鹽分最小感應値와 血壓의 聯關性에 關한 疫學的 硏究

趙聲鍾,宋東彬,車喆煥 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.3

High blood pressure has become a common finding in Korean population and a major public health problem leading to an increased mortality and morbidity in recent years. With this accumulating evidence has come increasing incentive to find safe and simple methods for preventing and controlling hypertension. Reduction of dietary salt has been advocated by some for such method. The effect of dietary salt intake to hypertension however is still not clear and it is a matter of controversy particulary on whether the method of reducing dietary salt would be effective in controlling the hypertension of the general population. The purpose of this study was to investigate this controversial matter by assessing the degree of association between dietary salt intake and blood pressure using the method of detecting salt recognition threshold in general population. A total of 680 rural and urban inhabitants were studied from June 1984 to January 1985. The result of study is as followings; 1. The relationship between salt recognition, threshold and optimal gustation of salt was observed to be high in pilot study with a correlation coefficient of 0.729 (p<0.001). 2. In hypertensive group, mean systolic and diastolic blood pressures (BP) were significantly higher in those having high salt recognition threshold (SRT) than those of low SRT. The same evidence could be observed neither in normotensive nor in total population groups. That is, in hypertensive group, the mean systolic BP for those of high SRT was higher than those of low SRT by 8.8 mmHg in male and 8.8mmHg in female, and the mean diastolic BP for those of high SRT was also higher than those of low SRT by 4.3 mmHg in male and 8.5mmHg in female respectively. 3. There was no significant difference in the prevalence rate of hypertension among those of high SRT compared with those of low SRT. 4. In multiple regression analysis using age, body mass index (weight/hight²), socioeconomic status, amount of alcohol consumption, amount of cigarettee smoking, family history of hypertensi no and salt recognition threshold as independent variables, the multiple correlation coefficients turned out to be from 0.36 to 0.47 indicating that these variables explain 13 to 22 percent of the variances of systolic and diastolic pressures. The variables showing relatively higher beta coefficients were age, body mass index and alcohol consumption in male, where as the body mass index, age and family history were the corresponding variables in female. The relationship of salt recognition threshold to blood pressure was turned out to be very low. These findings indicate that dietary salt intake would have a significant effect on blood pressure in hypertensive group (may include the salt sensitive individuals), while no relationship could be observed in normotensive group.

산포도와 머루중의 Polyphenol Oxidase에 관한 연구¹

성찬기,박희중,임흥빈,조성희 中央大學校 基礎科學硏究所 1997 基礎科學硏究所 論文集 Vol.11 No.-

Polyphenol oxidase was partially purified from fresh vitis flexuosa and vitis amurensis and its characteristics were studied. the experimental results were summarized as follows. 1.The enzyme activities were increased during the fruit developement gradually in two sample. 2.The optimum pH and temperature for activity were 5.5 and 30℃, respectively. 3.The enzyme was active with o-phenols and trihydroxyphenol, but inactive toward m-diphenols and monophenols. 4.The ?? value of the enzymes was 15.4 mM in vitis flexuosa and 12.5 mM in vitis amurensis with catechol as substrate. 5.Inhibitors sudies indicated that sodium diethyl-dithiocarbamate, L-cysteine, sodium bisulfite, L-ascorbic acid and 2-mercaptoeyhanol were the most potent. 6.The enzyme activity increament by ?? was much better than those by the other metal ions.

도시주거단지 입지특성에 따른 소음환경 연구 : 도로변 아파트단지를 대상으로

조성희,박수빈 부산대학교 가정대학 1994 家政大學硏究報告 Vol.20 No.-

The increase of road traffic niose in residential area has been considered to be a serious environmental problem to deteriorate a living condition. The understanding of noise environment in multi-family housing is needed for noise reduction. The study attempts to find out the characteristics of noise environment. For this purpose, the field survey has been carried out to investigate the noise environment(sound level, quality of sound) and the residents' responses (noiseness, annoyance) for noise environment based on 173 households living in 3 apartment compounds built in Pusan according to site location. The major fidings are as follows : 1. The sound levels by road traffic noise were measured by dB(A) and dB(Lin). The sound levels were : 77.0 dB(A), 86.6 dB(Lin) in D-Apt, 73.3 dB(A), 82.6 dB(Lin) in K-Apt, and 59.1 dB(A), 74.6 dB(Lin) in M-Apt. Especially, the difference between dB(A) and dB(Lin) was very big in case of M-Apt with a barriers for traffic noise reduction. 2. The internal sound levels were shown the sound attenuation by horizontal distance and by opening or shuting condition of windows. 3. The noiseness evaluations of noise environment were shown to correlate with sound level(dB(A) and site location of apartments. 4. The annoyance evaluations of noise enviroment were shown to correlate with sound level(dB(A) and quality of sound(frequency spectrum).

