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Lee, Byeong-Ha,Moon, Dae-Seung,Eom, Joo-Beom,Kim, Jin-Chae,Kim, Hok-Young,Paek, Un-Chul 한국광학회 2003 Current Optics and Photonics Vol.7 No.2
It is reported that the spectral loss of photonic crystal fiber (PCF) having a large hole-to-hole distance (~ 10 ${\mu}{\textrm}{m}$) is sensitive to micro- and macrobending when compared with the conventional single-mode fiber. In this paper, we will present the measurement result of the macro- and microbending characteristics of fabricated PCF with large hole-to-hole distance (> 10 ${\mu}{\textrm}{m}$) . For the macrobending experiment, the fiber was simply wound around a circular structure with variable diameter that could be reduced to a few centimeters. For the microbending case, regularly spaced silica rods were attached on a slide glass and pressed against the fiber by loading a stack of metal plates of known weight on the glass. The transmission loss spectrum shows a rather flat response to the to microbending, and this makes the PCF a good candidate for a wideband variable optical attenuator.
TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway
Lee Seul Gi,Chae Jongbeom,Woo Seon Min,Seo Seung Un,Kim Ha-Jeong,Kim Sang-Yeob,Schlaepfer David D.,Kim In-San,Park Hee-Sae,Kwon Taeg Kyu,Nam Ju-Ock 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Extracellular matrix proteins are associated with metabolically healthy adipose tissue and regulate inflammation, fibrosis, angiogenesis, and subsequent metabolic deterioration. In this study, we demonstrated that transforming growth factor-beta (TGFBI), an extracellular matrix (ECM) component, plays an important role in adipose metabolism and browning during high-fat diet-induced obesity. TGFBI KO mice were resistant to adipose tissue hypertrophy, liver steatosis, and insulin resistance. Furthermore, adipose tissue from TGFBI KO mice contained a large population of CD11b+ and CD206+ M2 macrophages, which possibly control adipokine secretion through paracrine mechanisms. Mechanistically, we showed that inhibiting TGFBI-stimulated release of adipsin by Notch-1-dependent signaling resulted in adipocyte browning. TGFBI was physiologically bound to Notch-1 and stimulated its activation in adipocytes. Our findings revealed a novel protective effect of TGFBI deficiency in obesity that is realized via the activation of the Notch-1 signaling pathway.
Lee, Soo Han,Kang, Hyun Jeong,Shin, Dong-Hun,Cho, Duk-Yeon,Song, Jin Mi,Lee, Han Cheol,Kim, Gwang Ha,Song, Geun Am,Sol, Mee Young,Kim, Jee Yeon,Choi, Kyung Un,Lee, Chang Hun,Huh, Gi Young,Park, Do You Gutenberg 2009 HISTOLOGY AND HISTOPATHOLOGY Vol.24 No.7
<P>The biological characteristics of intestinal-type early gastric cancers (ICs) differ based on mucin phenotypes. Beta-catenin delocalization is a predictive marker of aggressive biological behavior (submucosal invasion and lymph node metastasis) of ICs. The presumptive causative genetic alterations leading to delocalization of beta-catenin in ICs are still controversial, and there are only a few reports regarding beta-catenin expression in gastric cancer based on mucin phenotypes. Therefore, in the current study, the expression and mechanisms of delocalization of beta-catenin were elucidated on the basis of mucin phenotypes in 109 cases of ICs. There was increased cytoplasmic and nuclear beta-catenin expression (delocalization) in ICs with a predominant intestinal mucin phenotype (ICIP; 46.3% [25/54 cases]) compared to ICs with a predominant gastric mucin phenotype (ICGP; 20% [11/55 cases]). There were no beta-catenin or APC mutations in ICs. APC promoter hypermethylation was present in 49 of 105 (46.7%) cases of ICs. There was a significant relationship between APC promoter hypermethylation and beta-catenin delocalization in ICs, especially in ICIPs. There was no relationship between beta-catenin delocalization and APC gene loss of heterozygosity in ICs. In conclusion, we showed that beta-catenin delocalization was more evident in ICIPs, and APC promoter hypermethylation might play a role in delocalization of beta-catenin, especially in ICIPs.</P>
The Influence of Face Shields on the Quality of Colonoscopy in the Era of the COVID-19 Pandemic
Lee Jin Wook,Lee Hyo Jeong,Kim Dae Sung,Yoon Jiyoung,Hong Seung Wook,Hwang Ha Won,Lee Jong-Soo,Kim Gwang-Un,Lee Sinwon,Choe Jaewon,Park Jin Hwa,Yang Dong-Hoon,Byeon Jeong-Sik 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.3
