Development of a Checklist for Predicting Suicidality Based on Risk and Protective Factors: The Gwangju Checklist for Evaluation of Suicidality

Kim Sung-Wan,Park Woo-Young,Kim Honey,Jhon Min,Kim Ju-Wan,Kang Hee-Ju,Kim Seon-Young,Ryu Seunghyoung,Lee Ju-Yeon,Shin Il-Seon,Kim Jae-Min 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.6

Objective The aim of the study was to develop a checklist for mental health clinicians to predict and manage suicidality.Methods A literature review of the risk and protective factors for suicide was conducted to develop a checklist for evaluating suicidality.Results The fixed risk factors included sex (male), age (older individuals), history of childhood adversity, and a family history of suicide. Changeable risk factors included marital status (single), economic status (poverty), physical illness, history of psychiatric hospitalization, and history of suicide attempts. Recent discharge from a mental hospital and a recent history of suicide attempts were also included. Manageable risk factors included depression (history and current), alcohol problems (frequent drinking and alcohol abuse), hopelessness, agitation, impulsivity, impaired reality testing, and command hallucinations. Protective factors included responsibility to family, social support, moral objections to suicide, religiosity, motivation to get treatment, ability to cope with stress, and a healthy lifestyle. A final score was assigned based on the sum of the risk and protective factor scores.Conclusion We believe that the development of this checklist will help mental health clinicians to better assess those at risk for suicidal behavior. Further studies are necessary to validate the checklist.

Delayed Onset of Manic Symptoms in a Patient with Influenza A (H1N1) after administration of Oseltamivir (Tamiflu): A Case Report

Min Jhon,Ju-Wan Kim,Hee-Ju Kang,Seon-Young Kim,Ju-Yeon Lee,Sung-Wan Kim,Il-Seon Shin,김재민 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.1

Psychiatric side effects of oseltamivir can result in accident-proneness and suicide. Reportedly, such adverse psychiatric events are more common in children than in adults, but other risk factors are not known. We present a 13-year-old girl with influenza infection who developed manic symptoms after taking oseltamivir and receiving the human papillomavirus vaccination. While other research has found that psychiatric side effects associated with oseltamivir generally occur within 48 hours after beginning administration, in this case the manic symptoms developed on the fourth day after cessation of 5-day course of oseltamivir administration. Based on our review of this case, we recommend that clinicians should carry out vigilant monitoring of each patient’s mental state when the patient is young, has a family history of psychiatric disorder, has drug sensitivity and has received medical treatments such as vaccination before or after taking oseltamivir. In addition, as side effects of oseltamivir may occur more than 48 hours after administration, it will be necessary to observe patients for several days after the prescription of oseltamivir.

Decline in Hospital Visits by Patients with Schizophrenia Early in the COVID-19 Outbreak in Korea

Seunghyong Ryu,Hee Jung Nam,Seon-Hwa Baek,Min Jhon,Jae-Min Kim,Sung-Wan Kim 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.1

Objective: This study investigated trends in hospital utilization by patients with schizophrenia during the first wave of the COVID-19 outbreak in Korea. Methods: The Prophet algorithm was used to predict the monthly number of patients with schizophrenia in 2020 based on medical insurance data between 2010 and 2019. The projected expectations were compared with the actual number of patients receiving outpatient and inpatient treatment each month in the first half of 2020. We conduct interrupted time series analyses of short-term data to determine the significance of recent changes in the trend of hospital visits by patients with schizophrenia. Results: The prediction model showed that the actual number of patients receiving treatment each month during the early COVID-19 outbreak decreased by up to 3.6% compared to the projected expectations. The interrupted time series model also revealed a significant change in hospital utilization compared to the year before the onset of COVID-19 in Korea (F = 8.961, p = 0.010). Conclusion: This suggests that many patients with schizophrenia were not receiving adequate treatment during the COVID-19 outbreak. A strategy should be developed to keep treating patients with schizophrenia during the COVID-19 pandemic.