사업장 소음 폭로에 의한 일과성 역치 상승과 회복

조수헌,하미나,한상환,주영수,성주헌,강종원,윤덕로,송동빈,이명학,김선태 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

To determine the recovery time from noise-induced temporary threshold shift(TTS), a prospective field study was conducted at three worksites where workers are known to be exposed high level of noise. Subjects were selected according to answers on a questionnaire which inquired about otological history and previous noise exposure, including avocational, military and occupational exposures. After excluding employee with past otologic problems, recent exposure to high level noise, and under medications, total 92 employees participated in the study. Among 92 participants, complete consecutive audiometric examinations were carried out at 0∼2 hours, 5∼7 hours, 14∼16 hours after worktime noise exposure on 26 participants wearing hearing protectors and 22 participants wearing no protective devices. The difference between the hearing level 0∼2 hours after noise exposure and 5∼7 hours is statistically significant by paired t-test(p<0.01). The median recovery times calculated from the data of 22 participants wearing no protective hearing devices are 15.6 hours at 4000Hz, and 7.7 hours, 10.3 hours, 8.4 hours at 1000Hz, 2000Hz and 8000Hz respectively. These data suggest that when measuring the pure tone audiometry for noise exposed workers, at least 16 hours noise-free interval is required.

Clinical Analysis for Stereotatic Aspiration and Thrombolysis of Spontaneous Intracerebral Hemorrhage

황승균,조도상,김성학,박동빈 이화여자대학교 의과대학 2005 EMJ (Ewha medical journal) Vol.28 No.1

목적 : 저자들은 자발성 뇌출혈 환자에서 뇌 정위적 혈종 배액술 및 용해술의 경험을 분석하여 이 방법의 유용성, 안전성 및 예후인자 등을 평가하고자 한다. 방법 : 기질적인 원인 혹은 혈액 응고성 질환이 없으면서 천막상부 자발성 뇌출혈 용량이 25ml이상 되는 11명의 환자를 대상으로 하였다. 이 중 글라스고우 혼수계수가 5이하인 환자는 대상에서 제외하였다. 컴퓨터 전산촬영 유도하에 카테터를 자발성 뇌출혈에 정위적으로 유치하고 유로키나제를 주입한 후 현종을 흡인하여 제거하였다. 이 과정은 처음 혈종 용량의 절반 이하가 될 때까지 6시간 간격으로 반복하였다. 예후인자를 분석하기 위하여 환자를 두 개의 집단 즉, 글라스고우 결과계수가 4이상의 양호한 집단과 글라스고우 결과계수가 4이하의 불량한 집단으로 나누어 서로 비교분석 하였다. 결과 : 환자들의 평균연령은 59.8세이고, 초기 혈종의 용량의 범위는 15에서 72ml였다. 혈종 용량의 감소비율은 평균 74.2%였다. 시술 후 6개월 추적관찰결과, 56(50.9%)명의 환자는 양호한 회복을 보였고, 29(26.3%)명의 환자는 의존적인 상태였으며, 10(9.0%)명의 환자는 식물인간상태로 유지되었다. 그리고, 15(13.6%)명의 치료도중 사망하였다. 주요한 중요 예후인자는 젊은 나이, 적은 혈종용량, 높은 글라스고우 혼수계수 및 재출혈, 기존질환, 합병증이 없는 경우였다. 결론 : 자발성 뇌출혈 환자에서 뇌 정위적 혈종 배액술 및 용해술이 혈종의 용량을 감소에는 안전하고 효율적인 방법임을 알 수 있었다. 그리고, 불량한 예후인자를 가지고 있는 자발성 뇌출혈 환자는 주기적인방사선학적 검사와 더욱 세심한 시술이 필요할 것으로 사료된다 그리고, 앞으로 연구는 적절한 용해제 용량의 평가와 치사율과 장해율을 감안한 정밀한 비교분석이 있어야 한다고 생각된다.

