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김복연,김천태,이중정,박홍진,김창윤,강복수 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.1
The question of an association between occupational noise exposure and blood pressure has important public health implications. The harmful effects of hypertension are well known and noise is considered the most pervasive problem of all occupational exposures in Taegu City, Korea. A cross-sectional study on the effect of long-term noise exposure on blood pressure was done for 276 noise exposed workers(203 male workers, 73 female workers). Long-term noise exposure was measured by cumulative noise exposure level and noise-induced hearing loss. Hearing loss = 500Hz+2×1,000Hz+2×2,000Hz+4,000Hz -------------------------------------- 6 Questionnaire was administered to the workers, which includes age, sex, occupational history on the noise exposure, habits on alcohol drinking and smoking, practice of regular exercises, family history of hypertension. Type A behavior, question on stress, height, weight and blood pressure were measured. Serum triglyceride and low density lipoprotein(LDL) were also measured. Audiometry was done in the closed booth at 1,000, 2,000, 3,000, 4,000, 6,000, 8,000, 1,000 and 500Hz in order. Multiple logistic regression analysis revealed that cumulative noise exposure level(p〈0.05), serum triglyceride(p〈0.01), age(p〈0.01) and family history of hypertension(p〈0.05) predict hypertension (systolic blood pressure : 160㎜Hg or above, or diastolic blood pressure : 95㎜Hg or above) in male workers. In female workers, serum triglyceride(p〈0.01), LDL(p〈0.01) and family history of hypertension(p〈0.05) were predictors of hypertension (systolic blood pressure : 160㎜Hg or above, or diastolic blood pressure : 95㎜Hg or above). As the number of female workers with hypertension was too small, the multiple logistic regression was done according to hypertension criteria of systolic blood pressure greater than or equal to 140㎜Hg, or diastolic blood pressure greater than or equal to 90㎜Hg. Based on this criteria, cumulative noise exposure level(p=0.055) and age(p=0.057) predict hypertension. It is suggested that long-term noise exposure which was calculated by cumulative noise exposure level was a significant predictor of hypertension in noise exposed workers.
박용관,김태원,장영,김진호,강정원,천영욱,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Multiple myeloma is a disease caused by neoplastic plasma cells that synthesize abnormal amouts of immunoglobulin or immunoglobulin fragments. Light chain myeloma are regarded as a separate category characterized by a more malignant clinical course. Light chain myelomas are said to grow fastest of all and are associated with more osteolytic lesions, more hypercalcemia, and a higher incidence of renal failure and amyloidsis than either the IgG, IgA varienties The authors experienced a case of patients with λ-light chain myeloma. A 43-year-old male patient admitted to our hospital with the chief complaint of both rib and lower back pain. The radiologic findings showed multiple pathologic fracture in ribs. osteolytic lesions in 2nd, 3rd cervical spineimmuture plasma cells. Serum electrophoresis showed normal finding. Urine electrophoresis evealed an M-spike. Urine immunoelectrophoress demonstrated λ-monoclonal protein. With the cycle of melphalan, prednisone and α-interferon chemotherapy improved of pain was observed. So we reported the case with brief review of previous literature.
Role of Metabolism by Intestinal Bacteria in Arbutin-induced Toxicity In Vitro
Kang, Mi-Jeong,Ha, Hyun-Woo,Kim, Hyung-Gyun,Lee, Dae-Hun,Kong, Min-Jeong,Ahn, Young-Tae,Kim, Dong-Hyun,Shin, Beom-Soo,Kang, Won-Ku,Jeong, Hye-Gwang,Jeong, Tae-Cheon 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4
A possible role of metabolism by intestinal bacteria in arbutin-induced toxicity was investigated in mammalian cell cultures. Following an incubation of arbutin with intestinal bacteria, either Bifidobacterium longum HY81 or Bifidobacterium adolescentis, for 24 h, its aglycone hydroquinone could be produced and detected in the bacterial culture media. The bacterial growth was not affected up to 10 mM arbutin in the culture medium. When the toxicity of bacteria cultured medium with arbutin was tested in the HepG2 cell lines, the medium with arbutin was more toxic than either parent arbutin only or bacteria cultured medium without arbutin, indicating that metabolic activation might be required in arbutin-induced toxicity. In addition, bacteria cultured medium with arbutin could suppress LPS and ConA mitogenicity in splenocyte cultures prepared from normal mice. The results indicate that the present toxicity testing system might be applied for assessing the possible role of metabolism by intestinal bacteria in certain chemical-induced toxicity in mammalian cell cultures.
( Tae Cheon Jeong ),( Nam Hee Kim ),( Sang Kyu Lee ),( Mi Jeong Kang ),( Hye Gwang Jeong ),( Won Ku Kang ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2
Effects of diallyl sulfide (DAS) on thioacetamide-induced hepatotoxicity and immunotoxicity were investigated. When maleSprague-Dawley rats were treated orally with 100, 200 and 400 mg/kg of DAS in corn oil for three consecutive days, the activityof cytochrome P450 (CYP) 2E1-selective p-nitrophenol hydroxylase was dose-dependently suppressed. In addition, the activitiesof CYP 2B-selective benzyloxyresorufin O-debenzylase and pentoxyresorufin O-depentylase were significantly induced bythe treatment with DAS. Western immunoblotting analyses also indicated the suppression of CYP 2E1 protein and/or the inductionof CYP 2B protein by DAS. To investigate a possible role of metabolic activation by CYP enzymes in thioacetamide-inducedhepatotoxicity, rats were pre-treated with 400 mg/kg of DAS for 3 days, followed by a single intraperitoneal treatment with 100 and200 mg/kg of thioacetamide in saline for 24 hr. The activities of serum alanine aminotransferase and aspartate aminotransferasesignificantly elevated by thioacetamide were protected in DAS-pretreated animals. Likewise, the suppressed antibody responseto sheep erythrocytes by thioacetamide was protected by DAS pretreatment in female BALB/c mice. Taken together, our presentresults indicated that thioacetamide might be activated to its toxic metabolite(s) by CYP 2E1, not by CYP 2B, in rats and mice.