김정은 체제의 ‘강성국가’ 건설 전략과 전망 : ‘지식경제강국’을 중심으로

변상정(Byun, Sang Jung),최경희(Choi, Kyong Hui) 연세대학교 동서문제연구원 2012 동서연구 Vol.24 No.2

북한은 금년 공동사설에서 김정일이 1998년에 주장했던 ‘강성대국’ 건설 목표 중 미완의 ‘경제강 국’을 대체 계승하는 김정은 시대의 비전을 제시했다. 김일성의 주체사상으로 ‘정치(사상)강국’이 실현되고 김정일의 핵 보유로 ‘군사강국’이 완성되었으므로 김정은은 ‘새 세기 산업혁명’을 통한 ‘지식경제강국’ 건설을 선언한 것이다. ‘기계공업의 CNC화’로 상징되는 김정은의 ‘최첨단 돌파사 상’과 ‘지식경제강국 건설론’은 김정일 체제 출범시 제시되었던 ‘과학기술중시사상’과 ‘강성대국 건설론’을 계승한 것이다. 연하기계종합공장의 CNC기술 개발과 전 산업에의 CNC 도입은 ‘함남의 불길’과 함께 북한 사회 전체에 CNC화 도미노 현상이 확산되는 분위기를 만들고 있다. 김정 은의 ‘지식경제강국’은 북한의 정치체제와 경제구조의 근간을 훼손하지 않으면서 경제를 재건하기 위한 대안으로 제시된 것으로, 그 본질은 개방보다는 폐쇄적 ‘자력갱생’을 전제하고 있는 제한적 경제발전전략에 불과할 것으로 전망된다. Kim Jong Un, the first chairman of the National Defence Commission of the DPRK, made his first speech during a military parade to commemorate the centenary of the birth of his grandfather, Kim Il Sung. Kim Jong Un underlined that the most important national agenda is becoming a powerful nation through improving the national economy, and resolving the food shortage problem. In addition, he stressed that strong knowledge-based economy must be built by way of new industrial revolution. The economic policy Kim Jong Un set forth involved resolving the food crisis for the people, development of light industry, transition to a powerful knowledge-based economy, land management, and improvement of cultural and education projects. The nation must be established as a strong knowledge-based nation. It was acknowledged that the world is quickly transitioning to the informatization of the economy and North Korea must develop the national economy and build an economic structure that meets international demand. Science and technology should be the forerunner to incorporate science and technology with production and resolve all problems in the economic development process from the science and technology aspect. North Korea may have rebuilt its industries to some degree through the recent reconstruction initiatives. The phrase ‘CNC’ referring to a new initiative to computerize the industrial facilities that started August 2009. But considering North Korea’s inefficient and outdated industrial facilities, the recent reconstruction achievements hardly seem sustainable in the long term. Given the low sustainability of North Korea’s industrial growth, its industrial development is expected to reach its limits soon, forcing the country to consider getting out of isolation and embracing openness and change.

비만 치료 및 예방에 대한 한약의 효능 연구(Ⅱ) : 4종 처방이 비만 흰쥐의 면역조직화학적 변화에 미치는 영향

金蓮燮,卞晟僖,徐富一,金相贊,國萬,趙應行 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

We had experiment with several prescriptions in order to find cure and prevention effects for an obesity. We fed control gmup rats high fat diet and administered normal saline for Bweeb. And we fed experimental gmup ram high fat diet and administered exmct of four prescriptions for Bweek. The result were as follows: 1. The size of the epididymal fat cell of rats in Bikam-whan, Chekamhanghyuluiyiin-rang and Chekambohyulansin-tang groups showed a significant decrease in comparison with control group. 2. The fat drops area in hepatic lobule of rats in Bikam-whan, Cheknmhanghyuluiyiin-rang, Chekambohyulonrin-tang, and Chekambangpungrongseong-san groups showed a significant decrease in comparison with control group. 3. The area of the insulin granuls in islet of rats in Bikam-who4 Chekamhnnghyuluiyiin-tang and Chekambohyulonrin-tong group showed a significant decrease in comparison with control group. According to above these results, Bikam-whan. Cheknmhonghyuluiviin-tnng and Chekambohyulonrin-tang have shown to be capable of cure and prevent for an obesty.

