경연대회를 통한 초·중고생의 창의력 현황에 관한 연구

육근철,이희복,류해일,김현섭,김희수,박달원,심규철,박종석,신영숙,박상태,변두원,김태균 공주대학교 과학교육연구소 2002 과학교육연구 Vol.33 No.-

21세기의 정보화 산업사회와 지식기반 사회에서 우리의 아이들이 자신의 목소리로 세계 속에서 살아가게 하기 위해서는 다른 사람과 다른 아이디어를 낼 수 있도록 교육의 틀을 바꾸지 않으면 안된다. 다라서 21세기의 미래 사회를 살아갈 학생들을 가르치는 교육의 현장 역시 창의적인 인간을 길러낼 수 있도록 변해야 한다. 즉, 미래 사회를 대비하기 위해서는 각 개인의 개성을 존중하는 분위기에서 창의적인 능력을 지닌 인간을 양성해야 한다는 것을 의미한다. 따라서, 학교 안에서의 교육뿐만이 아니라 학교 밖에서도 다양한 학습 경험을 통해서 교육 과정이 추구하는 인간상을 구현할 수 있도록 활동할 수 있는 기회가 학생들에게 제공되어야 한다. 창의력을 발휘하여 문제를 해결하는 능력을 기르기 위해서는 개별적이 아닌 여러 명의 동료가 주어진 과제를 해결할 수 있는 기회를 갖고 짧은 시간이 아닌 장시간 동안 고민하고 그 해결책을 찾는 활동을 가질 기회가 필요하다. In order to educate our students with their special talents for the informational and knowledge based age expected in the 21st century, we must improve our educational programs such that students are able to create their own fresh ideas. Hence the present educational environment should be changed such that they are willing to respect others' characters and personality with their own original ideas. Therefore, we must make them have the opportunity that they can acquire many experiences through the school education and the social education program, so that they may grow up to the person with the humanity and creativity. In this study we have suggested new educational program where students engage themselves in long term research projects with collaboration of the team and creativity of individuals.

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

Cryptosporidium baileyi감염 병아리에 있어서 Fabricius-낭의 조직병리학적 변화

박배근,조성환,윤원기,김현수 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

Two-day old male chickens(DEKALB-Warren, Sex-Sal-Link) were inoculated orally with 2×10^6 oocysts of Cryptosporidium bailyei. Age-matched birds served as controls. A small number of oocysts were first recognized in the feces of chicks on day 3 post inoculation(PI). The OPD for the chickens increased with the lapse of days, reached a peak on day 9 PI, decreased rapidly thereafter, and became negative on days 33 PI. The protozoa had a prepatent period of 2 day and patent period of 3-32 days. On day 10 PI, infections were very heavy, in fact, there was a vitural monolayer of parasites in the microvillus region of the bursa of Fabricius(BF). Histopathological lesions in BF were characterized by severe eosinophilic infiltrates under the epithelium, loss of FAE and epithelium. The eosinophilic infiltrantes were detected in the follicles on day 15 PI. On days 27 PI, follicles were degenerated and necrosised. Mast cells were recognized in the epithelium on day 10 PI, reached a peak on day 43 PI and then rapidly decreased. Location of mast cell was matched with the region of parasited epithelium. Although the cryprosporidia was not detected in the epithelium of BF on day 59 PI, the mucosal change persisted accompanied by hyperplasia and metaplasia. The follicles were normally recovered or partially necrosised on day 59 PI.

IC Card와 X.509를 이용한 인증 프로토콜

박경배,임경묵,강경인,김정일,정근원,이광배,김현욱 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

As recently the need for electronic commerce and infra information system using Internet increases, several organizations have attempted to develop mutual authentication mechanism between Certification Authorities(CA's) as well as fundamental authentication mechanism, based on Public-key. In this paper, we propose a new efficient authentication protocol which is applicable to various servers. For the protocol, we complement Public-key certificate structure and authentication protocol defined in X.509 with self-arithmetic function and data security function of 1C card.

결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.

