Mitigating SYN flooding Attack and ARP Spoofing in SDN Data Plane

Ting-Yu Lin,Jhen-Ping Wu,Pei-Hsuan Hung,Ching-Hsuan Shao,Yu-Ting Wang,Yun-Zhan Cai,Meng-Hsun Tsai 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09

As the number of network devices increases rapidly, it becomes more and more difficult to defend network attacks. Large-scaled attacks, such as SYN flooding, may lead to heavy burden to the switches as well as the controller in a software defined network (SDN). In this paper, we investigate the SYN flooding and Address Resolution Protocol (ARP) spoofing attacks in SDN, and then propose mechanisms to address these two attacks. We also present a new scheme to detect SYN flooding by using only a few forwarding rules. Moreover, we utilize the Programming Protocol-independent Packet Processors (P4) technique to mitigate the burden of the controller.

Expression of Osteopontin in Non-small Cell Lung Cancer and Correlative Relation with Microvascular Density

Yu, Ting-Ting,Han, Zhi-Gang,Shan, Li,Tao, Jie,Zhang, Tao,Yuan, Shuai-Fei,Shen, Hong-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background and Objective: Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features. Methods: Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment. Results: Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000). Conclusion: OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.

Factors Related to Treatment Refusal in Taiwanese Cancer Patients

Chiang, Ting-Yu,Wang, Chao-Hui,Lin, Yu-Fen,Chou, Shu-Lan,Wang, Ching-Ting,Juang, Hsiao-Ting,Lin, Yung-Chang,Lin, Mei-Hsiang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Incidence and mortality rates for cancer have increased dramatically in the recent 30 years in Taiwan. However, not all patients receive treatment. Treatment refusal might impair patient survival and life quality. In order to improve this situation, we proposed this study to evaluate factors that are related to refusal of treatment in cancer patients via a cancer case manager system. Materials and Methods: This study analysed data from a case management system during the period from 2010 to 2012 at a medical center in Northern Taiwan. We enrolled a total of 14,974 patients who were diagnosed with cancer. Using the PRECEDE Model as a framework, we conducted logistic regression analysis to identify independent variables that are significantly associated with refusal of therapy in cancer patients. A multivariate logistic regression model was also applied to estimate adjusted the odds ratios (ORs) with 95% confidence intervals (95%CI). Results: A total of 253 patients (1.69%) refused treatment. The multivariate logistic regression result showed that the high risk factors for refusal of treatment in cancer patient included: concerns about adverse effects (p<0.001), poor performance(p<0.001), changes in medical condition (p<0.001), timing of case manager contact (p=.026), the methods by which case manager contact patients (p<0.001) and the frequency that case managers contact patients (${\geq}10times$) (p=0.016). Conclusions: Cancer patients who refuse treatment have poor survival. The present study provides evidence of factors that are related to refusal of therapy and might be helpful for further application and improvement of cancer care.

Imbalanced Data Classification Based on AdaBoost-SVM

Li Peng,Bi Ting-ting,Yu Xiao-yang,Li Si-ben 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.5

The classification of imbalanced data is one of the most challenging problems in data mining and machine learning research. Imbalanced dataset is a form that exists in reality area, which describes truly and objectively the essential characters of something. There will appear paucity of data and flooded in the classification of imbalanced dataset. Beside problems such as loss of information and data splitting phenomenon will also appear when using the traditional machine learning methods. So how to solve the classification problem of imbalanced data will be challenging. In this paper, aiming at the above problems, a classification algorithm based on AdaBoost-SVM is proposed. In the experiments with four typical forms of imbalanced data sets in UCI were validated the effectiveness of this strategy.