비만 치료 및 예방에 대한 한약의 효능 연구 ( Ⅷ )

金蓮燮,卞晟僖,金相贊,國萬,趙鷹行 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

Objects : We had experiment with Chekamhanghyuluiiin plus Zeae Stigma in order to find effects on cure and prevention of the obesity. Methods : We fed control group rats high fat diet(Harlan, U.S.A.) and administered normal saline during 8 weeks, and experimental group rats high fat diet(Harlan, USA) and administered Chekamhanghyuluiiin plus Zeae Stigma extract during 8 weeks. Results : 1. The body weight of all experimental group decreased than control group. 2. The average size of the epididymal fat cells in all experimental group decreased than control group but only 7CH5 group showed statistically significant difference with control group. 3. The fat drops area of hepatic lobule in all experimental group decreased than control group but 4CH10, 7CH5 and 7CH10 group showed statistically significant difference with control group. 4. The area % of the insulin granules in Langerhans islet of 7CH5 and 7CH10 group showed difference with control group. Conclusion : Chekamhanghyuluiiin plus Zeae Stigma could be effective for the obesity.

牧楡湯이 人體 肺癌細胞의 變化에 미치는 影響에 關한 分子生物學的 硏究

李炯周,金相贊,徐富一,金先熙,卞晟僖 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

This experimental study was performed to investigate the effects of Mokyou-Tang on cell cycle and gene expressions of human lung cancer cell. I examined the cell cycle progression and cell cycle-related gene expression in A549 using a flow cytometry and a quantitative PT-PCR analysis. The treatment groups, in accordance with concentration of Mokyou-Tang were classified as 3 group(MYT 100㎕/㎖, MYT 500㎕/㎖, MYT 1,000㎕/㎖), and according to treatment time, were classified as 2 group(24hours, 48hours). The results were summarized as follows; 1. In cell cycle stage, MYT 100㎕/㎖(48hours) and 1000㎕/㎖(48hours) groups were increased as compared with control group, especially 1000㎕/㎖(48hours) group showed eminent increase. 2. In p53 gene, MYT 500㎕/㎖(48hours) and 1000㎕/㎖(48hours) groups showed eminent suppressive effect to cancer cell. 4. CDKNI gene was decreased in all treatment groups, this mean that MYT has suppressive effect to proliferation of cancer cell. 4. In GADD45 gene was decreased in all treatment groups, this mean that MYT has suppressive effect to proliferation of cancer cell. The results suggest that MYT promotes G1 cell cycle arrest and suppresses the proliferation of cancer cell. Thus, it seems likely that MYT has suppressive effect to proliferation of lung cancer cell.

구자가 卵巢摘出로 誘發된 흰쥐의 骨多孔症에 미치는 影響 (2)

徐富一,金先熙,卞晟僖,金美麗 대한본초학회 1998 大韓本草學會誌 Vol.13 No.2

This study was performed to investigate the effects of Allii Tuberosi Semen(菲子) on osteoporosis after ovariectomy in rats. Control group received a daily po administration of normal saline for 4 weeks after oophorectomy(OVX). The other experimental group received a daily po administration of water extract of Allii Tuberosi Semen for 4 weeks after oophorectomy(OVX-ATS). Therefore, we measured levels of calcium, phosphorus, ash weights in femur. These results were as follows : 1. In the level of bone phosphorus, the result of OVX was 63.85±1.86㎎/㎗, but the result of OVX-ATS was 68.18±0.85㎎/㎗. But there was no statistical significance. 2. In the level of bone calcium, the result of OVX was 141.66±2.19㎎/㎗, but the result of OVX-ATS group was 164.82±3.74㎎/㎗. And the result of OVX-ATS showed significant increase in comparison with OVX. 3. In the level of bone ash weight, the result of OVX was 0.31±0.005(g), but the result of OVX-ATS was 0.33±0.002(g). And the result of OVX-ATS showed significant increase in comparison with OVX. The observations from these studies and the past studies(=A study on the effects of Allii Tuberosi Semen in ovariectomized osteoporosis of rats) suggest possible protective effect of Alli Tuberosi Semen water extract against bone loss in ovariectomized rats.

