외상성 뇌경막외 및 뇌경막하 혈종에서 혈종제거술 후 발생한 원발 병소 반대측 혈종에 대한 임상적 고찰

전은오,이상구,전영일,유찬종,김영보,박철완 최신의학사 2003 最新醫學 Vol.46 No.9-10

묘지 조성사업지의 비탈면 보호공법에 관한 연구(Ⅰ) : 강릉시 시범 공설묘지 조성사업을 중심으로

전근우,유남재,차두송,이명종,박완근,한상균 강원대학교 삼림과학연구소 2000 Journal of Forest Science Vol.16 No.-

강릉시 시범 공설묘지 조성사업은 경사 30˚ 의 표고차가 심한 산지를 절 · 성토하여 계단식 묘역단을 조성하는 공사로 수직고 15m이상의 대절토 및 성토부가 산재하고 있다. 특히 묘역단장후 주변 유입수 및 표면 유출수에 의한 비탈면 붕괴, 묘역단 유실 등의 피해가 발생할 경우 보수 또는 보강이 사실상 어려운 실정이며, 사회적 여론으로 확대될 가능성이 크므로 비탈면 보호에 필요한 녹화공법을 검토하였다. 구체적인 연구내용으로는 설계도면 및 현장답사를 통한 문제 비탈면 추출, 비탈면의 물리적 특성과 식생의 생육상황 파악, 비탈면 주변부의 식생조사와 유용식생 선발, 비탈면의 토양조건 분석 및 비탈면 토사의 기본물성 조사 등이며, 이를 기초로 하여 비탈면 현황 및 문제점을 파악하고, 그 대안을 제시하였다. The construction of a public cemetery in Kangnung city includes terraced graveyard with cutting or banking in mountain which has severe altitude differences with a slope of 30˚. Therefore, there are scattered cutting and banking sections with vertical height more than 15m. Especially, if the slope failure or the loss of a graveyard happens after graveyard establishment due to surface flow and inflow around, it is difficult to repair, causing serious public censure. Accordingly. revegetation works were examined that need protection of slope. The specific content of the study was the selection of slopes requiring special care through blueprint and field investigation the measurement of the physical property of slope and the situation of vegetative growth, the investigation of vegetation in slopes and the selection of vegetation, and the analysis of soil condition of slopes and the physical condition of slope sediment. On the basis of investigations some alternatives were proposed.Key words: public cemetery, slope protection works, revegetation works

흰쥐 전립선의 미세구조 분화에 미치는 Di-(2-ethylhexy1) phthalate의 영향

김완종,길영천,신길상 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

Di-(2-ethylhexyl)phthalate(DEHP) is a plasticizer and is known as one of endocrine disruptors. This study was carried out to investigate the ultrastructural changes of prostate during differentiation in male rat after oral administration of DEHP in dosages of 1g/kg, 2g/kg or 3g/kg in 0.5mℓ of corn oil daily for 15 days. In rats treated with DEHP, the prostate exhibited extensive histological alterations compared to that observed in controls. Many of the glandular lumens in the prostate were collapsed or reduced in width. The alteratrions of epithelial cells in the prostate of DEHP treaten rat were characterized by the increases of the nuclear to cytoplasm ratio and the heterochromatin, the reductions of rough endoplasmic reticulum and secretory vesicle, and the irregularity of nuclear envelope. In conclusion, DEHP altered the structure and function of male rat prostate, dose-dependently. It is suggested that these detrimental effects of DEHP are due to the decreased level of testosterone.

두경부편평상피암 연구의 3차원적 In Vitro 실험 모델 확립 : Spheroid 모델과 Raft 배양모델 Spheroid Model and Raft Culture Model

변성완,김춘동 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.1

Objectives : To establish new in vitro model systems that better reflect in vivo condition, multicellular tumor spheroids(MTS) and raft culture were developed using cell lines of squamous cell carcinoma(SCCHN) of the head and neck in these 3-dimensional systems. Materials and Methods : Four SCCHN cell lines were used for MTS and raft culture. Results : All cell lines formed MTS, but only Tu-138 showed a good stratification at the airliquid interface in the raft culture system. Conclusion : MTS and raft culture system were established successfully from the SCCHN cell lines.

