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- 저자 : ( Tayyaba Hasan ) (검색결과 3 건)
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( Han Hee Lee ),( Myung-gyu Choi ),( Tayyaba Hasan ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.1
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a spe cific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the sim plicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangio carcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nan otechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastroin testinal diseases.
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( Jae Myung Park ),( In Wook Kim ),( Ju Hee Kim ),( Tayyaba Hasan ),( Myung Gyu Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Porphyrin-based photosensitizers are most commonly used in photodynamic therapy (PDT). However, these drugs are exported extracellularly by a cell-membrane transporter, the ATP-binding cassette subfamily G member 2 (ABCG2), decreasing the PDT-induced cytotoxicity in cancer treatment. In this study, we showed that intracellular level of a porphyrin was increased by its Pegylated form, which enhance the PDT-induced cytotoxicity. Methods: Pancreatic cancer cells, AsPC-1 and MIA PaCa-2, were selected. We also used ABCG2-overexpressed MIA Paca-2 cells. We pretreated them with chlorine e6 (Che6) or its pegylated-Che6, then irradiated with a diode laser emitting at 670 nm wave length with total radiation dose of 6 J/cm2. We measured the intracellular level of Che6 and peglated-Che6 with fl uorescence meter, FACS and confocal microscope. Cell viability and survival was analyzed by MTT assay and clonogenic survival assay, respectively. Singlet oxygen level was quantified with photomultiplier-tube based singlet oxygen detection system. In-vivo PDT effects were investigated with AsPC-1 cell-bearing BALC/nude mice of the Che6 and pegylated-Che6. Results: The intracellular level of Che6 was higher in MIA PaCa-2 than AsPC-1 and MIA PaCa-2/ABCG2 cells. However, intracellular level of Che6 was increased by its pegylated form in AsPC-1 and MIA PaCa2/ABCG2 cells. Cell viability after PDT was signifi cantly decreased in MIA PaCa-2 compared to AsPC-1 and MIA PaCa-2/ABCG2. However, PDT using pegylated-Che6 caused the similar cytotoxicity among the three cancer cell lines. The production level of singlet oxygen was higher in pegylated-Che6 than Che6-treated cells. The tumor volume after PDT using pegylated-Che6 was signifi cant smaller than that of Che6 in AsPC-1-xenograft mouse model. Conclusions: Pegylated-photosensitizer escaped ABCG2 function, which suggests potential improvement of ABCG2-related resistant to porphyrin-based PDT in cancer treatment in pancreatic cancers.
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Polarization-sensitive optical frequency domain imaging based on unpolarized light.
Kim, Ki Hean,Park, B Hyle,Tu, Yupeng,Hasan, Tayyaba,Lee, Byunghak,Li, Jianan,de Boer, Johannes F Optical Society of America 2011 Optics express Vol.19 No.2
<P>Polarization-sensitive optical coherence tomography (PS-OCT) is an augmented form of OCT, providing 3D images of both tissue structure and polarization properties. We developed a new method of polarization-sensitive optical frequency domain imaging (PS-OFDI), which is based on a wavelength-swept source. In this method the sample was illuminated with unpolarized light, which was composed of two orthogonal polarization states (i.e., separated by 180° in the Poincaré sphere) that are uncorrelated to each other. Reflection of these polarization states from within the sample was detected simultaneously and independently using a frequency multiplexing scheme. This simultaneous sample probing with two polarization states enabled determination of the depth-resolved Jones matrices of the sample. Polarization properties of the sample were obtained by analyzing the sample Jones matrices through eigenvector decomposition. The new PS-OFDI system ran at 31K wavelength-scans/s with 3072 pixels per wavelength-scan, and was tested by imaging a polarizer and several birefringent tissues such as chicken muscle and human skin. Lastly the new PS-OFDI was applied to imaging two cancer animal models: a mouse model by injecting cancer cells and a hamster cheek pouch model. These animal model studies demonstrated the significant differences in tissue polarization properties between cancer and normal tissues in vivo.</P>
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