관상동맥 스텐트 내 재협착의 발생에 미치는 임상적 관동맥 조영술적 요인들

윤혁준,김기식,박형섭,이영수,현대우,한성욱,허승호,김윤년,김권배,박남희,원경숙 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

나이에 따른 대식세포의 IL-6 생산양상의 변화

윤원기,김무강,조성환,류시윤 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.2 No.-

The present study was designed to observe the age-related changes in the IL-6 production capabilities of the peritoneal macrophages. Pertioneal macrophages were collected from adult mature (13-20 weeks of age) and aged BALB/c mice (60-70 weeks of age). Macrophages were cultured in the presence of endotoxin (lipopolysaccharide lug/ml, Escherichia coli serotype 0111:B4). In aged mice, IL-6 levels in the culture supernatants were seemed to be relative high than that in adult mature mice.

化學物質 및 藥物로 因한 小兒急性中毒症의 臨床的 觀察

金基泰,朴基用,尹相元 대한소아과학회 1969 小兒科 Vol.12 No.4

브레이징 온도 변화에 따른 ZrO2와 Ti-6Al-4V의 접합 특성

기세호,박상윤,허영구,정재필,김원중 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: In this study, brazing characteristics of ZrO2 and Ti-6Al-4V brazed joints with increasing temperature were investigated. Materials and methods: The sample size of the ZrO2 was 3 mm × 3 mm × 3 mm (thickness), and Ti-6Al-4V was 10 mm (diameter) × 5 mm (thickness). The filler metal consisted of Ag-Cu-Sn-Ti was prepared in powder form. The brazing sample was heated in a vacuum furnace under 5 × 10-6 torr atmosphere, while the brazing temperature was changed from 700 to 800℃ for 30 min. Results: The experimental results shows that brazed joint of ZrO2 and Ti-6Al-4V occurred at 700 - 800℃. Brazed joint consisted of Ag-rich matrix and Cu-rich phase. A Cu-Ti intermetallic compounds and a Ti-Sn-Cu-Ag alloy were produced along the Ti-6Al-4V bonded interface. Thickness of the reacted layer along the Ti-6Al-4V bonded interface was increased with brazing temperature. Defect ratios of ZrO2 and Ti-6Al-4V bonded interfaces decreased with brazing temperature. Conclusion: Thickness and defect ratio of brazed joints were decreased with increasing temperature. Zirconia was not wetting with filler metal, because the reaction between ZrO2 and Ti did not occur enough. 연구 목적: 온도 변화에 따른 ZrO2와 Ti-6Al-4V의 접합 특성에 대해 알아보기 위하여 새로운 브레이징 합금을 제조하고, 브레이징 온도가 접합 특성에 미치는 영향에 대하여 조사하고자 하였다. 연구 재료 및 방법: 본 연구에서 사용된 시편으로는 실험용 ZrO2 모재(ZirBlank-PS, Acucera, Inc., Gyeonggi-do, Korea)는 소결 전의 블록형태(65 mm × 36 mm × 12 mm (t))이며, 이를 잘라 사포(#2400)로 표면연마 후 소결하였다. 소결된 ZrO2 시편의 크기는 3 mm × 3 mm × 3 mm (t) 이다. Ti-6Al-4V 모재(Ti 6Al 4V ELI CG Bar, TMS, Washington, USA)는 직경 10 mm × 5 mm (t)를 사용하였다. 소결된 ZrO2와 Ti-6Al-4V의 접합을 위하여 브레이징 합금을 제조하였다. 시편을 3군으로 나누어A군은 700℃에서, B군은 750℃에서, C군은 800℃에서 각각 브레이징 하였다. 브레이징 부의 두께와 결함율의 측정은 각 군당 하나의 시편으로 각 시편 당 5회씩 반복 측정하여 평균값을 취하였다. 결과: 브레이징 합금을 사용하여 진공 브레이징을 수행한 결과 ZrO2 와 Ti-6Al-4V 는 700℃ - 800℃에서 양호한 접합을 보였다. 브레이징 후 브레이징 온도 변화에 따른 브레이징 부의 두께 및 결함율의 변화는SEM을 사용하여 측정하였다. 브레이징 온도가 700℃에서 800℃로 증가함에 따라 CuTi 금속간 화합물 층 및 Ti-Sn-Cu-Ag계 화합물 층의 두께는 각각 4.5 ㎛에서 10.3 ㎛로, 3.1 ㎛에서 5.0 ㎛로 증가되었다. 또한 브레이징 온도가 700℃에서 800℃로 증가함에 따라 브레이징 접합계면의 결함율은 ZrO2 및 Ti-6Al-4V 계면에서 각각25%에서 16.3%, 5%에서 1.5%로 감소되었다. 결론: 브레이징 온도가 700℃에서 800℃로 증가됨에 따라, 브레이징 접합계면의 결함율은 ZrO2 및 Ti-6Al-4V 계면에서 모두 감소되었다. 이는 결함부에서 ZrO2와 활성원소인 Ti과의 반응이 충분히 일어나지 않아서 브레이징 합금이 ZrO2에 웨팅되지 않은 것이 원인이라고 사료된다.

