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Hyo Jeong Kim1,2,Jun Hyuek Yang,Hyun Soo Kim,Yeo Jin Kim,Wonhee Jang,Young Rok Seo,W. Jang,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1
I ntensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.
The compilation of Inventory of National Biological Resources with 111 Alert Alien Species in Korea
Soen-Yi Kim,Jin-Whoa Yum,Neung-Ho Ahn,Hye-Woo Byun,Mi-Jeong Jeon,Sung-Hee Jung,Hyun-Ki Choi,Youn-Bong Ku,Eun-Joo Woo,Min-Ha Kim,Wonhee Kim,Byung-Jik Kim,Hwa-Jung Kim,Min-Seock Do,Chang-Mu Kim 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.04
Kim, Sung Min,Choi, Jung Eun,Hur, Wonhee,Kim, Jung‐,Hee,Hong, Sung Woo,Lee, Eun Byul,Lee, Joon Ho,Li, Tian Zhu,Sung, Pil Soo,Yoon, Seung Kew John Wiley and Sons Inc. 2017 Journal of cellular biochemistry Vol.118 No.8
<P><B>ABSTRACT</B></P><P>The epithelial‐mesenchymal transition (EMT) is involved in many different types of cellular behavior, including liver fibrosis. In this report, we studied a novel function of RAR‐related orphan receptor gamma (ROR‐γ) in hepatocyte EMT during liver fibrosis. To induce EMT in vitro, primary hepatocytes and FL83B cells were treated with TGF‐β1. Expression of ROR‐γ was analyzed by Western blot in the fibrotic mouse livers and human livers with cirrhosis. To verify the role of ROR‐γ in hepatocyte EMT, we silenced ROR‐γ in FL83B cells using a lentiviral short hairpin RNA (shRNA) vector. The therapeutic effect of ROR‐γ silencing was investigated in a mouse model of TAA‐induced fibrosis by hydrodynamic injection of plasmids. ROR‐γ expression was elevated in hepatocyte cells treated with TGF‐β1, and ROR‐γ protein levels were elevated in the fibrotic mouse livers and human livers with cirrhosis. Knockdown of ROR‐γ resulted in the attenuation of TGF‐β1‐induced EMT in hepatocytes. Strikingly, ROR‐γ bound to ROR‐specific DNA response elements (ROREs) in the promoter region of TGF‐β type I receptor (Tgfbr1) and Smad2, resulting in the downregulation of Tgfbr1 and Smad2 after silencing of ROR‐γ. Therapeutic delivery of shRNA against ROR‐γ attenuated hepatocyte EMT and ameliorated liver fibrosis in a mouse model of TAA‐induced liver fibrosis. Overall, our results suggest that ROR‐γ regulates TGF‐β‐induced EMT in hepatocytes during liver fibrosis. We suggest that ROR‐γ may become a potential therapeutic target in treating liver fibrosis. J. Cell. Biochem. 118: 2026–2036, 2017. © 2016 The Authors. <I>Journal of Cellular Biochemistry</I> Published by Wiley Periodicals Inc.</P>
Microstepping with PI Feedback and Feedforward for Permanent Magnet Stepper Motors
Wonhee Kim,Induk Choi,Chung Choo Chung 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
In this paper, the stability of microstepping is investigated via Lyapunov method. Microstepping with proportional integral (PI) feedback and feedforward is proposed for the position tracking of a Permanent Magnet (PM) stepper motor. Given static inputs to the two phase PM stepper motor, it is proven that the stability of equilibrium points is guaranteed by LaSalle’s theorem. For position tracking, the relationships between the voltage input and current output of each phase for the position tracking are derived. From the relationships, microstepping with PI feedback and feedforward is developed for the position tracking. Experimental result shows that the position tracking performance of the proposed controller is improved compared to conventional microstepping.
