두개안면 섬유성 이형성증의 임상적 고찰

백롱민,오갑성,윤성호,백세민,황민호 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.3

Fibrous dysplasia is a benign pathologic condition of bone and causes facial deformities as well as functional problems. We have managed 32 craniofacial fibrous dysplasia form March 1989 to December 1993. The most common age distribution of surgery was second decade(34%) and third decade(53%). In our patients, the desease process usually begins in childhood and progresses throughout puberty and adolescence. Treatment was aimed at preventing and correcting functional problems and achieving normal facial aesthetics. The reconstruction with other combined surgery, i.e., mandibular and maxillary osteotomies, reduction malar plasty, malar augmentation and orbit, nasal reconstruction with bone graft. Postoperative results were satisfactory in most cases. In some patients, repeated contouring(16%) surgery might produce less morbidity than a single massive resection. In evaluating the extent of the lesion, computerized tomography prooved to be a good diagnostic tool. Aethetically and functionally satisfactory surgical results were achieved by bone shaving in combination with reconstructive surgery.

Streptococcus salivarius의 요소분해효소 활성에 관한 연구

정상백,최호영,민병순,박상진,이진용,최기운 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

Dental caries is induced by organic acids produced by oral bacteria. In order to prevent dental caries, therefore, it is essential to maintain neutral pH in the oral cavity. Urea plays a major role in oral pH homeostasis. Urea is hydrolyzed by bacterial ureases to ammonia, causing a pH elevation, Streptococcus salivarius has been shown to be a major contribution to oral ureolysis. Synthesis of urease by S. salivarius appears to be constituitive, but can be greatly enhanced by low pH. It is, therefore, conceivable that ureolytic activity of S. salivarius from a carious lesion is greater than that of the bacterium from a healthy tooth. In the present study, urease activity of S. salivarius isolates from dental plaque of carious lesions was compared with that of the isolates from plaques of the teeth and the dorsum of the tongue; 45 S. salivarius strains were isolated from carious lesions(>C2) of 21 individuals with dental caries and 30 strains from 10 individuals without dental caries. The results were as follows: 1. All the 21 individuals with dental caries harbored ureolytic S. salivarius whereas 3 of 13 individuals without dental caries harbored non-ureolytic strains of S. salivarius. 2. All the 45 S. salivarius isolates from carious lesions showed urease activity. In contrast, of 30 isolates from individuals without dental caries, 17 isolates(56.7%) did not demonstrate urease activity, or if any, very little(<5μmol/min/mg). 3. Urease activity of the isolates from carious lesions was greater than that of the isolates from individuals without dental caries:the urease activity ranged from 42 to 381μmol/min/mg and from 0 to 208μmol/min/mg, respectively. 4. At acid pH(5.5), the isolates which showed intermediate urease activity at pH 7.0 demonstrated even higher activity whereas the isolate with no or lower urease activity did not show any significant difference in their activity. However, the isolates with the greatest urease activity from both individuals with and without dental caries, exhibited a rather much lower urease activity at pH 5.5. The overall results suggest that isolates may have their own urease activity but the isolates exposed to chronic acidic environment of the carious lesion might elevate urease activity of S. salivarius, which in turn, might influence on survival of S. salivarius itself and other bacteria establishing a new oral bacterial ecosystem.

원인 불명의 실신 환자의 진단에 있어서 Head - up tilt Test 의 유용성과 혈관미주신경성 실신 환자의 임상적 특징

윤호중(Ho Joong Youn),정욱성(Wook Sung Chung),백상홍(Sang Hong Baek),김철민(Chul Min Kim),박인수(In Soo Park),김재형(Jae Hyung Kim),최규보(Kyu Bo Choi),홍순조(Soon Jo Hong) 대한내과학회 1994 대한내과학회지 Vol.47 No.2

