신경망 이론에 의한 황룡강의 홍수유출예측에 관한 연구

박성천,오창열,김동렬 東新大學校 工業技術硏究所 2004 工業技術硏究 Vol.10 No.-

This research overcomes limitation of physical model using storage function method that is used in flood routing method of flood forecasting-warning system of 5 basic principle basin of our country. We also developed a nonlinear-model of rainfall-runoff process using artificial neural networks (ANNs) that do not consider to hydrology structure of basin. The results show that the ANN_SA_9 selected in the present study generally well-performed the one-step ahead prediction of runoff in the study area, the Sunam station. Also, base on ANN_SA_9 which have the value of R2 more than 0.95 developed in this search, we can have a higher reliability to operate and manage the water resources and rivers plan more efficiently in the future.

雙補丸이 卵巢摘出로 骨多孔症을 誘發한 흰쥐에 미치는 영향

朴鍾元,崔相淳,金哲源,朴炳烈 한국전통의학연구소 2000 한국전통의학지 Vol.10 No.1

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. The purpose of this study is to examine what are the effects of the Ssangbohwan(SBH) on the ovariectomized rat model of postmenopausal osteoporosis. The results were summarized as follows : 1. Body weight in control group showed significant increase in comparison with sham, but that in SBH-treated showed no change in comparison with control. 2. The level of serum albumin in control group showed significant decrease in comparison with sham. That in SBH-treated was slightly decreased in comparison with control, which showed no efficacy. 3. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in SBH-treated was slightly decreased in comparison with control, which showed no efficacy. 4. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in SBH-treated showed no change in comparison with control. 5. The level of serum calcium in control group showed no change in comparison with sham, but that in SBH-treated was significantly decreased in comparison with control. 6. The level of serum T3 in control group showed no change in comparison with sham, but that SBH-treated showed significant decrease in comparison with control. 7. The level of serum T4 in control group showed significant increase in comparison with sham, and that in SBH-treated showed significant decrease in comparison with control. 8. Trabecular tibia strength in control group showed significant decrease in comparison with sham, but that in SBH-treated was slightly imcreased in comparison with control, which showed no efficacy. According to the above these results, SBH has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause

만성 간장 질환자에서 뇌 MRI 상의 pallidal index와 생물학적 망간지표들 간의 관련성

최영희,박능화,신정우,김효경,김성률,정태흠,박지강,이헌,유철인,이충렬,이지호,김양호 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : 만성 간장 질환자를 대상으로 T1강조 자기공명영상(MRI)에서 나타나는 담창구 부위의 고신호강도 소견(pallidal index, PI)과 생물학적 망간 지표들 간의 관련성을 알아본다. 방법 : B형간염 바이러스에 의한 간경변증으로 진단 받은 40세 이상의 환자 31명과 정상 대조군 10명을 대상으로 설문조사와 혈액 및 소변검사, 뇌 MRI를 시행하였다. 전체 41명 가운데 검사 전 수혈을 받았던 환자군 9명을 제외하고 전체 32명의 자료를 분석하였다. 망간 축적에 관련된 객관적 지표로서 T1 강조 MRI에서 나타나는 담창구 부위의 고신호강도를 전두부 백색질 신호강도로 나눈 수에 100을 곱하여 구한 PI를 택하였다. 환자군과 대조군 사이의 PI와 망간농도들의 평균을 비교하였다. 여러 변수들과 PI와의 상관성을 보기 위해서는 상관분석을 시행하였다. 결과 : 간장 질환자 22명 가운데 18명(81.8%)에서 뇌 MRI 상 고신호강도가 나타났다. 대조군 10명에서는 아무도 MRI 소견상 고신호강도가 나타나지 않았다. 간장 질환자에서의 평균 PI는 122.62로 대조군의 106.23보다 유의하게 높게 나타났다(p<0.01). 간장 질환자의 전혈에서 망간농도는 2.34㎍/㎗으로 대조군의 1.44㎍/㎗와 비교하여 유의하게 높게 나타났다(p<0.05). 혈장과 소변 내 망간농도는 대조군에서 다소 높게 나타났으나, 통계적으로 유의하지는 않았다. 또한 혈색소, 빌리루빈, AST가 대조군과 환자군 사이에서 유의한 차이가 있었다(p<0.05). 전혈(p=0.489, P<0.01, n=29)과 적혈구(p=0.573, P<0.01, n=22) 내 망간농도와 PI 사이에는 각각 유의한 상관관계가 있었다. 그러나 혈장과 소변 내 망간 농도와 PI와의 상관관계는 통계적으로 유의하지 않았다. 총빌리루빈 또한 PI와 유의한 상관관계를 나타내었다(p=0.509, P<0.01, n=32). 결론 : 전혈 또는 적혈구 내의 망간 농도가 뇌 내 망간 침착으로 인한 T1 강조 MRI상 담창구 부위의 고신호 강도를 잘 반영하는 유용한 지표이다. Objectives: The objectives of this study were to clarify which biological manganese exposure indices reflect the pallidal signal intensities in magnetic resonance imaging (MRI) in liver cirrhotics. Methods: We examined whole blood, plasma, RBC and urinary manganese concentrations, as well as, brain MRI in 22 cirrhotic patients and 10 healthy controls. From MRI scans we calculated the signal intensity of the globus pallidus using the pallidal index (PI), the ratio of the globus pallidus to subcortical frontal white-matter signal intensity in axial T1 -weighted MRl planes multiplied by 100. In addition, we studied the relationships between PI and other measurements. Results: The high signal intensity in the globus pallidus on T1-weighted MRI was observed in 18 (81.8%) patients. There was a significant correlation between whole blood and RBC manganese concentration, and PI on MRI. According to multiple linear regression, whole blood and RBC manganese concentration reflected PI on MRI better the other indices did. Conclusions: Whole blood and RBC manganese concentrations could be useful as biological manganese exposure indices that reflect PI on MRI.

