혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

韓國과 中國의 林産物 國際競爭力

張哲洙,張宇煥,鄭靖吉 한국산림경제학회 2002 산림경제연구 Vol.10 No.2

WTO 출범으로 세계 경제가 무역자유화를 통한 하나의 시장으로 빠르게 통합되고 있다. 특히 중국의 WTO가입은 세계무역뿐만 아니라 우리나라 임산업에도 크게 영향을 미칠 것으로 예상된다. 이러한 세계적 조류속에서 우리나라 임산업이 발전하기 위해선 경쟁력을 높여 나가는 것 외에는 대안이 없다. 여기에서는 우리나라 주요 수출임산물을 대상으로 한ㆍ중 임산물이 세계시장에서 갖는 국제 경쟁력, 상대국 또는 제3국에 대한 수출의존도, 상대국 또는 제3국 시장에서 보여주고 있는 상대적인 경쟁력, 그리고 각 국의 수입의존도 등을 비교 검토해 봄으로서 향후 우리나라 임산물의 대중국뿐만 아니라 제3국 시장으로의 수출확대를 위한 대응방안 마련에 기초자료를 제시하고자 하였다. With the launch of WTO, we can no longer think of our domestic interests and policies without reference to the wider global context. In particular, since China occuies important position in the world agriculture, forest industry, and trade, it is expected that China's joining to the WTO will substantially influence the world trade and forest industry in Korea. One alternative is to strengthen the international competition of our forest products for the development of our forest industry. In this context, the purposes of this paper are laid at the analysis on the international comparatives of some forest products in Korea and China, on the basis of Revealed Comparative Advantage Index(RCA), Exporting Dependent on a particular Country, Comparative Advantage by Countries (CAC), Market Share(MS), etc. This paper also suggests ways to strengthen the international competition of our forest producs in the market of China and Japan.

新農村建設(定住生活圈開發)을 위한 理論的 考察 및 開發需要調査

金鴻允,李弘柱,鄭禮杓,全禹亭,趙興洙,李信昊,全榮吉 안성산업대학교 1992 論文集 Vol.24 No.-

Rural of Koreas has rapidly changed through the process of industrialization and urbanization. During past 30 years, development differences between urban and rural, metroplitan area and area derived from a highly economic growth, bring about dual specialization that deepens overpopulation and sparsity. Therefore, with a new concern about rural, necessity of rural development policy that developes a settlement and life area for settlement for ensuing stablized settlement and living activity of rural people, has been drived step by step. For rural welfare establishment that is settled and good hereafter, this study aims at attempting a theoretical approach about the way of development for rural settlement as a new rural development strategy through examination of today's rural reality, under assumption that rural people must be able to obtain stable jobs and to be pleasant without leaving rural area, and rural settlement to be able to enjoy urban advantages must be realized. Therefore, items that must be obtained basically rural area to be a human settlement space are equipment connected with a dwelling house, production, consumption, job relaxation, infrastructure connected with transportation or communication network and environment. By the way, the best function of a human settlement space makes a basic pleasant settlement area to be in the middle of that. Then rationalization of land use must be realized as being a best condition for human life around space of a dewelling house. Besides, spacial accessibility about all equipment of inhabitants must be easy. That is, economic distance, social distance and cultural distance as well as spacial distance must be included. Also, those spacial functions must be realized on a basis of suitable enironment for a human settlement life. At the same tiem, the upper area must be connected with the lower area as the system of spacial settlement in settlement space. But truely, as rural people can't satisfy with services of the surrounding rural areas, they desire better city or metroplitan. The these problems bring about inequality between urban and rural. Therefore, here are urgent reasons that must be done rearing of rural central town and rural integrated development of unit area. So, these dys, to correct maldistribution of land use and inequality of settlement space that Korean society faces on, new strategies of rural integrated development for lift area for settlement than gives the meaning. That rural areas become like a place for human settlement life will be able to be chosen in the view of humanism. The say of thinking of rural residents(Jukans-myun, Anseong-gun, Kyeonggi-do) was surveyed in order to develop new rural settlement planning. From the data collected in this survey, rural life-style, view on traditional rural life, agriculture, farming, agri-policy, social attitude, and degree of satifaction of rural life, etc, were analyzed. Firstly, most of rural residents interviewed in this survey have the opinion of not leaving their home village if living conditions improved to a reasonable level in the near future. In decision-making process of village affairs, they want to participate actively and equally. Secondly, in spite of their acceptance of agriculture as a vital sector destined to national security, most of them think that framing should be little of promise. Thirdly, they have the negative attitude to urban-oriented social valued and also to the agricultural policy, while seeking consolation through human and traditional viewing of rural life style. Therefore, in the development of new rural settlement model, idea-making should be directed to the betterment of communal value of village life, stability of rural economy, rationalization of rural life style and enhancement of rural-type happiness.

