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Clinical Factors Potentially Influencing Eradication of Helicobacter pylori in Peptic Ulcer
남택만 ( Taek Man Nam ),( Dong Ho Lee ),( Na Young Kim ),( Sook Hyang Jung ),( Jin Wook Kim ),( Jin Hyeok Hwang ),( Young Soo Park ),( Sang Hyub Lee ),( Hyun Chae Jung ),( In Sung Song ) 대한소화기학회 2007 대한소화기학회 추계학술대회 Vol.2007 No.-
Kim, Tae Nyun,Park, Man Sik,Lee, Seong Keon,Yang, Sae Jeong,Lee, Kwan Woo,Nam, Moonsuk,Nam, Moon Suk,Park, Yong Soo,Woo, Jeong-Taek,Woo, Jeong Taek,Kim, Young Seol,Baik, Sei Hyun Macmillan Press 2012 Endocrine Vol.42 No.3
<P>The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) 5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG 7.0 mmol/L or 120-min post-challenge plasma glucose 11.1 mmol/L or A1C 6.5 %. For insulin sensitivity and β-cell function classified by the categories of A1C levels, ?Ins(30-0)/?Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group ( 5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and ?Ins(30-0)/?Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with ?Ins(30-0)/?Glu(30-0), and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes.</P>
남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5
연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).
Weon Taek Seo,Sang Hae Nam,Chang Kwon Lee,Kye Man Cho 한국식품영양과학회 2011 Preventive Nutrition and Food Science Vol.16 No.1
The potential probiotic of a total of 15 Bacillus species isolated from Korean soybean paste (doenjang) was evaluated. Among those tested, the CSY191 and CSY388 strains were selected as probiotic bacteria due to their acid and bile tolerance, respectively. These strains were classified as Bacillus subtilis based on morphological, physiological, and chemotaxonomic features as well as on phylogenetic analysis based on their 16S rDNA sequences. These strains CSY191 and CSY388 showed a significant survival with rate range of 30.0 to 58.3% and of 31.0% to 58.1%, respectively, under artificial gastric acidic conditions at pH 3.0. These CSY191 and CSY388 strains appeared to have high antimicrobial activity against Salmonella Typhimurium, Bacillus cereus and Listeria monocytogenes. Also, methanol extractions (surfactin-like compounds) of strain CSY191 and strain CSY388 activated RAW264.7 microphages and induced the production of nitric oxide (NO) in a concentration-dependent manner, respectively. Therefore, strain CSY191 and strain CSY388 can be used as potential probiotics.
남택근(Taek-Kun Nam),김진만(Jin-Man Kim),김대희(Dae-Hee Kim),임정빈(Jeong-Bin Yim) 한국항해항만학회 2010 한국항해항만학회 학술대회논문집 Vol.2010 No.춘계
본 연구에서는 전남 지역 해양 관광 활성화를 위한 방안들을 도출하고자 한다. 전남 서남권 지역은 천혜의 관광 자원이라 할 수 있는 도서와 해양 생물자원이 풍부한 해안선을 접하고 있다. 이에 본 연구에서는 도서지역과 해안선을 활용한 체험형 레저 스포츠를 통해 지역 내 해양관광 인구의 유입을 증가시키는 방안에 대해 제안 한다. 먼저, 역사적인 유래와 경치가 뛰어난 도서를 대상으로 한 산악자전거대회(일명 아일랜드챌린저) 대회의 개최와 이러한 대회를 통한 관광 유입효과에 대해 검토할 것이다. 다음으로 해안선을 배경으로 한 뻘배의 활용 방안과 지역 어촌계의 관광 상품과도 연계할 수 있는 방법에 대해 살펴볼 것이다. 이러한 활동을 통하여 지역 내 해양관광의 발달과 이를 통한 지역민의 소득증대에 기여할 수 있을 것이다. In this paper, the plan to invigorate regional marine tourism is discussed. The southwest area of Jeonnam province is famous for its beautiful islands and seashore line which has richness and variety of marine life. A solution of tourists increment by leisure sports utilizing island and coastline will be proposed MTB tournament held at islands that has historic backgrounds and scenic beauty and its effect on influx of tourist were tackled first. Next application of mud flats boot around seaside and connection with experience program of seaside village were also examined. These activities will contribute to development of marine tourism and increase of income for regional people.
Kwon, Nam Hoon,Park, Kun Taek,Jung, Woo Kyung,Youn, Hwa Young,Lee, Yeonhee,Kim, So Hyun,Bae, Wonki,Lim, Ji Youn,Kim, Ji Yeon,Kim, Jun Man,Hong, Soon Keun,Park, Yong Ho Elsevier 2006 Veterinary microbiology Vol.117 No.2
<P><B>Abstract</B></P><P>Methicillin resistant <I>Staphylococcus aureus</I> (MRSA) is one of the most important pathogens in human and veterinary hospitals. The isolation of MRSA from animals and foodstuffs has been reported with an increased incidence. However, methicillin (oxacillin) is not used in animal husbandry or in animal hospitals in Korea. In this study, three pre-MRSA and one silent <I>mecA</I>-carrying methicillin susceptible <I>S. aureus</I> (smMSSA) were isolated from retail chicken meat, and three MRSA were isolated from hospitalized dogs in Korea. The three pre-MRSA isolates were determined to have a staphylococcal cassette chromosome <I>mec</I> (SCC<I>mec</I>) type III, and the smMSSA isolate was not classified. The animal hospital isolates were found to contain SCC<I>mec</I> type II. Seven and 15 <I>S. aureus</I> isolated from hospitalized humans and bovine milk, respectively, were also examined in this study in order to determine the epidemiological origins of MRSA. Multilocus sequencing typing (MLST) revealed that the chicken meat and bovine milk isolates were closely related to the animal hospital isolates. The SCC<I>mec</I> characteristics and MLST analyses indicated the possibility of the human to animal transmission of MRSA. These results highlight the importance of identifying MRSA carriers as well as intercepting MRSA transmission because MRSA is becoming increasingly widespread without any plausible relationship with the use of methicillin (oxacillin).</P>