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Yi-Xiang Zhu,WEIWEI HUAN,Ling-yun Yao,Wan-Guo Yu,Ruihua Jiao,Yan-Hua Lu,Renxiang Tan 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.6
Fumigaclavine C (FC), which is produced by Aspergillus fumigatus, is a conidiation-associated ergot alkaloid with significant medical benefits. However, its application is restricted by low yields from submerged cultures. In this study, the technical feasibility of using molasses as a cost-effective ingredient for FC production in a two-stage culture of A. fumigatus was evaluated. The results indicated that molasses supplementation significantly enhanced FC accumulation by promoting conidiation and up-regulating hydroxymethylglutaryl-CoA reductase activity. Via the optimization of the two-stage process in the presence of molasses, FC production in shake flasks reached 226.9 mg/L, which was approximately three times that in the original medium (75.9 mg/L). The use of molasses as a cost-effective ingredient for FC fermentation was also successfully reproduced in a lab-scale bioreactor system in which the maximum FC production reached 215.0 mg/L. The FC production obtained in this study is the highest ever reported. This increased efficiency will enable large-scale production of FC and extend the application of molasses as a low-cost substrate for producing other conidiation-related secondary metabolites.
ADRVis : an Information Visualization Platform for Adverse Drug Reactions
Wei Jian-Xiang,Zhu Yun-Xia,Sun Jun,Xu Hou-Ming,Li Ming,Sun Yue-Hong 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.10
Adverse drug reactions (ADRs) are a serious threat to people's lives and property safety. Currently, drug instructions are the main way for people to obtain information on ADRs. Due to drugs’ limited pre-market clinical trials, adverse reactionsstated in drug instructions are often not sufficient. Avisualization platform for ADRs isput forward to address this problem. Adverse drug events (ADEs) data include actual clinical adverse reactions of drugs detected by drug monitoring administrationand can compensate for the insufficiency of drug instructions. Based on drug instructions and ADEs data, ADRVis isrealized by data analysis, model design and JAVA programming. ADRVis presentsthe relationship of 656 common drugs and their respective ADRs. Three case studies show that the platform has the capacities of visual presentation of ADRs and early warning of drug risks.The platform can provide people more rich information about drugs and help them understand ADRs more accurately and comprehensively.
Genetic Diversity for Rice Blast Management
(You Yong Zhu),(Hai Ru Chen),(Yun Yue Wang),(Zuos Hea Li),(Yan Li),(Jing Hua Fan),(Jian Bing Chen),(Jin Xiang Fan),(Shi Sheng Yang),(Guang Liang Ma),(Ling Ping Hu),(Jin Yu Zou),(Christopher C . Mundt) 한국균학회 2001 Proceedings of the Fifth Korea-China Joint Symposi Vol.- No.-
A Novel Method to Estimate the System Damping After Generator Tripping
Bin Zi-Jun,Liu Yun,Hao Si-Peng,Zhu Xin-Yao,Kong Xiang-Ping,Wang Ming-Shen 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2
Generator tripping strategies are generally decided by offline transient stability analysis. However, traditional methods can hardly ensure dynamic stability after GT. Simulation tests show that GT strategies change the topology and the state variables of a power system, which may weaken the system damping after GT. In order to estimate the system damping, this paper proposes a time-varying linearized model under unsteady states based on the virtual equilibrium point (VEP) theory. Then, the changes in dynamic characteristics caused by GT can be represented by the eigenvalues at VEPs before and after GT. An inertia equivalence system is mathematically formulated to analyze the effects of generator inertia, damping ratio, and controllers. Two indices are designed to estimate the system damping changes. Based on the indices, a framework is proposed to improve the current GT strategy decision-making system. The sensitivity analysis and the fault scanning verify the effectiveness and robustness of the proposed method and indices.
A new species of Hedysarum (Fabaceae, Hedysareae) from Xizang (Tibet), China.
최병희,Yasuhiko Endo,Xiang-yun Zhu 한국식물분류학회 2011 식물 분류학회지 Vol.41 No.3
A new species of Hedysarum (Fabaceae, Hedysareae) was found in Tibet, China. This new species, Hedysarum hirtifoliolum, belongs to sect. Hedysarum and is readily distinguishable in having greenish yellow flowers, pubescent above surface of leaflets and transversely obovate loments. So far, it is collected from only one locality in Tibet.
Lei Fang,Ran-ran Zhu,Zhen Sang,Xiao-ting Xu,Lin-yun Zheng,Yanwei Xiang,Chaoyang Guo,Zhenrui Li,Stephane Alexandre Espinosa,Qi Zhang,Chunlei Shan 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.2
Background: To meet the growing global demand for rehabilitation services, the World Health Organization (WHO) launched Rehabilitation 2030. This study was commissioned by the WHO to investigate the integration degree of traditional Chinese medicine (TCM) in Chinese health system rehabilitation services and the demand for TCM rehabilitation in China. Methods: Twenty TCM rehabilitation experts and relevant government administrators were invited to complete the questionnaire between September 2019 and January 2022. The development of traditional, complementary, and integrative medicine (TCI) rehabilitation in China was assessed primarily based on six different health system components. Results: 26 policies, regulations, and national strategic plans related to TCI rehabilitation were issued by relevant government departments since 2002; notably, 14 policies related to TCI rehabilitation development were intensively introduced from 2016 to 2021. These policies cover the three main areas of financing, infrastructure development, and service delivery. The National Administration of Traditional Chinese Medicine's investment in TCM clinical capacity infrastructure and scientific research in 2019–2021 increased by 66% compared to 2010–2012, and the average number of TCM hospitals with rehabilitation departments in 2020 increased by 6.5% compared to 2018. The proportion of community health service centers providing TCM services in primary medical and health institutions has increased by 30.8% over the past 10 years. Conclusion: Long-term continuous policies, substantial financial investment, and expansion of the scope of TCI rehabilitation services in primary care institutions have effectively contributed to the rapid development of TCI rehabilitation. However, human resources and financing mechanisms for TCI rehabilitation need further improvement.
An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.