제2형 당뇨병 환자에서 비만 지수와 죽상경화증 위험인자들과의 상관성

정병천,박순홍,이주영,이신원,정성창,김정국,하승우,김보완 대한비만학회 2003 The Korean journal of obesity Vol.12 No.2

연구배경: 비만은 제2형 당뇨병의 중요한 병인이면서 죽상경화성 동맥질환의 위험인자인 인슐린 저항성, 지질대사 이상 및 고혈압의 원인으로도 인정되고 있다. 한편 비만에 의한 대사성 및 혈관 합병증은전신적 지방량의 증가보다 복강내 지방축적이 병인적 중요성을 가지고 있다고 한다 그러나 국내의 제2형 당뇨병 환자를 차상으로 비만과 이들 죽상경화증 위험인자와의 상관관계를 연구 조사한 성적은 많지않다. 이에 제2형 당뇨병 환자에서 전신적 비만과 복강내 지방 축적을 반영하는 각각의 신체계측지수들과 죽상경화증 위험인자와의 상관성을 검토함으로써 국내 제2형 당뇨병 환자의 비만도가 대사성 및 혈관성 합병증에 미치는 영향과 신체계측지수들의 임상적 가치를 평가하고자 하였다. 방법 : 제2형 당뇨병 환자 425명 (남자 196명, 여자 229명)을 차상으로 하였다 임상적 단백뇨가 있거나 인슐린 치료, 혈압강하제 또는 지질대사개선제를 복용하는 환자는 제외시켰다. 전신 비만은 체용적지수 그리고 피부두겹 두께로 산출한 체지방률을, 복강내 지방축적도는 허리둘레 및 요둔위비를 이용하였다. 죽상경화증의 위험인자로는 혈당 조절 정도를 나타내는 공복 혈당과 당화혈색소 농도, 인슐린 저항성을 나타내는 공복 인슐린 및 C-peptide 농도, 지질 대사 상태를 나타내는 총 콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 저밀도지단백 콜레스테롤 농도 그리고 수축기 및 이완기 혈압을 선택하였다. 전신 비만지수 및 복부 비만지수와 이들 위험인자와의 상관관계는 연령과 당뇨병 이환기간을 보정하고 편상관분석법을 사용하였다. 결과: 1 여성군에서 남성군에 비해 체용적지수(24.2 대 23.0kg/㎡, p<0.01) 및 체지방률(23.8 대13.5%, p<0.01)은 다소 높았으나 허리둘레 (87.0 대 85.8 cm)와 요둔위비 (0.96 대 0.96)는 차이가 없었다. 2. 인슐린 저항성을 반영하는 공복 인슐린 및 C-peptide 농도는 체용적지수. 체지방률, 허리둘레 및 요둔위비가 커질수록 증가하는 양의 상관관계를 보였다(상관차수 0.21∼0.42, 모두 p<0.05). 3. 혈청 지질중에는 고밀도지단백 콜레스테롤만이 남성 환자군에서 비만지수들과 약한 음의 상관성을 보이는 경향이었고, 총 콜레스테롤 및 중성지방농도는 상관성이 없었다. 4. 수축기 및 이완기 혈압은 남성군에서만 체용적지수. 체지방률, 허리둘레 및 요둔위비가 커질수록 상승하는 양의 상관관계를 보였다(상관차수 0.21∼0.33, 모두 p.0.05). 결론. 국내 제2형 당뇨병 환자들의 전신 비만도 및 복부 비만도가 서구인에 비해 심하지는 않으나 포도당 대사, 인슐린 저항성, 지질 대사 및 고혈압에 위해한 영향을 미칠 수 있는 수준에 이르고 있으며 이는 결국 죽상경화증의 위험인자로도 작용하게 될 것임을 시사한다고 하겠다. 그리고 신체계측을 통한전신 비만 및 복부 비만 지수 모두가 당뇨병 및 죽상경화증의 위험을 간접적으로 예견하는 유용한 척도가 될 수 있을 것이다. Background: Obesity is the powerful risk factor for type 2 diabetes and also associated with a significantly increased risk of insulin resistance, dyslipidemia, hypertension and atherosclerosis. Although obese individuals have these diseases, the relationship between obesity and these diseases was not certain until regional fat distribution was taken into account. Reports about the relationship between obesity and the risk factors of atherosclerosis in type 2 diabetics in Korea are very rare. To evaluate the relative importance of anthropometric indices on the development of atherosclerosis and obesity-related metabolic and vascular complications, the correlations