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裵振善,睦愚均 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2
A clinical study was undertaken on the 35 cases of acalculous cholecystitis among 392 cases operated for the biliary disease during the period from. January 1980 through June 1987 admitted in the department of surgery Chungnam National University Hospital. The results obtained were as followings; 1. The incidence of acalculous cholecystitis was 8.9% and extragallbladder biliary stone 3.1% among all cholecystitis. 2. The incidence of acalculous cholecystitis was slight more prevalent in female in contrast to many reports, i. e. the ratio of male to female was 1 : 1.2. 3. In regard of the age distribution, 5th decade was most prevalent, followed by 7th, 4th, & 6th decade in order of frequency; 91.4% of all patients were older than 30 years. 4. Right upper quadrant pain (74%) was most frequent clinical symptom, followed by nausea and vomiting (57%), fever & chillness (54%), & epigastric pain (37%) in order of frequency. 5. 37% of patiients was within one week of duration of symptoms, 14% between 1∼2 weeks, & 63% of patients within 4 weeks, 6. Right upper quadrant tenderness (77%) was most frequent positive physical finding, followed by jaundice (26%), & right upper quadrant mass (20%). 7. The elevated SGPT(74%) was most frequent positive laboratory finding, followed by elevated SGOT (69%), elevated serum bilirubin above 1. 5mg% (66%), above 3.0mg% (40%), leukocytosis (37%) & elevated alkaline phosphatase (37%). 8. Ileus on simple abdomen (60%) was most frequent finding as diagnostic measures, nonvisualisation of gallbladder in oral cholecystography or cholescintigraphy (17%) ; in most cases, the findings were nonspecific, therefore it can be said that clinical findings were most important in the diagnosis of acalculous cholecystitis. 9. Preoperatively, it was diagnosed as chronic cholecystitis (37%), empyema gallbladder (11%), gallbladder stone (11%), choledocholithiasis (9%), & acalculous cholecystitis (6%). i. e. the preoperative diagnostic accuracy was very low. 10. The most frequent operation underwent was cholecystectomy with or without T-tube drainage (86%), followed by cholecytostomy (9%), & choledochojejunostomy (5. 7%). 11. Bile culture was performed in 14 cases, 79% being positive, among them E. coli was most frequent (29%), followed by Klebsiella (21%), Proteus mirabilis, Streptococcus intermidius, & Streptococcus epidermidis. 12. Regarding etiologic and predisposing factors, ascaris was found in 14% of cases, Clonorchis sinensis (9%), & common bile duct cancer (9%), gallblader cancer (9%), pancreas head cancer (6%), & unclear(37%). 13. Postoperative complications were developed in 8 cases (23%), among them wound infections were most frequent (4 cases), followed by wound dehiscence (1 case), intraabdominal abscess (1 ,case), biliary fistula (1 case), & cholangitis (1 case).
배진선,목우균 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
113 patients who were admitted and treated under the diagnosis of intestinal obstruction in the department of surgery, Chungnam National University Hospital from 1985. 3. 1. to 1987. 12. 31. , are analyzed, The results are as followings: 1) The sex ratio of male to female was 2 : 1. 2) As to the age distribution, 1st decade was most prevalent (43%), followed by 6th decade (14%), 3rd decade(12%), & 5th decade(12%). 3) 6% of patients was treated previously due to intestinal obstruction. 4) Most frequent symptoms were abdominal pain, vomiting, & abdominal distention. 5) Most frequent physical signs were abdominal distention, abdominal tenderness, followed by hyperperistalsis. 6) The most frequent cause of ileus was postoperative adhesion (50%), followed by intussusception(39%), & cancer(6%). 7) As to the method of treatment, 2/3 of patients with intestinal adhesion were successfully treated with tube decompression, and 2/3 of patients with intussusception with barium enema. 8) As to the method of operation, adhesiolysis was carried out in 40% of patients, and segm ental resection and anastomosis in 36% of patients. 9) Among the patients who had response to nasogastric or nasointestinal tube decompression, 80% of patients was improved within 48 hours, and 96% of patients within 72 hours. 10) Postoperation complications were occured in 24% of patients, such as pleural effusion, enterocutaneous fistula, paralytic ileus, & pneumonia.
A case of malignant otitis externa caused by Candida glabrata in a patient receiving haemodialysis
Bae, Woo Kyun,Lee, Kyun Sang,Park, Jeong Woo,Bae, Eun Hui,Kwon, Seong,Kim, Nam Ho,Choi, Ki Chul,Shin, Jong Hee,Cho, Hyong Ho,Cho, Yong Bum,Kim, Soo Wan Informa Healthcare 2007 Scandinavian journal of infectious diseases Vol.39 No.4
<P> A 74-y-old male receiving haemodialysis presented with right-sided otalgia, otorrhoea and diffuse swelling on the right external auditory canal. Following an initial successful treatment with prolonged intravenous antibiotics, the patient relapsed with a secondary infection in the same site due to Candida glabrata. We report an unusual case of malignant otitis externa caused by the fungus C. glabrata.</P>
Bae, Woo Kyun,Lee, Ji Hee,Lee, Sang Joon,Park, Myong Suk,Hwang, Jun Eul,Shim, Hyun Jeong,Cho, Sang Hee,Guo, Ding-Ding,Cho, Chong-Su,Park, In-Kyu,Chung, Ik Joo American Scientific Publishers 2011 Journal of nanoscience and nanotechnology Vol.11 No.2
<P>Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer.</P>
Woo Kyun Bae,JongUn Lee,Jeong Woo Park,Eun Hui Bae,Seong Kwon Ma,Suhn Hee Kim,Soo Wan Kim 대한생리학회-대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.6
The present study was aimed to determine whether there is an altered regulation of tubular transporters in gentamicin-induced nephropathy. Sprague-Dawley male rats (200∼250 g) were subcutaneously injected with gentamicin (100 mg/kg per day) for 7 days, and the expression of tubular transporters was determined by immunoblotting and immunohistochemistry. The mRNA and protein expression of OAT was also determined. Gentamicin-treated rats exhibited significantly decreased creatinine clearance along with increased plasma creatinine levels. Accordingly, the fractional excretion of sodium increased. Urine volume was increased, while urine osmolality and free water reabsorption were decreased. Immunoblotting and immunohistochemistry revealed decreased expression of Na<sup>+</sup>/K<sup>+</sup>-ATPase, NHE3, NBC1, and AQP1 in the kidney of gentamicin-treated rats. The expression of OAT1 and OAT3 was also decreased. Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of Na<sup>+</sup>/K<sup>+</sup>-ATPase, NHE3, NBC1, AQP1 and OAT.
