Microstructure and Mechanical Properties of Cold Drawn Ti–Nb–Ta–Zr–O Wires for Orthodontic Applications

Wei‑dong Zhang,Junye Ren,Bin Liu,Yong Liu,Zhenggang Wu,Jingwen Qiu 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.7

Ti–36Nb–2Ta–3Zr–0.35O (TNTZO) alloy is an excellent candidate for biomedical applications. In this study, a new methodcombining cold-swaging and cold-drawing was used to fabricate the TNTZO alloy wires with 0.3 mm diameter for orthodonticapplications. The microstructure and mechanical properties of cold-drawn and annealed TNTZO wires (referred toas TNTZO0.3and TNTZO0.3(HT), respectively) were investigated. The results show that the microstructure of cold drawnTNTZO0.3consists of main-sized elongated grains with 70 nm width. After annealing at 700 °C for 5 min, the microstructureof TNTZO0.3(HT) wires becomes equiaxial with a grain size of ~ 5 μm. The cold drawn TNTZO0.3wires exhibit improvedmechanical properties, higher tensile strength (about 1000 MPa) and similar elastic modulus (69 GPa), compared to annealedTNTZO0.3(HT) wires. Besides, TNTZO0.3has higher creep resistance and lower stress exponent (around 2), compared to Tiwires and TC4 wires with the same diameter. These results prove that TNTZO0.3wires have most of the ideal characteristicsof orthodontic wires.

漢語蘇州方言和合肥方言入聲字的比較研究

吳舒雅(Wu, Shu-Ya),李偉(Li, Wei),吳世畯(Oh, Se-Jun) 대한중국학회 2019 중국학 Vol.67 No.-

中國地域廣袤,方言種類繁多,但是,信息科技飛速發展的今天,方言正在悄然流逝,人們 對地方方言和傳統文化漸漸漠視和遺忘,方言的喪失必將導致傳統文化的失根,所以對方言的重視 和保護很重要。作為一名語言文化研究愛好者,希望通過研究比較更多的方言來讓人們更了解自己 的語言。方言作為母語,在我們學習第二語言的時候會直接影響到第二語言的習得,不僅存在積極 的促進作用,也存在消極的阻礙作用,這就需要我們對兩種語言進行深刻的了解和多方面的比較研究。蘇州和合肥分別歸屬於吳語區和江淮官話區,雖然是兩種方言,但是從地理位置上看,相互接連,可見兩種方言之間一定存在一些共同特點和差別。筆者就蘇州和合肥的語言上進行比較研究,選擇展現入聲字的中古音在兩地的今讀,分別從方言的聲母和韻母的對比進行分析和解說,以此來 找出兩種方言之間的差異。 However, with the rapid development of information technology, dialects are slipping away. People are gradually ignoring and forgetting local dialects and traditional culture. The loss of dialects will surely lead to the loss of traditional culture. As a language and culture research enthusiast, I hope to make people know more about their own language by studying and comparing more dialects. As the mother tongue, dialect will directly affect the acquisition of the second language when we learn the second language, which not only has a positive role in promoting, but also has a negative role in hindering, which requires us to have a deep understanding of the two languages and a comprehensive comparative study. Suzhou and Hefei belong to the wu-speaking area and the jianghuai guanhua area respectively. Although they are two dialects, they are connected with each other from the geographical position. It can be seen that there must be some common characteristics and differences between the two dialects. Based on a comparative study of the languages of Suzhou and Hefei, the author chooses to present the modern pronunciation of the Chinese ancient pronunciation of rusheng characters in the two places, and analyzes and explains the differences between the initial and final vowels of the dialects respectively, so as to find out the differences between the two dialects.

Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps Sinensis in the Bronchoalveolar Lavage Fluids Cells

Kuo, Yuh-Chi,Wu, Chia-Lin,Tasi, Wei-Jern,Wang, Jir-Yenn,Chang, Shi-Chung,Lin, Ching-Yuang,Shiao, Ming-Shi 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang₃,Ching-Yung Lin⁴,and Ming-Shi Shiao⁴¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang²,Ching-Yung Lin³,and Ming-Shi Shiao⁴.¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan. Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps sinensis in the Bronchoalveolar Lavage Fluids Cells. Proceedings of international Symposium on East-West Medicine, Seoul. 44-64, 1999.-Cordyceps sinensis is a major parasitic fungus on larva of Lepidoptera. It is one of the well know fungi used in traditional Chinese medicine for treatment asthma, lung and kideney diseases. Many fungi belonging to the genus Cordyceps have been demonstrated to produce natural products with various biological activities. Reported biological activities of genus cordyceps include:(a)inhibition of DNA and RNA synthesis;(b)enhancement of cell differentiation;(c)restruction of cytoskeleton;(d)inhibition of protein kinase activity;(e)antitumor activity on bladder, colon, lung carcinoma as well as fibroblastoma;(f)inhibition of the infection and revers transciptase activity of human immunodeficiency virus type 1; and(g) inhibition of methylation of nucleic acid. Thus, it is suggested that the extracts of Cordyceps sp. Contain antitumor, antiviral, and many other biological activities. In our previous studies, we proved that C. sinensis contains the antitumor and immunomodulatory agents. In the present studies, effects of C. sinensis on bronchoalveolar lavage fluids(BAL)cells were demonstrated. The crude methanolic extracts of C. sinensis were fractionated into 15 fractions by silica gel column chromatography. Effects of various fraction on BAL cells proliferation and lipopolysaccharide(LPS) stimulated interleukin-1β(IL-8),platelet activating factor(PAF), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8) production on BAL cells were determined. The result indicated that the CS-19-22 fraction suppressed BAL cells proliferation activated by LPS. The median inhibitory concentration(IC50) was 6㎍/ml. The CS-19-22 fraction also decreased IL-1β,PAF,IL-6, TNF-αand IL-8 production.The results of revers transcription-polymerase chain reaction(RT-PCR) demonstrated that the CS-19-22 fraction did not affect IL-1β,PAF,IL-6, TNF-α,and IL-8 mRNAs expression in BAL cells activated by LPS. By contrast, it inhibited the IL-10 mRNA expression but enhanced IFN-γand IL-12 mRNAs expression in activated BAL cells. Moreover, the CS-19-22 fraction blocked PAF-induced platelet aggregation. It is unlikely that cytotoxicity was involved. Because no cell deths were observable. We hypothesize that inhibitory mechanisms of CS-19-22 on BAL cells proliferation may be related to the impairments of gene expression and production of cytokines in BAL cells. The explanation of C. sinensis antiasthma function may involved the following(1)C.sinenesis contained immunomodulatory agents that stimulated IFN-γand IL-12 expression in TH1cells.(2)Enhanced secretion of IFN-γand IL-12 will inhibit the Tγcells immune responses Ex. Decreasing of IL-6 and IL-10 production.(3) The impairments of cytokines production in TH2 cells suppressed th BAL cells proliferation then more cytokines production Ex.IL-1β,PAF,IL-6,TNF-αand IL-8 in activated BAL cells were decreased. (4)The suppression of TH2cells immune responses will inhibit the growth and differentiation of B cells then IgE production will be decreased. (5)Reduced production of IgE will decreased asthma attack occurring in individuals. However, the results of the present study suggested that C. sinensis may also have acted to treat asthma in part by inhibiting BAL cells proliferation and cytokine gene expression and production. Future, experiments with treatment of animals with asthma with C. sinensis will be necessary to defined whether C. sinensis can reduce asthma injury. Plans are underway for the isolation of pure principal growth inhibitors and their mechanisms of action are subjected for further study.

Concurrent Weekly Docetaxel Chemotherapy in Combination with Radiotherapy for Stage III and IVA-B Nasopharyngeal Carcinoma