of these indices with the risk factors for atherosclerosis were studied. Methods: Patients with type 2 diabetes mellitus (n=425, male 196, female 229) who not used antihy- pertensives or anti-lipidemic agents were investigated. Body mass index (BMI) and percentage of body fat (%BF) estimated by skinfold-thickness in assessing generalized adiposity, and waist circumference (Wc) and waist-to-hip ratio (WHR) in assessing visceral adiposity were taken as anthropometric indices. We included the indicators of glycemic control (fasting blood sugar and HbAlc), insulin resistance (fasting serum insulin and C-peptide concentrations), lipid abnormalities (serum total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol concentrations), and systolic and diastolic blood pressure as risk factors for the development of atherosclerosis. Partial correlations of the anthropometric indices with those risk factors were investigated with adjustment of age and duration of illness. Results: 1. BMI and %BF in female patients group were higher than those in male (24.2 vs 23.0 kg/㎡, 23.8 vs 13.5%, respectively, p<0.01 in all) although Wc and WHR were similar between both groups. In general, both body adiposity and abdominal obesity in them were much lower than in the Western. 2. Serum insulin and C-peptide levels were positively correlated with BMI, %BF, Wc and WHR (r=0.21~42, p<0.05 in all). 3. Serum total cholesterol, triglyceride and LDL- cholesterol were not correlated with any anthropometric indices. A weak negative correlation of serum HDL-cholesterol with these indices was found in male patients group. 4. Both systolic and diastolic blood pressures were positively correlated with all these indices only in male group (r=0.21~33, p<0.05 in all). Conclusion: These results suggested that the severity of both generalized and visceral adiposity in these patients with type 2 diabetes mellitus were only mild but adiposity with abdominal distribution of body fat in diabetes mellitus could be a significant risk factor of developing atherosclerosis. In clinical practice, these anthropometric indices indicating general adiposity and abdominal obesity may provide useful information for predicting disease risks, especially of diabetes and cardio- vascular disease indirectly.

