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봄나물 섭취 후 이상 행동을 주요 증상으로 내원한 환자 1례
옥택근,김윤성,박찬우,문중범,최기훈,서정열,안희철,안무업,조준휘,Ohk Taek-Geun,Kim Yoon-Seong,Park Chan-Woo,Moon Joong-Bum,Choi Ki-Hoon,Seo Jeong-Yeul,Ahn Hee-Cheol,Ahn Moo-Wob,Cho Jun-Hwi 대한임상독성학회 2006 대한임상독성학회지 Vol.4 No.1
With well-being boom recently, the common people, but not experts, are increasingly taking in them directly by picking wild herbs. However, only experts can distinguish between edible vegetables and poisonous herbs from the wild herbs. Especially, it is not even easy for experts to distinguish them only by looking into buds in spring without flowers or fruit. So, sometimes many patients are being carried into the emergency room by the toxic symptom after taking by misunderstanding the poisonous herbs as edible vegetables. For herb intoxication as well as drug intoxication, what kinds of vegetables patients took in, and when and how much they took in them are important information for curing. Of course, in the case of intoxicating in the wild herbs, the patients can have a lot of symptoms and sings-hemodynamic alteration and abnormal neurologic sign as well as gastrointestinal symptoms-according to the kinds of herbs which they took in. Therefore, it is difficult to find the kinds of herbs which they took in through the specific symptoms. Recently we experienced a case with showing typical anticholinergic symptoms after ingestion of Scopolia japonica. As a result, the publicity activities about the wild plants needs because if the person without their previous knowledge take in the poisonous herbs, serious side effects can be produced..
Yoon soo Park,Hyun Jin Tae,Jeong Hwi Cho,In Shik Kim,Taek Geun Ohk,Chan Woo Park,Joong Bum Moon,Myoung Cheol Shin,Tae Kyeong Lee,Jae Chul Lee,Joon Ha Park,Ji Hyeon Ahn,Seok Hoon Kang,Moo Ho Won,Jun Hw 대한해부학회 2018 Anatomy & Cell Biology Vol.51 No.2
Cardiac arrest (CA) is sudden loss of heart function and abrupt stop in effective blood flow to the body. The patients who initially achieve return of spontaneous circulation (RoSC) after CA have low survival rate. It has been known that multiorgan dysfunctions after RoSC are associated with high morbidity and mortality. Most previous studies have focused on the heart and brain in RoSC after CA. Therefore, the aim of this research was to perform serological, physiological, and histopathology study in the lung and to determine whether or how pulmonary dysfunction is associated with low survival rate after CA. Experimental animals were divided into sham-operated group (n=14 at each point in time), which was not subjected to CA operation, and CA-operated group (n=14 at each point in time), which was subjected to CA. The rats in each group were sacrificed at 6 hours, 12 hours, 24 hours, and 2 days, respectively, after RoSC. Then, pathological changes of the lungs were analyzed by hematoxylin and eosin staining, Western blot and immunohistochemistry for tumor necrosis factor (TNF-). The survival rate after CA was decreased with time past. We found that histopathological score and TNF- immunoreactivity were significantly increased in the lung after CA. These results indicate that inflammation triggered by ischemia-reperfusion damage after CA leads to pulmonary injury/dysfunctions and contributes to low survival rate. In addition, the finding of increase in TNF- via inflammation in the lung after CA would be able to utilize therapeutic or diagnostic measures in the future.
'만병초' (Rhododendron brachycarpum)에 의한 전신 중독 2례
옥택근,김윤성,박찬우,문중범,이봉기,조병렬,김용훈,김성은,최기훈,서정열,안희철,안무업,조준휘,Ohk, Taek-Geun,Kim, Yoon-Seong,Park, Chan-Woo,Moon, Joong-Bum,Lee, Bong-Ki,Cho, Byung-Yeul,Kim, Yong-Hoon,Kim, Seong-Eun,Choi, Ki-Hoon,Seo, Jeong-Ye 대한임상독성학회 2006 대한임상독성학회지 Vol.4 No.2
Historically, the common folk have made use of various wild herbs for both food and medicinal purposes. However, the misuse of these wild herbs can lead to adverse consequences, including severe poisoning in some cases. In cases of poisoning from wild herbs, patients can exhibit a variety of symptoms depending on the herbs involved, which in addition to gastrointestinal symptoms may include hemodynamic alteration and abnormal neurologic signs. In the present case, two patients were admitted to the emergency room with symptoms of toxicity after consuming Rhododendron brachycarpum liquor. Rhododendron brachycarpum and other wild herbs contain the toxic material grayanotoxin. Because of its serious toxic symptoms, great caution must be exercised in using rhododendrons for food and medicinal purposes.
