Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

콩에서 발생하는 강낭콩일반모자이크바이러스(BCMV)와 땅콩위축바이러스(PSV)의 저항성 평가

이영훈, 윤영남, 강범규, 김현영, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

It has been reported several viral diseases in soybean. The occurrence of Bean common mosaic virus and Peanut stunt virus are able to induce severe problem because the main breeding target for viral disease was focused on Soybean mosaic virus. BCMV is a spcies of the genus Potyvirus of the family Potyviridae. BCMV reduces yield by as much as 80% and also adversely affects seed quality in common bean. BCMV has a worldwide distribution because of its high rates 35% of transmission via seeds produced by plants systemically infected prior to bloom. PSV is a species of the genus Cucumovirus of the family Bromoviridae. PSV has been reported to be economically damaging on beans worldwide. Although the virus is reportedly seed transmissible at very low rates, infected plants rarely produce pods with normal viable seeds. The most satisfactory management method of viral diseases such as BCMV and PSV is the use of resistant cultivars and healthy seed. For the overcome of genetic resistance by new virus such as BCMV and PSV, virus diseases monitoring and researches need to study deeply and continually. In this study, we conducted the resistance screen on BCMV and PSV for selection of resistance cultivars. We inoculated on 128 cultivars with PSV and BCMV respectively. These cultivars were classified through pathogenic response such as resistance, necrosis and susceptibility. In addition, 99 and 66 resistant cultivars were confirmed against PSV and BCMV respectively.

불평형 전원전압을 갖는 정류시스템에서 출력필터에 따른 입력 특성 분석

강수현,김상훈 강원대학교 산업기술연구소 2005 産業技術硏究 Vol.25 No.B

The rectifier characteristics and the quality of the input current worsens with the increase of unbalances or harmonics of the supply voltages. Rectifier input current harmonics interfere with proper power system operation, reduce rectifier power factor, and limit the power available from a given source. It is of importance to select appropriately the rectifier's outpur filter inductance to determine the rectifier input current waveform, the input current harmonics, and the power factor. This paper presents a quantitative analysis of single and three phase rectifier input current harmonics, total harmonic distortion, and power factor as a function of the output filter inductance under balanced and unbalanced conditions. Also, its performance under the supply voltage including harmonics be investigated. These results provide a reference for selecting resonable rectifier's output filter inductance for given harmonics or power factor criterion.

유리용융시 Nepheline Stone 생성에 관한 연구

강상훈,이경희,강원호 明知大學校 産業技術硏究所 1989 産業技術硏究所論文集 Vol.8 No.-

The formation of the Nepheline stone come from fusion-cast AZS Refractory and fusion-cast allumina Refractory which are use in Glass Melting Tank was investigated according to temperature variation. The results were Nephline Stone was formed easily with fused AZS Refractory in comparison with fused-cast Alumina Refractory below 1400℃ , Pendrite stone appeared with Nepheline at 1400℃ which comes from the fusion-cast AES Refractory and conrandum were found at 1500℃ comes from the fusion-cast Alumina Refractory.

健脾益氣法의 腫瘍治療活用에 對한 硏究

姜硏伊,金聖勳,金東熙 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.10 No.2

In review of "inviorating spleen an supplementing qi" of clinical and experimental studies on malignant tumor, we obtained the conclusions as follows 1. Asthenic splenic qi is an important factor in mutation, occurrence and development of tumor. 2. The anti-tumor mechanism of "invigorating spleen and supplementing qi" is improvement of immune suveillance, cntroling cell proliferating period and enhancing body metabolism. 3. "Invigorating spleen and supplementing qi" is often used with " nourishing kidney" or "expelling pathogen" for treating cnacer. 4. In experimental studies, "invigorating spleen and supplementing qi" has effects on inhibiting occurrence and development of tumor, protecting mutation, inhibiting recurrence and metastasis, immune activity, enhancing metabolism, promoting bone marrow hemopoietic cell proliferation, increasing anti-tumor effect and protecting normal cells. 5. In clinical studies, "invigorating spleen and supplementing qi" has effects on prolonging the survival period of cancer patients, improving clinical symptoms and quality of life of cancer patients, degrading the side effects of western therapie(operation, chemotherapy and radiotherapy). 6. "Invigorating spleen and supplementing qi" is an extensive discipline of syndrome differentiation used to inhibit occurence, development, recurrence and metastasis.

