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Kim, Woo Kyum,Wu, Chaoxing,Lee, Dea Uk,Kim, Hyoun Woo,Kim, Tae Whan Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.429 No.-
<P><B>Abstract</B></P> <P>Current-voltage (I–V) curves for the Al/polymer (9-vinylcarbazole) (PVK)/graphene oxide (GO):mica/PVK/indium-tin oxide (ITO) devices at 300K showed a current bistability with a maximum high conductivity (ON)/low conductivity (OFF) ratio of 2×10<SUP>4</SUP>, which was approximately 10 times larger than that of the device without a PVK layer. The endurance number of ON/OFF switchings for the Al/PVK/GO:mica/PVK/ITO device was 1×10<SUP>2</SUP> cycles, which was 20 times larger than that for the Al/GO:mica/ITO device. The “erase” voltages were distributed between 2.3 and 3V, and the “write” voltages were distributed between −1.2 and −0.5V. The retention time for the Al/PVK/GO:mica/PVK/ITO device was above 1×10<SUP>4</SUP> s, indicative of the memory stability of the device. The carrier transport mechanisms occurring in the Al/PVK/GO:mica/PVK/ITO and the Al/GO:mica/ITO devices are described on the basis of the I–V results and the energy band diagrams.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Organic bistable devices based on graphene oxide (GO):mica nanocomposites embedded in polymer (9-vinylcarbazole) (PVK) layers were fabricated. </LI> <LI> Maximum ON/OFF ratio of the current bistability for the devices with PVK buffers was 2×10<SUP>4</SUP>. </LI> <LI> Endurance number of ON/OFF switchings was more than dozens of cycles. </LI> <LI> The “erase” voltages were distributed between 2.3 and 3V, and the “write” voltages were distributed between −1.2 and −0.5V. </LI> <LI> Retention time for the device was above 1.2×10<SUP>4</SUP> s, indicative of the memory stability of the device. </LI> </UL> </P>
Kim, Jeong Lan,Park, Joon Hyuk,Kim, Bong Jo,Kim, Moon Doo,Kim, Shin-Kyum,Chi, Yeon Kyung,Kim, Tae Hui,Moon, Seok Woo,Park, Moon Ho,Bae, Jae Nam,Woo, Jong Inn,Ryu, Seung-Ho,Yoon, Jong Chul,Lee, Nam-Jin Cambridge University Press 2012 INTERNATIONAL PSYCHOGERIATRICS - Vol.24 No.4
<B>ABSTRACT</B><P>Background: The influences of demographics, culture, language, and environmental changes on Mini-Mental State Examination (MMSE) scores are considerable.</P><P>Methods: Using a sample of 7452 healthy, community-dwelling elderly Koreans, aged 55 to 94 years, who participated in the four ongoing geriatric cohorts in Korea, we investigated demographic influences on MMSE scores and derived normative data for this population. Geropsychiatrists strictly excluded subjects with cognitive disorders according to the protocol of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K) Clinical Assessment Battery (CERAD-K-C).</P><P>Results: Education (standardized <I>β</I> = 0.463), age (standardized <I>β</I> = −0.303), and gender (standardized <I>β</I> = −0.057) had significant effects on MMSE scores (p < 0.001). The score of MMSE increase 0.379 point per 1-year education, decrease 0.188 per 1-year older, and decrease 0.491 in women compared to men. Education explained 30.4% of the scores’ total variance, which was much larger than the variances explained by age (8.4%) or gender (0.3%). Accordingly, we present normative data for the MMSE stratified by education (0, 1-3, 4-6, 7-9, 10-12, and ≥ 13 years), age (60-69, 70-79, and 80-89 years), and gender.</P><P>Conclusions: We provide contemporary education-, age-, and gender-stratified norms for the MMSE, derived from a large, community-dwelling elderly Korean population sample, which could be useful in evaluating individual MMSE scores.</P>
Unrecorded prokaryotic species belonging to the class Actinobacteria in Korea
Kim, Mi-Sun,Jeong, Seong-Hwa,Kang, Joo-Won,Kim, Seung-Bum,Cho, Jang-Cheon,Cha, Chang-Jun,Im, Wan-Taek,Bae, Jin-Woo,Lee, Soon-Dong,Kim, Won-Yong,Kim, Myung-Kyum,Seong, Chi-Nam The National Institute of Biological Resources 2019 Journal of species research Vol.8 No.1
For the collection of indigenous prokaryotic species in Korea, 35 strains within the class Actinobacteria were isolated from various environmental samples (animals and clinical specimens) in 2017. Each strain showed high 16S rRNA gene sequence similarity (>98.8%) and formed a robust clade with recognized actinobacterial species. The isolates were assigned to 35 species, 22 genera, 15 families, and 8 orders of the class Actinobacteria. There are no official descriptions of these 35 bacterial species in Korea. Morphological properties, basic biochemical characteristics, isolation source, and strain IDs are included in the species descriptions.