Kim, Hyeongtae,Kim, Wonhee,Kang, Gu Hyun,Jang, Yong Soo,Choi, Hyun Young,Kim, Jae Guk,Kim, In Young,Kim, Minji Williams & Wilkins Co 2018 Medicine Vol.97 No.25
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Leukosan SkinLink (LS), which combines non-woven textile strips and tissue adhesive, offers the advantage of atraumatic treatment while effectively shortening the procedure time. We hypothesized that wound closure would be faster with LS than with surgical suture (SS) and the wound infection and dehiscence would be similar.</P><P><B>Methods:</B></P><P>A prospective, open label, single-center, randomized controlled trial was performed. Between November 2014 and April 2016, 49 patients with traumatic lacerations who presented to the emergency department were eligible for study inclusion.</P><P><B>Results:</B></P><P>The mean wound closure time was significantly lower in the LS group than in the SS group (1.48 ± 0.2 seconds vs 8.8 ± 3.6 minutes, <I>P</I> < .001). After adjusting the wound closure time according to the lacerations length, the time remained significantly lower in the LS group than in the SS group (1.0 ± 0.8 seconds vs 5.03 ± 2.5minutes, <I>P</I> < .001). During follow-up for 14 days, no significant differences in dehiscence and wound infection were observed between the 2 groups.</P><P><B>Conclusion:</B></P><P>Wound closure was approximately 4minutes faster with LS and there were no differences in wound infection and dehiscence rates. Thus, the LS could be used as a timesaving suture technique for acute traumatic lacerations in emergency department (ED).</P><P><B>Trial registration:</B></P><P>ClinicalTrials.gov NCT02333877</P>
Kim, Wonhee,Lee, Youngwoo,Shin, Donghoon,Chung, Chung Choo The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.5
This paper presents a compensative microstepping based position control with passive nonlinear adaptive observer for permanent magnet stepper motor. Due to the resistance uncertainties, a position error exists in the steady-state, and a ripple of position error appears during operation. The compensative microstepping is proposed to remedy this problem. The nonlinear controller guarantees the desired currents. The passive nonlinear adaptive observer is designed to estimate the phase resistances and the velocity. The closed-loop stability is proven using input to state stability. Simulation results show that the position error in the steady-state is removed by the proposed method if the persistent excitation conditions are satisfied. Furthermore, the position ripple is reduced, and the Lissajou curve of the phase currents is a circle.
Novel Position Detection Method for Permanent Magnet Stepper Motors Using Only Current Feedback
Wonhee Kim,Chung Choo Chung IEEE 2011 IEEE transactions on magnetics Vol.47 No.10
<P>In this paper, a position detection method using only current feedback is proposed for permanent magnet stepper motors. Using the Lyapunov stability analysis of microstepping, we show that the approximate position can be determined by the interpolation of the measured currents. The position estimation error in the constant velocity period is analyzed using the position tracking error of microstepping. A new compensation filter is proposed to reduce the position estimation error due to the mechanical dynamics. The Heydemann correction and the gradient searching method are used for calibrating the current signals. 16 phase-shifted sinusoids are implemented for the interpolation of the currents. The performance of the proposed method was validated by experiment.</P>
Lyapunov-based Microstepping Control of Sawyer Motors with PID Control
Wonhee Kim,Donghoon Shin,Dong Gyu Gang,Chung Choo Chung 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
Proportional-integral-derivative (PID) controls have been widely used for Sawyer motors. The electrical dynamics are generally neglected in general PIDs control since the electrical dynamics are faster than the mechanical dynamics. However, when the current control is used, the phase currents are reduced by back-emf and have the phase lags due to inductances. Thus, the electrical dynamics should be considered to improve the performance of PID control. In this paper, Lyapunov-based microstepping control of Sawyer motors with PID control is developed for improved performance of PID control. The proposed method consists of PID and Lyapunov-based controller. PID controllers make the desired forces and torque to track the position profiles of x and y with regulation of yaw. And the commutation scheme from the desired forces and torque to the desired phase currents are used. For the design of Lyapunov-based control, the stabilities of the equilibrium points are studied using Lyapunov method. Then, Lyapunov-based control is designed to compensate back-emfs and phase lags. Furthermore, the proposed method guarantees the exponential stabilities of desired currents for PID control. And, the closed-loop system is analyzed. The proposed method considering the electrical dynamics is designed without any coordinate transformation. Therefore, it could reduce the commutation delay. Simulation results show that the tracking performance of PID controller is improved by the proposed method.
Nonlinear Backstepping Control Design for Coupled Nonlinear Systems under External Disturbances
Kim, Wonhee,Kang, Chang Mook,Son, Young Seop,Chung, Chung Choo Hindawi Limited 2019 Complexity Vol.2019 No.-
<P>A nonlinear backstepping control is proposed for the coupled normal form of nonlinear systems. The proposed method is designed by combining the sliding-mode control and backstepping control with a disturbance observer (DOB). The key idea behind the proposed method is that the linear terms of state variables of the second subsystem are lumped into the virtual input in the first subsystem. A DOB is developed to estimate the external disturbances. Auxiliary state variables are used to avoid amplification of the measurement noise in the DOB. For output tracking and unmatched disturbance cancellation in the first subsystem, the desired virtual input is derived via the backstepping procedure. The actual input in the second subsystem is developed to guarantee the convergence of the virtual input to the desired virtual input by using a sliding-mode control. The stability of the closed-loop is verified by using the input-to-state stable (ISS) property. The performance of the proposed method is validated via numerical simulations and an application to a vehicle system based on CarSim platform.</P>