Decreased Expression of Na+/K+-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy
Woo Kyun Bae,이종운,박정우,배은희,마성권,김선희,김수완 대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.6
The present study was aimed to determine whether there is an altered regulation of tubular transporters in gentamicin-induced nephropathy. Sprague-Dawley male rats (200∼250 g) were subcutaneously injected with gentamicin (100 mg/kg per day) for 7 days, and the expression of tubular transporters was determined by immunoblotting and immunohistochemistry. The mRNA and protein expression of OAT was also determined. Gentamicin-treated rats exhibited significantly decreased creatinine clearance along with increased plasma creatinine levels. Accordingly, the fractional excretion of sodium increased. Urine volume was increased, while urine osmolality and free water reabsorption were decreased. Immunoblotting and immunohistochemistry revealed decreased expression of Na+/K+-ATPase, NHE3, NBC1, and AQP1 in the kidney of gentamicin-treated rats. The expression of OAT1 and OAT3 was also decreased. Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of Na+/K+-ATPase, NHE3, NBC1, AQP1 and OAT.
Continuous renal replacement therapy for the treatment of acute kidney injury
( Woo Kyun Bae ),( Dae Hun Lim ),( Ji Min Jeong ),( Hae Young Jung ),( Seong Ku Kim ),( Jeong Woo Park ),( Eun Hui Bae ),( Seong Kwon Ma ),( Soo Wan Kim ),( Nam Ho Kim ),( Ki Chul Choi ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.2
Background/Aims: Continuous renal replacement therapy (CRRT) has been widely used for treating critically ill patients with acute kidney injury (AKI). Whether CRRT is better than intermittent hemodialysis for the treatment of AKI remains controversial. We sought to identify the clinical features that can predict survival for the patients who are treated with CRRT. Methods: We analyzed the data of 125 patients who received CRRT between 2005 and 2007. We identified the demographic variables, the underlying diagnoses, the duration of CRRT, the mean arterial blood pressure (ABP) and the Simplified Acute Physiology Score (SAPS) II. The classification/staging system for acute kidney injury (AKI) was applied to all the patients, who were then divided into stage 1-3 subgroups. Results: The average age of the patients was 61.414.3 years and the mortality rate was 60% (75 of 125 patients). The survivors had a significantly higher mean ABP and a higher mean serum bicarbonate level, which were measured the day after CRRT, than the nonsurvivors (86.723.7 vs. 69.224.6 mm Hg, respectively, 21.43.5 vs. 16.45.4 mmol/L, respectively,; p<0.05 for each). The stage 3 AKI patients showed the worst parameters for the SAPS II score and the serum levels of creatinine and blood urea nitrogen. The mortality rate was higher for the stage 3 subgroup than the other groups (70.5%, p<0.05). Conclusions: The patients with AKI and who require CRRT continue to have a high mortality rate. A higher mean ABP and a higher serum bicarbonate level measured the day after CRRT may predict a more favorable prognosis. The staging system for AKI can improve the ability to predict the outcomes of CRRT patients.
Bae, Woo-Kyun,Lee, Jong-Un,Park, Jeong-Woo,Bae, Eun-Hui,Ma, Seong-Kwon,Kim, Suhn-Hee,Kim, Soo-Wan The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.6
The present study was aimed to determine whether there is an altered regulation of tubular transporters in gentamicin-induced nephropathy. Sprague-Dawley male rats ($200{\sim}250\;g$) were subcutaneously injected with gentamicin (100 mg/kg per day) for 7 days, and the expression of tubular transporters was determined by immunoblotting and immunohistochemistry. The mRNA and protein expression of OAT was also determined. Gentamicin-treated rats exhibited significantly decreased creatinine clearance along with increased plasma creatinine levels. Accordingly, the fractional excretion of sodium increased. Urine volume was increased, while urine osmolality and free water reabsorption were decreased. Immunoblotting and immunohistochemistry revealed decreased expression of $Na^+/K^+$-ATPase, NHE3, NBC1, and AQP1 in the kidney of gentamicin-treated rats. The expression of OAT1 and OAT3 was also decreased. Gentamicin-induced nephropathy may at least in part be causally related with a decreased expression of $Na^+/K^+$-ATPase, NHE3, NBC1, AQP1 and OAT.