정성일의 <오아시스> 비판에 투영된 관점의 가능성과 한계 - 정성일 영화비평에 대한 일고찰 -

박우성 ( Park Woo-sung ),정수완 ( Jung Su-wan ) 국제어문학회 2015 국제어문 Vol.0 No.67

본 연구는 영화비평가 정성일이 <오아시스>(이창동, 2002)에 대해서 쓴 비평문「판타지, 기만적인 환영술」을 비판적으로 분석한다. 그간 한국영화계에서 영화비평은 독립적인 분과로 논의되지 못했다. 산적하는 영화들 안에서 영화적 가치를 발굴해 정리하고 새로운 영화 언어를 대중 언어로 번역하는 것이 영화비평의 역할이라 했을 때 이는 문제가 있다. 영화비평에 대한 그간의 접근은 한국영화사의 맥락에서 특정 영화비평집단을 세대론적으로 조망하거나 특정 개인의 비평 세계를 전기적 관점에서 서술한 것에 머문 한계가 있다. 정성일은 1990년대 한국영화비평의 전성기를 주도했던 한국의 대표적인 영화비평가이다. 호불호가 갈리지만 그의 글은 대중들 사이에서 영화비평이라는 개념이 성립되는 과정에 주요한 이미지를 제공했다. 특히 본 연구가 다루는 정성일의<오아시스> 비판은 논쟁 참여를 전제해 작성된 덕분에 비평담론 자체가 중심에 서있고 무엇보다 정성일의 영화에 대한 태도가 여타의 글에 비해 명확하게 드러나는 특징이 있다. 더구나 그 논쟁은 영화의 윤리, 완성도, 자의식 등을 두고 벌어진 영화비평계 내부의 마지막 논쟁이라는 영화비평사적 의의도 있다. 나아가 영화 한편에 대한 긴 글이기 때문에 한국의 대표적 비평가가 영화를 비평하는 구체적 실천 양상이 현장감 있게 녹아 있기도 하다. 영화를 종교처럼 대한다는 비판이 존재하지만 정성일 영화비평의 경쟁력은 숏의 배치, 장르 문법, 카메라 시선과 같은 영화의 자의식을 정밀하게 분석하는 것에서 나온다. 영화란 무엇인가와 같은 근본적인 질문에 기반을 둔 이런 태도는 영화를 여타의 학문에 종속시킨 종래의 비평 태도와 차별되며 영화를 진지하게 바라보는 태도를 대중화시킨 의의가 있다. 하지만 그것만큼의 오류도 발견된다. <오아시스>를 비판할 때 투영되는 정성일의 관점의 가능성과 한계를 구체적으로 밝힘으로써 한국영화비평의 전성기를 주도했던 한 영화비평가의 개성적 세계관을 비판적으로 조망하는 것이 본 연구의 목적이다. 독립적인 분과로 인식되기는커녕 죽음까지 운운되는 영화비평의 위기 시대에 한국의 대표적 영화비평가의 세계관이 상징적으로 녹아 있는 글을 정밀하게 분석하는 것은 그것 자체로 의미 있다. This study analyzes the critique “Fantasy, deceptive hallucination” which sung-il jung wrote about < Oasis >(Changdong Lee 2002). Film critique has not been recognized and discussed as an independent field in the Korean film industry so far. It can be problematic if the role of film criticism is to get the cinematic values arranged among the pile of films and to translate new cinematographic language into the public language. The approach to the film critique to this point has limitation that in the context of Korean film industry, it viewed certain group of film critics in the perspective of theory of generation and it described certain person`s world of criticism in a biographical way. sung-il Jung is one of the representative film critics in Korea who lead the golden age of Korean film criticism in the 1990s. His writings provided important image in the process of establishing the concept of film critique among the public, even though they are controversial. The Jung`s criticisms this study exclusively deals with are based on the premise of argumentative participation, so the discourse is central and fundamental, and it brings out the cinematic view of Jung precisely compared to the other writings and articles, which is the advantages of this study. Moreover, the argument has significance in the field of film criticism for being the last dispute inside the field of film critique over the morals, degree of completion, and the consciousness of identity. Above and beyond, because this paper is a long writing about a movie, it contains detailed and vivid practical aspect which the representative critic of Korea criticizes the movie. Although there are criticisms of discussing movies like a form of religion, sung-il Jung`s film critique is competitive for detailed and precise analyze of films` sense of identity such as plot of shots, code of genre, and the eyes of cameras. This attitude based on the fundamental questions such as what is film is considered significant for popularizing and promoting earnest attitude toward movies, and is differentiated with the traditional attitudes of criticism which are to subordinate films in the other fields of study. However, due to being so, some errors are discovered. The purpose of this study is to critically outlook a distinctive world view of a film critic who enjoyed the film critique`s prime by concretely describing its possibilities and limitations through revealing Jung`s point of view which is his prerequisite for watching movies. The work of precise analyzing of one of the Korean representative film critics` writings which contains symbolic world view is significant and meaningful by itself in the time of the film criticisms` crisis when the idea of the demise of film criticism is being mentioned, let alone its separation as the independent field.