Background/Aims: The worldwide coronavirus disease 2019 pandemic has led endoscopists to use personal protective equipment (PPE) for infection prevention. This study aimed to investigate whether wearing a face shield as PPE affects the quality of colonoscopy. Methods: We reviewed the medical records and colonoscopy findings of patients who underwent colonoscopies at Asan Medical Center, Korea from March 10 to May 31, 2020. The colonoscopies in this study were performed by five gastroenterology fellows and four expert endoscopists. We compared colonoscopy quality indicators, such as withdrawal time, adenoma detection rate (ADR), mean number of adenomas per colonoscopy (APC), polypectomy time, and polypectomy adverse events, both before and after face shields were added as PPE on April 13, 2020. Results: Of the 1,344 colonoscopies analyzed, 715 and 629 were performed before and after the introduction of face shields, respectively. The median withdrawal time was similar between the face shield and no-face shield groups (8.72 minutes vs 8.68 minutes, p=0.816), as was the ADR (41.5% vs 39.8%, p=0.605) and APC (0.72 vs 0.77, p=0.510). Polypectomy-associated quality indicators, such as polypectomy time and polypectomy adverse events were also not different between the groups. Quality indicators were not different between the face shield and no-face shield groups of gastroenterology fellows, or of expert endoscopists. Conclusions: Colonoscopy performance was not unfavorably affected by the use of a face shield. PPE, including face shields, can be recommended without a concern about colonoscopy quality deterioration.
Lee, Hyunah,Ha, Min Jung,Shahbaz, Hafiz Muhammad,Kim, Jeong Un,Jang, Holim,Park, Jiyong Elsevier 2018 Journal of food engineering Vol.238 No.-
<P><B>Abstract</B></P> <P>The traditional process of manufacturing red bean powder (RBP) using high temperature and extensive cooking causes quality changes, such as an off-flavor, destruction of colors, and a reduced nutritional value of the product. In this study, RBP was manufactured using a novel process of wet grinding, high hydrostatic pressure (HHP), and freeze-drying. The impact of HHP treatment in this innovative manufacturing process on the microbial count, antioxidant activity, anti-nutritional factors, and physicochemical properties of RBP was evaluated by comparison with the conventional method of thermal treatment. Microbial populations in final RBP were reduced to 1.83, 1.55, and 1.05 log CFU/g when treated using HHP 400, 500, and 600 MPa, respectively. HHP treatment improved the nutritional profile and reduced the effects of anti-nutritional factors in RBP. The most effective reduction of trypsin inhibitor activity and phytic acid content was achieved using HHP at 600 MPa for 5 min. Total phenols, flavonoids, proanthocyanidins and total antioxidant capacity in HHP treated RBP were more effectively preserved than in thermally treated RBP. Preparation of RBP using a novel manufacturing process involving HHP treatment rather than a thermal treatment improved physico-chemical and functional properties and enhanced microbiological safety.</P> <P><B>Highlights for review</B></P> <P> <UL> <LI> Red bean powder was manufactured using a novel process. </LI> <LI> Process included wet grinding, high hydrostatic pressure (HHP), and freeze-drying. </LI> <LI> HHP effectively disinfected naturally occurring microorganisms in red bean powder. </LI> <LI> Nutritional and functional properties of red bean powder were effectively preserved. </LI> </UL> </P>
Transport Current Distribution of a SmBCO Coated Conductor
Lee, Jae-Young,Yoo, Jae-Un,Lee, Sang-Moo,Jung, Ye-Hyun,Youm, Do-Jun,Kim, Ho-Sup,Ha, Hong-Soo,Oh, Sang-Soo The Korean Society of Superconductivity and Cryoge 2007 한국초전도저온공학회논문지 Vol.9 No.4
The transport current distribution across the tape width of a SmBCO coated conductor was investigated. The current distribution was estimated by applying an inversion process to the field distribution measured in the vicinity of the tape by using a scanning Hall probe method. The obtained result is well consistent with one predicted by the Bean model, however, at the edges the current are not constant and do not generally plateau, on the contrary.
