Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

온수배관을 이용한 온실의 난방성능

윤용철(Yong Cheol Yoon),신익수(Yik Soo Shin),김현태(Hyeon Tae Kim),배승범(Seoung Beom Bae),최진식(Jin Sik Choi),서원명(Won Myung Suh) (사)한국생물환경조절학회 2012 생물환경조절학회지 Vol.21 No.2

본 연구는 온실의 난방 에너지 절감을 목적으로 온실 내부에 알루미늄 온수배관을 설치하여 난방효과에 대한 기초자료를 구축하고자 수행되었다. 그 연구결과를 요약하면 다음과 같다. 전체 실험을 포함하여 온실내의 높이별 온도편차는 4.0~7.0℃ 정도의 범위로서 그 차이가 크게 나타났다. 팬코일유니트(FCU)를 작동시킨 경우가 작동시키지 않은 경우에 비해 유출입수의 온도차가 3.3℃ 정도 크고, 소비전력량은 36.2~40.1% 정도 증가하였으며, 시간당 방열량은 44.6~52.0% 정도 증가하는 것으로 나타났다. 실험기간동안 순환유량은 0.48~0.49L · s<SUP>?1</SUP> 정도의 범위에 있었고, 평균유속은 1.53~1.56m · s<SUP>?1</SUP> 정도였다. 유출입수의 평균 온도차는 6.24~11.50℃이었다. 최저 외기온 ?14.0~?0.6℃ 범위에서 설정온도별 방열량은 135,930~307,150㎉ 정도의 범위로서 시간당 9,610~19,630㎉ · h<SUP>?1</SUP> 정도의 범위에 있었다. 이것은 최대난방부하의 약 23~53% 정도의 난방에너지를 공급할 수 있을 것으로 나타났다. 전체 방열량과 소비전력량은 각각 2,548,306㎉ 및 3,075.7㎾h이다. 화석연료인 경유로 난방할 경우, 소요되는 경유의 총 소비량은 281.6L 정도이고 비용은 321,000won인 것으로 나타났다. 농가용 전력요금을 적용하면 전력사용에 대한 총비용은 110,730won 정도로서 경유 소비 비용의 33.5% 정도로 나타났다. 실험구의 온도가 대조구보다 약 8.3~14.6℃ 정도 높게 나타났다. This research was conducted to obtain basic data with regard to the heating performance that would be produced by installing an aluminum hot water pipe inside the greenhouse with the goal of reducing the heating energy in greenhouse. The research results are summarized as follows. The degree of difference in relation to the temperature by height within the greenhouse during the entire experiment was significant - within the range of 4.0~7.0℃. The temperature difference between incoming and outgoing water was about 3.3℃ greater when FCU was activated compared to when it was not activated. Meanwhile, the amount of energy consumed increased about 36.2~40.1%. The amount of pyrexia per hour also increased by 44.6~52.0%. During the experiment period, circulated flux was within the range of 0.48~0.49 L · s<SUP>?1</SUP> while average fluid speed was 1.53~1.56 m · s<SUP>?1</SUP>. The average temperature difference between incoming and outgoing water was 6.24~11.50℃. The amount of heating value by each set temperature within the minimum outdoor temperature range of ?14.0~?0.6℃ was 135,930~307,150 ㎉, and the range was within the 9,610~19,630 ㎉ · h<SUP>?1</SUP> per hour. This demonstrated that about 23~53% heating energy of the maximum heating load could be supplied. Total radiating value and amount of energy consumed were 2,548,306 ㎉ and 3,075.7 ㎾h, respectively. When heating takes place using oil, which is a fossil fuel, the total amount of light oil consumed was 281.6 L while the cost was 321,000 won. When the electricity cost for farms is applied, the total cost was about 110,730 won, which is about 33.5% of the cost required compared to oil consumption. The temperature at in the experiment area was about 8.3~14.6℃ higher compared to that of the control area.

제한효소인 Sdi Ⅰ을 생성하는 Streptomyces 분리 균주의 수리동정

배무,서원나,송은숙,이계준 이화여자대학교 생명과학연구소 1994 생명과학연구논문집 Vol.5 No.-

제한효소인 Sdi I을 생산하는 한 균주(Streptomyces sp.264)를 토양으로부터 분리하여 형태적 관찰 및 수리동정을 실시하였다. 50여개의 분류 단위 형질을 분석하였고, 이 실험 결과를 TAXON program에 적용하여 종의 수리동정을 실시하였다. 그 결과 분리균 sp.264는 Streptomyces의 제 19주군집에 속하는 Streptomyces diastatochromogenes의 한 균주로 동정되었다. Numerical identification was applied for Streptomyces sp.264, an isolate producing a new restriction endonuclease Sdi I. The restriction enzyme would appear to be an isoschisomer of Xho I. Fifty taxonomic unit characters were tested and the data obtained were analyzed numerically by using the TAXON program. The isolate was identified to be the jamor cluster 19 of Streptomyces and best matched to S. diastatochromogenes. It was, therefore, concluded that the isolate was identified to be a member of Streptomyces diastatochromogenes.

