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Lee, Jeonghwan,Cho, Jang-Hee,Lee, Jong Soo,Ahn, Dong-Won,Kim, Chan-Duck,Ahn, Curie,Jung, In Mok,Han, Duck Jong,Lim, Chun Soo,Kim, Yon Su,Kim, Young Hoon,Lee, Jung Pyo Wolters Kluwer Health 2016 Medicine Vol.95 No.21
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Clinical outcomes in kidney transplant recipients (KTRs) with hepatitis B virus (HBV) have not been thoroughly evaluated. Here, we investigated recent posttransplant clinical outcomes of KTRs with HBV and compared them with KTRs with hepatitis C virus (HCV) and seronegative KTRs.</P><P>Of 3855 KTRs from April 1999 to December 2011, we enrolled 3482 KTRs who had viral hepatitis serology data; the patients were followed up for 89.1 ± 54.1 months. The numbers of recipients with HBV and HCV were 160 (4.6%) and 55 (1.6%), respectively. We analyzed the clinical outcomes, including overall mortality and graft failure, among patients who had undergone kidney transplantation.</P><P>Patients with HBV showed poorer survival (<I>P</I> = 0.019; adjusted hazard ratio [HR] = 2.370; 95% confidence interval [CI]: 1.155–4.865) than KTRs without HBV. However, the graft survival of patients with chronic hepatitis B did not differ from that of patients without HBV. Hepatic complications were the primary causes of mortality of KTRs with HBV. Mortality significantly correlated with a higher grade of inflammation (<I>P</I> = 0.002) and with the use of lamivudine or adefovir antiviral treatment (<I>P</I> = 0.016). HBV-positive KTRs treated with the new-generation antiviral agent entecavir showed improved patient survival compared with KTRs receiving lamivudine (log-rank <I>P</I> = 0.050). HCV did not affect patient survival; however, it increased the incidence of graft failure (<I>P</I> = 0.010; adjusted HR = 2.899; 95% CI: 1.289–6.519). KTRs with HCV had an increased incidence of acute rejection (log-rank <I>P</I> = 0.005, crude HR = 2.144; 95% CI: 1.341–3.426; <I>P</I> = 0.001).</P><P>KTRs with chronic hepatitis B may exhibit poor survival due to post-transplantation hepatic complications. Pretransplant histological liver evaluations and adequate antiviral management with potent nucleoside/nucleotide analogues are needed to improve the survival of KTRs with chronic hepatitis B even when liver function is within the normal range.</P></▼2>
Pyo, Soon Hyoung,Lee, Jeongjin,Park, Seongjin,Kim, Kyoung Won,Shin, Yeong-Gil,Kim, Bohyung IEEE 2013 IEEE Transactions on Biomedical Engineering Vol.60 No.9
<P>Recent advances in computing hardware have enabled the application of physically based simulation techniques to various research fields for improved accuracy. In this paper, we present a novel physically based nonrigid registration method using smoothed particle hydrodynamics for hepatic metastasis volume-preserving registration between follow-up liver CT images. Our method models the liver and hepatic metastasis as a set of particles carrying their own physical properties. Based on the fact that the hepatic metastasis is stiffer than other normal cells in the liver parenchyma, the candidate regions of hepatic metastasis are modeled with particles of higher stiffness compared to the liver parenchyma. Particles placed in the liver and candidate regions of hepatic metastasis in the source image are transformed along a gradient vector flow-based force field calculated in the target image. In this transformation, the particles are physically interacted and deformed by a novel deformable particle method which is proposed to preserve the hepatic metastasis to the best. In experimental results using ten clinical datasets, our method matches the liver effectively between follow-up CT images as well as preserves the volume of hepatic metastasis almost completely, enabling the accurate assessment of the volume change of the hepatic metastasis. These results demonstrated a potential of the proposed method that it can deliver a substantial aid in measuring the size change of index lesion (i.e., hepatic metastasis) after the chemotheraphy of metastasis patients in radiation oncology.</P>
Clinical outcomes of patients with hepatorenal syndrome after living donor liver transplantation
Lee, Jung Pyo,Kwon, Hyuk Yong,Park, Ji In,Yi, Nam‐,Joon,Suh, Kyung‐,Suk,Lee, Hae Won,Kim, Myounghee,Oh, Yun Kyu,Lim, Chun Soo,Kim, Yon Su Wiley Subscription Services, Inc., A Wiley Company 2012 Liver transplantation Vol.18 No.10