Factors Associated With Depression and Anxiety in Korean Adolescents During the COVID-19 Pandemic

Kim Honey,Jhon Min,Kim Ju-Wan,Kang Hee-Ju,Ryu Seunghyong,Kim Jae-Min,Lee Ju-Yeon,Kim Sung-Wan 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.7

Objective This study was performed to identify factors associated with depression and anxiety among Korean adolescents during the coronavirus disease (COVID-19) pandemic.Methods We conducted a cross-sectional study of 1,898 Korean adolescents (55.2% male, 44.8% female) ranging in age from 12 to 17 years (mean±standard deviaion age, 15.4±2.6 years). Depression and anxiety were defined as a Patient Health Questionnaire-9 score ≥10 and Generalized Anxiety Disorder-7 score ≥10, respectively. Other questionnaires included sociodemographic data, psychosocial stresses, and experiences in association with COVID-19. Psychiatric scales included Gratitude Questionnaire-6, Perceived Stress Scale-10, and UCLA Loneliness Scale-3.Results The prevalence rates of depressive and anxiety symptoms among participants were 13.8% and 21.0%, respectively. Multivariable logistic regression analysis revealed that female sex, fear of COVID-19 infection, low gratitude were risk factors for depression. Fear of COVID-19 infection, increased TV watching time, and academic-related stress were risk factors for anxiety.Conclusion Depression and anxiety were prevalent during the pandemic in Korean adolescents, and were associated with fear of COVID-19 infection. Providing appropriate information on COVID-19, helping adolescents manage academic-related stress and maintain daily life patterns, and implementing interventions to foster gratitude are important for preventing depression and anxiety in Korean adolescents.

Some Model Solute Affinity for a Tactic p-HEMA Membranes by K$_D$ Measurement

Lee, Eun-Hee,Jeon, Sang-Il,Jhon, Mu-Shik Korean Chemical Society 1984 Bulletin of the Korean Chemical Society Vol.5 No.5

Two series of membranes have been prepared by postcrosslinking highly syndiotactic and isotactic poly (2-hydroxyethyl methacrylate), P(HEMA). The crosslinker used was hexamethylene diisocyante (HMDIC). The distribution coefficients (K$_{D2}$) of the model solutes such as urea (and thiourea), their derivatives, homologous alcohol series and amide sreies in water-swollen tactic P(HEMA) membranes at $25^{\circ}C$ were mesaured. In addition, the concentration effects of acetamide and butyramid were also measured. On the basis of hydrophobic interaction and the structural factors of tactic P(HEMA) membranes, the hydrophobic adsorption of the solutes in the polymer matrix were discussed. The results showed that the more hydrphobic the solute is, the higher the $K_{D2}$ value is. And the polymer conformation also affects the distribution of solvents.

Two Cases of Posttraumatic Stress Disorder Caused by a Motor Vehicle Accident Treated with Virtual Reality Exposure Therapy

Ju-Wan Kim,Min Jhon,Hee-Ju Kang,Sung-Wan Kim,Jae-Min Kim 대한정신약물학회 2024 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.22 No.1

Exposure-response prevention is an effective approach to treat anxiety disorders. Virtual reality exposure therapy (VRET) is a promising treatment for patients with posttraumatic stress disorder (PTSD). New research has helped refine and update VRET. In this study, we introduce a form of VRET developed for patients suffering from PTSD after a traffic accident, and present two cases treated using this protocol. After 6 weeks of VRET treatment, the two participants not only improved their PTSD symptoms, but also improved their depressed mood, anxiety, and insomnia symptoms. Future studies of VRET for car accident-related PTSD should utilize a controlled design with randomization in order to account for numerous possible confounds.

Predictors of Remission in Acute and Continuation Treatment of Depressive Disorders

Ha-Yeon Kim,Hee-Joon Lee,Min Jhon,Ju-Wan Kim,Hee-Ju Kang,Ju-Yeon Lee,Sung-Wan Kim,Il-Seon Shin,김재민 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3

Objective: To identify factors predicting remission of depression during acute (12 weeks) and continuation treatment (12 months) using a 1-year, naturalistic prospective study design. Methods: Patients with depressive disorders were recruited from Chonnam National University Hospital in South Korea from March 2012 to April 2017. At baseline, 1,262 patients received outpatient therapy, and sociodemographic and clinical data were obtained. Clinical visits took place every 3 weeks during the acute treatment phase (at 3, 6, 9, and 12 weeks; n = 1,246), and every 3 months during the continuation treatment phase (at 6, 9, and 12 months; n = 1,015). Remission was defined as a Hamilton Depression Rating Scale score ≤ 7. Results: The remission rate was 43.3% at 12 weeks and 70.4% at 12 months. In multivariate analyses, remission during the acute treatment phase was more likely in patients with a shorter-duration present episode, higher functioning, and good social support. Remission during the continuation treatment phase was more likely in patients with fewer previous depressive episodes and/or a lower baseline stress score. Conclusion: Factors predicting depressive disorder remission may differ between the acute and continuation treatment phases.

Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from <i>Cervus nippon</i> (Deer Antler)

Yang, Hyun Ok,Kim, Sang Hee,Cho, So-Hye,Kim, Mi-Geum,Seo, Ji-Young,Park, Jung-Sun,Jhon, Gil-Ja,Han, So-Yeop The Pharmaceutical Society of Japan 2004 Chemical & pharmaceutical bulletin Vol.52 No.7

<P>A mixture of monoacetyldiglycerides was newly isolated from the chloroform extract of antlers of <I>Cervus nippon</I>, guided by the hematopoietic stimulation of stem cells. The structures of monoacetyldiglycerides were determined by various spectroscopic methods: FAB MS, CID tandem MS, and 1D and 2D NMR. A mixture of at least nine inseparable <I>sn</I>-3-monoacetyldiglycerides was identified: 1 [C<SUB>39</SUB>H<SUB>72</SUB>O<SUB>6</SUB> (C16 : 0/C18 : 1)], 2 [C<SUB>39</SUB>H<SUB>72</SUB>O<SUB>6</SUB> (C18 : 1/C16 : 0)], 3 [C<SUB>39</SUB>H<SUB>70</SUB>O<SUB>6</SUB> (C16 : 0/C18 : 2)], 4 [C<SUB>39</SUB>H<SUB>70</SUB>O<SUB>6</SUB> (C18 : 2/C16 : 0)], 5 [C<SUB>41</SUB>H<SUB>74</SUB>O<SUB>6</SUB> (C18 : 0/C18 : 2), 6 [C<SUB>41</SUB>H<SUB>74</SUB>O<SUB>6</SUB> (C18 : 2/C18 : 0)], 7 [C<SUB>41</SUB>H<SUB>74</SUB>O<SUB>6</SUB> (C18 : 1/C18 : 1)], 8 [C<SUB>43</SUB>H<SUB>74</SUB>O<SUB>6</SUB> (C18 : 0/C20 : 4)], and 9 [C<SUB>43</SUB>H<SUB>74</SUB>O<SUB>6</SUB> (C20 : 4/C18 : 0)]. Among these nine monoacetyldiglycerides in deer antlers, compound 3 was one of the major compounds and was efficiently synthesized from glycerol. Spectral data of synthetic monoacetyldiglyceride 3 were compared with the corresponding data for the mixture of natural monoacetyldiglycerides. The mixture of natural monoacetyldiglycerides from deer antlers showed potent activity on the hematopoiesis (stimulation index=1.40±0.05, <I>p</I><0.02 at 1 μg/ml), and synthetic monoacetyldiglyceride 3 showed even better activity (stimulation index=1.54±0.12, <I>p</I><0.001, at 1 μg/ml).</P>

Effect of Grain Size on the Electrical Properties of (Pb,La)TiO₃Thin Films Grown by Pulsed Laser Deposition for Memory Device

Kyoung Bo Han,Chang Hoon Jeon,Hee Sauk Jhon,Sang Yeol Lee 대한전기학회 2002 KIEE International Transactions on Electrophysics Vol.12C No.3

Highly sensitive non-enzymatic wireless glucose sensor based on Ni–Co oxide nanoneedle-anchored polymer dots

Hyeong Jun Jo,Arnab Shit,Hee Sauk Jhon,Sung Young Park 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-

Polymer dot (PD)-bridged nickel cobalt oxide (NiCo2O4 (NCO)) nanoneedle-assembled globe-shapedclusters for high-performance glucose sensors were prepared via the consecutive calcination andpackaging of PDs using the hydrothermal technique. The sp2-conjugated bridge of electrons, abundantlyavailable catechol functionalized active sites offered by the PDs, and porous structure of NCO createdeffective electron transport routes for electrocatalytic reactions. The remarkable synergy between theconductive PDs and NCO conferred the PDs-bridged NCO (PDs-NCO) exceptional electrocatalytic activityfor glucose detection. Under the optimal applied potential of +0.5 V, the developed PDs-NCO-coated Nifoam (NF) electrode presented the broad detection range from 5 mM to 0.25 mM, sensitivity of806.17 mA mM 1 cm 2, detection limit of 2.75 mM, and exceptional selectivity. Furthermore, the PDs-NCO-coated NF electrode achieved the specific capacitance of 35.63 F g 1 at the current density of0.5 A g 1 and superb cycling stability including the 96.7% specific capacitance retention over 5000charge-discharge cycles. In addition, glucose-sensing could be easily monitored using a wireless sensoron a smartphone. The combination of NCO and PDs represents an innovative approach for constructinghigh-performance, reusable, non-enzymatic glucose sensors with low detection limit, high sensitivity,and excellent selectivity.