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RISS 인기검색어
- 검색키워드
- 저자 : ( Vinoth Kumar Kothandan ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Identification of Neuregulin-2 as a novel stress granule component
( Jin Ah Kim ),( Aravinth Kumar Jayabalan ),( Vinoth Kumar Kothandan ),( Ramesh Mariappan ),( Younghoon Kee ),( Takbum Ohn ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.8
Stress Granules (SGs) are microscopically visible, phase dense aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes formed in response to distinct stress conditions. It is generally considered that SG formation is induced to protect cells from conditions of stress. The precise constituents of SGs and the mechanism through which SGs are dynamically regulated in response to stress are not completely understood. Hence, it is important to identify proteins which regulate SG assembly and disassembly. In the present study, we report Neuregulin-2 (NRG2) as a novel component of SGs; furthermore, depletion of NRG2 potently inhibits SG formation. We also demonstrate that NRG2 specifically localizes to SGs under various stress conditions. Knockdown of NRG2 has no effect on stress-induced polysome disassembly, suggesting that the component does not influence early step of SG formation. It was also observed that reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. [BMB Reports 2016; 49(8): 449-454]
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Development of nano-immunotherapy for cancer treatment: achievements and scopes
Raj Akhil,바부아말,Kothandan Vinoth Kumar,박인규,황승림 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.6
Background Cancer immunotherapy, which activates the immune system of the human body to fight cancer cells, is a new paradigm for cancer treatment that follows first-generation chemotherapeutics and second-generation cancer-targeting agents. Cancer patients who respond to immuno-oncology drugs can experience continuous anticancer effects because cancer immunotherapy uses the memory and adaptiveness of the human immune system. Immunotherapeutics such as immune checkpoint inhibitors, immune cell therapies, anticancer vaccines, and antibody-drug conjugates are changing the present cancer treatment landscape owing to their anticancer efficacy and improvement in the survival rate of cancer patients. However, the clinical use of cancer immunotherapy has limitations, such as variation in the therapeutic response rate between patients and side effects including cytokine storm syndrome and immunosuppressive barriers. Area covered In this review, we describe cancer immunotherapy related to the tumor immune microenvironment and discuss the achievements and scope of nano-immunotherapy for cancer treatment. Expert opinion Tumors have complex characteristics, and immune cell types are diverse. The recent exploration for overcoming the limitations of cancer immunotherapy has paved the way towards the use of nanoparticles for the delivery of immunotherapeutics and/or anticancer agents near the tumor tissue, as well as for immuno-bioimaging.
ScienceON
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