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RISS 인기검색어
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- 저자 : ( Yao Cao ) (검색결과 70 건)
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Jing Yao,Xiaoming Cao,Yang Zhang,Yao Li 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.5
The purpose of this thesis is to develop a double cylinder synchronization control system to address the high precision control requirement of this system. First, the dual-input dual-output coupling mathematical model of the hydraulic press synchronization control system was built using mechanism modelling. Then, the mathematical model of compensating and decoupling links is established by the input and load disturbance decoupling control method based on feedback compensation. Next, a cross-coupled fuzzy PID controller is designed, which is then combined with full decoupling compensation method. Finally, the coupling characteristics of the synchronization control system and the synchronization control performance of the hydraulic cylinders under the cross-coupled fuzzy PID controller combined with the decoupling control algorithm were tested and evaluated in a principle experiment platform. The results indicate that the robustness and the ability to resist interference load are improved under the theory and control strategy outlined in this paper.
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Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.
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Doping effect on the adsorption of Na atom onto graphenes
Li-Hua Yao,Wen-Qiang Cao,Mao-Sheng Cao 한국물리학회 2016 Current Applied Physics Vol.16 No.5
We investigate the adsorption of Na atoms on pristine graphene and four types of defect graphenes using the first-principles calculations. The adsorption energies, electronic structures, Na storage capacities and the average potentials of Na atoms on different graphenes are calculated. The adsorption energies of Na atoms on B-doped, vacancy and B-doped vacancy graphenes are 1.93 eV, 2.46 eV, and 2.08 eV, respectively, which are much lower than that of Na on the pristine graphene (0.71 eV) and Na on Ndoped graphene (0.27 eV). The orbital hybridizations in the B-doped, vacancy and B-doped vacancy graphenes can be observed from the partial density of states, while there is no obvious orbital hybridization in the N-doped graphene as well as the pristine graphene. The B-doped vacancy graphene has the best Na storage capacity, while B-doped and vacancy graphenes also possess better Na storage capacities than those of the pristine graphene and N-doped graphene. This work demonstrates that the graphene introducing both B dopant and vacancy is expected to be a potential material for storing Na.
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Cao, Jian,He, Yuanqing,Li, Guohui,Chen, Keping,Kong, Jie,Wang, Fenghua,Shi, Jing,Yao, Qin Korean Society of Sericultural Science 2011 International Journal of Industrial Entomology Vol.22 No.2
Protein kinase C (PKC) is involved in many cellular signaling pathways, it participates in many physiological processes, such as cell cycle, growth, proliferation, differentiation and apoptosis. To investigate the effect of PKC on the silkworm midgut tissue infection of Bombyx mori parvo-like virus (BmPLV), a B. mori atypical protein kinase C (BmaPKC) gene was cloned from larval midgut tissue, expressed in E. coli and purified. Additionally, the BmPLV susceptible silkworm strain and resistant silkworm strain were used to test the effect of the B. mori infection on BmPLV. The result showed that BmaPKC encodes a predicted 586 amino acid protein, which contains a C-terminal kinase domain and an N-terminal regulatory domain. The maximum expression amount of the soluble (His)6-tagged fusion protein was detected after 0.8 mmol/L IPTG was added and cultured at $21^{\circ}C$. The (His) 6-tagged fusion protein revealed about 73 kDa molecular weight which confirmed by western blot and mass spectrography. Furthermore BmaPKC protein were detected at 0-72 h post-infection in BmPLVinfected larval midgut tissue, western blot showed that as time went on, the expression of BmaPKC increased gradually in susceptible strain, the expression quantity on 72 h is 5 times of 0 h. However, in resistant strain, the expression quantity is slightly lower than susceptible strain. But no significant change in resistant strain was observed as time went on. The available data suggest that BmaPKC may involve in the regulation of BmPLV proliferation.
