Increased bone mineral density according to increase of skeletal muscle mass in 534 Korean women: A retrospective cohort study conducted over 2.7 years

( Sun Mie Kim ),( Seok Hyun Kim ),( Jin Ju Kim ),( Min Jeong Kim ),( Hyuk Tae Kwon ),( Chang Suk Suh ),( Young Min Choi ),( Jung Gu Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.2

Objective To determine the impact of the changes in the amount of abdominal fat, directly measured by computed tomography, body composition, and the metabolic syndrome (MetS) risk factors on the bone mineral density (BMD) of Korean women. Methods A retrospective cohort study involving 534 Korean women aged 29 to 78 years, who had undergone both dual-energy X-ray absorptiometry and abdominal adipose tissue analysis by computed tomography scan more than twice between January 2004 and December 2010. The changes in the BMD values were examined in association with the changes in fat amount, body composition parameters, and risk factors of MetS. Results On cross sectional analysis, there was a significant positive correlation between femoral BMD and total abdominal fat amount at the initial visit. However, the correlation disappeared when the impact of change of the fat amount on the change in BMD was analyzed over the study period. When the MetS and body composition parameters were analyzed, a significantly positive correlation was found between skeletal muscle mass and BMD. There was no significant relationship between the MetS risk factors or other body composition parameters and BMD throughout the study period after adjusting for age (time interval). Conclusion Among body composition parameters, only increased skeletal muscle mass had a positive correlation with increased BMD over the study period of 2.7 years.

폐경이행기 여성에서 폐경 예측지표로서 혈중 anti-Mullerian hormone, follicle-stimulating hormone, 초음파상의 동난포 개수 및 임상적 증상들의 유용성 평가

김선미 ( Sun Mie Kim ),김석현 ( Seok Hyun Kim ),이정렬 ( Jung Ryeol Lee ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),이중엽 ( Joong Yeup Lee ),김기철 ( Ki Chul Kim ),황도영 ( Yeong Hwang ),김정구 ( Jung Gu Kim ),문신용 ( S 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2

목적: 폐경이행기 한국 여성에서 폐경 예측 지표로서 혈중 anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, 자궁내막 두께, 초음파상의 동난포 개수 및 임상적 증상들의 유용성을 평가하고자 하였다. 연구방법: 45-55세 사이의 폐경이행기 여성 104명이 참여하였으며 평균 13.1개월 간격으로 두 번에 걸쳐 방문하였다. 각 방문 시 최근의 월경력을 확인하고 골반 초음파검사를 시행하여 동난포 개수 및 자궁내막 두께를 측정하였으며 호르몬검사를 위한 혈액을 채취하였다. 최종 평가 지표는 두 번째 방문(T2) 시의 폐경 여부였으며 통계적 분석은 SPSS ver. 17.0을 사용하였다. 결과: 104명의 참여자 중 두 번째 방문시기에 폐경이 된 여성은 33명이었다. 두 번째 방문 시 폐경된 여성들은 그렇지 않은 여성들과 비교하여 첫 번째 방문 시의 FSH, estradiol, 자궁내막 두께, 동난포 개수, 최종 월경일로부터 경과일 및 최종 월경일과 그 이전 주기와의 기간에 있어 유의한 차이를 보였다. 그러나 AMH 수치는 두 그룹 간 유의한 차이를 보이지 않았다. 모든 인자들 중 최종 월경일로부터 경과일 및 최종 월경일과 그 이전 주기와의 간격이 폐경 발생과 유의한 상관관계를 보인 지표였다. 결론: 폐경이행기 여성에서 1년 정도의 짧은 간격을 두고 볼 때 AMH는 폐경을 예측하는 지표가 되지 못하였다. 첫 번째 방문 시 최종 월경일로부터 경과한 기간이 1년 후 폐경 예측의 더욱 유용한 지표이다. Objective: To assess the efficiency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical findings as predictive markers of menopause in late reproductive-aged Korean women. Methods: A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2. Results: Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed significantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were significantly associated with the occurrence of menopause. Conclusion: This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.

최우수 논문상 : 최우수 논문상 (생식내분비학)

김선미 ( Sun Mie Kim ),( Seok Hyun Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Joong Yeup Lee ),( Ki Chul Kim,Md ),( Do Yeong Hwang ),( Jung Gu Kim ),( Shin Yong Moon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Objective: To assess the effi ciency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical fi ndings as predictive markers of menopause in late reproductive-aged Korean women. Methods: A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2. Results: Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed signifi cantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were signifi cantly associated with the occurrence of menopause. Conclusion: This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.