신경세포이주장애질환을 가진 간질환자에 대한 수술 체험

황승균,정천기,오창완,이상건,지제근,김현집,한대희,이상복 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3

Neuronal migration disorders(NMD's) are a rare group of development structural lesions characterized by disorganization of cortical architecture with aberrant columnar and laminar neuronal arrangement, often causing intractable seizures. During September 1994 to February 1995, we operated on six patients with NMD to treat intractable seizures. Male to female ratio of these 6 patients was 2 : 4, and mean age at seizure onset was 14 years old(range 6-28 years), indicating early onset of epilepsy. Mean age at seizure surgery was 29 years old(range 23-41 years), and mean follow-up duration after operation was 4 months(range 3-6 months). In their past medical history, three patients had experienced febrile seizure at pediatric age, and one of them had a history of anoxic damage during delivery. Following preoperative localization, the lesion was removed completely in five patients. In the other one patient, part of the lesion was located in the speech and motor area, leading to partial removal. On histologic examination two of them showed cortical dysplasia and the other four revealed microdysgenesis. During follow-up for six months, five patients were free of seizure and in the other one patient, whose lesion was removed incompletely, the frequency of seizure decreased by 95%.

소아에서 구개 및 인두편도 절제술 후 체중 변화

김춘동,변성완 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.1

Objectives : There are controversial evidences that children gain weight to a significant extent after adenotonsillectomy, usually associated with a general improvement in health. This study is aimed to evaluate the growth disturbance in children with adenotonsillar hypertrophy and the effect of adenotonsillectomy on subsequent growth in them. Methods : Ninty-one children adenotonsillectomized had their weights recorded preoperatively, and reweighted twelve months after surgery. Results : The results showed the patients were generally not underweighted before surgery. Their median weight was on the 59.5 percentile. Their weights after surgery had increased by an average of 20 percent over what would have been expected. This increase in weight was not confined to underweight children but to the entire group. Conclusion : Upper airway obstruction resulting from adenotonsillar hypertrophy might be suspected as a possible cause in the workup of children with suboptimum growth.

납(Pb)이 흰쥐 신장의 미세구조와 metallothionein 양상에 미치는 영향

김완종,한상철,길영천 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2

The present study was carried out to investigate the effects of lead on ultrastructure and metallothionein (MT) in the kidney of rat given lead acetate. Rats were intraperitoneally injected with 10mg, 30mg or 50mg of lead acetate per kg body weight everyday for three days, and the kidney tissues were removed at 24 hours after repeated injections. The tissues were prepared for light and electron microscopy and immunohistochemistry of metallothionein(MT). By light microscopy, the shrinkage of glomerulus and the presence of blood cells in tubular lumen were observed in the kidney of rat given lead acetate. The reaction products for MT by immunohistochemical analysis appeared strongly in the cells consisting tubular walls in experimental groups. By electron microscopy, there were numerous cytoplasmic vacuoles and bundles of collagen fibrils, indicating the interstitial fibrosis. These results suggest that lead causes the degenerative changes of ultrastructure and increases MT content in rat kidney.