Alnico 8 型 硬質磁性材料의 磁氣的 性質에 미치는 添加元素의 影響

徐圓根,金澤基,金潤培 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.1

In order to study the alloying elements effects on the magnetic properties in Alnico 8 (Fe-35Co-14Ni-7Al-5Ti-3Cu) permanent magnet alloy, some Alnico 8-type alloys which are different in composition of Ni, Cu, Ti and Al were prepared by induction melting. They were thermomagnetically treated at 740℃ - 840℃ for 3-15 min and then aged at 600℃ for 15hours. The magnetic properties and the optimum thermomagnetic treatment condition were investigated. The results were as follows ; 1) The region of the high temperature α phase, the zone of the solution treatment, is extended by Al and Ti, but that is reduced by Ni and Cu. 2) In the composition range of 10-14 wt.% of Ni, the coercive force decreases greatly with decreasing the Ni content with little change of the residual magnetization and the squareness of demagnetization curve. The optimum thermomagnetic treatment condition appeared at high temperature and short time with decreasing the Ni content. 3) In the composition range of 1-3wt.% of Cu, the coercive force decreases greatly with decreasing the Cu content, but the residual magnetization shows increasing tendency with decreasing the Cu content. The optimum thermomagnetic treatment condition appeared at low temperature and long time with decreasing the Cu content. 4) In the composition range of 5-8wt.% of Ti, the coercive force increases with increasing the Ti content, but the residual magnetization decreases with increasing Ti content. The optimum thermomagnetic treatment temperature was not dependent on the Ti content, but the optimum thermomagnetic treatment time appeared at long time with increasing the Ti content.

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

자외선 A가 마우스의 접촉과민반응의 저하에 미치는 영향에 관한 연구

한승경,박윤기,허원,이승헌,이해을 연세대학교 원주의과대학 1991 원주의대논문집 Vol.4 No.1

돼지생식기호흡기 증후군(PRRS) 바이러스 감염시킨 돼지 기관의 병리학적 관찰

조성환,김현수,윤원기,전무형,류시윤,박배근,손화영,김무강 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

The porcine reproductive and respiratory syndrome virus was inoculated into swine tracheal organ culture. The ballooning degeneration of the tracheal ciliated epithelium and a decrease of ciliary activity from the tracheal organs infected with PRRS virus were observed one day post-infection(PI). Tracheal epithelium showed degeneration and focal necrosis 2 days PI. Epithelial necrosis and loss of cilia and epithelial cells became more severe 3 and 4 days PI. An entire loss of cilia and epithelial cells were recognized 4 days PI, however, control tracheal organs were normal during the period of the experiment except a little decrease of ciliary activities with time..

Cryptosporidium baileyi감염 병아리에 있어서 Fabricius-낭의 조직병리학적 변화

박배근,조성환,윤원기,김현수 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

Two-day old male chickens(DEKALB-Warren, Sex-Sal-Link) were inoculated orally with 2×10^6 oocysts of Cryptosporidium bailyei. Age-matched birds served as controls. A small number of oocysts were first recognized in the feces of chicks on day 3 post inoculation(PI). The OPD for the chickens increased with the lapse of days, reached a peak on day 9 PI, decreased rapidly thereafter, and became negative on days 33 PI. The protozoa had a prepatent period of 2 day and patent period of 3-32 days. On day 10 PI, infections were very heavy, in fact, there was a vitural monolayer of parasites in the microvillus region of the bursa of Fabricius(BF). Histopathological lesions in BF were characterized by severe eosinophilic infiltrates under the epithelium, loss of FAE and epithelium. The eosinophilic infiltrantes were detected in the follicles on day 15 PI. On days 27 PI, follicles were degenerated and necrosised. Mast cells were recognized in the epithelium on day 10 PI, reached a peak on day 43 PI and then rapidly decreased. Location of mast cell was matched with the region of parasited epithelium. Although the cryprosporidia was not detected in the epithelium of BF on day 59 PI, the mucosal change persisted accompanied by hyperplasia and metaplasia. The follicles were normally recovered or partially necrosised on day 59 PI.

한국 재래 우 및 산양 위장관의 somatostatin cell에 대한 면역조직화학적 분포

조성환,김현수,박배근,윤원기,손화영 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

The relative frequency and distribution of somatoatatin immunoreactive cells were investigated by the immunohistochemical method in the gastrointestinal tract of the Korean native cattle and goat. The results obtained were as follows: In the Korean native cattle, somatoststin cells were a few in the pyloric and duodenal region and rarely seen in fundic region, jejunum, ileum, cecum, proximal colon, central coil, distal colon and rectum. In the Korean native goat, somatostatin cells were the most numerous in the pyloric region and the next in the fundic region. And they were a few in the duodenum, not detected in the cecum and sparse in the jejunum, ileum, proximal colon, central coil, distal colon and rectum.