Lee, Hyunah,Shahbaz, Hafiz Muhammad,Ha, Namho,Kim, Jeong Un,Lee, Sang Jun,Park, Jiyong The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.1
Background: Korean ginseng (Panax ginseng Meyer) powder is in rising demand because powder forms of foods are convenient to handle and are highly preservable. However, ginseng powder (GP) manufactured using the conventional process of air drying and dry milling suffers nutrient destruction and a lack of microbiological safety. The objective of this study was to prepare GP using a novel process comprised of UV-TiO<sub>2</sub> photocatalysis (UVTP) as a prewashing step, wet grinding, high hydrostatic pressure (HHP), and freeze-drying treatments. Methods: The effects of UVTP and HHP treatments on the microbial population, ginsenoside concentration, and physiological characteristics of GP were evaluated. Results: When UVTP for 10 min and HHP at 600 MPa for 5 min were combined, initial 4.95 log CFU/g-fw counts of total aerobes in fresh ginseng were reduced to lower than the detection limit. The levels of 7 major ginsenosides in UVTP-HHP-treated GP were significantly higher than in untreated control samples. Stronger inhibitory effects against inflammatory mediator production and antioxidant activity were observed in UVTP-HHP-treated GP than in untreated samples. There were also no significant differences in CIELAB color values of UVTP-HHP-treated GP compared with untreated control samples. Conclusion: Combined processing of UVTP and HHP increased ginsenoside levels and enhanced the microbiological safety and physiological activity of GP.
Lee, Hyejin,Lee, Sang-Jin,Bae, Gyu-Un,Baek, Nam-In,Ryu, Jae-Ha MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.12
<P>Cachexia and sarcopenia are the main causes of muscle atrophy. These result in a reduction in the muscle fiber area, myo-protein content, and muscle strength, with various molecular modulators being involved. Although several reports have proposed potential therapeutic agents, no effective treatments have been found for muscle atrophy. We searched for myogenic modulators from medicinal plants to treat muscle diseases. We isolated six alkaloids from <I>Corydalis turtschaninovii</I> and evaluated their myogenic potential by using the MyoD reporter gene assay in C2C12 cells. Among the tested compounds, canadine showed the strongest transactivation of MyoD and increased MHC expression during myogenesis. The activation of p38 MAP kinase and Akt are major mechanisms that contribute to the myogenesis by canadine. Canadine increased the number of multinucleated and cylinder-shaped myotubes during myogenesis of C2C12 myoblasts. To determine the preventive effect of canadine in cancer-induced muscle wasting, differentiated C2C12 myotubes were treated with conditioned media from CT26 colon carcinoma culture (CT26 CM) in the presence of canadine. Canadine ameliorated the muscle protein degradation caused by CT26-CM by down-regulating the muscle specific-E3 ligases, MAFbx/atrogin-1 and MuRF1. In this study, we found that canadine from <I>C. turtschaninovii</I> stimulates myogenesis and also inhibits muscle protein degradation. Therefore, we suggest canadine as a protective agent against muscle atrophy.</P>