Case Report : Mature oocyte retrieval during laparotomic debulking surgery following random-start controlled ovarian stimulation for fertility preservation in a patient with suspected ovarian cancer

( Seul Ki Kim ),( Myo Sun Kim ),( Hoon Kim ),( Sun Mie Kim ),( Jung Ryeol Lee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.6

Herein, we report a case of successful mature oocyte retrieval during laparotomy after random-start controlled ovarian stimulation (COS) in a 21-year-old nulliparous woman with suspected recurrent ovarian immature teratoma. The patient had been diagnosed with stage IIIC immature teratoma two years earlier following a staging operation, including right oophorectomy and left ovarian cystectomy. And she had subsequently undergone four rounds of postoperative adjuvant chemotherapy with bleomycin, etoposide, and cisplatin. Approximately two years after the initial surgery, she was strongly suspected of having recurrent ovarian immature teratoma on radiologic followup. We performed random-start COS and in vivo oocyte retrieval during laparotomic debulking surgery including left oophorectomy. Eight mature oocytes were successfully retrieved and vitrified for fertility preservation. The final pathologic diagnosis was mature cystic teratoma of the ovary and peritoneal implants consistent with gliomatosis peritonei. This is the first case report in which random-start COS and in vivo oocyte retrieval were performed.

Gene Expression Profile in Carpal Tunnel Syndrome Patients

Kim, Hye-Won,Kim, Ki-Nam,Seo, Sang-Hui,Lee, Seung-Ho,Sohn, Sung-Hwa,Kim, Yu-Ri,HaLee, Young-Mie,Shim, Jae-Sun,Ahn, Duck-Sun,Kim, Meyoung-Kon The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.4

Carpal tunnel syndrome (CTS) is one of the most common disorders by under pressure of the median nerve at the wrist in these days. However, pathological mechanism of CTS is unknown. We carried out this study to identify the changes of gene expression and to evaluate possible mechanism in CTS. 120 CTS patients and 30 control patients were included in this study. Patients with a history of diabetes, hypertension, thyroid diseases, and arthritis were excluded. CTS patients were divided to three experimental groups-Mild, Moderate, and Severe group-according to elecrodiagnosis. Radioactive cDNA microarrays (Nylon membrane including 1,152 genes) were used to examine the difference of gene expression profile in CTS. We identified up-regulated genes by more than 2.0 value of z-ratio, and down-regulated genes by less than-2.0 value of z-ratio. 20 genes such as the ITGAL, ITGAM, PECAM1, VIL2, TGFBR2, RAB7, RNF5 and NFKB1 were up-regulated, and 28 genes such as PRG5, CASP8, CDH1, IGFBP5, CBX3, HREV107, PIN, and WINT2 were down-regulated. These genes were related with TGF beta signaling pathway, NF-Kb signaling pathway, antiapoptotic pathway and T cell receptor signaling pathway. However, there were no differences in gene expression profiles according to severities of symptoms. We suggest that CTS could be related with proinflammatory mechanism and antiapoptotic mechanism.

Prevalence and Determinants of High-risk Human Papillomavirus Infection in Women with High Socioeconomic Status in Seoul, Republic of Korea

Kim, Ki-Dong,Kim, Jin-Ju,Kim, Sun-Mie,No, Jae-Hong,Kim, Yong-Beom Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

We aimed to estimate the prevalence of high-risk human papillomavirus (HPV) infections in women of high socioeconomic status (SES) in Seoul, Republic of Korea and to identify risk factors. This study included 13,386 women visiting a prestigious healthcare center located in Seoul between 2003 and 2008. High-risk HPV infections were detected in 994 (7%) and the age-standardized prevalence was 8%. Abnormal Pap smear results ${\geq}$ atypical squamous cells of unknown significance (ASCUS) were observed in 280 of 12,080 women (2%). Based on univariate analysis, age, level of education and number of children were associated with high-risk HPV infections. Based on multivariate analysis, age and high-risk HPV infections had an inverse relationship. In women with high SES in Seoul, the prevalence of high-risk HPV infection was 7% and the age-standardized prevalence was 8%. Age was a strong determinant of high-risk HPV infection.

