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EFFECTS OF IMAGE CLOSENESS ON THE PERSUASIVENESS OF ADVERTISEMENT
Sungmi Lee,Kyuha Kim,Yung Kyun Choi 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7
The study examines the role of image closeness in advertising persuasiveness. To understand how consumers process different degree of image closeness in advertising, we apply construal level theory (CLT) suggests consumers’ perceived spatial distance of visual stimuli influence their level of construal. It also investigates how advertising’s message appeals (rational vs. emotional) and product types (utilitarian vs. hedonic) moderate the effects of construal level on advertising effectiveness. Drawing on CLT, the authors hypothesize that rational appeals will be more persuasive when consumers perceive the product image in advertising as spatially close, while emotional appeals will be more persuasive when consumers perceive it as spatially distant. The study employed 2(near vs. far distance)x2(rational vs. emotional appeal)x2 (utilitarian vs. hedonic product) factorial design. A total of 232 people (108 males) participated in the experiment. Results revealed that spatial distance and advertising appeals had significant interaction effects on attitude towards ad and brand attitude. Particularly, when the image shot looks close, rational appeals are more persuasive than emotional appeals. Comparatively, when the image looks distant, emotional appeals are more persuasive than rational appeals. The two-way interaction between advertising appeals and product type are also significant for attitude toward ad and brand attitude. Particularly, rational appeals for utilitarian product were more persuasive and while emotional appeals for hedonic product were more persuasive. Finally, three way interaction between spatial distance, advertising appeals, and product type had significant effects on brand attitude. When the image looks close, the superior effects of rational appeal compared to emotional appeal was greater in utilitarian product than in hedonic product. Conversely, when the image looks distant, the superior effects of emotional appeal compared to rational appeal was greater in hedonic product than in utilitarian product. Theoretical and practical implications are discussed.
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Difference in the Gut Microbiome between Ovariectomy-Induced Obesity and Diet-Induced Obesity
( Sungmi Choi ),( Yu-jin Hwang ),( Min-jeong Shin ),( Hana Yi ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.12
During menopausal transition, the imbalance of estrogen causes body weight gain. Although gut microbiome dysbiosis has been reported in postmenopausal obesity, it is not clear whether there is any difference in the microbiome profile between dietary-induced obesity and postmenopausal obesity. Therefore, in this study, we analyzed intestinal samples from ovariectomized mice and compared them with those of mice with high-fat diet-induced obesity. To further evaluate the presence of menopause-specific bacteria-gene interactions, we also analyzed the liver transcriptome. Investigation of the 16S rRNA V3-V4 region amplicon sequence profile revealed that menopausal obesity and dietary obesity resulted in similar gut microbiome structures. However, Bifidobacterium animalis was exclusively observed in the ovariectomized mice, which indicated that menopausal obesity resulted in a different intestinal microbiome than dietary obesity. Additionally, several bacterial taxa (Dorea species, Akkermansia muciniphila, and Desulfovibrio species) were found when the ovariectomized mice were treated with a high-fat diet. A significant correlation between the above-mentioned menopause-specific bacteria and the genes for female hormone metabolism was also observed, suggesting the possibility of bacteria-gene interactions in menopausal obesity. Our findings revealed the characteristics of the intestinal microbiome in menopausal obesity in the mouse model, which is very similar to the dietary obesity microbiome but having its own diagnostic bacteria.
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최성미 ( Sungmi Choi ),조상헌 ( Sang-heon Cho ),이하나 ( Hana Yi ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.5
During the second half of the 2000s, the significant impact of human microbiome on human diseases and health conditions was found. Since the Human Microbiome Project, many microbiome studies have been reported in domestic and international references. Gastrointestinal tract microbiome has been most investigated so far, and the association with illness has been demonstrated in many diseases. Recently, the range of study was extended to multiple human organs, such as the respiratory tract, skin, and urogenital tract. Given the scale and speed of research and development in recent years, the role of microbiome in many diseases would be established before long. In this review, we aimed to summarize the current status of microbiome studies in Korea and foreign countries with an emphasis on respiratory tract microbiome. The main concept and analytical methods for microbiome research, associations of microbiome and diseases, and research projects on Korean microbiome are reviewed. (Allergy Asthma Respir Dis 2016:4:311-320)
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Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice
Choi, Seung Hee,Leem, Jaechan,Park, Sungmi,Lee, Chong-Kee,Park, Keun-Gyu,Lee, In-Kyu Canadian Science Publishing 2017 Canadian journal of physiology and pharmacology Vol.95 No.2
<P> Dipeptidyl peptidase 4 (DPP-4) inhibitors are widely used antihyperglycemic agents for type 2 diabetes mellitus. Recently, increasing attention has been focused on the pleiotropic actions of DPP-4 inhibitors. The aim of the present study was to examine whether gemigliptin, a recently developed DPP-4 inhibitor, could ameliorate features of metabolic syndrome. Mice were fed a Western diet (WD) for 12 weeks and were subsequently divided into 2 groups: mice fed a WD diet alone or mice fed a WD diet supplemented with gemigliptin for an additional 4 weeks. Gemigliptin treatment attenuated WD-induced body mass gain, hypercholesterolemia, adipocyte hypertrophy, and macrophage infiltration into adipose tissue, which were accompanied by an increased expression of uncoupling protein 1 in subcutaneous fat. These events contributed to improved insulin sensitivity, as assessed by the homeostasis model assessment of insulin resistance and intraperitoneal insulin tolerance test. Furthermore, gemigliptin reduced WD-induced hepatic triglyceride accumulation via inhibition of de novo lipogenesis and activation of fatty acid oxidation, which was accompanied by AMP-dependent protein kinase activation. Gemigliptin ameliorated WD-induced hepatic inflammation and fibrosis through suppression of oxidative stress. These results suggest that DPP-4 inhibitors may represent promising therapeutic agents for metabolic syndrome beyond their current role as antihyperglycemic agents. </P>
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최영(Choi Young),진성미(Jin Sungmi) 중앙대학교 한국인적자원개발전략연구소 2010 역량개발학습연구 Vol.5 No.3
조직구성원들이 인식하는 조직메타포는 조직을 이해하고 관리하는 데 적절한 수단이며 조직의 특성과 미래 발전방향을 제시할 수 있는 실질적인 도구가 될 수 있다. 본 연구는 HRD분야의 연구와 실천의 일차적인 대상인 `조직`에 대한 분석의 한 방법으로서 메타포 분석을 적용할 수 있는지를 살펴보고자 한다. 이를 위해 국방부 본부 조직을 사례로 하여, 국방부 조직전문가들을 대상으로 면담 및 설문조사, 포커스그룹 인터뷰 등을 실시하여 국방부 본부 조직에 대한 125개의 메타포를 수집하였다. 수집된 자료는 Morgan이 제시한 8가지 메타포를 적용하여 각 주제별 메타포를 분석하였다. 분석 결과, Morgan의 8가지 메타포 분류체계가 국방부 조직구성원들의 조직 인식에 적용됨을 확인하였다. 본 연구 결과는 조직의 HRD담당자들이 어떠한 시각을 가지고 조직을 바라보고 관리해야 할 것인가 하는 측면에서 메타포 분석의 활용을 시도할 수 있음을 보여주었다. 마지막으로, 향후 HRD와 조직 연구에 있어 메타포 활용에 대한 시사점을 제시하였다. In order to understand and manage contemporary organizations, metaphor analysis of an organization can be useful as it provides a future direction of the organization. The purpose of this study was to apply a metaphor analysis method as a tool for analyzing organizations to identify its applicability to organization study. For this purpose, the Ministry of National Defence was chosen as a research case, and data were collected from individual interviews, survey, and focus group interview with organizational experts in the NMD. The metaphor analysis from participants produced 125 metaphors about the MND as an organization, and those were categorized into 8 themes as used by Morgan`s study. The result confirmed that Mongan`s 8 categories in organizational metaphor is useful as an analytical tool for identifying the members` perceptions about the MND. In addition, the study result suggested that HRD practitioners can use metaphor analysis to understand and manage the organization. Future directions were recommended to use metaphor analysis in HRD research.
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Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells
Park, Sungmi,Kim, Jeong-Kook,Oh, Chang Joo,Choi, Seung Hee,Jeon, Jae-Han,Lee, In-Kyu Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.3
<P>Scoparone, which is a major constituent of <I>Artemisia</I> capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, and it is used for the traditional treatment of neonatal jaundice. Therefore, we hypothesized that scoparone could suppress the proliferation of VSMCs by interfering with STAT3 signaling. We found that the proliferation of these cells was significantly attenuated by scoparone in a dose-dependent manner. Scoparone markedly reduced the serum-stimulated accumulation of cells in the S phase and concomitantly increased the proportion of cells in the G0/G1 phase, which was consistent with the reduced expression of cyclin D<SUB>1</SUB>, phosphorylated Rb and survivin in the VSMCs. Cell adhesion markers, such as MCP-1 and ICAM-1, were significantly reduced by scoparone. Interestingly, this compound attenuated the increase in cyclin D promoter activity by inhibiting the activities of both the WT and active forms of STAT3. Similarly, the expression of a cell proliferation marker induced by PDGF was decreased by scoparone with no change in the phosphorylation of JAK2 or Src. On the basis of the immunofluorescence staining results, STAT3 proteins phosphorylated by PDGF were predominantly localized to the nucleus and were markedly reduced in the scoparone-treated cells. In summary, scoparone blocks the accumulation of STAT3 transported from the cytosol to the nucleus, leading to the suppression of VSMC proliferation through G1 phase arrest and the inhibition of Rb phosphorylation. This activity occurs independent of the form of STAT3 and upstream of kinases, such as Jak and Src, which are correlated with abnormal vascular remodeling due to the presence of an excess of growth factors following vascular injury. These data provide convincing evidence that scoparone may be a new preventative agent for the treatment of cardiovascular diseases.</P>
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