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폐경기 여성에서의 Cyclofenil의 효능에 관한 연구 : 갱년기 장애 및 Ca 장흡수에 관하여
노흥규,윤상임,성기양,이경숙,이강욱 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1
In postmenopausal syndrome, most common symptoms are those of vasomotor irritability such as hot flush and palpitation, irritable bladder symptoms and dyspareunia according to atrophy of urogenital epithelium, anxiety, nervousness, depression and insomnia. Approximately 40 percent of women in postmenopausal period develop symptoms serious enough to seek medical assistance. Among non-steroid agents, cyclofenil(4, 4' cyclohexidene methlyene diphenoacetate) is known to be a quite interesting substance according to the action at the level of the hypophyseal and hypothalamic centers by reducing the incretion of FSH and restoring normal endorphin, dopamine and norepinephrine activities, thus favorably affecting the whole postmenpausal neurovegutative symptomatology. In order to evaluate effect of cyclofenil on postmenopausal symptomatology and calcium metabolism, we examined 32 patients with postmenopausal syndrome before and after 200mg/day of oral cyclofenil treatment for 30-60 days. The results were as follows: 1. With 30 days of cyclofenil administration, subjective symptoms such as facial flush, palpitation, anxiety, nervousness and dyspareunia were improved significantly (p<0.001, p<0.001, p<0.01, p<0.005, respectively). But insomnia and depression were improved significantly after 60 days of cyclofenil administration (p<0.05, p<0.001, respectively). 2. Intestinal calcium absorption rate disclosed tendency of improvement without statistical significance 30 days after cyclofenil treatment. 3. Serum calcium and phosphorus level were not changed significantly before and after cyclofenil. 4. There was no definite evidence of side effects such as uterine bleeding due to cyclofenil. In conclusion, we thought that cycofenil is effective in management of postmenopausal syndrome but for the effect on calcium metabolism, further evaluation should be needed.
당뇨병환자에서 게이트심장혈액풀신티그라피를 이용한 심기능 평가
윤상임,송치운,이진홍,안미애,성기양,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Major cardiovascular complications of diabetes are coronary atherosclerosis, diabetic dilated cardiomyopathy, autonomic neuropathy and those are major causes of morbidity and mortality in diabetic patients. Gated blood pool heart scan is noninvasive and useful method for evaluation of functional status of heart in diabetics. We evaluated 52 patients with diabetes and divided 3 groups. Group 1 were 11 patients without proteinuria or with proteinuria less than 550mng during 24 hours. Group 2 were 9 patients with proteinuria more than 550mg during 24 hours and group 3 were 32 patients with endstage renal diasese due to diabetes. We performed 99mTc-HSA cardiac gated blood pool scan and used left ventricular ejection fraction(LVEF), peak ejection rate(PEF) to indices of LV systolic function and peak filling rate(PER) to index of LV diastolic function. The results were follows : 1) LVEF, PER were significantly lower in diabetics with ESRD than diabetics without ESRD, but there were no significant difference between normal controls and diabetics without ESRD 2) PFR was significantly lower in diabetics than normal controls, but there were no significant differences in diabetics with or without nephropathy. 3) There were negative correlation between PER, PFR and duration of diabetes. On the basis of results, PFR is a LV functional index of GBPS which can disclose early change of LV dysfunction in patients with diabetes.