Whole Cell-mediated Biocatalytic Synthesis of Helicid Cinnamylate and Its Biological Evaluation as a Novel Tyrosinase Inhibitor

Rong-ling Yang,Xi Chen,Yu-ye Song,Qian-lin Zhu,Muhammad Bilal,Yu Wang,Zheng Tong,Ting-ting Wu,Zhao-Yu Wang,Hong-zhen Luo,Xiang-jie Zhao,Ting-ting He 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.3

Tyrosinase inhibitors are clinically effective for treating some dermatological disorders related to melanin hyperpigmentation. Accordingly, the discovery and development of tyrosinase inhibitors have great value in the pharmaceutical and cosmetic industry. Here, a novel tyrosinase inhibitor, 6′-O-cinnamoyl-helicid (helicid cinnamylate) was successfully synthesized by a simple and effective biocatalytic approach with Aspergillus oryzae cells. Investigation of the effects of several key variables on helicid cinnamylate synthesis found that the reaction conversion, reaction rate and regioselectivity reached 99%, 9.40 mM/h and > 99%, respectively, at the optimal conditions with anhydrous acetone as the solvent, whole-cell concentration of 40 mg/mL, and the molar ratio of vinyl cinnamate to helicid of 10 at 45°C. The whole-cells retained 68.87% of its initial activity after reusing for seven batches, indicating a potent application potential in non-aqueous biocatalytic systems. It was worth noting that helicid cinnamylate demonstrated a more potent tyrosinase inhibitory activity with an IC50 value of 3.55 mM than helicid (IC50 = 4.48 mM) and arbutin (IC50 = 5.48 mM), which suggest that helicid cinnamylate could be developed as a more potential tyrosinase inhibitor. In conclusion, this study provides a novel whole-cell catalytic approach for the synthesis of helicid cinnamylate and insight into its application as a tyrosinase inhibitor.

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway

Yu Hai-Fan,Zheng Lian-Wen,Yang Zhan-Qing,Wang Yu-Si,Wang Ting-Ting,Yue Zhan-Peng,Guo Bin 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

TAZ, as a crucial effector of Hippo pathway, is required for spermatogenesis and fertilization, but little is known regarding its physiological function in uterine decidualization. In this study, we showed that TAZ was localized in the decidua, where it promoted stromal cell proliferation followed by accelerated G1/S phase transition via Ccnd3 and Cdk4 and induced the expression or activity of stromal differentiation markers Prl8a2, Prl3c1 and ALP, indicating the importance of TAZ in decidualization. Knockdown of TAZ impeded HB-EGF induction of stromal cell proliferation and differentiation. Under oxidative stress, TAZ protected stromal differentiation against oxidative damage by reducing intracellular ROS and enhancing cellular antioxidant capacity dependent on the Nrf2/ARE/Foxo1 pathway. TAZ strengthened the transcriptional activity of Nrf2 which directly bound to the antioxidant response element (ARE) of Foxo1 promoter region. Additionally, silencing TAZ caused accumulation of intracellular ROS through heightening NOX activity whose blockade by APO reversed the disruption in stromal differentiation. Further analysis revealed that TAZ might restore mitochondrial function, as indicated by the increase in ATP level, mtDNA copy number and mitochondrial membrane potential with the reduction in mitochondrial superoxide. Additionally, TAZ modulated the activities of mitochondrial respiratory chain complexes I and III whose suppression by ROT and AA resulted in the inability of TAZ to defend against oxidative damage to stromal differentiation. Moreover, TAZ prevented stromal cell apoptosis by upregulating Bcl2 expression and inhibiting Casp3 activity and Bax expression. In summary, TAZ might mediate HB-EGF function in uterine decidualization through Ccnd3 and ameliorate oxidative damage to stromal cell differentiation via Nrf2/ARE/Foxo1 pathway.