<P><B>Abstract</B></P><P>Liver transplantation (LT) is the treatment of choice for hepatorenal syndrome (HRS). However, the clinical benefits of living donor liver transplantation (LDLT) are not yet well established. We, therefore, investigated the outcomes of patients with HRS who underwent LDLT and patients with HRS who received transplants from deceased donors. This study focused on 71 patients with HRS out of a total of 726 consecutive adult Korean patients who underwent LT at a single Asian center. We compared 48 patients who underwent LDLT with 23 patients who underwent deceased donor liver transplantation (DDLT). Patients with HRS showed poorer survival than patients without HRS (<I>P</I> = 0.01). Poorer survival was associated with higher in‐hospital mortality for patients with HRS (18.3% versus 5.2%, <I>P</I> < 0.001). In comparison with DDLT, LDLT was associated with younger donors and shorter ischemic times. The survival rate with LDLT was significantly higher than the survival rate with DDLT (<I>P</I> = 0.02). Among patients with high Model for End‐Stage Liver Disease scores (≥30) or type 1 HRS, the survival rates for the LDLT group were not inferior to those for the DDLT group. LDLT significantly improved recipient survival after adjustments for several risk factors (hazard ratio = 0.20, 95% confidence interval = 0.05‐0.85, <I>P</I> = 0.03). Kidney function was significantly improved after LT, and there was no difference between LDLT and DDLT. No patients in the HRS cohort required maintenance renal replacement therapy. In conclusion, LDLT may be a beneficial option for patients with HRS. Liver Transpl 18:1237–1244, 2012. © 2012 AASLD.</P>
Lee, Seung-Pyo,Park, Sung-Ji,Kim, Yong-Jin,Chang, Sung-A,Park, Eun-Ah,Kim, Hyung-Kwan,Lee, Whal,Lee, Sang-Chol,Park, Seung Woo,Sohn, Dae-Won,Choe, Yeon-Hyeon BioMed Central 2013 Journal of cardiovascular magnetic resonance Vol.15 No.-
<P><B>Background</B></P><P>Severe aortic stenosis (AS) patients with late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) or left ventricular (LV) systolic dysfunction are known to have worse outcome. We aimed to investigate whether LGE on CMR would be useful in early detection of subclinical LV structural and functional derangements in AS patients.</P><P><B>Methods</B></P><P>118 patients with moderate to severe AS were prospectively enrolled. Echocardiography and CMR images were taken and the patients were divided into groups according to the presence/absence of LGE and of LV systolic dysfunction (LV ejection fraction (EF) <50%). The stiffness of LV was calculated based on Doppler and CMR measurements.</P><P><B>Results</B></P><P>Patients were grouped into either group 1, no LGE and normal LVEF, group 2, LGE but normal LVEF and group 3, LGE with depressed LVEF. There was a significant trend towards increasing LV volumes, worsening of LV diastolic function (E/e’, diastolic elastance), systolic function (end-systolic elastance) and LV hypertrophy between the three groups, which coincided with worsening functional capacity (all p-value < 0.001 for trend). Also, significant differences in the above parameters were noted between group 1 and 2 (E/e’, 14.6 ± 4.3 (mean ± standard deviation) in group 1 vs. 18.2 ± 9.4 in group 2; end-systolic elastance, 3.24 ± 2.31 in group 1 vs. 2.38 ± 1.16 in group 2, all p-value < 0.05). The amount of myocardial fibrosis on CMR correlated with parameters of diastolic (diastolic elastance, Spearman’s ρ = 0.256, p-value = 0.005) and systolic function (end-systolic elastance, Spearman’s ρ = -0.359, p-value < 0.001).</P><P><B>Conclusions</B></P><P>These findings demonstrate the usefulness of CMR for early detection of subclinical LV structural and functional deterioration in AS patients.</P>
Mass Spectrometry Analysis of In Vitro Nitration of Carbonic Anhydrase II
Lee, Soo Jae,Kang, Jeong Won,Cho, Kyung Cho,Kabir, Mohammad Humayun,Kim, Byungjoo,Yim, Yong-Hyeon,Park, Hyoung Soon,Yi, Eugene C.,Kim, Kwang Pyo Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.3
Protein tyrosine nitration is considered as an important indicator of nitrosative stresses and as one of the main factors for pathogenesis of inflammation and neuronal degeneration. In this study, we investigated various nitrosative modifications of bovine carbonic anhydrase II (CAII) through qualitative and semi-quantitative analysis using the combined strategy of Fourier transformation ion cyclotron resonance mass spectrometry (FT-ICR MS) and ion-trap tandem mass spectrometry (IT-MS/MS). FT-ICR MS and its spectra were used for the search of the pattern of nitrosative modifications. Identification of nitrosatively modified tyrosine sites were executed through IT-MS/MS. In addition, we also tried to infer the reason for the site-specific nitrosative modifications in CAII. In view of the above purpose, we have explored- i) the side chain accessibility, ii) the electrostatic environment originated from the acidic/basic amino acid residues neighboring to the nitrosatively modified site and iii) the existence of competing amino acid residues for nitration.
