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이종섭,기선완 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.1
The author reviewed pharmacotherapy for obsessive compulsive disorder. Serotonin reuptake inhibitors (SRIs) and The tricyclic antidepressant clomipramine are the first line therapies for patients with obsessive compulsive disorder (OCD), with the side-effect profile of selective SRIs (SSRIs) being more favorable than clomipramine. As many as 40% to 60% of patients with OCD may not response to adequate trials of SRIs. Not all patients tolerate SSRIs, and delay in full therapeutic responses often occur. Thus, other pharmacological approaches to treating patients with OCD have been investigated. Augmentation and monotherapy have been explored with serotonergic enhancers, dopamine and 5-HT antagonists , enhancers of second -messenger systems, and GABAergic agents with varying efficacy.
만성 정신분열증 환자에 있어 Clozapine 투여에 의한 비정형적 Prolactin반응
이홍식,김찬형,기선완 대한신경정신의학회 1994 신경정신의학 Vol.33 No.3
Objects : Typical antipsychotic drugs robustily increase prolactin both in rodents and in man. Unlike in rodents, Meltzer(1989) found that acutely administered clozapine did not increases serum prolactin levels in schizophrenia and his preliminary data suggested that prolactin levels might even be reduced during clozapine treatment. Methods : We investigated the serum prolactin levels in chronic schizophrenics, who were assigned to clozapine(N=28) or haloperidol(N=20) for eight weeks. Blood samples were obtained biweekly during the study period, and serum prolactin concentrations were measured by standard double-antibody radioimmunoassay. Results : The serum prolactin levels were not changed in the schizophrenic patients to whom clozapine had been administrated, otherwise marked increases in serum prolactin level were observed in the haloperidol treatment group. Conclusion : Our results suggest that clozapine differs from typical antipsychotics(e.g., haloperidol) in its failure to produce serum prolactin elevation in schizophrenic patients.
강국희,이인선,박완수 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.2
The ferrnetnation characteristics and microbial changes during the storage of salted Chinese cabbage cultivars were investigated. When 10 Chinese cabbage cultivars produced in fall were salted up to 3 and stored at 0%, their pHs were lowered with different modes. and total acid contents were increased with the same way as pH. Results on microbial counts was the best in "noranmat'.
( Seon Mi Lee ),( Jae Yoon Jo ),( Yeon Jee Lee ),( Hee Jung Lee ),( Wan Ju Kim ),( Won Jun Choi ),( Soon Ae Lee ),( Jeong Kyu Shin ),( In Ae Cho ),( Jong Hak Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
We report ths case of 52-year-old woman with endometrioid IA Cancer in endometrium who presented with right sided pleural effusion and ascites. During post operation care period, When the patient inserted state with J-P drainage in pelvic cavity, Rt. pleural effusion was reduced. However, after removal J-P drainage, Rt. pleural effusion was incereased. Additionaly, thoracentesis result was transudate and negative for malignancy. It supported Rt. pleural effusion is caused from peritoneal cavity to pleural cavity through Rt. diaphragm defect due to pressure difference, that is hydrothorax. According to hydrothorax pathogenesis, If the volume of non-malignant fluid exceed in peritoneal area, the fluid can migrate into pleural cavity thorugh transdiaphragmatic leakage. Therefore, We carefully assume that patients who have hydrothorax are better prognosis than metastatic malignant pleural effusion. Because malignant metastasis occurs through transmissive transference or lymphatic transference, adjuvant therapy like chemotherapy have to implement more extensively. So, We need to collect cases of Gynecology cancer patients who have hydrothorax with non-malignant pleural effusion and do not have hydrothorax with malignant pleural effusion. And then, We have to compare prognosis each cases. Indeed, If difference of theses prognosis is meaningful, hydrothorax, the passage from peritoneal cavity into pleural cavity, will be influential prognostic factor of Gynecology cancer patients.
Presacral Neurilemmoma, mimicking teratoma, and simultaneously occurring of Lt. ovarian teratoma
( Seon Mi Lee ),( Jae Yoon Jo ),( Hee Jung Lee ),( Yeon Jee Lee ),( Wan Ju Kim ),( In Ae Cho ),( Jeong Kyu Shin ),( Won Jun Choi ),( Jong Hak Lee ),( Won Young Paik ),( Soon Ae Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Neurilemmoma, also known as schwannoma, is a benign tumor originating from the neural sheath of the peripheral, sympathetic and cranial nerve. Though it occurs most commonly in head and neck area, the neurilemmoma of presacral area is rare. Here, simultaneously, a neurilemmoma, arising in the presacral area and teratoma, arising in the Lt. ovary of a 66-year-old woman, who was presented with fecal incontinence, is described. Actually, We misdiagnosed a presacral neurilemmoma as presacral teratoma. Surgical excision was performed by transabdominal laparoscopy. The patient is no evidence of fecal incontinence, and does well daily, without evidence of the disease. Because it is relatively easy to misdiagnose a presacral neurilemmoma as teratoma, fibroma, ovarian carcinoma, etc., it is critical to perform differential diagnosis of pelvic masses, using radiological and histological methods.
