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Xiao-Hui Wang,Yang Gao,Run-Dong Gao,Jing Wang,Xi-La Liu 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.3
Epoxy-coated reinforcing bars are widely used to protect the corrosion of the reinforcing bars in the RC elements under their in-service environments and external loads. In most field surveys, it was reported that the corrosion resistance of the epoxy-coated reinforcing bars is typically better than the uncoated bars. However, from the experimental tests conducted in the labs, it was reported that, under the same loads, the RC elements with epoxy-coated reinforcing bars had wider cracks than the elements reinforced with the ordinary bars. Although this conclusion may be true considering the bond reduction of the reinforcing bar due to the epoxy coating, the maximum service loads used in the experimental research may be a main reason. To answer these two phenomena, service performance of 15 RC beam specimens with uncoated and epoxy-coated reinforcements under different fatigue loads was experimentally studied. Influences of different coating thicknesses of the reinforcing bars, the fatigue load range and load upper limit as well as fatigue load cycles on the mechanical performance of RC test specimens are discussed. It is concluded that, for the test specimens subjected to the comparatively lower load range and load upper limit, adverse effect on the service performance of test specimens with thicker epoxy-coated reinforcing bars is negligible. With the increments of the coating thickness and the in-service loading level, i.e., fatigue load range, load upper limit and fatigue cycles, the adverse factor resulting from the thicker coating becomes noticeable.
Wang, Wei-Lan,Tang, Zhi-Hui,Xie, Ting-Ting,Xiao, Bing-Kun,Zhang, Xin-Yu,Guo, Dai-Hong,Wang, Dong-Xiao,Pei, Fei,Si, Hai-Yan,Zhu, Man Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: Many clinical trials have been conducted to evaluate sorafenib for the treatment of advanced NSCLC, but the results for efficacy have been inconsistent. The aim of this study was to evaluate the efficacy and safety of sorafenib in patients with advanced NSCLC in more detail by meta-analysis. Methods: This meta-analysis of randomized controlled trials (RCTs) was performed after searching PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, and the proceedings of major conferences for relevant clinical trials. Two reviewers independently assessed the quality of the trials. Outcomes analysis were disease control rate (DCR), progression- free survival (PFS), overall survival (OS) with 95% confidence intervals (CI) and major toxicity. Subgroup analysis was conducted according to sorafenib monotherapy, in combination with chemotherapy or EGFR-TKI to investigate the preferred therapy strategy. Results: Results reported from 6 RCTs involving 2, 748 patients were included in the analysis. Compared to sorafenib-free group, SBT was not associated with higher DCR (RR 1.31 (0.96- 1.79), p=0.09), PFS (HR 0.82 (0.66-1.02), p=0.07) and OS (HR 1.01 (0.92-1.12), p=0.77). In terms of subgroup results, sorafenib monotherapy was associated with significant superior DCR and longer PFS, but failed to show advantage with regard to OS. Grade 3 or greater sorafenib-related adverse events included fatigue, hypertension, diarrhea, oral mucositis, rash and HFSR. Conclusions: SBT was revealed to yield no improvement in DCR, PFS and OS. However, sorafenib as monotherapy showed some activity in NSCLC. Further evaluation may be considered in subsets of patients who may benefit from this treatment. Sorafenib combined inhibition therapy should be limited unless the choice of platinum-doublet regimen, administration sequence or identification of predictive biomarkers are considered to receive better anti-tumor activity and prevention of resistance mechanisms.
Proteomic Profiles of Mouse Neuro N2a Cells Infected with Variant Virulence of Rabies Viruses
( Wang Xiao Hu ),( Shou Feng Zhang ),( Cheng Long Sun ),( Zi Guo Yuan ),( Xian Fu Wu ),( Dong Xia Wang ),( Zhuang Ding ),( Rong Liang Hu ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.4
We characterized the proteomes of murine N2a cells following infection with three rabies virus (RV) strains, characterized by distinct virulence phenotypes (i.e., virulent BD06, fixed CVS-11, and attenuated SRV9 strains), and identified 35 changes to protein expression using twodimensional gel electrophoresis in whole-cell lysates. The annotated functions of these proteins are involved in various cytoskeletal, signal transduction, stress response, and metabolic processes. Specifically, a-enolase, prx-4, vimentin, cytokine-induced apoptosis inhibitor 1 (CIAPIN1) and prx-6 were significantly up-regulated, whereas Trx like-1 and galectin-1 were down-regulated following infection of N2a cells with all three rabies virus strains. However, comparing expressions of all 35 proteins affected between BD06-, CVS-11-, and SRV9-infected cells, specific changes in expression were also observed. The up-regulation of vimentin, CIAPIN1, prx-4, and 14-3-3 θ/δ, and downregulation of NDPK-B and HSP-1 with CVS and SRV9 infection were ≥2 times greater than with BD06. Meanwhile, Zfp12 protein, splicing factor, and arginine/serine-rich 1 were unaltered in the cells infected with BD06 and CVS- 11, but were up-regulated in the group infected with SRV9. The proteomic alterations described here may suggest that these changes to protein expression correlate with the rabies virus`` adaptability and virulence in N2a cells, and hence provides new clues as to the response of N2a host cells to rabies virus infections, and may also aid in uncovering new pathways in these cells that are involved in rabies infections. Further characterization of the functions of the affected proteins may contribute to our understanding of the mechanisms of RV infection and pathogenesis.