전기경련치료(ECT)시 뇌파의 비선형 분석 : 단일증례 연구 A Single Case Study

강웅구,이운철,정선주,윤세창,조맹제,이상훈,김용식 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 비선형 분석을 통해 전기경련 치료(ECT)의 적절성 및 효과를 판정할 수 있는 새로운 변인을 추출해 낼 가능성을 탐색하기 위하여 한 여성 우울증 환자에서 ECT중 기록한 뇌파의 단일증례 분석을 하였다. 방 법 : 1주일 간격을 둔 두 ECT 회기에서 치료전 안정상태, 마취후-경련전상태, 경련상태, 경련후 뇌파억제상태, 치료후 안정상태의 다섯 상태에 따른 뇌파를 디지털 기록한 데이터를 분석하였다. 결 과 : 분석의 결과 1) 뇌파가 10차원 이하 저차원의 결정론적 성질을 가지고있으며 2) 뇌파는 비정상적(non-stationary)이지만 비선형 지수들이 각 상태 뇌파를 안정적으로 구분해 줄 수 있고 3) ECT 회기의 진행에 따라 경련중 뇌파의 결정론적 성질이 증가하며 4) ECT 회기의 진행에 따라 치료전후 안정상태 뇌파의 최대발산지수(PLE) 및 상관차원이 증가한다는 사실을 관찰할 수 있었다. 결 론 : 단일증례에 대한 다양한 비선형 분석의 결과는 ECT의 치료효과를 정량화할 수 있는 변인으로서 PLE, 상관차원 등 비선형 변수들이 사용될 수 있을 가능성을 제시한다. Objectives : In order to search for new parameters for the evaluation of the adequacy of electroconvulsive therapy(ECT), the authors performed a non-linear analysis of electroencephalogram(EEG) recorded during the course of electroconvulsive therapy(ECT) in a single female patient with depression. Methods : Digitized EEG recordings from two ECT sessions spaced one week were analyzed at five different stages ; pretreatment stable, postanesthetic-preictal, ictal, postical suppression and posttreatment stable stages. Results : Our analysis showed that 1) EEG signals had low dimensional(below 10 dimensions) deterministic characteristics 2) although EEG was nonstationary signal, non-linear parameters could reliably differentiate between various stages we examined. 3) the deterministic property of ictal EEG increased according to the progression of sessions and 4) the primary Lyapunov exponent(PLE) and correlation dimension of pre- and post-treatment stable stage EEG increased according to the progression of sessions. Conclusion : In this single case study, results of various non-linear analyses suggested that non-linear variables extracted from EEG recordings during ECT may have utilities as tools for the quantitative evaluation of ECT.

The Effect of Epidural Ketamine used with Patient-Controlled Analgesia on Postoperative Pain

강훈,박상희,이동훈 충북대학교 의과대학 충북대학교 의학연구소 2008 忠北醫大學術誌 Vol.18 No.1

Purpose: Acute pain can be abolished by intravenous administration of ketamine in doses insufficient to induce anesthesia. Therefore we designed this study to see if this subanesthetic dosage of ketamine administered epidurally with patient-controlled analgesia (PCA) after abdominal surgery can also provide sufficient analgesic effect on postoperative pain. Materials and Methods: 20 consecutive patients were allocated randomly to receive either ketamine (n=10) or placebo (n=10) for pain relief after surgery. At 30 minutes before the end of surgery patients were attached to an PCA infusor programmed to epidurally deliver same amount of placebo or ketamine 3-5 mg/h (72-120 mg/day) in combination with background PCA regimen composed of bupivacaine, morphine, fentanyl etc for 48 hours postoperatively. Patients were evaluated for pain on ten-point Verbal Analogue Scale (VAS) and nausea on a four-point scale at 30 minutes, and 1, 6, 12, 24 hours after surgery. Results: The pain score in the placebo group is not significantly higher than in ketamine group postoperatively. While the pain scores in the two groups were very similar, throughout the 24 hours period, the incidence of nausea/emesis was also similarly low in both groups. Conclusion: It was found that a fixed rate epidural infusions of ketamine (3-5 mg/h) are ineffective in controlling pain after surgery. 연구목적: 강력한 진통작용를 나타내는 케타민은 마취농도 이하의 용량을 정맥투여함으로써 수술 후 통증같은 급성 통증을 치료할 수 있다. 저자들은 이와 같은 마취농도 이하의 저용량을 경막외에 투여하는 경우도 급성통증에 비슷한 효과가 있는지 알아보고자 본 연구를 시행하였다. 대상 및 방법: 연구 대상 환자는 충북대학교병원 수술실에서 복부에 정규 외과 수술을 받은 후 48시간 이상 자가통증조절(Patient-Controlled Analgesia)을 이용하여 통증치료를 받은 성인 남녀 환자들이며 환자들은 무작위로 ketamine군(n=10)과 위약 대조군(placebo, n=10)의 두 군으로 나누고 수술 종료 30분 전에 미리 준비한 patient-controlled analgesia에 ketamine (3-5 mg/h) 혹은 placebo를 섞어서 투여하기 시작하였다. 수술 후 회복실 또는 병실에서 필요한 경우 급성통증을 예방하기 위하여 ketorolac 30 mg을 정맥 투여하였다. 환자의 통증과 부작용에 대한 평가는 회복실에서 그리고 수술 후 1, 6, 12, 24 시간에 시행하였다. 결과: 두 군 간에 인구학적 차이는 없었으며 수술 직 후 회복실에서 통증의 정도는 두 군 간에 유의한 차이가 없었으며 오심 및 구토 등의 부작용도 의미 있는 차이를 보여주지 않았다. 결론: 마취농도 이하의 저용량의 ketamine (3-5 mg/h)을 경막외에 투여하는 경우 의미있는 진통효과를 보여주지 못하였다.