Wei, Wei-Hong,Cai, Xiu-Yu,Xu, Tao,Zhang, Guo-Yi,Wu, Yong-Feng,Feng, Wei-Neng,Lin, Li,Deng, Yan-Ming,Lu, Qiu-Xia,Huang, Zhe-Li Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Background and Purpose: Cisplatin is the most common chemotherapeutic agent for loco-regionally advanced nasopharyngeal carcinoma (NPC); however, toxicity is a limiting factor for some patients. We retrospectively compared the efficacy and toxicity of weekly docetaxel-based and cisplatin-based concurrent chemoradiotherapy in loco-regionally advanced NPC. Methods and Materials: Eighty-four patients with Stage III and IVA-B NPCs, treated between 2007 and 2008, were retrospectively analyzed. Thirty received weekly docetaxel-based concurrent chemotherapy, and 43 were given weekly cisplatin-based concurrent chemotherapy. Radiotherapy was administered using a conventional technique (seven weeks, 2.0 Gy per fraction, total dose 70-74 Gy) with 6-8 Gy boosts for some patients with locally advanced disease. Results: Median follow-up time was 42.3 months (range, 8.6-50.8 months). There were no significant differences in the 3-year loco-regional failure-free survival (85.6% vs. 92.3%; p=0.264), distant failure-free survival (87.0% vs. 92.5%; p=0.171), progression-free survival (85.7% vs. 88.4%; p=0.411) or overall survival (86.5% vs. 92.5%, p=0.298) of patients treated concurrently with docetaxel or cisplatin. Severe toxicity was not common in either group. Conclusions: Weekly docetaxel-based concurrent chemoradiotherapy is potentially effective and has a tolerable toxicity; however, further investigations are required to determine if docetaxel is superior to cisplatin for advanced stage NPC.

FBW7 Upregulation Enhances Cisplatin Cytotoxicity in Non-small Cell Lung Cancer Cells

Yu, Hao-Gang,Wei, Wei,Xia, Li-Hong,Han, Wei-Li,Zhao, Peng,Wu, Sheng-Jun,Li, Wei-Dong,Chen, Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Introduction: Lung cancer is extremely harmful to human health and has one of the highest worldwide incidences of all malignant tumors. Approximately 80% of lung cancers are classified as non-small cell lung cancers (NSCLCs). Cisplatin-based multidrug chemotherapy regimen is standard for such lesions, but drug resistance is an increasing problem. F-box/WD repeat-containing protein 7 (FBW7) is a member of the F-box protein family that regulates cell cycle progression, and cell growth and differentiation. FBW7 also functions as a tumor suppressor. Methods: We used cell viability assays, Western blotting, and immunofluorescence combined with siRNA interference or plasmid transfection to investigate the underlying mechanism of cisplatin resistance in NSCLC cells. Results: We found that FBW7 upregulation significantly increased cisplatin chemosensitivity and that cells expressing low levels of FBW7, such as NCI-H1299 cells, have a mesenchymal phenotype. Furthermore, siRNA-mediated silencing or plasmid-mediated upregulation of FBW7 resulted in altered epithelial-mesenchymal transition (EMT) patterns in NSCLC cells. These data support a role for FBW7 in regulating the EMT in NSCLC cells. Conclusion: FBW7 is a potential drug target for combating drug resistance and regulating the EMT in NSCLC cells.

A novel rate control initialization algorithm for H.264

Wei Wu,Hae Kwang Kim IEEE 2009 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.55 No.2

<P>This paper presents a novel rate control initialization algorithm for H.264. Firstly the first instantaneous decoding refresh frame in a video sequence is intra-coded to get the mean absolute difference (MAD) value, then the average MAD value of the second, third and fourth frames which are inter-coded is computed, finally the initial quantization parameter is determined depending on the bits per pixel and the two MAD values. When compared with the algorithm JVT-G012 (2003) which is the current recommended algorithm implemented in the H.264 reference software JM13.0 and the algorithm by H.Wang and S.Kwong (see IEEE Trans. Circuits Syst. Video Techno!., vol.18, no.1, p.140-4, Jan. 2008), the proposed algorithm can increase the average peak signal-to-noise ratio of reconstructed video by up to 1.241 dB and 1.262 dB, respectively.</P>

Isolation and Identification of Bacillus amyloliquefaciens BY01 with High Productivity of Menaquinone for Cheonggukjang Production

Wu, Wei-Jie,Ahn, Byung-Yong The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.5

To develop a cheonggukjang with high content of menaquinone (MK), bacterial strains were isolated from good quality cheonggukjang, and MK productivities of isolated strains were determined by high-performance liquid chromatography. After sensory evaluation and MK determination, a potential probiotics, BY01, with acceptable sensory quality and high productivity of MK was isolated. Fermentation under aerobic condition produced more MK than that obtained under anaerobic condition, and the synthesized MK mainly remained in the form of endocellular deposit. To identify species of strain BY01, biochemical tests and gyrase B gene (gyrB) sequence analysis were carried out, and strain BY01 was identified as Bacillus amyloliquefaciens. The content of MK in cheonggukjang fermented with B. amyloliquefaciens BY01 reached 7.54 ${\mu}g$/g, 2-fold higher than that of commercial cheonggukjang products. This is the first report on the isolation of B. amyloliquefaciens as a superior MK producer in cheonggukjang fermentation.

