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뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열
장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-
Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.
Aspergillus coreanus NR 15-1과 Aspergillus oryzae NR 2-5의 원형질체 형성의 최적조건
정혁준,유대식 한국산업미생물학회 2001 한국미생물·생명공학회지 Vol.29 No.1
한국 전통누룩으로부터 분리·동정된 Aspergillus coreanus NR 15-1로부터 glucoamylase활성이 높은 X11(Arginine^-) 변이주와 A. oryzae NR 2-5로부터 α-amylase활성이 높은 Z6 (Adenine^-) 변이주의 원형질체융합을 위한 원형질체 형성의 최적조건을 검토했다. 원형질체 형성을 위한 세포벽 분해효소는 X11 변이주와 Z6 변이주 모두 cellulase와 driselase를 복합적으로 각각 10mg/ml되게 사용하였을 때 원형질체 형성율이 가장 높았다. 삼투압 안정체는 X11 변이주에서는 0.4 M NaCl이, Z6 변이주에서는 0.6 M NaCl이 가장 효율적이었다 원형질체 형성을 위한 반응 최적 pH는 X11 변이주와 Z6 변이주 모두 pH 5.0에서 가장 높은 원형질체 형성율을 나타내었으며 pH 6.0에서는 형성율이 반 이하로 감소하였다. 반응 최적온도는 두 변이주 모두 30℃가 가장 적합하였으며 그 이상의 온도에서는 원형질체 형성율이 감소하였다. 원형질체 형성을 위한 세포벽 분해효소의 반응 최적시간은 X11 변이주에서는 반응 5시간에, Z6 변이주에서는 반응 6시간이 원형질체 형성율이 가장 높았다. 원형질체의 재생율에 있어서는 두 변이주 모두 반응 4시간 때 X11 변이주가 11.3%로, Z6 변이주는 11.6%로 가장 높았으며 재생되는 원형질체의 수도 가장 많아 반응 시간은 4시간이 적당한 것으로 나타났다. 이상의 조건에서 형성된 원형질체의 평균 크기는 X11 변이주가 3~6㎛ 이며, Z6 변이주는 4~9㎛ 로 다양한 크기의 원형질체가 형성되었으며 원형질체 형성율은 각각 6.54 × 10 exp (7) protoplasts/ml와 3.04 × 10 exp (7) protoplasts/ml이었다. Aspergillus coreanus NR 15-1 and Aspergillus oryzae NR 2-5 from traditional Korean Nuruk were selected as parental strains producing starch hydrolysis enzymes. X11(Arginine^-) mutant from A. coreanus NR 15-1 showed high glucoamylase activity and total acid productivity. Z6(Adenine^-) mutant from A. oryzae NR 2-5 showed the highest α-amylase activity. Therefore, both X11 and Z6 mutants were selected and investigated for the optimal conditions of protoplast formation for protoplast fusion. Mixture of equal amount of cellulase and driselase(10 mg/ml each) was the most effective as lytic enzymes. The optimal pH and temperature for protoplast formation were 5.0 and 30℃, respectively. The most effective reaction for protoplast formation time was 4 hours. The maximum of protoplast formation of X11 mutant and Z6 mutant were 6.54 × 10 exp (7) protoplasts/ml and 3.04 × 10 exp (7) protoplast/ml, and the regeneration frequencies of the protoplasts were 11.3% and 11.6%, respectively. The size of the protoplasts from X11 and Z6 mutants were 3~6 ㎛ and 4~9 ㎛, respectively.
S-131 Incidence of Hepatocellular carcinoma in korean screenee with chronic hepatitis B
( Jung Rock Moon ),( Jae-jun Shim ),( Tae-woong Choi ),( Chi Hyuck Oh ),( Soyung Park ),( Yu Jin Um ),( Byung-ho Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: To optimize efficacy of National Liver Cancer Screening Program (NLCSP) for subjects with HBsAg positive, it is crucial to know the incidence of HCC and its predisposing factors in the program. Methods: From January 2010 to December 2014, all the HBsAg positive participants who received at least two or more abdominal ultrasonography under NLCSP were retrospectively enrolled in a single tertiary hospital. Annual incidence of HBV-related HCC was calculated and related clinical factors were investigated. Results: During 5 years, 541 subjects were enrolled. Liver cirrhosis was diagnosed in 212 (39.2%) by ultrasonography or upper endoscopy. Esophageal varices were found in 63 (14.8%). Total bilirubin, albumin, platelets, and aminotransferases were normal in most subjects. HBV DNA were less than 2,000 IU/mL in 356 subjects (79.6%). Mean follow-up time was 2.4 years and 16 new HCCs were diagnosed. Annual incidence of HBV-related HCCs were 980 per 100,000 patient year (1% per year). Subjects more than 60 years old (2.2% per year) had higher risk of HCC development than those under 60 years (0.6% per year, p<0.005). Presence of LC (2.2% per year) also showed higher risk of HCC than LC-free state (0.2% per year, p<0.0001). In cirrhotic patients over 60 years old, the incidence increased up to 3.8% per year.Conclusions: Despite of high rate of antiviral therapy, incidence of HBV-related HCC is not low in participant of NLCSP in Korea. Old age and presence of LC are associated with higher risk of HCC development.
The effect of Parkinson’s disease on total knee arthroplasty: a systematic review and meta-analysis
( Jung-ro Yoon ),( Tae-hyuck Yoon ),( Seung Hoon Lee ) 대한슬관절학회 2023 대한슬관절학회지 Vol.35 No.-
Purpose The purpose of this systematic review was to determine the effect of Parkinson’s disease (PD) on clinical outcomes and complications after total knee arthroplasty (TKA). Our systematic review was conducted to answer the following questions: (1) does TKA negatively affect clinical outcomes in patients with PD? and (2) does TKA cause more complications in patients with PD? Methods A rigorous and systematic approach was used, and each selected study was evaluated for methodological quality. Data on study design, total number of cases enrolled, follow-up duration, PD severity, clinical outcome, and complications after TKA were analyzed. Results Fourteen studies were included. Nine studies reported clinical scores. TKA significantly increased knee and functional scores in the PD group. However, compared with knee and functional scores in the non-PD group, the increase in scores in the PD group was not statistically significant, but tended to be less than that in the non-PD group. Eleven studies reported complications. In six studies, there was no difference in the complication rate between the PD and non-PD group or did not include a control group. In five studies, the PD group had higher medical complication rates and similar or higher surgical complication rates than the non-PD group. Conclusions Patients with PD who underwent TKA showed satisfactory functional improvement and pain reduction. However, these outcomes were not as good as those in the non-PD group. The PD group had a higher probability of occurrence of medical complications than the non-PD group. Further, the PD group had a similar or higher surgical complication rate than the non-PD group.