1930年代 京城府 철근콘크리트조 公立 普通學校와 小學校 建築에 관한 硏究

강상훈,심우갑 대한건축학회 2003 대한건축학회논문집 Vol.19 No.7

This study aims to clarify the emerging of Modernism in Korean elementary schools which were built of reinforced concrete in 1930's through the survey and research of 49 public elementary schools which built in Seoul from 1895 to 1942. Throughout the wooden and brick building period(1985-1925), reinforced concrete elementary school buildings emerged first in 1924, reinforced concrete buildings were the most popular elementary school cuildings of 1930's. This reinforced concrete period could be divided into former period(1924-1933) and latter period(1933-1939) in which characteristics of Modernism are found. The high efficiency of reinforced concrete in heat insulation, fire resistance, durability and high density made reinforced concrete elementary school buildings which were built slightly earlier than Korean's would be model of Korean reinforced concrete school buildings. The policy on wide spreading of elementary school from 1920's and its acceleration from 1933 arouse popularization of elementary school and increasing needs for rapid and econimic construction. This made mid-1930's reinforced concrete school buildings have Modernism characteristics with existing school planning and design which to universal and rational design characteristics of Modernism.

방사선치료 후 영구치 치배 발육장애 증례보고 : REPORT OF CASE

강명봉,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

두경부 악성 종양에 대한 방사선치료는 유용한 방법이다. 하지만 방사선치료의 부작용으로 다양한 구강내 합병증을 동반한다. 이 글에서 치열 발육 단계에 방사선치료를 받은 두 증례를 보고하는 바이다. 첫 번째 증례는 생후 19개월에 급성 골수성 백혈병으로 진단 받아 방사선치료를 받은 7세 여자 환아로 영구치 치배의 선천적 결손과 왜소치 소견을 보였다. 두 번째 증례에서는 생후 13개월에 양측성 망막아세포종으로 진단 받아 방사선치료를 받았고 영구치 치배의 선천적 결손, 왜소치, 치근의 저형성 그리고 법랑질 저형성증 소견을 보였다. Radiotherapy for head and neck tumors is a viable treatment modality. However, a wide range of potentially debilitating dental complications may be accompanied by this treatment. We report two cases of developmental disturbance of permanent tooth germs after radiotherapy. The one was that of a seven-year-old girl, who had congenitally missing teeth, and microdontia of permanent tooth germs. she had received radiotherapy for acute myelocytic leukemia at the age of 19 months. The other was that of a nine-year-old boy, in which congenitally missing teeth, microdontia, root hypoplasia, and enamel hypoplasia of permanent teeth were observed. He had undergone a course of radiotherapy for bilateral retinoblastoma at the age of 13 months.

양식장 배출물 발효물의 어류 사료 첨가에 따른 넙치, Paralichthys olivaceus의 혈액학적 변동에 미치는 영향

강주찬,지정훈,송승엽,문상욱,강지웅,이영돈,김세재 한국어병학회 2004 한국어병학회지 Vol.17 No.1

본 연구는 우리나라 주요 양식어류인 넙치, Paralichthys olivaceus를 대상으로 육상수조식양식장 배출물 발효물의 어류 사료 첨가에 따른 혈액학적 변동에 미치는 영향을 검토하였다. 젖산균 및 효모를 사용하여 발효한 양식장 배출물의 이화학적 분석을 실시하였고, 발효물을 0.1, 0.5, 1.0 및 5.0% 농도로 8주간 투여하였다. 투여 4주째 및 8주째에 각 투여 구간별로 혈액학적 항목을 중심으로 그 차이를 확인하였다. 배출물 발효농도별 유의한 차이는 나타나지 않았지만, 분석시기에 따른 적혈구수, 혈색소 농도 및 혈색소 지수가 증가하는 경향을 나타내었으나, 주요 혈청 무기 및 유기성분은 배출 발효물 농도별로 유의한 차이는 나타나지 않았다. 또한 혈청 효소학적 조사에서는 조사시기별로 변동은 나타났지만, 동일 조시시기에서 각 구간별 유의한 차이는 나타나지 않았다. 따라서 이러한 육상 약식장 유래의 배출물 발효산물에 대한 다양한 방면의 연구가 진행되어야겠다. Effects of oral administration with fermented product from sewage in land-based seawater fish farm on haematological disturbance in the olive flounder, Paralichthys olivaceus was investigated. After 4 weeks of conditioning with a basal diet, fish were divided into 4 groups and provided experimental diet (0.1,0.5, 1.0 and 2.0%) supplement of fermented sewage for 80 days. Proximal analysis was performed for the product of sewage which was fermented by lactic acid and yeast. RBC count, hemoglobin concentration and hematocrit value were increased according to the treated periods, however, no statistical difference was observed between control and treatment groups. There were no significant difference in serum organic, inorganic compounds and enzyme activities between control and treatment groups. This study hypothesized that the supplement of fermented product from sewage in land-based seawater fish farm might be an additive sup plement for source of fish diet in view of haematological examination. Recycling of the sewage may be an economic artificial sources of diet for fish aquaculture practices.