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Yao Peng,Ning Yan,Jinzhen Cao 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7
Three kinds of tree bark extractives from trembling aspen (Populus tremuloides) (AE), lodgepole pine (Pinuscontorta) (LE), and western red cedar (Thuja plicata) (RE) were produced and used as antioxidants. The antioxidationactivities of those extractives were evaluated and compared with commercial antioxidant butylated hydroxytoluene (BHT). The obtained extractives were applied as natural photostabilizers to produce wood flour/polypropylene (WF/PP) compositesat an addition level of 2 wt%. The composites were subjected to QUV accelerated weathering tester for a total of 1200 h. Thechanges in surface color, surface morphology, and surface chemistry of composites were investigated during the exposure. The results showed that all bark extractives alleviated the photodegradation of composites successfully. Among them, REwas proved to be the most effective. It exhibited excellent UV absorption and similar free-radical inhibition ability comparedwith BHT. Consequently, composites containing RE exhibited less discoloration, less severe surface cracking, and lesschanges in surface chemistry during the whole weathering process. Overall, these results revealed that RE had great potentialas a natural photostabilizer in polymer systems.
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Cao Miao,Yao Qinghua 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.6
In order to measure the dispersion coefficient of glass and other transparent material rapidly and accurately, the paper studies the dispersion coefficient measurement system based on CCD imaging automatic alignment technology. On the basis of consideration of the air refractive index impacting on the measurement accuracy of dispersion coefficient, this paper rebuilds the mathematical model by the traditional dispersion coefficient measurement formula. Using the measuring angle technology of precision grating, the paper realizes the digital measurement of deflection angle of refracted ray. Sub-pixel edge detection algorithm is adopted to realize the automatic alignment of double line to single line, which has reduced artificial error of the dispersion coefficient in the measurement process. Finally, the paper combined the multichannel small collimator designed technology and the modern control technology to achieve the high precision measurement of refractive index. Demarcating the measurement system by known dispersion coefficient of optical glass, testing results and error of standard is less than ±2.3×10-6 absolutely.
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Cao Miao,Yao Qinghua 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.7
In order to measure the dispersion coefficient of glass and other transparent material rapidly and accurately, the paper studies the dispersion coefficient measurement system based on CCD imaging automatic alignment technology. On the basis of consideration of the air refractive index impacting on the measurement accuracy of dispersion coefficient, this paper rebuilds the mathematical model by the traditional dispersion coefficient measurement formula. Using the measuring angle technology of precision grating, the paper realizes the digital measurement of deflection angle of refracted ray. Sub-pixel edge detection algorithm is adopted to realize the automatic alignment of double line to single line, which has reduced artificial error of the dispersion coefficient in the measurement process. Finally, the paper combined the multichannel small collimator designed technology and the modern control technology to achieve the high precision measurement of refractive index. Demarcating the measurement system by known dispersion coefficient of optical glass, testing results and error of standard is less than ±2.3×10-6 absolutely.
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Cell-Free Massive MIMO: Zero Forcing and Conjugate Beamforming Receivers
Yao Zhang,Haotong Cao,Meng Zhou,Longxiang Yang 한국통신학회 2019 Journal of communications and networks Vol.21 No.6
In this paper, the uplink performance of cell-free massivemulti-input multi-output (mMIMO) system with the zero-forcing(ZF) and conjugate beamforming (CB) receivers is investigated. Anovel tight approximate rate expression for the ZF receiver is derived,which provides us with a tool for easily quantifying the impactsof the multi-antenna access point (AP), estimation error, pilotcontamination, and power control scheme. Then, leveraging on thetrackable ZF rate expression and the pre-studied CB rate expression,two power control algorithms are proposed. In particular, thefirst algorithm elaborates on maximizing the total rate, subjectingto the quality-of-service (QoS) constraint and each user power constraint. This algorithm utilizes the sequential convex approximationmethod to solve the non-convex issues. In addition, the secondaims at maximizing the rate of one user, in which the remainingusers can meet their QoS constraints. It can be characterized as ageometry programming. Simulation results are provided to showthat the ZF receiver is superior to the CB receiver in terms of sumrate and our proposed algorithms work well in many respects.
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