아로마 요법이 신생아의 스트레스 호르몬에 미치는 영향

김재철,천성희,변상현 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Aromatherapy, one of complementary medicine was known that specific essential oil extracted from plants affect emotion and physiology of human by transmission of smell signal from olfactory cells to limbic system of brain. This study was intended to reveal the effect of aromatherapy by comparison of stress hormone and vital sign between the aromatherapy group and the control group. From June, 2001 to August, 2002, the aromatherapy group(n=12) and the control group (n=13) were selected randomly in NICU, Chungnam National University Hospital. We applied aromatherapy to the aromatherapy group 3 times every 20 minutes for 7 days and 24 hours urine collection for free cortisol and epinephrine was performed day 0(before initial aromatherapy) and day 7(after the last aromatherapy). After aromatherapy, no difference of change of vital sign was noted in aromatherapy group. Epinephrine concentration after aromatherapy decreased from 1.28±1.13μg/d to 0.84±0.58μg/d(p-value<0.05). Free cortisol concentration after aromatherapy decreased from 4.74±3.99μg/d to 1.60±0.84μg/d.(p-value<0.05). At birth, there was a marked increase in plasma stress hormone and after birth, stress hormone of neonate except acute or chronic ill baby decrease gradually. But in aromatherpy group, neonatal stress hormone decreased faster than nonaromatherapy group.

Oriental Medicines Effects on cure and Prevention of an Obesity(4)

( Sung Hui Byun ),( Yonng Kyu Kwon ),( Jun Seok Byun ),( Yun Seob Kim ),( Sang Chan Kim ) 한약응용학회 2002 한약응용학회 학술대회 Vol.2002 No.-

비만치료 및 예방에 대한 한약의 효능 연구(Ⅲ)

변성희(Sung Hui Byun),김상찬(Sang Chan Kim) 한의병리학회 2001 동의생리병리학회지 Vol.15 No.2

현삼메탄올 추출물이 LPS로 유도된 Raw 264.7 cell에서의 TNF-α, IL-1β, IL-6 및 nitric oxide 생성에 미치는 영향

변성희 ( Sung Hui Byun ),양재하 ( Chae Ha Yang ),김상찬 ( Sang Chan Kim ) 대한본초학회 2005 大韓本草學會誌 Vol.20 No.2

간성상세포에서 상엽(桑葉) 추출물의 섬유화 억제 효과

변성희 ( Sung Hui Byun ),박상미 ( Sang Mi Park ),김상찬 ( Sang Chan Kim ),조일제 ( Il Je Cho ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.4

Objectives : Mori Folium was popularly used as one of the traditional medicinal herbs. Although M. Folium has been cultivated for rearing silkworm historically, it`s use has been expanded as natural therapeutic agent for the treatment of filariasis, diabetes and dropsy in East Asia. However, little has been known about the effect of M. Folium on liver fibrosis. Therefore, we would like to explore an anti-fibrogenic potential of M. Folium extract (MFE) using immortalized human hepatic stellate cell line, LX-2 cells. Methods : We examined the effects of MFE on the transforming growth factor β1 (TGFβ1)-induced liver fibrosis in LX-2 cells. Cell viability, Smad binding element-driven luciferase activity, phosphorylations level of Smad 2/3, and expression level of TGFβ1-dependent target genes were monitored in the MFE-treated LX-2 cells. Results : Up to 30 μg/ml MFE treatment did not show any possible toxic effect in LX-2 cells. MFE inhibited TGFβ1-inducible Smad binding element-driven luciferase activity and decreased the TGFβ1-inducible phosphorylations of Smad 2 and Smad 3 in hepatic stellate cell in a dose dependent manner. Furthermore, increases of plasminogen activator inhibitor type 1, TGFβ1 and matrix metalloproteinases 2 genes by TGFβ1 were also attenuated by MFE treatment. Conclusions : These findings suggested that MFE would be used as a potential therapeutic agent for the treatment liver fibrosis, which might be mediated by the inhibition of TGFβ1-inducible Smad 2/3 transactivation and target genes expression.