통일을 대비한 남북한 도서관 정책과 제도에 관한 연구

한상완,김태수,전현주,이승채 한국문헌정보학회 1996 한국문헌정보학회지 Vol.30 No.1

동서간의 냉전을 종식하고 탈 이데올로기 시대에 돌입한 세계정세는 체제와 이념을 극복하고 자국의 경제적 이익과 국민의 복지를 중심으로하여 자국 우위의 경제 중심으로 변해가고 있다. 이러한 세계 정세속에서 경쟁력을 확보하고 분단된 민족의 화합을 위하여 남북한이 통일되어야 할 것이다. 남북한이 통일되면 문명의 큰 흐름이 정보사회로 변전하는 이때에 정보를 효과적으로 수집, 가공, 축적, 제공하는 제도적 장치인 도서관 정책과 제도를 어떻게 운용할 것인가 하는 과제는 국가의 중대사이다. 그런 관점에서 이 연구는 다음과 같은 결론을 얻었다. 첫째, 통일을 대비하여 민족도서관을 건설하는데 있어서 1)정보사회형 정책과 제도 개념 2)민족문화중심의 정책과 제도개념을 도입하는 것이 필요하다. 둘째, 통일에 앞서 우선적으로 남북한 도서관간의 협력구도를 마련하는 것이 필요하다. 이러한 협력은 종합목록의 작성, 자료의 상호대차, 자료의 공동활용을 위한 표준화된 목록규칙의 작성, 학위논문의 교환 등과 같은 실질적 이익을 가져다 주는 부분에서부터 시작해서 점차 자원을 필요로 하는 영역으로 확산되어야 한다. 셋째, 통일을 대비한 도서관 정책과 제도를 개발하는 일은 지배 모델로서의 통합흡수형이 아닌 상호의존 모델로서의 병존협력의 개념위에서 수행되어야 한다. 넷째, 통일을 대비한 도서관 정책원리에는 1)자유경쟁의 논리 2)사회교육을 통한 의식의 개혁 3)자주의식과 인류애 4)과학적 내지는 합리적 사고 5)직업에 대한 소명의식 6)민주시민정신 7)공동체의식 8)공익정신 9)세계정신을 포함시킬 것이 요구된다. 다섯째, 통일을 대비한 도서관 제도모형은 남북한의 도서관이 1)도서관의 위상통일 2)도서관 정책 및 제도 전문연구기관의 설립 3)전문인력의 교류 4)정보자료의 교류 5)학술정보망의 구축 6)문헌정보학 교육체계의 확립과 수준향상 7)현대화 및 정보기술 개발과 이양 등을 내용으로 갖추고 그 구체적인 사안들을 공동개발할 필요가 있다. 끝으로, 남북한의 도서관은 그 개념, 운영목적, 자원의 내용 및 이용방법 등이 모두 상이하다고 할 수 있다. 도서관의 존재이유와 그 실용성의 측면들을 고려할 때, 남북한의 도서관은 통일이라고 하는 사회적 변화에 직면하여 그 충격이 최소한의 것이 되도록 상호 공조체제를 구성할 필요가 있다 The world has moved from the Cold War between the east and the west, and moved toward the age without idealogy. It places emphasis on economic benefit and welfare of its own nation as its main point. With this world trend, in order to secure the competitiveness and the reconciliation of the divided nation, the north and the south Korea should be united. Once the north and the south are united, information society will be altered with the huge flow of the civilization. At the same time, the issue of how to operate library policies and system, in which effective acquisition, manipulation, accumulation, and dissemination of information occurs, would be very important. From this point of view, the following conclusions are obtained in this study. Firstly, when building a national library preparing for the national unification, it is essential to introduce 1)the concept of policy and system for information society and 2)that of policy and system which has national-culture as its focus. Secondly, it is essential to prepare the cooperative-structure between libraries prior to the national unification. This kind of cooperation should gradually expand to an extent that allows actual benefits such as building union catalog, inter-library loan system, resource sharing, standardized cataloging rules, and exchange of dissertation... etc. Thirdly, developing the library policies and systems for the national unification must be based on the concept of the mutual cooperation as inter-dependent model, rather than on the concept of the incorporation-absorption as a dominant model. The next point, the principles of the followings in preparing the library policies should be considered: 1)free-competition, 2)revolution of consciousness through the social education, 3)independence and love for humanity, 4)scientific or reasonable thinking, 5)job responsibility, 6)democratic citizenship, 7)mind for collective life, 8)spirit of public interest, 9)globalization In addition, the model of the library systems preparing for the national unification should include the followings: 1)uniformity of library system and its authority, 2)establishment of research institutes for library policy and system, 3)exchange of library experts and information resources, 4)building library networks, 5)establishment of education systems for the library and information science and enhancement of its quality, 6)modernizing and developing information technology and its transfer. Finally, the libraries in the north and the south has different concepts, goals, information resources, and the different ways of using them. Considering the practical aspects of the libraries and the reasons for their existence, they must structure the mutual cooperative system so as to minimize the shock when confronting the social changes, so-called the national unification

흰쥐 간의 재생에 관한 세포화학적 연구

길영천,김완종,한상철 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.2

The present study was designed to evaluate the regeneration process, the localization of metallothionein(MT) and alkaline phosphatase(ALP), and the liver function during the liver regeneration of rat. The weight of control rat liver was about 4.3% of body weight. But after hepatectomy, the remaining liver weight was about 1.3% of body weight. The remaining liver seemed to begin regenerating at 24 hours after partial hepatectomy, and to complete at 7∼10days after hepatectomy. In control rat liver, metallothionein(MT) was scarcely found in the cell. But MT was found in both the cytoplasm and the nucleus of hepatocyte at 6 hours after hepatectomy, and MT reaction was found in the cytoplasm of liver at 24 hours after hepatectomy. From 5 days after hepatectomy, MT reaction became weak in the cytoplasm of hepatocytes. In control rat liver, the reaction products of alkaline phosphatase(ALP) were scarcely found in the nucleus. But in the experimental group, ALP was found at the membrane of hepatocyte contacted with the lumen. Activities of glutamate oxaloacetate transaminase(GOT) and glutamate pyruvate transaminase (GPT) of serum increased until 24 hours after hepatectomy, then returned to the normal level in about 2 days after hepatectomy. In conclusion, It is suggested that regenerating hepatocytes reveal characteristics of typical cell proliferation and carry out normal function.