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Overexpression of the transforming growth factor-β-inducible gene H3, βIG-H3 In Lupus nephritis
( Wern Chan Yoon ),( Jung Yoon Choe ),( Chae Gi Kim ),( Yong Ho Song ),( Seung Hie Chung ),( Sang Gyung Kim ),( Jong Sup Bae ),( In San Kim ),( Sung Won Lee ),( Won Tae Chung ),( Jung Yoon Choe ) 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-
한국인에서 류마티스 관절염과 비타민 D 수용체 유전자 다형성과의 연관성에 관한 연구
윤원찬(Wern Chan Yoon),김채기(Chae Gi Kim),송용호(Yong Ho Song),김상경(Sang Gyung Kim),전창호(Chang Ho Joen),김옥동(Ok Dong Kim),최정윤(Jung Yoon Choe) 대한내과학회 2002 대한내과학회지 Vol.62 No.2
N/A Background : The purpose of this study was to determine whether the distribution of vitamin D receptor (VDR) polymorphisms in rheumatoid arthritis (RA) patients group is different from that of the control group and whether there is a relationship between VDR genotype and radiographic severity or bone mineral density (BMD) of RA patients. Methods : The VDR genotype was determined by polymerase chain reaction and digestion with three restriction enzymes Taq I, Apa I and Bsm I in 78 healthy women and 97 female RA patients. Hand X-rays were scored by Larsen's method and bone mineral density was measured by dual energy X-ray absorptiometry (DEXA) in RA patients. Results: VDR genotypic distributions in Koreans were much different from Caucasians in each control and RA patient groups. Especially, tt allele and BB allele were very rare, prominently differentiating from Caucasians. But within Koreans, no significant difference of VDR genotypic frequency was observed between control group and RA patients group. And there was no significant relationship of VDR genotype with radiographic scores, nor with BMD scores in RA patients. Conclusion: The distribution of VDR polymorphisms in Korean RA patients was not different from controls. The VDR polymorphisms correlate neither with the radiographic severity of RA, nor with BMD scores in Korean RA patients.(Korean J Med 62:209-217, 2002)
류머티스 관절염과 골관절염 환자에서 Transforming growth factor β의 발현 양상
김채기,윤원찬,송용호,김상경,최정윤,Kim, Chae-Gi,Yoon, Wern Chan,Song, Yong-Ho,Kim, Sang-Gyung,Choe, Jung-Yoon 대한면역학회 2001 Immune Network Vol.1 No.3
The transforming growth $factor-{\beta}$ ($TGF-{\beta}$) is a multifunctional cytokine modulating the onset and course of autoimmune disease as shown in experimental models. In synovial inflammation, there is a potential role for $TGF-{\beta}$ in repairment, the inhibition of cartilage and bone destruction, and the down-regulation of immune response. The biologic effects of $TGF-{\beta}$ depend on the cell type, the isoform and the availability of active $TGF-{\beta}$. We investigated $TGF-{\beta}$ expression in patients with rheumatoid arthritis (RA) and compared to those of osteoarthritis (OA). And we determined a correlation between $TGF-{\beta}1$ and $TGF-{\beta}2$, and also the relationships between each $TGF-{\beta}$ isoform and the parameters for disease activity of RA. Methods: The study population consisted of 20 patients with RA and 20 patients with OA. The commercial ELISA kit was used to study $TGF-{\beta}1$ and $TGF-{\beta}2$ levels in peripheral blood (PB) and synovial fluids (SF). Results: 1) While PB $TGF-{\beta}1$ level was of no difference between RA and OA patient groups, SF $TGF-{\beta}1$ level was higher in RA group than OA group. Similarly, PB $TGF-{\beta}2$ levels of RA and OA groups was not different, but SF $TGF-{\beta}2$ levels was higher in RA group than OA group. 2) In patients with RA, the $TGF-{\beta}1$ levels were higher than $TGF-{\beta}2$ in both the PB and SF, while in patients with OA, there showed higher readings for $TGF-{\beta}1$ than $TGF-{\beta}2$ in SF but no difference between $TGF-{\beta}1$ and $TGF-{\beta}2$ levels in PB. 3) In patients with RA, there were no correlations between PB $TGF-{\beta}1$ and PB $TGF-{\beta}2$ levels, nor between SF $TGF-{\beta}1$ and SF $TGF-{\beta}2$ levels. At the same way, there was no correlation between PB $TGF-{\beta}1$ and SF $TGF-{\beta}1$ levels, nor between each levels of $TGF-{\beta}2$ in patients with RA. 4) There was also no correlation between each $TGF-{\beta}$ isoform and the parameters for disease activity such as ESR, CRP, tender joint count, swollen joint count, rheumatoid factor, and the duration of morning stiffness except between in PB $TGF-{\beta}1$ and disease duration of RA (r=0.637, p<0.01). Conclusion: Each $TGF-{\beta}$ isoforms were higher in synovial fluid of patients with RA than that of patients with OA. The data from the RA patients demonstrated different patterns of expressions of the isoforms depending on which compartment (PB or SF) was investigated. The quantification of different $TGF-{\beta}$ isoform is thought to be important when $TGF-{\beta}$ is measured under disease conditions of RA.