아황산가스가 흰쥐 허파조직내 Laminin 활서에 미치는 영향에 대한 면역조직학적 연구

배성만,정호삼,서윤경,백두진,김원규,윤지희 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.2

Sulfur dioxide (SO_2), a kind of air pollutant, causes harmful damage to human body. In particular, inhalation of sulfoxide dioxide has been demonstrated to result in the injury to the upper respiratory duct. However, mechanisms by which SO_2 affects these tissues remain to be clarified. In the present study, to investigate the mechanism of SO_2 effects, the influence of SO_2 exposure was examined in terms of the injury of lung and the expression pattern of laminin in the basal lamina. The basal lamina is an important tissue for the regulation of internal respiration by composing of air-blood barrier. Sprague-Dawley rats repetitively exposed to a mixture of O_2 gas and SO_2 gas (250 ppm) for 30 minutes a day were sacrificed to observe the distribution of laminin in the alveolar septum as well as the morphological alteration of alveoli using immunohistological methods. The resutls we observed were as follows: 1. Alveoli from SO_2-exposed rats (for 5 days) were strongly stained with anti-laminin antibody, suggesting laminin expressed at the high level, at week 1 to 3 upon exposure to SO_2 2. At week 1 to 3 after exposure of rats to SO_2, alveolar septa were collapsed, leading to the reduction of alveolar volume along with morphological changes to irregular shapes. 3. At week 4 to 6 after exposure of rats to SO_2, alveoli were weakly stained with anti-laminin antibody, suggesting laminin expression was decreased during this period. 4. Rats sacrificed at week 7 upon exposure to SO_2 exhibited the expansion of new alveoli and the expression of laminin was partially recovered up to the intermediate level. Taken together, these results demonstrate that the expression of laminin was enhanced in the early phase, followed by downregulation in the late phase. Moreover, lung injury and resolution were correlated with the level of laminin. Thus, these results suggest that SO_2 suppresses the expression of laminin, which may be associated with the neo-generation of lung tissue.

인체대장암에서의 Cyclin 유전자의 발현

백원기,서민호,서성일,문성희,박종욱,최병길,배옥석 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.2

무기 알루미늄 염으로부터 침전법으로 제조한 알루미나 분체의 소결특성에 미치는 음이온의 영향

배원태,박민준,이국림 慶尙大學校生産技術硏究所 1994 生産技術硏究所論文集 Vol.10 No.-

In order to investigate the effects of inorganic anions(??, ??, ??) on the dispersion of aluminum hydrate precipitates in the solution, transition of precipitates, and the sinterability of alumina powders, three kinds of aluminum salts[Al₂(SO₄)₃.14H₂O, AI(NO₃)₃.14H₂O, AICI₃. 6H₂O]were used as starting materials. The dispersion power of the divalent anion was lower than monovalent anions. But the particle size of alumina powder obtained from the calcined precipitate containing divalent anion appeared smaller tnan that of the precipitates containing monovalent anions due to the difference of the transition path and the staring temperature of the consolidation of the transition aluminas. The fired densities of the specimens sintered at 1550℃ for 3hours showed 3.94g/㎤, 3.90g/㎤, and 3.88g/㎤ for Al₂(SO₄)₃.14H₂O, AI(NO₃)₃.14H₂O, and AICI₃. 6H₂O, respectively.

카올린으로부터 용융 Al의 SiO₂에 대한 선택적 침식을 이용한 Al₂O₃-Al 복합체의 제조

배원태,박민준,박외철 慶尙大學校生産技術硏究所 1994 生産技術硏究所論文集 Vol.10 No.-

½By the use of selective corrosion reaction of molten Al with the SiO₂, Al₂O₃-Al co-continuous ceramic-metal composite was prepared. The optimum conditions to provide maximum value of the mechanical properties such as flexual strength' and fracture toughness has been investigated. The preform was formed at 250㎏/㎝²pressure, fired at 1400℃, and subsequently soaked for 1 hour. The preform corroded with molten Al at 1000℃ for 24 hours had the highest value of mechanical properties. This material showed the bulk density of 3.25g/㎤, 4-point MOR of 280 Mpa, and ?? of 8 MPa. ??. The calculated relative density of the final product consisted of about 50 wt% of aluminum was approximately above 97,5%. If the content of alumina, which provides stiffness, was increased, flexural strength of this material will be greatly imporved. Then the practical applications for brake rotors, piston crowns, cylinder liners, etc. would be expected.

고등학교 레슬링선수들의 운동스트레스 요인이 운동탈진에 미치는 영향

배원호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study aims to analyze the degree of stress and exhaustion of wrestlers, reveal the importance of psychological factors as well as physical and technical ability to those and further provide the basic materials for reducing the stress and exhaustion for wrestlers and coaches and enhancing game performance. It conducts exhaustion with subjects of 400 high school students and as a result of performing one-way ANOVA and multiple correlation analysis, the following conclusions are obtained. 1-1. In the analysis of stressors by game performance, superior athlete group showed higher stress in the bur-out exercise and competition, and fear of failure and punishment and non-superior group showed it in school work and entering higher school. 1-2. In the analysis of stressors by exercise types, the Greco-Roman style group showed higher stress in the burden of exercise and competition, school work and entering higher school, and the freestyle group showed it in the fear of failure and punishment. 1-3. In the analysis of stressors by weight, the lightweight group showed higher stress in the fear of failure and punishment, middleweight group showed it in the burden of exercise and competition and heavyweight group did it in schoolworkand entering higher school. 1-4. In the stressors by athlete positions, top group showed higher stress in the burden of exercise and competition, schoolwork and entering higher school, middle group did it in the fear of failure and punishment and personal loss. 2-1. In the analysis of exhaustion factors by game performance, superior group showed higher stress in non-personificationfactor and non-superior group showed it in personal achievement. 2-2. In the analysis of exhaustion factors by exercise types, the Greco-Roman style group showed higher stress in the factor of personal achievement and the fresstyle group did it in emotional and non-personification factors. 2-3. In the exhaustion factors, heavyweight group showed higher stress in personal achievement. 2-4. In the exhaustion factors by athlete positions, top group showed higher stress in emotional factor and bottom group showed it in personal achievement and non-personification factors. 3. Correlation between Stressors and Exhaustion Factors and Multiple Regressive nalysis