Efficacy of oxytocin antagonist infusion in improving in vitro fertilization outcomes on the day of embryo transfer: A meta-analysis

Kim, Seul Ki,Han, E-Jung,Kim, Sun Mie,Lee, Jung Ryeol,Jee, Byung Chul,Suh, Chang Suk,Kim, Seok Hyun The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.4

Objective: Uterine contraction induced by the embryo transfer (ET) process has an adverse effect on embryo implantation. The aim of this study was to determine the effect of oxytocin antagonist supplementation on the day of ET on in vitro fertilization outcomes via a meta-analysis. Methods: We performed a meta-analysis of randomized controlled trials (RCTs). Four online databases (Embase, Medline, PubMed, and Cochrane Library) were searched through May 2015 for RCTs that investigated oxytocin antagonist supplementation on the day of ET. Studies were selected according to predefined inclusion criteria and meta-analyzed using RevMan 5.3. Only RCTs were included in this study. The main outcome measures were the clinical pregnancy rate, the implantation rate, and the miscarriage rate. Results: A total of 123 studies were reviewed and assessed for eligibility. Three RCTs, which included 1,020 patients, met the selection criteria. The implantation rate was significantly better in patients who underwent oxytocin antagonist infusion (19.8%) than in the control group (11.3%) (n = 681; odds ratio [OR], 1.92; 95% confidence interval [CI], 1.25-2.96). No significant difference was found between the two groups in the clinical pregnancy rate (n = 1,020; OR, 1.57; 95% CI, 0.92-2.67) or the miscarriage rate (n = 456; OR, 0.76; 95% CI, 0.44-1.33). Conclusion: The results of this meta-analysis of the currently available literature suggest that the administration of an oxytocin antagonist on the day of ET improves the implantation rate but not the clinical pregnancy rate or miscarriage rate. Additional, large-scale, prospective, randomized studies are necessary to confirm these findings.

Vitamin D deficiency in women with polycystic ovary syndrome

Kim, Jin Ju,Choi, Young Min,Chae, Soo Jin,Hwang, Kyu Ri,Yoon, Sang Ho,Kim, Min Jeong,Kim, Sun Mie,Ku, Seung Yup,Kim, Seok Hyun,Kim, Jung Gu The Korean Society for Reproductive Medicine 2014 Clinical and Experimental Reproductive Medicine Vol.41 No.2

Objective: To investigate: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. Methods: We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls. Results: Women with PCOS showed no differences in the level of 25-hydroxy vitamin D ($19.6{\pm}6.6ng/mL$ in patients vs. $20.1{\pm}7.4ng/mL$ in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOS patients or controls. Conclusion: Our study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.

TRANCE, a TNF Family Cytokine, Promotes Angiogenesis : Its angiogenic Action and Signaling Mechanism in Human Endothelial cells

Kim, Young-Mi,Kim, Young-Myoung,Lee, You Mie,Kim, Hae-Sun,Choi, Yongwon,Kim, Kyu-Won,Lee, Soo-Young,Kwon, Young-Guen 이화여자대학교 세포신호전달연구센터 2001 고사리 세포신호전달 심포지움 Vol. No.3

TNF-related activation-induced cytokine(TRANCE), a member of the TNF family, is highly expressed on osteoblasts and plays a key role in the control of bone development. Because angiogenesis is the crucial first step in the processes of proper bone formation, we tested the hypothesis that TRANCE is able to induce the growth of new blood vessels. TRANCE evoked a time- and dose-dependent activation of the mitogen-activated protein kinases ERK1/2, AKT and NF-B in human umbilical vein endothelial cells(HUVECs). TRANCE stimulated in vitro DNA synthesis, chemotactic motility, and capillary-like tube formation of HUVECs. Both Matrigel plug assay in mice and chick chorioallantoic membrane(CAM) assay revealed that TRANCE potently induced neovascularization in vivo. These results indicate that TRANCE, presumably via activation of the endothelial TRANCE receptor, stimulates various angiogenic signaling pathways in endothelial cells. Thus, TRANCE may act as an important modulator of angiogenesis under the physiological and pathological conditions.

Mucosal Healing Predicts the Long-Term Prognosis of Intestinal Behçet’s Disease

Yim, Sun Mie,Kim, Duk Hwan,Lee, Hyun Jung,Jang, Hui Won,Park, Soo Jung,Hong, Sung Pil,Kim, Tae Il,Kim, Won Ho,Cheon, Jae Hee Springer-Verlag 2014 Digestive diseases and sciences Vol.59 No.10