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MLVA Genotyping of Brucella abortus isolated from cattle in Korea
Jin-Ju Lee(Jin-Ju Lee),Eun-Ji Yum(Eun-Ji Yum),Eun-Ji Park(Eun-Ji Park),Min-Kyeong Kim(Min-Kyeong Kim),Min-Hoe Lee(Min-Hoe Lee),So-Ra Sung(So-Ra Sung),Hee-Soo Lee(Hee-Soo Lee),Bang-Hun Hyun(Bang-Hun Hy 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
Lee, Boeun,Kim, Yu Kyeong,Lee, Ji Youn,Kim, Young Joo,Lee, Yun-Sang,Lee, Dong Soo,Chung, June-Key,Jeong, Jae Min SAGE Publications 2017 Journal of cerebral blood flow and metabolism Vol.37 No.6
<P> Metabotropic glutamate receptor type 1 (mGluR1) is related with various neurological and psychiatric diseases, such as anxiety, depression, epilepsy, Parkinson’s disease, and neuropathic pain. Hence, mGluR1 is an important target for drug development and imaging. We synthesized [<SUP>18</SUP>F]cEFQ (3-ethyl-2-[<SUP>18</SUP>F]fluoroquinolin-6-yl cis-(4-methoxycyclohexyl)methanone) as a PET tracer for selective mGluR1 imaging and evaluated its properties in rodents. A chloroquinoline precursor was labeled by a nucleophilic substitution reaction, and the resulting [<SUP>18</SUP>F]cEFQ was obtained with high radiochemical purity (>99%) and specific activity (63-246 GBq/µmol). The log D value was 3.24, and the initial brain uptake at 10 min was over 4% of injected dose per gram in BALB/c mice. According to PET/CT and autoradiography in SD rats, [<SUP>18</SUP>F]cEFQ showed wide distribution in the whole brain and the highest uptake in the cerebellum. Pre-treatment with unlabeled cEFQ or the mGluR1-specific antagonist JNJ16259685 blocked the uptake of [<SUP>18</SUP>F]cEFQ. However, the uptake was not blocked by pre-treatment with the mGluR5-specific antagonist ABP688. The trans isomer [<SUP>18</SUP>F]tEFQ did not show high uptake in the mGluR1-rich region. [<SUP>18</SUP>F]cEFQ was straightforwardly prepared using a chloro-derivative precursor. Its feasibility as a specific and selective PET agent for imaging mGluR1 was proved by in vitro and in vivo experiments using rodents. </P>
Lee, Ga Young,Park, Chan Yoon,Cha, Kyeong Sun,Lee, Seung Eun,Pae, Munkyong,Han, Sung Nim Elsevier 2018 The Journal of nutritional biochemistry Vol.55 No.-
<P>Vitamin D has an immunoregulatory effect on both innate and adaptive immunity. Contradictory results regarding vitamin D and natural killer (NK) cell functions have been reported with in vitro studies, but little is known about this in vivo. We investigated whether vitamin D levels (50, 1000 or 10,000 IU/kg of diet: DD, DC or DS) affect NK cell functions in mice fed a control or high-fat diet (10% or 45% kcal fat: CD or HFD) for 12 weeks. The splenic NK cell activity was significantly higher in the CD-DS group than the HFD-DS group, and the CD-DS group showed significantly higher NK cell activity compared with the CD-DD and CD-DC groups. However, no difference in NK cell activity was observed among the HFD groups fed different levels of vitamin D. The splenic population of NK cells was significantly higher in the CD-DS group than the HFD-DS group. There was no difference in the intracellular expression of IFN-gamma and the surface expression of NKG2D and CD107a in NK cells by both dietary fat and vitamin D content. The splenic mRNA expression of Ifng and CcI5 was significantly lower in the HFD groups compared with the CD groups, but there was no difference in the mRNA levels of Vdup I and Vdr among the groups. Taken together, these results suggest that dietary vitamin D supplementation can modulate innate immunity by increasing NK activity in control mice but not in obese mice. This effect might be mediated through alternation of the splenic NK cell population. (C) 2018 Elsevier Inc. All rights reserved.</P>
Behaviour of bentazon in the presence of rice plants in a lysimeter
Lee, Jae Koo,Fu¨hr, F.,Kyung, Kee Sung,Oh, Kyeong Seok 한국농화학회 1990 Applied Biological Chemistry (Appl Biol Chem) Vol.33 No.2
In order to simulate the rice paddy fields, two lysimeters of 0.25㎡ surface area were manufactured with stainless steel of 8mm thickness. When the herbicide ^(14)C-bentazon was applied to the surface by the conventional method for the control of weeds of rice plants, the leachates from the lysimeters contained 1.14%(lysimeter 1) -6.29%(lysimeter 2)of the originally applied radioactivities up to the 37th week after the application. The appromate amounts of COz evolved from the surfaces of the lysimeters in the presenece of rice plants during the experimental period of 20 weeks were about 1.33%(lysimeter 1) - 3.68%(lysimeter 2). No volatilization of bentazon from the soil surfaces was observed. The C-radioactivities detect in straw, ear without rice grain, chaff, and hulled rice grain after harvest corresponded to 2.5-3.2, 0.1, 0.05, and 0.03ppm, respectively, in two lysimeters. Partition of the ^(14)C-radioactivity pre sent in the leachates revealed that 96.1-98.95% of it remained in the organic phase(ethyl acetae), indicating that the leachates contain very small amounts of polar compounds resulting from the degradation of bentazon. In the time-course of the absrorption and translocation, the maximum amount of ^(14)C-radioactivity in the shoots, amounting to 4.08-7.57ppm, appeared 21 days agter the application. The degradation of bentazon in soil increased with soil temperature. The degradation products of small amounts detected in the leachates were identified as 6-0H and 8-0H bentazon by TLC and autoradiography.