Won-Bin Lee,Hyun-Jun Choi,Young-Pyo Cho,Myung-Hyo Ryu,Jee-Hoon Jung 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2
The practical design methodology of a three-phase dual active bridge (3ph-DAB) converter applied to low voltage direct current (LVDC) applications is proposed by using a mathematical model based on the steady-state operation. An analysis of the small-signal model (SSM) is important for the design of a proper controller to improve the stability and dynamics of the converter. The proposed lead-lag controller for the 3ph-DAB converter is designed with a simplified SSM analysis including an equivalent series resistor (ESR) for the output capacitor. The proposed controller can compensate the effects of the ESR zero of the output capacitor in the control-to-output voltage transfer function that can cause high-frequency noises. In addition, the performance of the power converter can be improved by using a controller designed by a SSM analysis without additional cost. The accuracy of the simplified SSM including the ESR zero of the output capacitor is verified by simulation software (PSIM). The design methodology of the 3ph-DAB converter and the performance of the proposed controller are verified by experimental results obtained with a 5-kW prototype 3ph-DAB converter.
Erratum to: “Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide”
Lee, Byung Ryong,Lee, Yeom Pyo,Kim, Dae Won,Song, Ha Yong,Yoo, Ki-Yeon,Won, Moo Ho,Kang, Tae-Cheon,Lee, Kwang Jae,Kim, Kyung Hee,Joo, Jin Ho,Ham, Hun Ju,Hur, Jang Hyun,Cho, Sung-Woo,Han, Kyu Hyung,Lee Springer-Verlag 2013 Molecules and cells Vol.36 No.1
Weighted DOP With Consideration on Elevation-Dependent Range Errors of GNSS Satellites
Won, Dae Hee,Ahn, Jongsun,Lee, Seung-Woo,Lee, Jiyun,Sung, Sangkyung,Park, Heung-Won,Park, Jun-Pyo,Lee, Young Jae IEEE 2012 IEEE transactions on instrumentation and measureme Vol.61 No.12
<P>This paper proposes the weighted dilution of precision (WDOP) with consideration of the satellite elevation angle in order to improve the performance of dilution of precision (DOP), which is a standard tool to quantify the positional precision of the Global Navigation Satellite System (GNSS). The WDOP is calculated by assigning different weights to visible GNSS satellites depending on their elevation angles. In order to demonstrate the effectiveness of WDOP, the conventional DOP and WDOP were mathematically analyzed and a comparative analysis was conducted using actual Global Positioning System data. Results showed that WDOP represents the position error trends more accurate than the conventional DOP, particularly when low-elevation measurements were used for positioning calculation. Therefore, the WDOP could be a promising replacement of DOP as a tool for representing and quantifying errors in GNSS positioning.</P>
Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine
Lee, Jingyun,McKinney, Kimberly Q.,Pavlopoulos, Antonis J.,Niu, Meng,Kang, Jung Won,Oh, Jae Won,Kim, Kwang Pyo,Hwang, Sunil Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.3
Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonstrated an increased number of protein identification in EV. Comparative MS analyses of urinary EV from control subjects and bladder cancer patients identified a total of 1,222 proteins. Statistical analyses provided 56 proteins significantly increased in bladder cancer urine, including proteins for which expression levels varied by cancer stage (P-value < 0.05). While urine represents a valuable, non-invasive specimen for biomarker discovery in urologic cancers, there is a high degree of intra- and inter-individual variability in urine samples. The enrichment of urinary EV demonstrated its capability and applicability of providing a focused identification of biologically relevant proteins in urological diseases.