Request and Question Perspective in Interlanguage Pragmatics

Sung Kyu Yun,Woo-hyun Jung 한국사회언어학회 2004 사회언어학 Vol.12 No.2

Yun, Sung Kyu & Jung, Woo-hyun. 2004. Request and Question Perspective in Interlanguage Pragmatics. The Sociolinguistic Journal of Korea, 12(2). This paper is an interlanguage pragmatic study of request and question perspective. It aims to explore whether there are any differences in request perspective between American English native speakers and Korean EFL learners. To this end, this study employed a Discourse Completion Test, which consisted of eight situations. Data were collected from three different groups: native speakers of English; Korean learners of English; native speakers of Korean. The results showed that the learners deviated from native pragmatic norms in the choice of perspective in a relatively systematic way. The same held even more obviously in the use of please in interacting with request perspective. It was also shown that the mismatch between the native and nonnative groups in perspective was an instance of pragmatic transfer. The results suggested that the notions of imposition and politeness operated differently in perspective between the native and nonnative groups. It is expected that this study will shed light on the phenomenon of interlanguage pragmatics and the aspect of pragmatic transfer, revealing how learners differ from native speakers with respect to request perspective and what causes the differences.

물리적 환경인자를 활용한 도시의 쾌적성 평가

이우성 ( Woo Sung Lee ),곽행구 ( Haeng Goo Gwak ),정성관 ( Sung Gwan Jung ),박경훈 ( Kyung Hun Park ) 한국지리정보학회 2007 한국지리정보학회지 Vol.10 No.1

본 연구는 도시의 물리적 환경인자를 이용하여 쾌적성을 평가하고, 이를 토대로 대기, 수질 등 환경질과의 상관성을 파악하여 쾌적성 평가결과의 실효성을 검증하고자 한다. 물리적 환경인자는 공원·녹지, 경관, 수환경, 토지이용의 항목으로 분류하고, 11개의 세부인자를 설정하였다. 설정된 인자를 토대로 GIS 도면을 작성한 후, 중첩분석을 이용하여 최종적인 쾌적성 평가도면을 작성하였다. 분석결과를 살펴보면, 1, 2등급은 전체면적의 40.8%로 행정구역상 달성군, 동구, 수성구를 중심으로 나타났으며, 쾌적성이 낮은 6~7등급은 중구, 서구, 달서구 등을 중심으로 전체의 5.7%를 점하고 있었다. 다음으로 실효성 검증을 위해 실시한 쾌적성과 환경오염의 상관분석 결과, 대기의 경우 SO2와 r=-0.649의 상관성을 가졌으며, 수질의 경우 TN, TP와 r=-0.643, -0.642의 높은 음(-)의 상관관계를 가지는 것으로 분석되었다. The purpose of this study is to assess the urban amenity on physical environmental factors, and to verify the effectiveness of the amenity map using correlation analysis of the environmental quality. The physical environmental factors were set to 4 items of green space, landscape, water environment and land use, and the items were composed of 11 detail factors. Based on the factors, GIS maps were constructed and the amenity map was produced using overlay analysis. The results of this study are as follow; the proportion of 1~2 ranks was 40.8% of total area around Dalseong-gun, Dong-gu, Suseong-gu. The lower 6~7 ranks in the amenity assessment was 5.7% of total area around Jung-gu, Seo-gu, Dalseo-gu. According to the results of correlation analysis between the amenity and environmental observed data, SO2 among the air pollution material had a negative correlation with amenity(r=-0.649, p<0.05). In case of water pollution, TN and TP had the negative correlations with amenity (r=-0.643, P<0.01; r=0.642, p<0.01).

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.

한국인에서 혈소판 당단백 Ⅱb/Ⅲa 유전자 다형성과 관동맥 성형술 후 재 협착과의 관계

이민수,이정우,김보영,임대승,강정아,김정희,김윤철,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Platelet aggregation is the final pathway of acute coronary syndrome such as acute myocardial infarction and unstable angina. Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and yon Willebrand factor and it plays an important role in platelet aggregation and in the pathogenesis of acute coronary syndrome. It is known that polymorphism of the gene that encoding platelet glycoprotein IIb/IIIa(PI^A1/A2) is strongly related to acute coronary syndrome in Caucasian, but not in Koreans. We investigated relationship between platelet glycoprotein llb/Illa gene polymorphism and restenosis of coronary artery after angioplasty in Koreans. Total 371 patients(M=251. F=120) were enrolled. Angioplasty group comprised 143 patients who underwent coronary angioplasty, and in the angioplasty group, restenosis group comprised with the 65 patients who had restenotic lesion over 50% of luminal diameter in follow-up coronary angiography. Normal group comprised 153 patients who had no significant angiographic lesion and variant angina group comprised 75 patients who were positive in ergonovine test. Genomic DNA was extracted from peripheral arterial blood. To determine the frequency of P1^A1/A2 genotype, polymerase chain reaction(PCR) was done and the product was restricted with Mspl. 3%. agarrose gel electrophoresis showed restriction fragment length polymorphism. Clinical profile and risk factor were also reviewed. Among all 371 patients of study group, genotype of only one patients in restenosis group if is proven to be PI^A1/A2 heterozygote. All patients of normal study group, no restenosis group, and the other patients in restenosis group have an PI^A1 homozygote genotype. In our study, platelet glycoprotein IIb/Illa polymorphism has no relationship with restenosis of the coronary artery after angioplasty in Koreans. But the genotypic frequency of platelet glycoprotein IIb/IIIa gene polymorphism in Koreans is concordant with that of previous studies.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.

The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection

Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.