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Yingmei Wang,Shiqian Zhang,Lihui Wei,Zhongqiu Lin,Xinyu Wang,Jianliu Wang,Keqin Hua,Manhua Cu,Jiandong Wang,Shixuan Wang,Wen Di,Yudong Wang,Ruifang An,Mingrong Xi,Ruixia Guo,Qi Zhou,Xing Xie,Fengxia X 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratorysyndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk ofbeing infected with the coronavirus and are more likely to develop severe complications, ascompared to the general population. The increasing spread of COVID-19 presents challengesfor the clinical care of patients with gynecological malignancies. Concerted efforts should beput into managing gynecological malignancies in an orderly manner by strictly implementingthe measures that are specifically developed for controlling the spread of COVID-19. We havedrafted Recommendations on Management of Gynecological Malignancies during the COVID-19 Pandemicbased on our experience on controlling COVID-19 pandemic in China. We recommendthat patients with gynecological malignancies should be managed in hierarchical andindividualized manners in combination with local conditions related to COVID-19. Medicalcare decision should be balanced between controlling COVID-19 pandemic spread and timelydiagnosis and treatment for gynecologic oncology patients.
Xinyu Wang,Na Zhang,Dongyao Li,Miaoshu Wang,Chen Li,Hongtao Tian 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.11
Lactobacillus plantarum is an essential probiotic in the human gastrointestinal tract. L. plantarum BF_15, a functional probiotic isolated from the feces of breast-fed infants, has been reported in many in vitro and in vivo studies with strong gastrointestinal adaptability and outstanding anti-oxidative activities. Therefore, the whole genome of L. plantarum BF_15 was sequenced. Several genes, encoding the gastrointestinal adaptability-related proteins, were identified, including genes related to gastrointestinal environment-induced stress resistance, adhesive performance, and ability to transport and metabolize resistant starch and oligosaccharides. Genes related to alleviating oxidative stress were also found. Further functional verification was carried out by RT-qPCR on the 10 and 12 key adhesion and antioxidant genes. Overall, this study might provide a critical basis for L. plantarum BF_15 as a potential candidate for probiotics.
Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse
Xinyu Wan,Xiaomin Yang,Fan Yang,Tianyi Wang,Lixia Ding,Lili Song,Yan Miao,Xiang Wang,Yani Ma,Chengjuan Luo,Jingyan Tang,Longjun Gu,Jing Chen,Yanjing Tang,Jun Lu,Benshang Li 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3
PurposeAnti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T therapy in B-ALL patients with extramedullary relapse are rarely issued even disqualified in some clinical trials. Here, we examined the efficacy of 19CAR-T in patients with both bone marrow and extramedullary involvement.Materials and MethodsCAR-T cells were generated by transfection of primary human T lymphocytes with a lentiviral vector expressing anti-CD19 single chain antibody fragments (scFvs) with the cytoplasmic domains of 4-1BB and CD3ζ, and used to infuse patients diagnosed as having r/r B-ALL with extramedullary origination. Clinical responses were evaluated by the use of bone marrow aspiration, imaging, and flow cytometry. ResultsEight patients received 19CAR-T infusion and all attained complete remission (CR). Only one patient was bridged to hematopoietic stem cell transplantation (HSCT). Although three patients relapsed after infusion, they received 19/22CAR-T infusion sequentially and attained a second remission. To date, five patients are in continuous CR and all eight patients are still alive. The mean follow-up time was 21.9 months, while the 24-month estimated event-free survival is 51.4%. Conclusion19CAR-T therapy can lead to clinical remission for extramedullary relapsed pediatric B-ALL patients. However, the problem of CD19+ relapses after CAR-T remained to be solved. For patients relapsing after CAR-T, a second CAR-T therapy creates another opportunity for remission for subsequent HSCT.
Xylazole inhibits NO-cGMP pathway in fetal rat nerve cells
Xinyu Wang,Yue Wu,Lin Liu,Hui Bai,Zhiheng Zhang,Mingchao Zhao,Tianwen Ma,Xiaopeng Song,Lina Jia,Liangyu Lv,Yue Yu,Xinyu Xu,Hong Chen,Li Gao 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1
Background: Xylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown. Objectives: This study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl. Methods: Fetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 μg/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated. Results: Xyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity in nerve cells. These findings suggested that Xyl inhibited the NO-cGMP signaling pathway in nerve cells in vitro. Conclusions: This study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.
