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Background:Sensitization to food allergens is associated with development of food allergy. Although rates of sensitization to food allergens are different according to countries, there has not been surveyed on the sensitization rate to each food allergen in Korean population. The aim of this study was to evaluate the food allergen sensitization rate among patients who visited allergy clinics at several university hospitals in Korea. Methods:This study was carried out on 1,425 patients who visited allergy clinics with various allergic symptoms. They had skin prick test for 62 items to evaluate sensitization to food allergens. Result:The food allergens of which sensitization rate was above 1% were pupa of a silkworm, shrimp, chestnut, curry, potato, soybean, rice flour, buckwheat, cabbage, mackerel, abalone, lobster, turban shell, arrowroot in decreasing order. The sensitization rate of pupa was highest among them by 9.4% and that of shrimp followed by 5.8%. The sensitization rates of food allergens were generally higher in males and young adults than in those of females and old people. Atopic patients for inhalant allergens showed higher sensitization rates of food allergens than non-atopic patients for inhalant allergens. Conclusion:Common food allergens sensitized in a Korean population were different from those in other countries. Pupa of a silkworm, shrimp, chestnut, curry, potato, soybean, rice flour, buckwheat, cabbage, mackerel were the 10 most common food allergens sensitized in Korean population above 10 years old. (J Asthma Allergy Clin Immunol 23: 502-14, 2003)
김선신 ( Sun Sin Kim ), 최승호 ( Seung Ho Choi ), 박민정 ( Min Jeoung Park ), 김영선 ( Young Sun Kim ), 임정윤 ( Jeong Yoon Yim ), 임선희 ( Seon Hee Lim ), 장윤석 ( Yoon Seok Chang ), 김윤근 ( Yoon Keun Kim ), 신찬수 ( Chan Soo Shin ), ) 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 2005 천식 및 알레르기 Vol.25 No.3
김신선(Sin Sun Kim), 김기환(Kee Hwan Kim), 김지일(Ji Il Kim), 안창혁(Chang Hyeok An), 김정수(Jeong Soo Kim), 유승진(Seung Jin You), 임근우(Keun Woo Lim), 채현석(Hiun Suk Chae), 구영미(Young Mi Ku), 장은덕(Eun Deok Chang) 대한외과학회 2006 Annals of Surgical Treatment and Research Vol.71 No.3
Kim,,Bo-Hyun,Jung,,Ji-Ung,Ko,,Ki-Sung,Kim,,Won-Sin,Kim,,Sun-Mi,Ryu,,Jae-Sung,Jin,,Jung-Woo,Yang,,Hyo-Jung,Kim,,Ji-Su,Kwon,,Hyuck-Chan,Nam,,Sang-Yoon,Kwak,,Dong-Hoon,Park,,Yong-Il,Koo,,Deog-Bon,Choo,,Y 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
Gangliosides are a family of sialic acid-containing glycosphingolipids that are abundant in neurons and have a variety of functions in developing and mature tissues. We examined the expression of ganglioside GT1b in the embryonic preimplantation stage after freezing and thawing processes to determine the regulatory roles of ganglioside GT1b in early embryonic development. ICR mouse embryos at the two-cell stage obtained by flushing the oviducts were frozen by two cryopreservation procedures, slow freezing using a programmable freezer or vitrification by direct plunging into liquid nitrogen. Slow freezing was conducted with equilibration in 1.5 M 1,2-propanediol or 5% equilibration glycerol. Vitrification was applied with a 10-15 min equilibration in 7.5% ethylene glycol (EG), 7.5% dimethylsulfoxide (DMSO), and 30 sec in a solution of 15% EG, 15% EMSO and 0.5 M sucrose. Immediately after thawing, the survival rate of the embryos was assessed by their morphology and ability to develop to blastocysts in culture. The survival rate of vitrified and thawed embryos (92%) was significantly higher than that of slow frozen and thawed embryos (76%) (P<0.05). A tendency of higher blastocyst rate was found in the vitrified and thawed embryos compared to that of the slow frozen and thawed embryos. Confocal immunofluorescence staining confirmed that surviving embryos expressed ganglioside GT1b, with the strongest expression at the compacted eight-cell or later stage embryos. Ganglioside GT1b was not observed in the TUNEL-positive, apoptotic embryos, suggesting that cryopreservation had induced DNA breaks in them. These results suggest that ganglioside GT1b may play an important role in embryo survival or development.
