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KHUNMANEE SUREERAT,Chun So Young,Ha Yun-Sok,Lee Jun Nyung,Kim Bum Soo,Gao Wei-Wei,Kim In Yong,Han Dong Keun,유승권,Kwon Tae Gyun,Park Hansoo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3
BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney’s ability to filter waste and excess water. Hydrogels are promising material for medical applications owing to their excellent adaptability and filling ability. Herein, we proposed a hyaluronic acid/gelatin (CHO-HA/Gel-NH2) bioactive hydrogel as a cell carrier for therapeutic kidney regeneration in IgAN. METHODS: CHO-HA/Gel-NH2 hydrogel was fabricated by Schiff-base reaction without any additional crosslinking agents. The hydrogel concentrations and ratios were evaluated to enhance adequate mechanical properties and biocompatibility for further in vivo study. High serum IgA ddY mice kidneys were treated with human urine-derived renal progenitor cells encapsulated in the hydrogel to investigate the improvement of IgA nephropathy and kidney regeneration. RESULTS: The stiffness of the hydrogel was significantly enhanced and could be modulated by altering the concentrations and ratios of hydrogel. CHO-HA/Gel-NH2 at a ratio of 3/7 provided a promising milieu for cells viability and cells proliferation. From week four onwards, there was a significant reduction in blood urea nitrogen and serum creatinine level in Cell/Gel group, as well as well-organized glomeruli and tubules. Moreover, the expression of pro-inflammatory and profibrotic molecules significantly decreased in the Gel/Cell group, whereas anti-inflammatory gene expression was elevated compared to the Cell group. CONCLUSION: Based on in vivo studies, the renal regenerative ability of the progenitor cells could be further increased by this hydrogel system.
Wei Ha 서울대학교 교육연구소 2016 Asia Pacific Education Review Vol.17 No.4
This paper examines the effects of roommates on students’ academic outcomes exploiting the randomized roommate assignment system at a selective Chinese university. Unlike earlier studies that could not measure students’ academic quality precisely, this paper makes two important improvements in measuring their English proficiency and overall academic aptitude. I find that randomly assigned roommates’ average pre-treatment academic abilities are not significant determinants of students’ academic performance across a number of different specifications. However, students are significantly influenced by roommates’ decisions in terms of the number of elective course credits taken and the choice of major.
Soo-Ha Kwon,William Wei-Kai Lao,Che-Hsiung Lee,Angela Ting-Wei Hsu,Satomi Koide,Hsing-Yu Chen,Ki-Hyun Cho,Eiko Tanaka,Young-Woo Cheon,Tommy Nai-Jen Chang 대한성형외과학회 2021 Archives of Plastic Surgery Vol.48 No.6
Background The demand for aesthetic procedures continues to grow globally, particularly in East Asian countries. The popularity of specific aesthetic procedures varies, however, depending on the particular East Asian geographical region being studied. This study aimed to evaluate the experiences of and attitudes toward aesthetic procedures in five East Asian countries/regions, including China, Japan, South Korea, Hong Kong, and Taiwan. Methods To recruit participants, an online questionnaire was designed and distributed on social media networks between May 2015 and March 2016. The statistical analysis was conducted using SPSS software, version 22.0. Results A total of 3,088 people responded (approximately 600 in each country/region). Of these, 940 participants (47.8%) responded that they had experienced at least one aesthetic procedure in the past. Taiwan had the highest number of participants who had experienced at least one procedure (264/940, 41%), with primarily non-surgical experiences. Only in South Korea did surgical cosmetic experiences exceed non-surgical cosmetic experiences (55.9% vs. 44.1%). The popularity of particular procedures and the motivation for undergoing aesthetic procedures varied by country. Conclusions The popularity of aesthetic procedures continues to evolve. Similar trends were observed across the East Asian regions; however, each country had its unique demands and preferences. The information provided by this study can help aesthetic plastic surgeons further understand the patients in their corresponding region, customize their practice, and develop the requisite skills.
Recent progress in electrochemical reduction of CO2 into formate and C2 compounds
Wei Jyun Wang,Louis Scudiero,Ha Su 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.3
Global warming and climate change enhanced by the high atmospheric CO2 concentration have been correlated to the frequency of extreme weather causing a significant amount of property damage and loss of human lives. Among current atmospheric CO2 concentration control strategies, the electrochemical reduction of CO2 (eCO2R) process is a promising technology that can utilize CO2 gas as a feedstock to produce valuable C1 and C2 compounds at room temperature. Since the eCO2R reaction is limited by high activation energy and mass transfer, the choice of the electrocatalyst and the configuration of the CO2 electrolyzer have a significant impact on the activity and selectivity of the eCO2R process. This review discusses current technological advancements of electrocatalytic materials and the design of the gas diffusion electrodes that increase energy efficiency and reduce the mass transfer resistance of the CO2 conversion into C1 with a focus on formate and C2 chemical compounds. A techno-economic analysis is briefly provided, and future and technical challenges of the CO2 conversion at the industrial scale into formate and C2 products are also addressed.