Wang Xiao Dong,Gleaves Michael,Meredith David,Allan Rob,Nave Colin The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.2
E-science refers to the large-scale science that will increasingly be carried out through distributed global collaborations enabled by the Internet. The Grid is a service-oriented architecture proposed to provide access to very large data collections, very large scale computing resources and remote facilities. Web services, which are server applications, enable online access to service providers. Web portal interfaces can further hide the complexity of accessing facility's services. The main use of synchrotron radiation (SR) facilities by protein crystallographers is to collect the best possible diffraction data for reasonably well defined problems. Significant effort is therefore being made throughout the world to automate SR protein crystallography facilities so scientists can achieve high throughput, even if they are not expert in all the techniques. By applying the above technologies, the e-HTPX project, a distributed computing infrastructure, was designed to help scientists remotely plan, initiate and monitor experiments for protein crystallographic structure determination. A description of both the hardware and control software is given together in this paper.
Hyperthermia Promotes Apoptosis and Suppresses Invasion in C6 Rat Glioma Cells
Wang, Dong-Chun,Zhang, Yan,Chen, Hai-Yan,Li, Xiao-Li,Qin, Li-Juan,Li, Ya-Juan,Zhang, Hong-Yi,Wang, Shuo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Gliomas are a group of heterogeneous primary central nervous system tumors. Hyperthermia has proven to be a potential therapeutic tool for cancers in the clinic. However, the molecular mechanisms of hyperthermia remain unclear. The objective of this study was to investigate the effects of hyperthermia on the invasiveness in C6 glioma cells and related molecular pathways. Here our data show hyperthermia stimulated the release of tumor necrosis factor-alpha (TNF-${\alpha}$) and decreased C6 glioma cell migration and invasive capability at 30, 60, 120 and 180 min; with increased spontaneous apoptosis in C6 glioma cells at 120 min. We also found mitogen-activated protein kinase (P38 MAPK) protein expression to be increased and nuclear factor-kappa B (NF-${\kappa}B$) protein expression decreased. Based on the results, we conclude that hyperthermia alone reduced invasion of C6 glioma cells through stimulating TNF-${\alpha}$ signaling to activate apoptosis, enhancing P38 MAPK expression and inhibiting the NF-${\kappa}B$ pathway, a first report in C6 rat glioma cells.
Xiao, Zhong-Yue,Ru, Yi,Sun, Jiang-Tao,Gao, She-Gan,Wang, Yu-Feng,Wang, Li-Dong,Feng, Xiao-Shan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Objective: To determine whether CDX2 and villin protein expression are associated with intestinal metaplasia (IM) in gastric cardiac mucosa and to explore the relationship with evolution of gastric cardiac adenocarcinoma (GCA). Methods: We studied 143 gastric cardiac biopsy or resection specimens from Henan province China, including 25 cardiac gastritis specimens with IM, 65 dysplasia specimens with IM and 35 gastric cardiac adenocarcinoma specimens and stained them for CDX2 and villin by the immunohistochemical SP method. 15 normal gastric cardiac biopsy specimens were also collected as control. Results: (1) Normal gastric mucosa presented no CDX2 and villin expression. The positive rates of CDX2 protein in cardiac gastritis with IM, dysplasia with IM, and carcinoma tissues were 84.0% (21/25), 66.7% (32/48) and 36.4% (20/55), respectively. While the positive rates of villin protein in cardiac gastritis with IM, dysplasia with IM, and carcinoma tissues were 76.0% (19/25), 70.8% (34/48) and 45.5% (25/55), respectively. There were significant differences among the three groups for both CDX2 and villin (P<0.01). Spearman's rank correlation coefficient(rho) showed a close correlation between the two proteins (r=0.843, P<0.01) and both were positively related with tumor differentiation (both P<0.05), but not associated with age, sex, invasion and metastasis of lymph node (P>0.05). Conclusion: Our results suggest that ectopic expression of CDX2 and villin may be involved in early-stage IM and tumorigenesis in gastric cardia and the expression of villin may be regulated by CDX2.