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Takashi Motohashi,Akira Yabuno,Hiroshi Michimae,Tetsuro Ohishi,Miwa Nonaka,Masashi Takano,Shin Nishio,Hiroyuki Fujiwara,Keiichi Fujiwara,Eiji Kondo,Toru Sugiyama,Tsutomu Tabata 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.1
Objective: The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m2every 4weeks. While 40 mg/m2has recently been used in clinical practice, evidence supporting thisuse remains lacking. Methods: This phase III randomized, non-inferiority study compared progression free survival (PFS) for patients with platinum-resistant ovarian carcinoma between anexperimental arm (40 mg/m2PLD) and a standard arm (50 mg/m2PLD) until 10 courses,disease progression or unacceptable toxicity. Eligible patients had received ≤2 prior lines. Stratification was by performance status and PFS of prior chemotherapy (<3 months versus ≥3months). The primary endpoint was PFS and secondary endpoints were overall survival (OS),toxicity profile, clinical response and tolerability. The total number of patients was 470. Results: The trial was prematurely closed due to slow recruitment, with 272 patients randomizedto the experimental arm (n=137) and standard arm (n=135). Final analysis was performed with234 deaths and 269 events for PFS. In the experimental arm vs. standard arm, median PFS was4.0 months vs. 4.0 months (hazard ratio [HR]=1.065; 95% confidence interval [CI]=0.830–1.366)and median OS was 14.0 months vs. 14.0 months (HR=1.078; 95% CI=0.831–1.397). Hematologictoxicity and oral cavity mucositis (≥grade 2) were more frequent in the standard arm than in theexperimental arm, but no difference was seen in ≥grade 2 hand-foot skin reaction. Conclusion: Non-inferiority of 2 PLD dosing schedule was not confirmed because the trialwas closed prematurely. However, recommendation of dose reduction of PLD should bebased both on efficacy and safety. Trial Registration: UMIN Clinical Trials Registry Identifier: UMIN000003130
Keiichi Fujiwara,Hiroyuki Fujiwara,Hiroyuki Yoshida,Toyomi Satoh,Kan Yonemori,Shoji Nagao,Takashi Matsumoto,Hiroaki Kobayashi,Hughes Bourgeois,Philipp Harter,Anna Maria Mosconi,Isabel Palacio Vazquez 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.5
Objective: The addition of maintenance olaparib to bevacizumab demonstrated a significant progression-free survival (PFS) benefit in patients with newly diagnosed, advanced ovarian cancer in the PAOLA-1/ENGOT-ov25 trial (NCT02477644). We evaluated maintenance olaparib plus bevacizumab in the Japan subset of PAOLA-1. Methods: PAOLA-1 was a randomized, double-blind, phase III trial. Patients received maintenance olaparib tablets 300 mg twice daily or placebo twice daily for up to 24 months, plus bevacizumab 15 mg/kg every 3 weeks for up to 15 months in total. This prespecified subgroup analysis evaluated investigator-assessed PFS (primary endpoint). Results: Of 24 randomized Japanese patients, 15 were assigned to olaparib and 9 to placebo. After a median follow-up for PFS of 27.7 months for olaparib plus bevacizumab and 24.0 months for placebo plus bevacizumab, median PFS was 27.4 versus 19.4 months, respectively (hazard ratio [HR]=0.34; 95% confidence interval [CI]=0.11–1.00). In patients with tumors positive for homologous recombination deficiency, the HR for PFS was 0.57 (95% CI=0.16–2.09). Adverse events in the Japan subset were generally consistent with those of the PAOLA-1 overall population and with the established safety and tolerability profiles of olaparib and bevacizumab. Conclusion: Results in the Japan subset of PAOLA-1 support the overall conclusion of the PAOLA-1 trial demonstrating that the addition of maintenance olaparib to bevacizumab provides a PFS benefit in patients with newly diagnosed, advanced ovarian cancer. Trial Registration: ClinicalTrials.gov Identifier: NCT02477644
A scheme on multi-tier heterogeneous networks for citywide damage monitoring in an earthquake
Fujiwara, Takahiro,Watanabe, Takashi,Shinozuka, Masanobu Techno-Press 2013 Smart Structures and Systems, An International Jou Vol.11 No.5
Quick, accurate damage monitoring is strongly required for damage assessment in the aftermath of a large natural disaster. Wireless sensor networks are promising technologies to acquire damage information in a citywide area. The wireless sensor networks, however, would be faced with difficulty to collect data in real-time and to expand the scalability of the networks. This paper discusses a scheme of network architecture to cove a whole city in multi-tier heterogeneous networks, which consist of wireless sensor networks, access networks and a backbone network. We first review previous studies for citywide damage monitoring, and then discuss the feature of multi-tier heterogeneous networks to cover a citywide area.
A scheme on multi-tier heterogeneous networks for citywide damage monitoring in an earthquake
Takahiro Fujiwara,Takashi Watanabe,Masanobu Shinozuka 국제구조공학회 2013 Smart Structures and Systems, An International Jou Vol.11 No.5
Quick, accurate damage monitoring is strongly required for damage assessment in the aftermath of a large natural disaster. Wireless sensor networks are promising technologies to acquire damage information in a citywide area. The wireless sensor networks, however, would be faced with difficulty to collect data in real-time and to expand the scalability of the networks. This paper discusses a scheme of network architecture to cove a whole city in multi-tier heterogeneous networks, which consist of wireless sensor networks, access networks and a backbone network. We first review previous studies for citywide damage monitoring, and then discuss the feature of multi-tier heterogeneous networks to cover a citywide area.
A Class of Multiuser Interference Free Modulations Produced by General Orthogonal Modulations
Yasunaga, Takashi,Oka, Ikuo,Ata, Shingo,Fujiwara, Chikato 통신위성우주산업연구회 2004 Joint Conference on Satellite Communications Vol.2004 No.-
Suppression of multiuser interference effects in a frequency-selective fading channel is big issue in mobile communication system. In this paper, a parameter of modulations is discussed to develop new modulations which do not yield multiuser interference in CDMA. The modulations are shown to be in a certain class of general orthogonal modulations. The general orthogonal modulations are based on orthogonal vectors, which are obtained by multidimensional rotations and have parameters of rotation planes and rotation angles. We find the parameters of general orthogonal modulations that preserves orthogonality among users in the frequency-selective channel. The derived parameters express the new modulations, whose transfer matrices are expressed by a Kronecker product of two rotation matrices. We obtain the parameters that maximize constellation distance by computer simulations. Numerical results of distance are demonstrated to compare the performance of widely used CDMA and the new modulations proposed in this paper.