Increased immunoreactivity of c???Fos in the spinal cord of the aged mouse and dog.
Ahn, Ji Hyeon,Shin, Myoung Chul,Park, Joon Ha,Kim, In Hye,Lee, Jae-Chul,Yan, Bing Chun,Hwang, In Koo,Moon, Seung Myung,Ahn, Ji Yun,Ohk, Taek Geun,Lee, Tae Hun,Cho, Jun Hwi,Shin, Hyung-Cheul,Won, Moo-H SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.2
<P>Expression of c-Fos in the spinal cord following nociceptive stimulation is considered to be a neurotoxic biomarker. In the present study, the immunoreactivity of c-Fos in the spinal cord was compared between young adult (2-3 years in dogs and 6 months in mice) and aged (10-12 years in dogs and 24 months in mice) Beagle dogs and C57BL/6J mice. In addition, changes to neuronal distribution and damage to the spinal cord were also investigated. There were no significant differences in neuronal loss or degeneration of the spinal neurons observed in either the aged dogs or mice. Weak c-Fos immunoreactivity was observed in the spinal neurons of the young adult animals; however, c-Fos immunoreactivity was markedly increased in the nuclei of spinal neurons in the aged dogs and mice, as compared with that of the young adults. In conclusion, c-Fos immunoreactivity was significantly increased without any accompanying neuronal loss in the aged spinal cord of mice and dogs, as compared with the spinal cords of the young adult animals.</P>
Rufinamide pretreatment attenuates ischemia-reperfusion injury in the gerbil hippocampus
Park, Chan Woo,Lee, Tae-Kyeong,Cho, Jeong Hwi,Kim, In Hye,Lee, Jae-Chul,Shin, Bich-Na,Ahn, Ji Hyeon,Kim, Sung Koo,Shin, Myoung Cheol,Ohk, Taek Geun,Cho, Jun Hwi,Won, Moo-Ho,Lee, Young Joo,Seo, Jeong Y Informa UK (Taylor Francis) 2017 Neurological research Vol.39 No.11
Park, Seung Min,Park, Chan Woo,Lee, Tae-Kyeong,Cho, Jeong Hwi,Park, Joon Ha,Lee, Jae-Chul,Chen, Bai Hui,Shin, Bich-Na,Ahn, Ji Hyeon,Tae, Hyun-Jin,Shin, Myoung Cheol,Ohk, Taek Geun,Cho, Jun Hwi,Won, Mo Medknow PublicationsMedia Pvt Ltd 2016 Neural regeneration research Vol.11 No.7
<P>Ischemic preconditioning (IPC) is a condition of sublethal transient global ischemia and exhibits neuroprotective effects against subsequent lethal ischemic insult. We, in this study, examined the neuroprotective effects of IPC and its effects on immunoreactive changes of antioxidant enzymes including superoxide dismutase (SOD) 1 and SOD2, catalase (CAT) and glutathione peroxidase (GPX) in the gerbil hippocampal CA1 region after transient forebrain ischemia. Pyramidal neurons of the stratum pyramidale (SP) in the hippocampal CA1 region of animals died 5 days after lethal transient ischemia without IPC (8.6% (ratio of remanent neurons) of the sham-operated group); however, IPC prevented the pyramidal neurons from subsequent lethal ischemic injury (92.3% (ratio of remanent neurons) of the sham-operated group). SOD1, SOD2, CAT and GPX immunoreactivities in the sham-operated animals were easily detected in pyramidal neurons in the stratum pyramidale (SP) of the hippocampal CA1 region, while all of these immunoreactivities were rarely detected in the stratum pyramidale at 5 days after lethal transient ischemia without IPC. Meanwhile, their immunoreactivities in the sham-operated animals with IPC were similar to (SOD1, SOD2 and CAT) or higher (GPX) than those in the sham-operated animals without IPC. Furthermore, their immunoreactivities in the stratum pyramidale of the ischemia-operated animals with IPC were steadily maintained after lethal ischemia/reperfusion. Results of western blot analysis for SOD1, SOD2, CAT and GPX were similar to immunohistochemical data. In conclusion, IPC maintained or increased the expression of antioxidant enzymes in the stratum pyramidale of the hippocampal CA1 region after subsequent lethal transient forebrain ischemia and IPC exhibited neuroprotective effects in the hippocampal CA1 region against transient forebrain ischemia.</P>