타타늄의 열처리 조건에 따른 동전위 양극분극특성 및 표면 미세구조 변화

주동현,이용렬,정영화,양홍서,박상원,이도재,송호준,박영준 大韓齒科器材學會 2002 대한치과재료학회지 Vol.29 No.2

The corrosion resistance of metallic implants is essential for successful implant osseointegration. Moreover, the implant surface should have appropriate surface roughness for the attachment of the osteoblast and collagen fibrils. When titanium is exposed to air a thermodynamically very stable oxide film is formed at once. This oxide is very thin and yet it protects the metal from corrosion instantaneously. However, the oxide would not be ideal, and it would be supposed that the state of oxide film would be various by the different conditions when it is formed. The objective of this study was to evaluate the electrochemical properties and surface microstructural changes of titanium after passivation treatment or exposure to high heat (in vacuum or in air). ASTM grade 2 commercially pure titanium (Ti) disks of 10㎜ diameter were wet ground and polished with 240 and 600 grit SiC, and then ultrasonically cleaned with distilled water and ethanol. Cleansed as-received samples (As-R group) were passivated with 30% nitric acid solution at 50℃ for 15 minutes to make the Pas group. The Std-V samples were made by treating the Ti disks in vacuum quartz tube (10^-8 Torr) at 530℃ for 40 min for stress relieving, followed by annealing at 700℃ for 90 min, and then slow cooling to room temperature. The Std-A samples undergo identical procedure as the Std-V group except that it is done in air. For 530℃-V samples, Ti disks were heated at 530℃ for 40 minutes and slow cooled to room temperature. The 1000℃-V samples were produced by heating Std-V specimens again at 1000℃ for 2 hr, followed by cooling to room temperature. 530℃-A and 1000℃-A samples were also prepared. Potentiodynamic anodic polarization measurement, SEM, AFM and XRD analysis were performed to evaluate the effects of the various treatments. The difference in the mean values of E_corr between groups showed statistically significant difference (P<0.05), but that of I_corr did not show significance (P>0.05). When Ti surface was passivated there was a shift of corrosion potential (E_corr) in the noble direction and a lower corrosion current density (I_corr) value. Std-A samples showed most noble E_corr value among the tested groups. 530℃-V samples showed more noble E-corr than other tested groups except Std-A group. 1000℃-V samples showed more noble E-corr than those of Std-V sample. In the case of Std-, 530℃- and 1000℃-groups, -A sub-groups showed better corrosion resistant characteristics than -V sub-groups in regard to E-corr and I_corr values. In the SEM observations, the surfaces of the As-R samples showed only scratch line on smooth surface. In Pas samples, thick oxide layer covered the surface under high magnification observation. 530℃-A samples were covered by oxide granules, and Std-A samples had 25~50 nm-thick acicular oxides. The 1000℃-A samples were covered by coarse oxide crystals with a granule diameter of 0.1~0.6 μm having a gross appearance of milky white color, which was identified by XRD as a rutile. On the other hand, 1000℃-V samples showed an Widmansta¨tten structrue of which the orientation of the lattice is formed along crystallographic planes of the parent crystals. On the AFM observation, 530℃-A samples showed RMS roughness of 79.38 nm which is 5 times rougher than those of the As-R samples. Std-A sample had a roughness of 330.47 nm which is about 20-times rougher than that of the As-R sample. 1000℃-A samples were covered by coarse granular oxides and the roughness were about 0.56 μm. Vacuum sub-group samples showed a more smooth surface than air sub-group samples, and the oxide film was more dense. Due to variability of the surface treatment and heat treatment conditions, the process of the oxide formation seems to be affected thereby making the corrosion properties and surface micro-morphology different. However, more various electrochemical analysis together with surface analysis, and an investigation for the effects of those on the osteoblast cell adhesion and calcium phosphate apposition are needed for the improvement of the osseointegration rates of the titanium implants.