류마티스 관절염의 관절액 Total Fibronectin의 임상적 의의
김학준 ( Hak Jun Kim ),박정기 ( Jeong Ki Park ),여동근 ( Dong Geun Yoe ),윤원찬 ( Wern Chan Yoon ),정의달 ( Ye Dal Jung ),조선주 ( Sun Joo Cho ),김상경 ( Sang Gyung Kim ),전창호 ( Chang Ho Jeon ),김채기 ( Chae Ki Kim ),송용호 ( Yo 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3
목적: 류마티스 관절염에서의 염증 자극에 대한 활막 또는 관절액의 fibronectin에 관한 연구는 염증 기전이나 RA의 병인을 규명할 수단이 될 수 있다. 최근에 단클론성 항체의 개발로 체액중 total fibronectin의 측정이 가능하게 되어 RA와 OA의 관절액의 그 농도를 측정하였고, RA 환자를 대상으로 하여 이 측정값의 임상적 가치를 살펴 보고자 하였다. 방법: 무릎 관절 종창을 보이는 RA 및 OA 환자 68명을 대상으로 하여 약 2mL의 관절액을 채취하고 total fibronectin을 단클론성 항체를 이용하여 측정하였고, RA 환자 38명을 대상으로 6가지 기존의 질병활성도를 횡단면연구로 조사하였다. 결과: 1. RA 환자와 OA 환자의 관절액내 total fibronectin의 농도(mean±SD)는, RA가 148.4±72.6μg/ml, OA가 39.5±16.9μg/ml로 OA 환자에 비하여 RA 환자에서 유의하게 증가되어 있다 (p<0.001). 2. RA 환자의 관절액내 total fibronectin의 농도는 질병이환 기간(r=-0.272, p=0.199), 조조강직 기간(r=0.252, p=0.313), ESR (r=0.082, p=0.711), Ritchie index (r=0.217, p=0.359), CRP (r=0.131, p=0.550), 류마티스 인자(r=-0.010,p=0.963)와는 유의한 연관성을 보이지 못했다. 결론: 이상에서 RA 환자에서 관절액 중 total fibronectin의 농도는 OA 환자에서 보다 명확히 높기 때문에 원발성 OA 환자의 그것과 병인론적으로 구별됨을 알 수 있었으나, 임상적으로는 RA의 활성도를 나타내는 지표로 쓰일 수는 없다고 생각된다. Objective: A study on fibronectin, which is synthesized in response to inflammatory process of joint destruction, can be of great value in identifying the mechanism of inflammation or disease activity of rheumatoid arthritis (RA). This study attempts to measure the concentrations of total fibronectin in synovial fluid of patients with RA and osteoarthritis (OA), and compare it with the clinical disease activity parameters of RA available. Methods: A total 68 patients suffering from knee pain and joint effusion was examined. Synovial fluids of thirty-eight RA patients and thirty OA patients were measured by using monoclonal fibronectin antibody. Cross-sectional analysis was undertaken to correlate the fibronectin levels of the RA patients with the clinical disease activity parameters available. Results: 1. Mean synovial fibronectin level of RA (148.4±72.6㎍/ml) was significantly higher than that of OA (39.5±16.9㎍/ml)(p<0.001). 2. The fibronectin levels in RA do not seem to have significant relationship with the parameters such as disease duration, the duration of morning stiffness, Ritchie index, ESR, CRP, and rheumatoid factor. Conclusion: In conclusion, the synovial total fibronectin concentration can clearly distinguish RA from OA. However, it would be unlikely to be used as a parameter of disease activity.
2형 당뇨병과 정신지체를 동반한 염색체 6번 장완의 간질성 결손(q21q23)1예
김학준,박정기,이지현,손호상,정의달,조선주,윤원찬,여동근 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.2
Chromosomal abnormalities such as Klinefelter syndrome, Down syndrome, Turner syndrome, Prader-Willi, Bardet-Biedi syndrome were associated with diabetes mellitus. Over 30 cases of interstitial deletions of the long arm of chromosome 6 with vastly variable breakpoints and clinical features have been reported in the literature. The clinical findings varies and most often includes mental retardation, microcephaly, and craniofacial anomalies. We report a case of interstitial deletion (del(6)(q21q23)) with type 2 diabetes mellitus and mental retardation