전동공구 내구성 평가 실험장치 개발

박근석,변영철,강이석,강배희,이동욱,차원준 忠南大學校 産業技術硏究所 1997 산업기술연구논문집 Vol.12 No.2

For the endurance test, it is necessary to test the portable electric tools under the same condition as the actual operation condition. It is also essential that the test equipment is convenient to fix the tool. Those are necessary to control the loaded torque and to acquire and analyze the test data with a computer. In this study, we have developed an endurance test equipment for portable electric tools, where a hydraulic control system with a proportional relief valve was applied to control the load for the test. The developed test equipment used an industrial hydraulic pump as a load supplier to ensure a firm endurance of the test equipment itself. The data acquisition system has been automated by composing with a personal computer and RS-232C communication nets. This test equipment reduced the manhour for the test and also improved the reliability of the tested data which were measured and graphed.

골다공증 진단에 피부 두께의 임상적 유용성 평가

박원근,최민주,김호찬,조성제,박전홍 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The study was carried out to examine how much clinically useful was the skin thickness in diagnosis of osteoporosis. The project was to look into not only the presumption that patients with osteoporosis have the skin loss at the similar rate of the reduction in the collagen content of the bone but also the correlation between the collagen content and the skin thickness. The skin thickness was measured on the dorsal hand(right) of the patients using an ultrasonic technique with a 20 MHz focused ultrasonic transducer. Measurements of the bone density of the patients were made on both the lumbar spine (L2-4) and the femoral neck using Dual­Energy X­ray Absorptionmeter(DEXA, Norland). An ultrasonic bone densitometer(Mark 6000, Medison Co. Korea) was taken to measure the speed of sound (SOS) on the calcaneus. It was observed that there were some degrees of correlation between the bone density obtained by the DEXA and the SOS of the calcaneous (P<0.01). There was no evidence that the skin thickness was correlated with the DEXA produced bone density and ultrasonically measured SOS.

형태학적 정량법에 의한 췌장도의 연구 : 년령의 증가가 미치는 영향 Effect of Increasing Age

박건영,이원복,라봉진 중앙대학교 의과대학 의과학연구소 1982 中央醫大誌 Vol.7 No.4

Diabetes Mellitus which can be caused by various factors is known to induce changes in the pancreatic islets. With Wistar albino rats, this experiment was designed to observe quantitatively the islet changes due to increasing age and sex difference by using the method of Cardell on sections of tissues. The experminental animals were bred with regular diet, and were sacrificed at the age of ten, twenty, thirty, forty, and fifty weeks, repective.y. The pancreatic tissue were fixed in Bouin's solution, and their sections were stained with hematoxylin and eosin. the long and short diameters of pancreatic islet were measured with ocular micrometer under the microscope and its surface area per 100㎟ of the pancreas was calculated. REsults obtained are as follows: 1. The pancreatic islet of the young animals show normal aooearance but those of the old are enlarged. 2. The increase in the body weight is marked more in the male than in the female. 3. The surface area of the islets per 100㎟ of the pancreas shows significant increase in the male, but its increase in the female is not significant. 4. Even though the size of pancreatic islets in the rats of forty-week-old group is small, the fraction of surface area of the islets shows the increase. It seems to mean the hyperplasia of the islets. 5. From the above results the sex and increase in the age can be the causes of diabetes mellitus, and the changes of its pancreatic islets are hyperplasia as well we hypertrophy.

일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.

형질전환 담배 식물체에서 개똥쑥 Terpene Synthase의 발현

박성길,홍성현,최근원,이윤형,정인식 경희대학교 생명자원과학연구원 2002 硏究論文集 Vol.22 No.-

Expression of Artemisia annua terpene synthase in transgenic tobacco plants was examined. A full length cDNA encoding terpene synthase was cloned into pILTAB357 vector and transgenic tobacco plants were generated. The integration of this gene was analyzed by genomic DNA PCR and Southern blot analysis. The transcription of the terpene synthase gene in tobacco was confirmed by RT-PCR and northern blot analysis.