슬관절부 골절에 대한 임상적 고찰

김기용,조우신,빈성일,백승일 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

The knee joint is the largest weight bearing joint. As the fractures of Knee joint in volve the articular surface and the surrounding soft tissues, permanent disabilities such as deformities, joint stiffness, instability and post-traumatic arthritis may ensue following treatment. Many authors have recommended various methods of treatment for these fractures. Recently, however, a trend toward internal fixation has become evident and good results have been reported by several authors. This study is to present 40 cases of knee joint fractures which were treated at Asan Medical Center from May 1989 to April 19992. The results were as follows ; 1. The causes of injury were traffic accident(60%), fall down(12.5%), slip down(12.5%) and sports injury(10%). 2. There were 23cases in 22 males and 17 females in series and average was 46.8 years ranging from 19 years to 82 years. 3. In femoral condylar fractures, the most frequent type was C2(8 cases ; 42.2%) and in tibial condylar fractures, B1(7 vases ; 35.5%) by the A.O. classification. 4. 7 Cases were treated by conservative method 32 cases by operative method and 1 cases by amputation. 5. Satisfactory results were obtained 73.3% in femoral condylar fractures and 88.2% in tibial condylar fractures by operative treatment. We concluded that satisfactory results were obtained from operative treatment with procedures of anatomical reduction, rigid fixation and early joint motion.

탈지대두박에서의 Isoflavone의 분리를 위한 흡착제의 조건

여경은,조성빈,김우정 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

탈지대두박을 이용한 isoflavone의 분리 및 정제를 위한 최적 조건을 찾고자 absorption resin인 Amberlite XAD-1180를 사용하여 흡착제의 활성화용매의 농도, 흡착된 isoflavone의 용출용매의 농도, 용출용매의 양과 용출속도, 시료와 흡착제의 비율 그리고 수지에 미치는 pH와 ion의 영향을 조사하였다. 수지의 활성화와 용출에는 Amberlite XAD-1180의 경우 methanol 75%로 활성화시키기 ethanol 80%로 용출시키는 경우가 가장 높은 값을 보였으며, 이때 사용하는 absorption resin은 isoflavone 흡착을 위해 사용한 단백질제거 탈지대두박용액양의 약 0.5배로, ethatnol의 양은 단백질제거 탈지대두박용액 양의 4배를 사용하여 flow rate 12mL/min의 경우가 적절한 조건임이 밝혀져 흡착제 사용이 isoflavone 함량을 최고 2~3배까지 향상시키는 결과를 보였다. 이때 분리된 isoflavone의 순도는 최고 40%까지 얻을 수 있었다. pH와 ion의 영향에서는 pH는 5.0,NaCl은 0.25N 이하에서 isoflavone의 유출량이 높았다. Conditions for sorption and elution of isoflavone with using amberlite XAD-1180 were studied to separate Isoflavone from defatted soybean flour (DSF). Isoflavone analyzed were daidzin, genistin, glycitin, daidzein, genistein and glycitein by HPLC. The result showed that washing Amberlite XAD-1180 with 75% methanol and then elution of isoflavone with 80% ethanol resulted the highest amounts of isoflavone recovered from the absorption resin. The most proper eluent factor was 4(eluent/sample volume), the sample factor was about 2(the volum of sample/the weight of resin) ad flow rate 12 mL/min. The pH 5.0 and less than 0.25 N NaCl were found to be proper for seperation of isoflavone. The isoflavone contents after seperation with absorption resin were about 40% in dry weight basis.

고조파 분석을 이용한 고저항 지락사고 검출에 관한 연구

강승호,조성빈,김철환 成均館大學校 科學技術硏究所 1999 論文集 Vol.50 No.1

High Impedance Fault(HIF) is defined as fault that general overcurrent relay can not detect or interrupt. When HIF occurs in transmission line, arc with energized high voltage conductor is happened and results in fire hazard, equipment damage or personal threat. This paper proposed the HIF fault detection method using harmonic analysis and showed the arc model which can he implemented within Electromagnetic Transients Program(EMTP). Harmonic analysis is efficient and useful for the detection of HIF in power system because it shows good characteristics about odd harmonic components of current when HIF occurs.

여러 가지 안정화 물질이 오미자 색소 추출물의 가열 변색에 미치는 영향

전향숙,김현정,조성빈 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.5

The effects of selected stabilizers and sugars on color deterioration of anthocyanin in Schizandra fructus were examined at 100℃ for 120~180 min. Among four test sugars, it was found that fructose accelerated the thermal color deterioration while maltose retarded the color deterioration by 40%. Maltodextrin and γ-cyclodextrin showed the highest stabilizing effect on the thermal color deterioration of crude pigment extract from Schizandra fructus(CPES) containing 2mg% of anthocyanin. Addition of maltodextrin or γ-cyclodextrin 5% retarded thermal color deterioration of CPES. In gel system, 5% of maltodextrin also retarded the color deterioration by 15~20% during storage at 25℃ and 35℃.