PAWP, a Sperm-specific WW Domain-binding Protein, Promotes Meiotic Resumption and Pronuclear Development during Fertilization

Wu, Alexander T. H.,Sutovsky, Peter,Manandhar, Gaurishankar,Xu, Wei,Katayama, Mika,Day, Billy N.,Park, Kwang-Wook,Yi, Young-Joo,Xi, Yan Wei,Prather, Randall S.,Oko, Richard American Society for Biochemistry and Molecular Bi 2007 The Journal of biological chemistry Vol.282 No.16

Defining the Stressome of Mycobacterium avium subsp. paratuberculosis In Vitro and in Naturally Infected Cows

Wu, Chia-wei,Schmoller, Shelly K.,Shin, Sung Jae,Talaat, Adel M. American Society for Microbiology 2007 Journal of Bacteriology Vol.189 No.21

<B>ABSTRACT</B><P><I>Mycobacterium avium</I> subsp. <I>paratuberculosis</I> causes an enteric infection in cattle, with a great impact on the dairy industry in the United States and worldwide. Characterizing the gene expression profile of <I>M. avium</I> subsp. <I>paratuberculosis</I> exposed to different stress conditions, or shed in cow feces, could improve our understanding of the pathogenesis of <I>M. avium</I> subsp. <I>paratuberculosis</I>. In this report, the stress response of <I>M. avium</I> subsp. <I>paratuberculosis</I> on a genome-wide level (stressome) was defined for the first time using DNA microarrays. Expression data analysis revealed unique gene groups of <I>M. avium</I> subsp. <I>paratuberculosis</I> that were regulated under in vitro stressors while additional groups were regulated in the cow samples. Interestingly, acidic pH induced the regulation of a large number of genes (<I>n</I> = 597), suggesting the high sensitivity of <I>M. avium</I> subsp. <I>paratuberculosis</I> to acidic environments. Generally, responses to heat shock, acidity, and oxidative stress were similar in <I>M. avium</I> subsp. <I>paratuberculosis</I> and <I>Mycobacterium tuberculosis</I>, suggesting common pathways for mycobacterial defense against stressors. Several sigma factors (e.g., <I>sigH</I> and <I>sigE</I>) were differentially coregulated with a large number of genes depending on the type of each stressor. Subsequently, we analyzed the virulence of six <I>M. avium</I> subsp. <I>paratuberculosis</I> mutants with inactivation of differentially regulated genes using a murine model of paratuberculosis. Both bacterial and histopathological examinations indicated the attenuation of all gene mutants, especially those selected based on their expression in the cow samples (e.g., <I>lipN</I>). Overall, the employed approach profiled mycobacterial genetic networks triggered by variable stressors and identified a novel set of putative virulence genes. A similar approach could be applied to analyze other intracellular pathogens.</P>

Catalysts for Cross-sector Collaboration in Disaster Response

Wei-Ning Wu 위기관리 이론과 실천 2017 위기관리 이론과 실천 세미나발표논문집 Vol.2018 No.-

Cross-sector collaboration has been considered a practical approach for enhancing the capacity of local governments to deliver public services and respond wicked problems of catastrophic events. Taiwan is prone to various natural and man-made disasters, and many countries have learned greatly from the emergency management experiences of Taiwan. While much has been written about the importance and functions of collaboration, very few has examined systematically what factors determine the effective collaboration in emergency response among different municipalities or various public agencies from the perspectives of emergency agencies. This study identifies factors that impact the effectiveness of collaborating emergency services with other public agencies in the local level of Taiwan. Using survey data from local fire branch heads, this research demonstrates that the ability of local fire branch heads to mobilize resources in emergency management process and the quality of citizen engagement in emergency exercise would influence the effective cross-sector collaboration in emergency response with other local fire branches.