Xinyue Wang,Junxia Ma,Weili Xiong 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.3
In this paper, the parameter estimation of bilinear state-space systems with missing outputs is studied. The bilinear model is transformed into a linear time-varying state-space model, and Kalman smoother with a timevarying gain is adopted to estimate missing outputs and unmeasurable states. Under the expectation-maximization (EM) algorithm scheme, an iterative estimation algorithm based on Kalman smoother is derived, in which the unknown parameters, missing outputs, and unmeasurable states can be estimated simultaneously. Two simulation examples, including a numerical example and a three-tank system experiment, are adopted to verify the effectiveness of the proposed algorithm.
Backstepping Synchronous Control of Simplified Supersonic Missile
Xinyu Wang 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.12
A new kind of novel control method which is named backstepping synchronous control is firstly proposed in this paper. It is a kind of method that can applied in any general system as widely as PID control, variable structure control and any other control method. Synchronization was most frequently used in secure communication and else in the past, but here its concept was successfully used to construct a new control method. It is similar to model referenced adaptive control but it is still different from that. An auxiliary system with several virtual synchronous inputs and a real input is constructed to cope the uncertainties of original system. The synchronous inputs are designed to realize the synchronization between auxiliary system and original system. Since the real input is designed according to the auxiliary system without uncertainty by using backstepping method, so it is easy to design. Because the synchronous input is decoupling so it is easy to cope with uncertainties. In this paper, simplified supersonic missile system was taken as an example to show the design process and stability analysis of the new method. Also, it was compared with traditional PID control and backstepping control method. At last, detailed numerical simulations were done to testify the effectiveness of the proposed method.
Xinyu Qu,Junjun Qiu,Lili Jiang,Xiaorong Qi,Guonan Zhang,Weiwei Feng,Yudong Wang,Yincheng Teng,Xipeng Wang,Xiaoqing Guo,Keqin Hua 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2
Background: The impact of para-aortic lymphadenectomy (PALD) on prognosis and quality of life (QoL) for IB2-IIA2 cervical cancer patients remain controversial. And whether intraoperative frozen pathology exam on common iliac lymph nodes could help predict para-aortic lymph node (PALN) metastasis was unanswered with high-level evidence. Methods: A multi-center, randomized controlled study is intended to investigate the effect of PALD on the prognosis and QoL in cervical cancer patients and to assess the value of intraoperative frozen pathological evaluation of common iliac nodes metastasis for the prediction of PALN metastasis. After choosing whether to receive intraoperative frozen pathological examination of bilateral common iliac lymph nodes, eligible patients will be randomly assigned (1:1) to receive PALD or not. The primary end point is 2-year progression-free survival (PFS). The secondary end points include 5-year PFS, 2-year overall survival (OS), 5-year OS, adverse events (AEs) caused by PALD, AEs caused by radiotherapy and QoL. A total of 728 patients will be enrolled from 8 hospitals in China within 3-year period and followed up for 5 years.
Xinyue Zhang,Bushi Dai,Shucheng Ren,Zenan Hu,Xin Zheng,Yao Wang,Hongbin Sun,Dun Niu,Linshan Wang 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5
Due to the complexity of the contaminations in wastewater, a universal adsorbent that takes many sorts of pollutant is desired. A multi-functioning magnetic Fe3O4-cored magnesium-aluminum layered double oxide (Fe3O4@LDO) composite was prepared and employed as an adsorbent for removing F-, Sb(III) and MO from water, respectively, which are three typical contaminants with different molecule sizes as water contamination. The effect of pH contact time and initial concentrations of pollutants on the removal rates of each contaminant were investigated. Fe3O4@LDO composite showed excellent adsorption performance for all of the three molecules F-, Sb(III) and MO, and their maximum adsorption capacities are as high as 258, 391, and 506mg/g, respectively. The adsorption process of F-, Sb(III) and MO on Fe3O4@LDO fitted well to Langmuir model and pseudo-second-order kinetic model. The adsorption mechanisms of F-, Sb(III) and MO on Fe3O4@LDO were investigated. We discovered that iron ions diffused from Fe3O4 nanospheres contributed to the good performance of the absorbent.
( Wang Xinyue ) 현대영미어문학회 2023 현대영미어문학회 추계학술대회 발표논문집 Vol.2023 No.-
This paper reports the results of a study to identify the corpus-based differences between Chinese English writings and their corresponding machine translation systems, such as ChatGPT and Google Translate. We randomly selected 100 English abstracts written by Chinese scholars and machine translation systems, respectively. These abstracts are analysed using 10 text analysis measures with Coh-Metrix 3.0 in terms of lexical diversity, syntactic complexity, readability and cohesion. Data analysis revealed that, firstly, all text measures showed significant differences between human writing and ChatGPT and Google Translate translated texts, with the exception of cohesion. Secondly, the analyses revealed the discrepancy between the productions of different machine translation systems. This study contributes to a better understanding of machine translation systems and has important implications for pedagogy and assessment in this field.