덕유산 국립공원 저서성대형무척추동물의 군집변동 및 생물학적 수질평가
이영미,노상은,조희욱,이종은 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-
A biological assessment of water quality was carried out in Deogyusan National Park from April 2005 to August 2005. The benthic macroinvertebrates collected seasonally from 5 field sites were identified mostly up to species level. The benthic macroinvertebrates collected from the surveyed sites were composed of 105 species, 74 genera, 46 families, 12 orders, 4 classes and 3 phyla. Dominant species occurring in all the surveyed sites was white color Chironomus sp. of Diptera. The dominance index(DI) showed the highest as 0.666 at site 3 and the lowest as o.388 at site 5. The species diversity index(H') showed the highest as 3.998 at site 5 and the lowest as 2.752 at site 3. Ecological score of benthic macroinvertebrate(ESB) Showed the highest as 199 at site 5 and the lowest as 149 at site 3. All surveyed sites were Oligosaprobic that the water quality estimated by ecological score of benethic macroinvertebrate community
혈액투석중인 만성신부전 환자에서 골대사 지표로써의 Osteocalcin치
송치운,이진홍,안미애,윤환중,윤상임,성기양,이강현,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Background : Serum osteocalcin is synthesized by osteoblast and has been shown to be sensitive indicator of bone turnover inpatients with various metabolic bone disease. In renal osteodystrophy, serum osteocalcin is elevated due to decreased renal clearance and elevated level of PTH. This study was done to evaluate the usefulness of serum osteocalcin as a marker of bone metabolism and the correlation with other biochemical markers of bone metabolism. Methods : We measured serum osteocalcin, calcium, phosphorus, ALP(alkaline phosphatase) and PTH(parathyroid hormone) in 37 patients with end stage renal disease on hemodialysis. Osteocalcin was determined by radioimmunoassay and PTH was determined by radioimmunometric assay. Results : 1) The mean level of serum osteocalcin in ESRD patients was 233.8± 218.2ng/ml which was significantly higher than that of controls(p<0.0001). 2) The mean level of serum PTH in ESRD patients was 40.5± 43.8pg/ml was significantly higher than that of controls(p<0.005). 3) There was a significant positive correlation between the level of serum PTH, ALP and the level of serum osteocalcin in ESRD patients. 4) By using multiple regression, PTH is most reliable factor that affect to elevated level of serum osteocalcin ( beta coefficient = 0.687, Sig T<0.05). Conclusion : Serum osteocalcin as a marker of bone metabolism in ESRD patients is more useful than other biochemical marker such as serum calcium, phosphorus, ALP and PTH is a most reliable factor that affect to elevated level of serum osteocalin.
( Sang Woong Youn ),( Byung Soo Kim ),( Minsu Kim ),( Dae Young Yu ),( Youngdoe Kim ),( Kwang Joong Kim ),( Jee-Ho Choi ),( Sang Wook Son ),( Eun-So Lee ),( Young Suck Ro ),( Young Lip Park ),( YoungJ 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Postmarketing surveillance is conducted to establish drug safety and effectiveness under real practice. Objectives: To validate ustekinumab’s effectiveness and safety in the treatment of adult Korean patients with plaque psoriasis under real practice. Methods: This was a prospective, observational, and multi-center study. The study subjects were aged 18 years and above, who were administered ustekinumab for treating plaque psoriasis. Results: The study included 977 patients; 66.9% were male, with a mean±standard deviation of BSA(%) of 27.0±18.3 and mean PASI of 18.1±9.7. The effectiveness analysis included 581 patients who had at least one follow-up assessment and met treatment criteria per local label and reimbursement guidelines; of these patients, 287 had effectiveness data for visit 6. The timing of visit 6 occurred at 53.7±2.1, weeks; at visit 6 91.6%, 51.2%, and 9.4% achieved PASI75, PASI90, and PASI100 responses, respectively. Adverse events (AEs) occurred in 11.5% yielding an incidence rate of 21.5/100 patient-years (PYs). Serious AEs occurred in 0.8% with an incidence rate of 1.2/100 PYs. The estimated 1-year drug retention rate was 87.7%. Multiple logistic regression analyses showed that higher baseline PASI score and no prior biologic exposure were significant predictors for PASI90 response at visit 6. Conclusion: Ustekinumab is effective and safe, with high drug retention in the treatment of adult Korean patients with plaque psoriasis in real-world practice.
노정훈,신상욱 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23
In this paper, we present the design and evaluation of a thermal stimulus analysis system, which plays an important role in diagnosing central nervous system. The designed sensing system receives the reflected light from the animal paw and detects an abrupt decrease of the reflected light intensity which decreases more than 50% intensity with 3 mm withdrawal. The thermal stimulation is made by a focused halogen lamp light, and constant current power supply was used to give a stablized radiation control. Digital timer system has very good time resolution of less than 2.0 ms. However, it was found that there is a latent time lag of the radiation power, which gives significant error in withdrawal time estimation. A feedback stimulation system was suggested using Si PIN diode by emitting power estimation.
盧澈均,裵相旭 慶一大學校 1995 論文集 Vol.12 No.2
Fuzzy modeling based on fuzzy set theory is a valuable approach for the identification of complex and ill-de-fined processes which defy to be modeled by the conventional mathematical approaches. In this paper, the fundamental aspects of fuzzy model identification algorithm based on fuzzy relational equations approach which is a fuzzy modeling methodology are described. And an empirical comparison is performed for the off-line identification algorithms developed with different fuzzy implication operators. According to the comparison results, the suzzy implication operators which produce the fuzzy models of better quality are discussed.