N/A Background: Syncope, defined as a transient loss of consciousness, is a frequently encountered symptom, but despite thorough clinical and invasive diagnostic investigation, the cause of syncope remains unexplained. In recent years, head-up tilt test has been of increasing interest as a diagnostic aids in patients with unexplained syncope. We studied to define the usefulness of various diagnostic test in the evaluation of patients with recurrent syncope, to assess the usefulness of head-up tilt test in the working of syncope of unknown origin and to evaluate the clinical characteristics of subgroups of patients with syncope induced by head-up tilt test. Methods: Between June, 1991 and November, 1992 at St. Mary`s hospital, 21 patients with history of syncope and 24 control subjects without history of syncope underwent 60° head-up tild test for 60 min. Results: 1) The definite cause for recurrent syncope were diagnosed in 10 of patients (47,6%) after clinical and invasive tests. 2) During head-up tilt test, vasovagal responses were provoked in 5 of 21 patients (23.8%) with recurrent syncope and 1 of 24 patients (4.2%) without syncope (p<0,05). 3) The head-up tilt test induced symptomatic bradycardia or hypotension in 3 of 10 patients (30%.) with negative electrophysiologic results. 4) During tilt induced vasovagal response, a) mean heart rate decreased to 42±24 beat/min from supine control of 70±12 beat/min (p<0. 05), b) mean systolic blood pressure decreased to 95±12 mmHg from supine control of 120±S mmHg (p<0,05), c) mean diastolic blood pressure decreased to 60±21mmHg from supine control of 72±13 mmHg (p<0.05), d) the time interval to onset of vasovagal response was 22±12 min. Conclusions: 1) In a large proportion of patients with recurrent syncope, the diagnosis remains unexplained despite a neurologic and cardiologic investigation including an electrophysiologic study. 2) Vasovagal responses are frequent cause in patients with recurrent unexplained syncope. 3) The head-up tilt test may be a simple, safe and highly yielding provocative test in the investigation of syncope of unknown origin.

반하(Pinellia ternata)가 랫드의 수컷 생식기계에서 3β-HSD,SGP-2 및 AR 유전자 발현에 미치는 영향

연정민, 백인정, 김윤배, 노재섭, 황방연, 김순선, 조대현, 이범준, 윤영원, 남상윤 충북대학교 동물의학연구소 2005 Journal of Biomedical and Translational Research Vol.6 No.2

본문참조

안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

상악골에 발생한 악성섬유성조직구종의 치험례

이상철,김여갑,류동목,이백수,윤옥병,신민철 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

급성 충수염으로 진단된 예측 불가 염증성 맹장 종물에 대한 외과적 고찰

민경진,백무준,채만규,김성용,이문수,김창호,김재준,송옥평 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: An unexpected inflammatory cecal mass of uncertain etiology was encountered during surgery for presumed appendicitis. In this case, the surgeon couldn't exclude differential diagnosis which were severe appendicitis involving the cecal region, diverticular disease, other inflammatory bowel diseases, and neoplasm. Therefore, this finding leads to a therapeutic dilemma for the surgeon, when making surgical decisions during the operation. The aim of this study was to resolve this dilemma, a retrospective review was undertaken in this study. Methods: A retrospective study was performed to review the management of this problem at Soonchunhyang University Chunan Hospital for eight and half years from July 1991 to December 1999. A review of the emergency operation records identified 50 patients who had undergone ileocecal resection or right hemicolectomy for an inflammatory ileocecal mass of uncertain etiology when operated on for probable appendicitis. Results: Altogether, 39 patients underwent ileocecal resection, and 11 patients underwent right hemicolectomy. The final pathologic diagnosis was appendiceal abscess in 32 patients (63%), cecal diverticulitis in 7 patients (14%), neoplasm in 6 patients (12%), appendiceal phlegmon in 3 patients (6%), ileal tuberculosis in 1 patient (2%) and Anisakiasis in another patient (2%). The neoplasm of the 6 neoplasm patients was ascending colon cancer for 4 patients and cecal cancer for 2 patients. There was no mortality in this group. Conclusion: Although most inflammatory cecal masses are caused by benign disease, all cases in which the intraoperative diagnosis is unclear, any pathologic diagnosis including neoplasm cannot be ruled out. So this suggest ileocecal resection or right hemicolectomy to remove a possible underlying malignancy, and to decrease morbidity and mortality.

