR], 1.18; 95% confidence interval [CI], 1.11–1.25). Both sexes with underestimation of body size showed an association with UEB compared to those with accurate estimations (girls: AOR, 1.19; 95% CI, 1.09–1.30; boys: AOR, 1.16; 95% CI, 1.08–1.26). CONCLUSIONS: Underestimating body shape can provoke UEB among Korean adolescents. The need for appropriate school health interventional programs to prevent underestimating body shape is emphasized to avoid UEB.

A bio-inspired superhydrophobic electrospun Silicon nanofiber coating for Improvement of oil Purification

Yejin Liang(LIANG YEJIN),Heechul Choi(최희철),Minbeom Kim(김민범),Eunmok Yang(양은목),Soyoung Kim(김소영) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

Practical Considerations in Providing End-of-Life Care for Dying Patients and Their Family in the Era of COVID-19

Kim, Yejin,Yoo, Shin Hye,Shin, Jeong Mi,Han, Hyoung Suk,Hong, Jinui,Kim, Hyun Jee,Choi, Wonho,Kim, Min Sun,Park, Hye Yoon,Keam, Bhumsuk Korean Society for Hospice and Palliative Care 2021 한국호스피스.완화의료학회지 Vol.24 No.2

In the era of coronavirus disease 2019 (COVID-19), social distancing and strict visitation policies at hospitals have made it difficult for medical staff to provide high-quality end-of-life (EOL) care to dying patients and their families. There are various issues related to EOL care, including psychological problems of patients and their families, difficulties in EOL decision-making, the complicated grief of the bereaved family, moral distress, and exhaustion of medical staff. In relation to these issues, we aimed to discuss practical considerations in providing high-quality EOL care in the COVID-19 pandemic. First, medical staff should discuss advance care planning as early as possible and use the parallel planning strategy. Second, medical staff should play a role in facilitating patient-family communication. Third, medical staff should actively and proactively evaluate and alleviate dying patients' symptoms using non-verbal communication. Lastly, medical staff should provide care for family members of the dying patient, who may be particularly vulnerable to post-bereavement problems in the COVID-19 era. Establishing a system of screening high-risk individuals for complicated grief and connecting them to bereavement support services might be considered. Despite the challenging and limited environment, providing EOL care is essential for patients to die with dignity in peace and for the remaining family to return to life after the loved one's death. Efforts considering the practical issues faced by all medical staff and healthcare institutions caring for dying patients should be made.

A polydiacetylene-based colorimetric chemosensor for malondialdehyde detection: a food spoilage indicator

Kim, Sangwan,Lee, Sunjong,Ahn, Yejin,Kim, Hyun Ki,Koh, Joonseok,Kim, Sung Dong,Kim, Bong-Gi The Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.33

<▼1><P>A polydiacetylene-based colorimetric sensor was devised to detect malondialdehyde as a food spoilage indicator.</P></▼1><▼2><P>A colorimetric chemosensor adopting polydiacetylene derivatives was rationally designed to detect malondialdehyde (MDA) as a potential food spoilage indicator. A newly developed diacetylene monomer containing an active methylene group effectively reacted with the aldehyde units of the MDA molecule <I>via</I> Knoevenagel-type condensation and resulted in a CC bond, judging from the results of FT-IR spectroscopy. When the monomer was incorporated into polydiacetylene liposomes, they exhibited a strong change in color from blue to red in the presence of MDA molecules, even though their sensitivity was partly affected by the feed ratio of the applied diacetylene monomers during liposome preparation. In addition, it was verified that the devised MDA chemosensor selectively responded to the divalent MDA, rather than the monovalent butanal. The detection limit of the optimized MDA chemosensor was about 250 μM in solution, but when a film-type MDA chemosensor was fabricated through the accumulation of the liposomes on top of a nylon membrane and then applied, the detection limit improved dramatically, reaching down to 10 μM at room temperature, even by judging the change in color with the naked eye. To confirm that the change of the resulting Hue angle can reflect the detection sensitivity of the MDA chemosensor under different experimental conditions, CIELAB analysis was conducted with the film-type MDA sensor. The results indicated that the Hue angle changed according to the MDA concentration, and the resulting slope can be quantitatively correlated with the sensitivity of the colorimetric detection system.</P></▼2>

Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation

Kim, Hyun-Kyung,Ham, Kyung A,Lee, Seung-Woo,Choi, Hong Seok,Kim, Hong-Sug,Kim, Hong Kyung,Shin, Hae-Sol,Seo, Kyoung Yul,Cho, Yejin,Nam, Ki Taek,Kim, In-Beom,Joe, Young Ae MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.24

<P>Peroxidasin (PXDN) is a unique peroxidase containing extracellular matrix motifs and stabilizes collagen IV networks by forming sulfilimine crosslinks. PXDN gene knockout in Caenorhabditis elegans (C. elegans) and Drosophila results in the demise at the embryonic and larval stages. PXDN mutations lead to severe eye disorders, including microphthalmia, cataract, glaucoma, and anterior segment dysgenesis in humans and mice. To investigate how PXDN loss of function affects organ development, we generated Pxdn knockout mice by deletion of exon 1 and its 5′ upstream sequences of the Pxdn gene using the CRISPR/Cas9 system. Loss of both PXDN expression and collagen IV sulfilimine cross-links was detected only in the homozygous mice, which showed completely or almost closed eyelids with small eyes, having no apparent external morphological defects in other organs. In histological analysis of eye tissues, the homozygous mice had extreme defects in eye development, including no eyeballs or drastically disorganized eye structures, whereas the heterozygous mice showed normal eye structure. Visual function tests also revealed no obvious functional abnormalities in the eyes between heterozygous mice and wild-type mice. Thus, these results suggest that PXDN activity is essential in eye development, and also indicate that a single allele of Pxdn gene is sufficient for eye-structure formation and normal visual function.</P>