http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sung Ho Kyung,Kim Jin Yong,Heo Jeonghun,Seo Haesook,Jang Young soo,Kim Hyewon,Koh Bo Ram,Jo Neungsun,Oh Hong Sang,Baek Young Mi,Park Kyung-Hwa,Shon Jeung A,Kim Min-Chul,Kim Joon Ho,Chang Hyun-Ha,Park 대한의학회 2020 Journal of Korean medical science Vol.35 No.30
Background: The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care. We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea. Methods: Using a modified World Health Organization clinical record form, we obtained clinical data for 3,060 patients with COVID-19 treated at 55 hospitals in Korea. Disease severity scores were defined as: 1) no limitation of daily activities; 2) limitation of daily activities but no need for supplemental oxygen; 3) supplemental oxygen via nasal cannula; 4) supplemental oxygen via facial mask; 5) non-invasive mechanical ventilation; 6) invasive mechanical ventilation; 7) multi-organ failure or extracorporeal membrane oxygenation therapy; and 8) death. Recovery was defined as a severity score of 1 or 2, or discharge and release from isolation. Results: The median age of the patients was 43 years of age; 43.6% were male. The median time from illness onset to admission was 5 days. Of the patients with a disease severity score of 3–4 on admission, 65 (71.5%) of the 91 patients recovered, and 7 (7.7%) died due to illness by day 28. Of the patients with disease severity scores of 5–7, 7 (19.5%) of the 36 patients recovered, and 8 (22.2%) died due to illness by day 28. None of the 1,324 patients who were < 50 years of age died; in contrast, the fatality rate due to illness by day 28 was 0.5% (2/375), 0.9% (2/215), 5.8% (6/104), and 14.0% (7/50) for the patients aged 50–59, 60–69, 70–79, and ≥ 80 years of age, respectively. Conclusion: In Korea, almost all patients of < 50 years of age with COVID-19 recovered without supplemental oxygen. In patients of ≥ 50 years of age, the fatality rate increased with age, reaching 14% in patients of ≥ 80 years of age.
Elucidation of Bacterial Pneumonia-Causing Pathogens in Patients with Respiratory Viral Infection
( Hwa Sik Jung ),( Byung Ju Kang ),( Seung Won Ra ),( Kwang Won Seo ),( Yangjin Jegal ),( Jae-bum Jun ),( Jiwon Jung ),( Joseph Jeong ),( Hee-jeong Jeon ),( Jae-sung Ahn ),( Taehoon Lee ),( Jong Joon 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4
( Sang Hwa Kim ),( Yun Ji Kim ),( Yeon Soo Jung ),( Seung Joo Chon ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Si Hyun Cho ),( Young Sik Choi ),( Byung Seok Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: In order for Korean red ginseng (KRG) to be widely used for alleviating menopausal symptoms, the safety of KRG on breast must be ensured. The purpose of this study was to investigate the effects of KRG on breast cells. Methods: MCF-7 and MCF-10A cells were treated with different concentrations of KRG extracts for 48h. Cell viability was evaluated by MTT assay, and apoptosis was assessed by flow cytometry. The expression of apoptosis-related proteins was determined by western blot analysis. Estrogen receptor(ER) affinity of KRG was examined by ER binding assay. Results: KRG extract inhibited growth and induced apoptosis both MCF-7 and MCF-10A cells in a dose-dependent manner. Treatment with KRG extract increasedthe expression of pro-apoptotic proteins BAX, BAK, and BAD as well as decreased expression of anti-apoptotic proteins Bcl-2 and Bcl-XL in both cells. The expressions of Fas and FasL were increased in lower doses, but soon decreased in higher doses in both cells. Activities of caspase-3, -8 and -9 increased in MCF-10A, but differently expressed in MCF-7. Competition ofKRG to E2 was significant in MCF-7, according to the increased dose of RG, whereas ER binding was hardly shown in MCF-10. Conclusion: KRG induced apoptosis via extrinsic and intrinsic pathway in MCF-7 breast cancer cells and MCF-10A non-malignant cells.KRG may be safely used in postmenopausal women to reduce the vasomotor symptoms.