Gastrointestinal stromal tumor pretending gynecological mass
( Seon Mi Lee ),( Jae Yoon Jo ),( Hee Jung Lee ),( Yeon Jee Lee ),( Wan Ju Kim ),( In Ae Cho ),( Jeong Kyu Shin ),( Won Jun Choi ),( Jong Hak Lee ),( Won Young Paik ),( Soon Ae Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Gastrointestinal stromal tumor(GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Because The tumor is usually located in the stomach and proximal small intestine, If GIST is detected in pelvic cavity, it is easy to misdiagnose as gynecological mass such as ovarian cancer, uterine myoma, uterine sarcoma, etc. This case is here. A 78-year-old woman presented with abdominal discomfort with pelvic mass. We performed blood test including CA 125, CA 19-9 and pelvic ECT. Pelvic ECT revealed heterogenous density mass, measuring 9cm and possibility of uterine exophytic myoma or Lt. ovarian cancer was suggested. And then, we performed exploratory laparotomy operation. But the mass was found in jejunum and was finally diagnosed as GIST throughout histopathological examination. Although GIST is low incidence tumor and does not have specific appearance on radiological examination, Gynecologists need to be alert of extra gynecological pathology in patients presenting with an unusual pelvic mass.
Lee Yeon Jung,Lee Hyeon-Ah,Kim Kyong Ah,Baik Myungjae,Paik Jong-Woo,Seol Jinmi,Lee Sang Min,Lee Eun-Jin,Lee Haewoo,Lim Meerae,Jun Jin Yong,Ki Seon Wan,Jeon Hong Jin,Kwon Sun Jung,Lee Hwa-Young 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.5
Objective North Korean defectors (NKDs) have experienced substantial difficulties during the migration and settlement in South Korea. They have a high prevalence of depression, post-traumatic stress disorder, and suicidal behaviors. The high prevalence of mental disorders among NKDs can lead to a high suicide rate. However, there are no suicide prevention programs for NKDs. This study aims to customize a suicide prevention program with content suitable for NKDs’ particular circumstances.Methods A multidisciplinary research team developed this program based on domestic and international gatekeeper training programs for suicide prevention and articles related to suicide prevention.Results We developed a multi-part gatekeeper training program, “Suicide CARE for NKDs.” In the “Introduction,” trainees learn about the need for the program and its importance. In “Careful observation,” trainees learn to recognize linguistic, behavioral, and situational signals of suicide risk. In “Active listening,” trainees learn how to ask about suicidal thoughts and to listen empathetically. In “Risk evaluation and expert referral,” trainees learn to evaluate suicide risk and to connect NKDs with institutes or services.Conclusion We expect this program to become useful for training gatekeepers to prevent suicide among NKD. A future follow-up study is needed to confirm the efficacy of the program.
Bioinformatics Resources of the Korean Bioinformation Center (KOBIC)
Lee, Byung-Wook,Chu, In-Sun,Kim, Nam-Shin,Lee, Jin-Hyuk,Kim, Seon-Yong,Kim, Wan-Kyu,Lee, Sang-Hyuk Korea Genome Organization 2010 Genomics & informatics Vol.8 No.4
The Korean Bioinformation Center (KOBIC) is a national bioinformatics research center in Korea. We developed many bioinformatics algorithms and applications to facilitate the biological interpretation of OMICS data. Here we present an introduction to major bioinformatics resources of databases and tools developed at KOBIC. These resources are classified into three main fields: genome, proteome, and literature. In the genomic resources, we constructed several pipelines for next generation sequencing (NGS) data processing and developed analysis algorithms and web-based database servers including miRGator, ESTpass, and CleanEST. We also built integrated databases and servers for microarray expression data such as MDCDP. As for the proteome data, VnD database, WDAC, Localizome, and CHARMM_HM web servers are available for various purposes. We constructed IntoPub server and Patome database in the literature field. We continue constructing and maintaining the bioinformatics infrastructure and developing algorithms.