A Mixed-methods Study on Early Childhood Educators’ Aesthetic Literacy and Aesthetic Teaching Practices

Yu-Ting Chen The Pacific Early Childhood Education Research Ass 2022 Asia-Pacific journal of research in early childhoo Vol.16 No.2

As aesthetic education has become an important component of school curricula in Taiwan, aesthetic education for children is valued in early schooling. This study explores early childhood educators’ aesthetic literacy and aesthetic teaching practices in north Taiwan. The researcher conducted a mixed-methods study, including a survey and interviews, with 490 early childhood educators participating in the survey, 10 of whom participated in the interviews. The findings indicate that: (1) the early childhood educators’ mean score for aesthetic teaching practices was better than that for aesthetic literacy. (2) The high achievers in aesthetic literacy had better aesthetic teaching practices than the moderate achievers and low achievers. (3) There was a significantly positive correlation between aesthetic literacy and aesthetic teaching practices. (4) The 10 interviewed early childhood educators believed that their aesthetic teaching practices were influenced by their aesthetic literacy. They played important roles as aesthetic guides and providers to help the children explore the environment, as well as exploring, creating, and appreciating the arts. This study provides a lens for examining aesthetic education in early schooling in Taiwan, as well as valuable information about early childhood aesthetic education and teacher education in an Asian context.

H-mode experimental integrated modeling of impurity injection to control divertor heat flux on HL-2A

Yu Peng,Huang Qianhong,Zhong Yijun,Wu Ting,Wang Jun,Wang Zhanhui,Gong Xue-yu 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.8

Based on the METIS integrated modeling platform, combined with the experimental data of the #34512 shot detached divertor operation on the HL-2A, this paper selects suitable physical models, and compares and analyzes the integrated modeling results with the experimental results. The modeling results are in good agreement with the experimental results. On this basis, the reason for the decrease of the peak heat fux on the divertor targets is investigated using the METIS simulator. The results show that the two factors of entering the H-mode and the radiation enhancement efect generated by impurity injection work together to reduce the heat fow on the targets. Finally, the diferent efects of N, Ar and Ne impurity gases on the heat fux reduction of the targets are simulated under the condition that the plasma line-average efective charge (Zef) is kept unchanged. The results show that N and Ar are both better than Ne in controlling the heat fow on the targets, and N has the best compatibility in the core, which can not only reduce the boundary heat fow but also maintain the core confnement performance.

A novel and efficient procedure for the preparation of 4,40-bis(chloromethyl)biphenyl by chloromethylation of biphenyl catalyzed by PEG1000-DAIL under homogeneous catalysis in aqueous media

Yu Lin Hu,Qiang Ge,Peng Cheng Wang,Ting Ting Lu,Ming Lu 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.4

As described in this article, 4,40-bis(chloromethyl)biphenyl was obtained in 85% excellent yield by chloromethylation of biphenyl catalyzed by the recyclable temperature-dependant phase-separation system that comprised the dicationic acidic ionic liquid PEG1000-DAIL and methylcyclohexane under homogeneous catalysis in aqueous media. Compared to other synthetic methods, the novel method not only enhanced the yield, but also made the operating units easy workup. The mechanism of chloromethylation reaction and the process of catalysis in the thermoregulated ionic liquid bi-phase system were proposed.

Fabrication of polyacrylic acid-based composite binders with strong binding forces on copper foils for silicon anodes in lithium-ion batteries

Ting-Ting Su,Wen-Feng Ren,Jiang-Meng Yuan,Ke Wang,Bing-Yu Chi,Run-Cang Sun 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-

The commercial application of silicon (Si) anodes with high theoretical capacity is hampered by the poorcyclic stability because the huge volume change of Si during discharge/charge processes results in thepulverization of electrode materials and the electric contact loss of electrode materials with copper(Cu) foils. Binders play an important role for adhering active materials and conductive additives togetheronto Cu foils. Herein, we design and develop a three-dimensional networked composite binder (PAA-co-SN) via an amidation reaction between polyacrylic acid (PAA) and thiourea (SN). The granular anchors(CuxS) are constructed at the interface between PAA-co-SN binders and Cu foils, resulting from the reactionof S and Cu during the drying processes of Si electrodes. When used as binders for Si nanoparticles,they exhibit stable cyclic performance (1580 mAh g1 after 500 cycles). The anchoring mechanismbetween composite binders and Cu foils provides a strategy for the improvement of electrochemicalproperties of Si-based anodes for lithium-ion batteries.