Paratubal serous borderline tumor
( Hwa Sook Moon ),( Sang Gap Kim ),( Jin Kuk Choi ),( Gun Sik Park ),( Kyung Seo Kim ),( Ja Seong Koo ),( Gyeong Il Nam ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Methods A 60-year-old woman, G0P0A4L0, was referred to our hospital with a pelvic mass. She had history of appendectomy, cholecystectomy and hypertension. Transvaginal ultrasound demonstrated 8.47 x 6.24 cm sized pelvic cyst with heterogenous echo at right adnexal region. MRI findings revealed that cystic mass was 8.3 cm sized and the lesion included about 1cm sized lobular contour mural nodule. Routine laboratory tests including tumor markers were in normal limits. She underwent operative laparoscopy. At the time of surgery, the uterus and both ovaries were atrophic, a cystic mass was detected at right fallopian tube. Exploration of the whole abdomen was performed and there was no additional abnormality. The surface of cyst was clear and well marginated with turbid yellowish fluid inside. Fluid within the peritoneal cavity was collected for cytology. Right salpingo-oophorectomy was performed without rupture of the cyst. Frozen biopsy was reported as a paratubal serous borderline tumor. We performed total laparoscopic hysterectomy and left salpingo-oophorectomy. Results The operative time was 70 minutes with blood loss of about 30mL. The patient recovered well. There was no intraoperative or postoperative complication. The final histological diagnosis was paratubal serous borderline tumor confined to right fallopian tube. The result of the peritoneal washing cytology was negative. No adjuvant chemotherapy or radiotherapy was applied. Until the last follow-up 9 months following surgery, the patient remained disease-free and no local or remote metastasis has been documented. Conclusions Paratubal borderline tumors are extremely rare and little is known about the clinicopathologic characteristics and the optimal treatment of these tumors. Further studies are needed to find the optimal management for paratubal serous borderline tumor.
( Hwa Sook Moon ),( Ja Seong Koo ),( Kyung Seo Kim ),( Byeong Gyu You ),( Hyun Jung Kim ),( Sung Eun Moon ),( Sang Kook Kim ),( Sung Hun Min ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To evaluate the efficacy of ultrasound-guided sclerotherapy with 95% ethanol in the treatment of endometrioma in terms of ovarian reserve. Methods: We retrospectively reviewed the records of 67 patients with ovarian endometrioma, 32 of whom were treated with sclorotherapy and 35 with laparoscopic cystectomy. Results: Clinical characteristics including patient age, duration of infertility, cyst location, and symptoms showed no significant difference between the two groups. Changes in AMH level were smaller in the sclerotherapy group compared to laparoscopic cystectomy group (sclorotherapy group: 1.24 ± 1.4, laparoscopic cystectomy group: 1.96 ± 1.9). However, the difference was not statistically significant. Conclusion: Ultrasound-guided sclerotherapy with 95% ethanol is a safe treatment for ovarian endometriosis, providing relief if related symptom while preserving healthy ovarian tissue and avoiding early menopause.
Elucidation of Bacterial Pneumonia-Causing Pathogens in Patients with Respiratory Viral Infection
( Hwa Sik Jung ),( Byung Ju Kang ),( Seung Won Ra ),( Kwang Won Seo ),( Yangjin Jegal ),( Jae-bum Jun ),( Jiwon Jung ),( Joseph Jeong ),( Hee-jeong Jeon ),( Jae-sung Ahn ),( Taehoon Lee ),( Jong Joon 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.4
Background: Bacterial pneumonia occurring after respiratory viral infection is common. However, the predominant bacterial species causing pneumonia secondary to respiratory viral infections other than influenza remain unknown. The purpose of this study was to know whether the pathogens causing post-viral bacterial pneumonia vary according to the type of respiratory virus. Methods: Study subjects were 5,298 patients, who underwent multiplex real-time polymerase chain reaction for simultaneous detection of respiratory viruses, among who visited the emergency department or outpatient clinic with respiratory symptoms at Ulsan University Hospital between April 2013 and March 2016. The patientsc medical records were retrospectively reviewed. Results: A total of 251 clinically significant bacteria were identified in 233 patients with post-viral bacterial pneumonia. Mycoplasma pneumoniae was the most frequent bacterium in patients aged <16 years, regardless of the preceding virus type (p=0.630). In patients aged ≥16 years, the isolated bacteria varied according to the preceding virus type. The major results were as follows (p<0.001): pneumonia in patients with influenza virus (type A/B), rhinovirus, and human metapneumovirus infections was caused by similar bacteria, and the findings indicated that Staphylococcus aureus pneumonia was very common in these patients. In contrast, coronavirus, parainfluenza virus, and respiratory syncytial virus infections were associated with pneumonia caused by gram-negative bacteria. Conclusion: The pathogens causing post-viral bacterial pneumonia vary according to the type of preceding respiratory virus. This information could help in selecting empirical antibiotics in patients with post-viral pneumonia.