국내 의료기관의 항생제 사용 실태와 규제 시스템 조사

방지환,송경호,박완범,김성한,조재현,김홍빈,김남중,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 이전 연구들에 따르면 아직까지 국내에서 불필요한 항생제 사용은 무시할 수 없는 수준이며, 특히, 수술환자들에 대한 예방적 항생제 투여가 문제로 지적되고 있다. 많은 병원에서 불필요한 항생제 처방을 제한하려는 노력을 하고 있지만 구체적인 현황에 대한 자료는 적은 실정이다. 이에 본 연구자 등은 국내 의료기관의 항생제 규제 시스템의 현황과 수술시 예방적 항생제 사용의 적정성을 알아보고자 한다. 재료 및 방법 : 전임 감염내과 전문의가 근무하는 의료기관 55곳에 대해 설문조사를 시행하였다. 설문의 내용은 적정한 항생제 사용을 유도하기 위한 정책 및 규제 프로그램, 실제 각 의료기관의 예방적 항생제 사용 현황 등으로 이루어져 있다. 결과 : 55개의 의료기관에 보낸 설문 중 44개가 회수되었다. 회신한 의료기관에서 항생제 처방 관리는 제한항생제 시스템을 가장 많이 이용하고 있었고(95.5%), 항생제에 대한 교육(79.5%), 전산시스템에서 관리(59.1%), 감염내과에 의뢰(54.5%), 항생제 사용 실적 검토(52.3%) 등의 순이었다. 대개의 병원에서 glycopeptides (100.0%), carbapenems (93.0%), quinupristin/dalfopristin 또는 linezolid(93.0%), 4세대 cephalosporin (74.4%), caspofungin 또는 voriconazole (62.8%), liposomal amphotericin B (60.5%) 등을 제한항생제로 분류하여 관리하고 있었다. 모든 의료기관에서 위절제술 및 유방절제술시에 불필요하게 예방적 항생제를 사용하고 있었다. 슬관절치환술의 경우 2세대 cephalosporin을 예방적으로 사용하는 경우가 가장 많았으며(30.2%), 관상동맥우회술의 경우 3세대 cephalosporin을 예방적으로 사용하는 경우가 가장 많았다(47.2%). 예방적 항생제의 투여 기간을 살펴보면 위절제술시 70.5%에서 4일을 초과하여 사용하고 있었고, 유방절제술시에는 63.6%에서, 슬관절치환술시에는 81.8%에서, 관동맥우회술시에는 81.1%에서 4일을 초과하여 장기간 예방적 항생제를 투여하고 있었다. 한편, 예방적 항생제 투여시 aminoglycoside계 항생제를 병용하는 경우도 많았다. 결론 : 아직까지 국내 의료기관에서 항생제 오남용을 막기 위한 노력이 더 필요할 것으로 생각되며, 특히 수술시 예방적 항생제의 올바른 투여에 많은 관심이 필요하다. Background : Previous studies in Korea showed that unnecessary antibiotic use could not be neglected, especially in prophylactic use. Currently many hospitals employ diverse antibiotic stewardship programs, but there are few studies on surveillance of such programs. So, we planned this study to evaluate current status of antimicrobial stewardship and adequacy of antimicrobial prophylaxis in surgery. Materials and Methods : We sent questionnaires about policy on antibiotic usage, control program for adequate antibiotic prescription, and actual status of prophylactic antibiotic usage to 55 infectious disease physicians in each hospital. Results : Of 55 contacted infectious diseases clinicians, 44 answered the questionnaire. Majority of hospitals employed restricted antimicrobial system (95.5%), education (79.5%), control by order communicating system (59.1%), consult to infectious disease physicians (59.1%), and review of cumulative antimicrobial usage (52.3%) to prevent inadequate antibiotic use. Glycopeptides were designated as a restricted antimicrobial agent in 100.0% of hospitals; carbapenems, 93.0%; quinupristin/ dalfopristin or linezolid, 93.0%; the 4th generation cephalosporins, 74.4%; caspofungin or voriconazole, 62.8%; liposomal amphotericin B, 60.5%, and so on. Unnecessary perioperative prophylactic antimicrobial agents were prescribed in gastrectomy and mastectomy in all the hospitals. The second generation cephalosporins and the third generation cephalosporins were the most commonly prescribed prophylactic antimicrobial agents in total knee replacement arthroplasty (TKRA) and coronary artery bypass graft surgery (CABG) respectively. In 70.5% of institutes they use prophylactic antimicrobial agents more than four days in gastrectomy; 63.6% in mastectomy; 81.8% in TKRA; 81.1% in CABG. Unnecessary combination of aminoglycosides with other antimicrobial agents for prophylactic use was another common problem. Conclusion : This study shows that more effort is required to diminish antimicrobial misuse or overuse, especially in prophylactic use for surgical patients.