퉁퉁마디로부터 염에 의하여 유도되는 Aldolase 유전자의 분리 및 발현분석

차준영,네티 엘마와티,김순길,이증주,임채오,정우식,이곤호,손대영 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Soil salinity is one of the most serious abiotic stresses limiting the productivity of agricultural crops. To cope with salt stress, plants respond with physiological, developmental and biochemical changes, including the synthesis of a number of proteins and the induction of gene expression. Salicornia herbacea is a halophytic plant that grows in salt marches and on muddy seashores. In order to understand the biochemical and molecular mechanisms of salt tolerance in S. herbacea, we isolated several genes that involved in the salt tolerance by mRNA differential display.Here we report the cloning of a cDNA encoding fructose-1, 6-bisphosphate aldolase, named ShADL, which is 1293 bp long and contains an open reading frame consisted of 359 amino acids with calculated molecular mass of 39 kDa. ShADL protein showed 86% identity with Arabidopsis and 78% with aldolase of common ice plant. Northern blot analysis revealed that the transcript of ShADL gene was increased dramatically depending on the NaCI concentrations.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.

소아에서 발생한 랑게르한스세포 조직구증 - 6예의 임상 및 병리조직학적 고찰 -

정한길(Han Gil Chung),김동건(Dong Kun Kim),정예리(Yae Lee Chung),양우익(Woo Ick Yang) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2

N/A Background:Langerhans cell histiocytosis (LCH) is a broad spectrum of clinical diseases having proliferation of Langerhans cells in common. LCH may be manifested in a variety of ways, ranging from a spontaneously regressing skin lesion to a multisystemic life-threatening disorder. Congenital self-healing reticulohistiocytosis is widely regarded as a limited form of LCH. It is present at birth or shortly thereafter and involute spontaneously. Objective:Our purpose was to investigate the relationship between clinicopathologic characteristics and prognosis of LCH in children. Methods:Six children with LCH were investigated clinically and histopathologically. Immunostains were performed with CD1a and S100 antibodies in 5 cases using paraffin-embedded sections and an electron microscopic examination was done in 1 case. Results:Among the 6 cases of LCH, 4 cases were confined to the skin, and 2 cases showed internal organ involvement. All LCH confined to the skin showed resolution of the skin lesion in 1 year, and 2 cases involving internal organ showed bad prognosis. Histopathological findings showed large histiocytes with eosinophilic cytoplasm in common. Immunohistochemical stains (5 cases) showed positive reactions with CD1a and S-100, and electron- microscopical observation in one case demonstrated laminated dense bodies. There was no significant histopathological or immunohistochemical difference between LCH confined to the skin which showed resolution of lesions and LCH involving internal organs with grave prognosis. Conclusions:Clinical types of Langerhans cell histiocytosis could not be differentiated only from (Korean J Dermatol 2000;38(2):191~197)

백서의 말초 신경병증성 통증모델에서 Capsaicin에 의한 역방향성 임펄스의 차단이 기계적 이질통의 발현에 미치는 영향

신진우 ( Jin Woo Shin ),함경돈 ( Kyung Don Hahm ),임중우 ( Joong Woo Leem ),박철호 ( Chul Hoo Park ),구승우 ( Seung Woo Ku ),최윤 ( Yoon Choi ),임정길 ( Jung Gil Leem ),이청 ( Chung Lee ) 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.1