광중합형 수복용 복합레진의 강도에 미치는 Thermal Cycling의 영향

백상현,채민수,배태성 대한치과기재학회 1996 대한치과재료학회지 Vol.23 No.1

This study was performed to investigate the effects of thermal cycling on the strength of light cured restorative composite resins. Five commerically available light-activated composite resins(Photo Clearfil A : CA. Lite-Fil A : LF, Clearfil Photo Posterior : CP, Prisma AP.H. : PA, Z100 : ZH) were used. The specimens of 12mm in diameter and 0.7mm in thickness were made, and a thermal cycling test of 1000 cycles at 15 seconds dwell time each in 5℃ and 55℃ baths was performed. In order to investigate the deterioration of composite resins in the thermal cycling test, the bi-axial flexure strengths were measured, and the surface after thermal cycling test were examined by SEM. The results obtained were summarized as follows; 1. Biaxial flexure strength significantly decreased due to the thermal cycling(P<0.01). 2. Biaxial flexure strengths showed the maximum value of 125.65MPa for ZH group and the minimum value of 64.86MPa for ZA group, after thermal cycling test, Biaxial fleure strengths of ZH and CP group were higher then those of PA, CF, and CA groups after thermal cycling test(p<0.05). 3. Fracture surfaces showed that the composite resin failure developed along the matrix and the filler/resin interface region, and the cracks propagated in the conical shape from the maximum tensile stress zone.

상악 및 하악의 전방 분절 절골술을 이용한 안면 프로파일 성형술의 임상적 고찰

백세민,오갑성,윤은성,백롱민,임재호 大韓成形外科學會 1996 Archives of Plastic Surgery Vol.23 No.5

Mid and lower facial convexity is more common in Oriental people than in Caucasian and it is thought to be caused by a more anterior position of dental and skeletal structures rather than soft tissue structures, a more procumbent dentition, and a more acute interincisial angle. To improve their lower facial profile, we performed maxillary and mandibular anterior segmental osteotomies in 96 patients, by way of using palatal mucoperiosteal flap for vascular circulation of the antrior segment and plates and screws for rigid fixation. We also used wafer splint which had been made through model surgery which dental cast and tracing of cephaloghram had been needed. We could get the accurate diagnosis and know how much and which direction the anterior segment should move to get the satisfactory result or improved lower facial profile and corrected occlusal relationship with the teeth. No major complications occurred throughout the followup period except three of over0recessed lip and two of septal deviation, otherwise most of the patients were satisfied with the result.

연속 매몰 봉합법의 다양한 임상적 적용: 비절개 이중검 성형술

백세민,최준,이용국,황소민,박성규 대한미용성형외과학회 1997 Archives of Aesthetic Plastic Surgery Vol.3 No.1

The double eyelid operation is one of the most common cosmetic surgery performed in orientals, and there are numerous studies about surgical procedures of that. In the case of appropriate candidates, the non-incision technique makes excellent cosmetic results, with the advantages of shorter operating time, less morbidity, less pain, no scarring and easy revision of shape. But, usually the non-incision technique is recommended in the cases with thin upper eyelid, small amount of orbital fat, less redundant skin of upper eyelid and in whom a wide fold is not desired so on. Therefore, the disadvantages of this method are that it cannot be applied to all patients. The postoperative complications are disappearance or faded fold, formation of cyst of lumps, asymmetry etc. and the incidence of these complications is slightly higher than those of the incisional method. In this study , the double eyelid operation using the continuous buried suture method was performed in 210 patients for formation of double eyelid from Jan. 1993 to Dec. 1995. In conclusion very good results can be obtained by the continuous buried suture method even in the cases of puffy upper eyelid. This method can make a double eyelid shape in the fashion the patient wants and can be a new indication for correction of unilateral double eyelid. This method is safe, satisfactory and take shorter postoperative recovery time and it can reduce the incidence of postoperative complications.