Kim,,Kyung-Mook,Kwon,,Hyouk-Soo,Jeon,,Sung-Gyu,Park,,Chang-Han,Sohn,,Seong-Wook,Kim,,Duck-In,Kim,,Sun-Sin,Chang,,Yoon-Seok,Kim,,Yoon-Keun,Cho,,Sang-Heon,Min,,Kyung-Up,Kim,,You-Young The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.2
<P>A number of case reports on occupational asthma caused by herbal medicines have been issued, for example, on Sanyak, Chunkung, Banha, and Brazilian ginseng. Recently, cases of occupational asthma induced by Sanyak and Korean ginseng have been reported, but the pathogenic mechanisms involved are unknown. This study was carried out to evaluate the immunologic mechanism underlying Korean ginseng-induced occupational asthma. A patient engaged in Korean ginseng wholesale was referred for recurrent dyspnea, wheezing, and nasal symptoms, which were aggravated at work. Allergen bronchial provocation testing to Korean ginseng extract showed a typical immediate response, and skin prick testing to Korean ginseng extract also showed a strong positive response. Moreover, serum-specific IgE levels to Korean ginseng extract were significantly higher than in controls. Enzyme-linked immunosorbent assay (ELISA) inhibition tests showed a dose-dependent inhibition by Korean ginseng, but not by <I>Dermatophagoides farinae</I>, wheat flour, or Chinese balloon flower. Sodium dodecylsulfate-poly-acrylamide gel electrophoresis (SDS-PAGE) and immunoblotting revealed four specific Immunoglobulin E (IgE) binding components at 26, 30, 47, and 60 kDa, which were not bound by control sera. These results strongly suggest that occupation asthma induced by Korean ginseng is induced via an IgE-mediated mechanism.</P>
Background : Atopy and bronchial hyperresponsiveness (BHR) which are characteristics of asthma, are strongly correlated but independently inherited traits. The relative contribution of maternal and paternal condition to the risk of offspring's condition is not certain. Objective : The aim of this study was to evaluate maternal or paternal contribution to childhood atopy and BHR in a population-based sample of 140 Korean nuclear families. Subjects and Methods : A total of 486 subjects (133 mothers, 132 fathers and 221 offsprings) participated in this study. All subjects provided questionnaire data and 483 subjects underwent allergy skin prick test with 13 inhalant allergens. Total serum IgE levels were determined in 444 subjects and methacholine bronchial provocation test were performed in 483 subjects. Results : Serum total IgE level in the offspring was correlated with both maternal and paternal total IgE (mother : R=0.273, p<0.01 : father : R=0.200, p<0.01). Bronchial hyperresponsiveness was associated with parental atopy index (mother: R=0.175, p<0.01: father : R=0.205, p<0.01) and maternal BHR (R=0.201, p<0.01). The development of wheezing in the offspring was significantly associated with maternal BHR, but not paternal. Conclusion : These results suggest that maternal BHR does confer more risk than paternal BHR to risk of offspring's BHR. (J Asthma Allergy Clin Immunol 22: 695-702, 2002)
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The design wave and deck clearance of an offshore structure are very important factors to secure the stability of the structure after construction. In case that the structure is installed on a deep flat bottom, the deck clearance may be determined from the maximal wave crest height which can be sought by directly applying a nonlinear wave theory (Cnoidal or Stream function theory) to the design wave condition. But it is often the case that the structure is placed on a shallow underwater shoal having a steep slope due to construction expense and convenience. In this case, the wave height and depth conditions at the structural position may easily exceed the wave breaking condition beyond which the nonlinear wave theory cannot be applied. In the present study, a numerical method using a shallow water wave propagation model based on Boussinesq equation is demonstrated to reproduce the nonlinear wave deformation along up the shallow underwater shoal and the maximal wave crest height at the structural position. The method is applied to check the validity of the existing deck height of Gageocho Ocean Research Station installed on an underwater shoal in Korea. The station was damaged by typhoon Muifa in 2011 with the cellar deck and its appurtenance seriously deformed or destroyed.
충격쇄파압은 권파성 파랑이 구조물 전면에 갑자기 충돌할 때 발생하며 접촉면에서 공기포켓의 생성여부에 따라 충격쇄파압의 작용특성이 달라진다. 수괴의 직접적인 충돌에 따른 Wagner형은 접촉면에서 단일 압력 첨두치를 보이는 반면, Bagnold형은 공기포켓의 진동에 의하여 비접촉면에서도 압력의 첨두치를 보이는 특성이 있다. 본 연구에서는 시공 중의 수중터널 벌크헤드의 배면(육측면)에 발생하는 충격쇄파압을 고찰하였다. Navier-Stokes 방정식을 직접 푸는 수치해석을 적용하여 벌크헤드 인근에 발생하는 쇄파를 모의한 결과, 벌크헤드의 배면에서 강한 Bagnold형 충격쇄파압이 발생함을 확인하였다. 본 충격쇄파압의 존재는 동일 조건에 대하여 수행한 수리모형실험에 의해서도 확인되었으며, 실험결과와 수치해석결과가 대체적으로 유사한 성향을 보임을 확인하였다. The breaking wave pressure occurs when a plunging breaker instantaneously impinges on structural surface, and appears differently depending on whether or not to form air pockets at the instant of contact. The Wagner type normally forms a single pressure peak at the contact spot due to the direct collision of water volume to the structure whereas in the Bagnold type the time lagged oscillation of the air pocket causes pressure peaks even at areas away from the spot. In the present study, the Bagnold's impact pressure is numerically and experimentally investigated for the bulkhead of an underwater tunnel under construction which is subjected to nearby breaking waves. A numerical solver of Navier-Stokes equations was applied to reproduce the breaking waves near a bulkhead, and the results showed the Bagnold's impact pressure occurring on the back (land side) face of the bulkhead. The existence of the impact pressure was also verified by a hydraulic model testing, and it was found that the experimental results well conformed to their numerical counterparts.