4기통 커먼레일 DME 엔진의 분사조건 보정방법에 대한 연구

정재우(Jae-woo Chung),강정호(Jung-ho Kang),김남호(Nam-ho Kim),정수진(Soo-Jin Jeong),이호길(Ho-gil Lee),강우(Woo Kang) 한국자동차공학회 2008 한국 자동차공학회논문집 Vol.16 No.5

사마귀양 육아종의 임상양상을 보인 피부 효모균증 1예

정우길,박준수,박윤기,이광훈 대한의진균학회 2002 대한의진균학회지 Vol.7 No.1

We report a case of cutaneous cryptococcosis resembling verrucous granuloma on the lower lip in a 18-year-old temale. She presented with a 3×1.5 ㎝ sized painful verrucous granuloma with white, yellowish crust on the lower lip for 1 year. She had gotten many shunt operations for unexplained hydrocephalus. Histopathological examination showed numerous encapsulated round spores, epithelioid cells and giant cells in the dermis. A tissue culture on Sabouraud's dextrose agar without cycloheximide showed whitish creamy colonies. The organism was identified as Cryptococcus neoformans. The lesion disappeared with the treatment of oral itraconazole (100㎎/day) for 12 weeks. [Kor J Med Mycol 7(1): 42-46]

신경교종에서의 p53, MDM2 단백질 발현과 세포증식능

정동섭,박영섭,허필우,김문찬,이길송,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.1

In gliomas, the most frequently studied tumor suppressor gene is the p53 gene which has been found to be mutated in a considerable fraction of astrocytomas and glioblastomas. Mutations that alter the function of the p53 gene product are thought to play a critical role in glial tumorigenesis. The murine double minute 2(MDM2) gene has been shown to code for a cellular protein that forms a complex with the p53 tumor suppressor gene product and inhibits its function. The fact that MOM2 can negatively regulate p53 suggests MDM2 could function as an oncogene when overexpressed. We investigated the expression of p53. MDM2 and proliferative activity of the tumor cells in 71 cases of gliomas(17 cases of differentiated astrocytomas, 25 cases of anaplastic astrocytomas and 29 cases of glioblastomas). Their paraffin-em-bedded tissue sections were immunostained with monoclonal antibody(p53 and PCNA, proliferating cell nuclear antigen) and polyclonal antibody(MDM2) for detection of p53, MOM2 and PCNA respectively. The results were as follows : The p53 staining was positive in 28 cases(39.4%) and MDH2 staining in 5 cases(7.0%) of 71 gliomas. The p53 positive-staining was detected in 2 cases(11.8%) of 17 differentiated astrocytomas. 9 cases(36.0%) of 25 a-naplastic astrocytomas and 17 cases(58.6%) of 29 glioblastomas. The p53 expression was associated with malignancy grade(P<0.005) and proliferative activity was strongly associated with malignancy grade(P=0.0001). The p53 expression was closely associated with proliferative activity : p53-positive tumors had significantly higher median PCNA-labeling index than p53-negative tumors(40.6±10.1% versus 19.6±15.0%)(P=0.0001). But, MDM2 expression was not associated with proliferative activity(P=0.4575). The proportion of p53 immunoreactivity had significant association with proliferative activity : the more the proportion of p53 immunoreactivity increased, the higher PCNA-labeling index elevated(P=0.0001). None of the tumors with MDM2 expression showed immunoreactivity for p53. These results suggest that the mutation of p53 gene plays a critical role in malignant transformation in glioma and it could be the prognostic factor for histologically same grade gliomas, and that a subset of human gliomas escapes from p53-re-gulated growth control by amplification and overexpression of MDM2. Therefore, gene study targeting these genes may be useful for the management of human glioma as a diagnostic modality.