임베디드 장치용 사용자 인터페이스 라이브러리 설계 및 개발

김시관,홍상렬,박형순 금오공과대학교 2006 論文集 Vol.27 No.-

임베디드 시스템 장치에서 사용자에게 정보를 제공하고 사용자의 입력을 받기 위한 언터페이스의 중요성은 인터넷의 발전 및 휴대 전화 PDA 등과 같은 개인 정보 접속 장치의 대중화로 점차 커져가고 있다. 개인 정보 접속 장치뿐만 아니라 산업 현장에서 사용되고 있는 임베디드 시스템에서도 장치 제어 및 감시에 사용될 GUI의 요구 증가는 계속 되고 있다. 하지만 임베디드 장치의 제어 및 감시를 위한 GUI 라이브러리의 개발은 아직 미비한 실정이다. 따라서 임베디드 시스템 장치를 제어하고 감시하기 위한 기존의 GUI 라이브러리 보다 더 발전된 Gill 라이브러리를 설계하고 개발하였다. 그리고 새로운 GUI 리아브러리를 이용한 데모 프로그램을 작성하였다.

Heterologous Production of Epothilones B and D in Streptomyces venezuelae

Sung Ryeol Park,Je Won Park,Ah Reum Han,Yeon-Hee Ban,Young Ji Yoo,Eun Ae Choi,Yeo Joon Yoon 한국생물공학회 2008 한국생물공학회 학술대회 Vol.2008 No.10

Biosynthesis of Plant-Specific Flavones and Flavonols in Streptomyces venezuelae

( Sung Ryeol Park ),( Ji Hyu Paik ),( Mi Sun Ahn ),( Je Won Park ),( Yeo Joon Yoon ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.9

Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography-electrospray ionization-mass spectrometry

Park, Je Won,Jung, Won Seok,Park, Sung Ryeol,Park, Byoung Chul,Yoon, Yeo Joon Wiley 2007 Journal of mass spectrometry Vol.42 No.9

<P>A method employing silicone oil density centrifugation, solid-phase extraction (SPE) cleanup, and LC-ESI-MS/MS analysis was developed for the rapid, selective, sensitive, and quantitative detection of an intracellular pool of short organic acid-CoA esters in actinomycetes. The detection limit was determined to be approximately 0.8 pmol (1.2 ng/ml) for each standard CoA-ester analyzed by the present LC-ESI-MS/MS method. A selected ion chromatogram for a typical fragment ion (m/z 428) specific to CoA-esters enabled the detection of eight intracellular CoA-esters involved in both primary and secondary metabolisms. The application of this method to bacterial metabolomic study is demonstrated by the profiling of the intracellular CoA-ester pools in the wild-type Streptomyces venezuelae strain producing polyketide antibiotics (methymycin and pikromycin), a polyketide synthase (PKS)-deleted S. venezuelae mutant, and a S. venezuelae mutant expressing the heterologous PKS genes. By quantifying the individual CoA-esterlevel in three different genotypes of the S. venezuela e strain, further insight could be gained into the role of CoA-estersin polyketide biosynthesis. This analytical approach can be extended to the quantification of the size and composition of in vivo CoA-ester pools in various microbes, and can provide a detailed understanding of the relationship between the in vivo CoA-ester pool and the production of pharmaceutically important polyketides. Copyright © 2007 John Wiley & Sons, Ltd.</P>

Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects

Park, Sung Ryeol,Han, Ah Reum,Ban, Yeon-Hee,Yoo, Young Ji,Kim, Eun Ji,Yoon, Yeo Joon Springer-Verlag 2010 Applied microbiology and biotechnology Vol.85 No.5

Application of impulse oscillometry to adult asthma with preserved lung function

( Sung-ryeol Kim ),( Kyungchul Kim ),( Jinyeong Moon ),( Sang Chul Lee ),( Kyung Hee Park ),( Jae-hyun Lee ),( Jung-won Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Purpose: Spirometry has limitations in evaluating asthma with preserved lung function. Whereas, impulse oscillmetry (IOS) can detect not only airway resistance, but also reactance. Therefore, it is pressumed that IOS can help diagnosis of adult asthma with preserved lung function. However, the application of IOS to these patients have not been adequately investigated. Method:One thousand two hundred fifty-five patients with suspected asthma, who visited the Allergy and Asthma Clinic of Severance Hospital from 2015 to 2018, were enrolled. Patients performed pulmonary function test (PFT) and IOS. Among them, 117 patients were excluded due to parenchymal lung disease or chronic obstructive lung disease (COPD), or asthma- COPD overlap. Five hundred thirty-eight patients with asthma were excluded due to decreased lung function (predicted forced expiratory volume in 1 second < 80%). Six hundred asthma patients with preserved lung function were compared with 195 non-asthma patients. Then, among 600 asthma patients, asthma control status of 277 patients, who performed second PFT, were also analyzed. Result: Most IOS parameters were significantly higher in asthma patients than in non-asthma patients. Among the IOS parameters, Area of Reactance (AX) was the most appropriate parameter for predicting asthma (the area under a receiver operating characteristic curve (AUC) = 0.757). Optimal cut-off value for AX to diagnose asthma was 0.605. Its sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 52.4%, 91.6%, 91.4%, and 52.9%, respectively. Change rate of AX between 1st and 2nd IOS showed highest AUC (0.678) for predicting the stable asthma status. Conclusion: IOS is a useful utility for diagnosis and management of adult asthma with preserved lung function.