Kim, Jong-Choon,Shin, Dong-Ho,Kim, Sung-Ho,Bae, Chun-Sik,Kim, Joon-Kyum,Cha, Shin-Woo,Han, Jung-Hee,Lee, Hyun-Sook,Chung, Moon-Koo Korean Society of ToxicologyKorea Environmental Mu 2004 Toxicological Research Vol.20 No.1
The present study was carried out to investigate the potential adverse effects of CKD-602 by a 5-day repeated intravenous dose in Sprague-Dawley rats. The test article, CKD-602, was administered intravenously to male and female rats at dose levels of 0.07, 0.22, 0.67, 2.0 and 6.0 mg/kg/day for 5 days consecutively. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period after cessation of the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. There were 2 and 5 treatment related deaths in the 0.67 and 2.0 mg/kg/day dose groups of both genders, respectively. Treatment related clinical signs, including hair loss, skin paleness, decreased locomotor activity, emaciation, and changes in stool were observed in a dose-dependent manner from the third day after initiation of the injection. Decrease or suppression of body weight was also observed dose-dependently in males and females of the treated groups. Gross postmortem examinations revealed a dose-dependent increase in the incidence and severity of atrophy or hypertrophy and white membrane formation in the spleen, atrophy of the thymus, diffuse white spots and paleness of the liver, paleness of the lung, kidney and adrenal gland, and dark red discoloration and dark red contents in the alimentary tract. Based on these results, it was concluded that the 5-repeated intravenous injection of CKD-602 to male and female rats resulted in increased incidence of abnormal clinical signs and death, decreased or suppressed body weight, and increased incidence of abnormal gross findings. In the present experimental conditions, the $LD_{50}$ value was 2.07 (95% confidence limit not specified) mg/kg/day in both genders and the $LD_{10}$ value was 1.72 (95% confidence limit not specified) mg/kg/day in both genders.
History, Classes and Mechanism of MonocIonal Antibodies as Cancer Therapeutics
Woo-Hyuck Choi and Sang Kyum Kim 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-
Monoclonal antibodies (mAbs) for use as therapeutics for various diseases, especially cancer, have been extensively investigated and developed in recent decades. Since the first appearance of murine mAbs which are of fulIy murine structure, several antibody formats such as chimeric, humanized, and ones comprising fully human structure have been presented consecutively. These advances were mainly stemmed from the efforts to mitigate the immunogenic potential of this category of drug. Owing to their long half-life and versatility in ef-fecter functions, IgG1 is most frequently selected for the backbone of therapeutic mAbs. Among the various ef-feclor functions by which IgG exert their designated role as therapeutics, antibody-dependent cellular cytotoxicity is commonly utilized to take care of tumorigenesis by virtue of its effectiveness in killing cancer cells‘ Recently, approaches to strengthen power of native rnAbs have been developed, which include conjugation of antibody with various effector molecules and antibodies armed with moieties targeting more than one epitopes. Several mole-cules specifically overexpressed in tumorigenic state, such as ErbB family proteins, VEGF, cytotoxic T Iympho-cyte-associated antigen 4, CD20, have been targeted by various successful therapeutic rnAbs. While mAbs have lots of advantages compared to small molecules as therapeutics, they are readily immunogenic which lead them to lose activity or induce hypersensitivity reactions. With several novel formats or modifications other than original immunoglobulin structure, mAbs are still evolving and expanding their roles as anti-cancer therapeutics
Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L.
Kim, Mi-Ran,Lee, Jeong Yong,Lee, Hyang-Hee,Aryal, Dipendra Kuma,Kim, Yoon Gyoon,Kim, Sang Kyum,Woo, Eun-Rhan,Kang, Keon Wook 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
A bioassay-guided fractionation of the ethylacetate soluble fraction from the flower buds of Tussilago farfara L. (Compositae) yielded two flavonoids, quercetin 3-O-β-L-arabinopyranoside and quercetin 3-O-β-D-glucopyranoside. These two sugar conjugates of quercetin exhibited higher antioxidative activity than their aglycone, quercetin by NBT superoxide scavenging assay. Moreover, treatment with quercetin 3-O-β-L-arabinopyranoside significantly increased the total glutathione (GSH) contents and the protein level of γ-glutarnylcysteine ligase (γ-GCL), a key enzyme required for glutathione (GSH) synthesis in a rat hepatocyte cell line. Subcellular fractionation and reporter gene analysis using antioxidant response element (ARE) construct revealed that quercetin 3-O-β-L-arabinopyranoside increased the level of nuclear Nrf2 and reporter activity, and that these were associated with the induction of the γ-GCL gene. After 24 h incubation of cells with quercetin 3-O-β-L-arabinopyranoside, 23% of the glycoside was converted to its aglycone, quercetin, but γ-GCL was not induced by 7 μM (23%) quercetin. These results suggest that the two quercetin-glycosides isolated from T. farfara L. have direct antioxidative properties, and that quercetin 3-O-β-L-arabinopyranoside increases the cellular GSH level by inducing the γ-GCL gene. These novel effects of quercetin-glycosides are suggestive to underlie the potential putative chemopreventive effects of T.farfara L.
Inhibition of the Induction of Nitric Oxide Synthase by Kobusin
Kim, Sang-Kyum,Pokharel, Yuba-Raj,Kim, Ok,Woo, Eun-Rhan,Kang, Keon-Wook Korean Society of ToxicologyKorea Environmental Mu 2007 Toxicological Research Vol.23 No.2
We isolated a lignan, kobusin from Geranium thunbergii and studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in a monocyte/macrophage cell line, RAW264.7 cells. Kobusin inhibited lipopolysaccharide (LPS)-stimulated NO production and the expression of iNOS in a concentration-dependent manner. To identify the mechanistic basis for its inhibition of iNOS induction, we examined the effect of kobusin on both the luciferase reporter activity using $NF-{\kappa}B$ minimal promoter and the nuclear translocation of p65. Kobusin suppressed the reporter gene activity and the LPS-induced movement of p65 in to nucleus. $NF-{\kappa}B$ activation is controlled by the phosphorylation and subsequent degradation of $I-{\kappa}B{\alpha}$, and in the present study, we found that $I-{\kappa}B{\alpha}$ phosphorylation was also inhibited by kobusin. Our findings indicate that kobusin may provide a developmental basis for an agent against inflammatory diseases.