다결정 니켈표면과 산소 기체와의 상호 작용

안운선,이순보,부진효,박유용 성균관대학교 기초과학연구소 1986 論文集 Vol.37 No.2

The interaction of the gaseous oxygen molecule with polycrystalline nickel surface has been studied by the XPS through the wide range above the room temperature. For relatively lower oxygen exposure, only an O(1s) peak was observed at 530.2 eV, which is associated with the dissociative adsorption. On the other hand, with increasing oxygen exposures, two peaks was appeared at 529.7eV and 531.3eV. These peaks are attributed to nickel oxide and Ni_2O_3, respectively. The latter oxide is ascribed due to the excess adsorption over the NiO stoichiometry. However at high temperatures above 423K, the dissociative adsorption and oxidation was found to take place simultaneously. As a whole, through these XPS study it is found that the interaction of the oxygen with the polycrystalline nickel surface commences through three steps: the fast dissociative adsorption following slow initiation process, rapid oxidation corresponding to the epitaxial NiO formation, and finally the bulk oxide formation.

북미인디안의 환경친화적인 복식 소재에 관한 연구 : 전통복식을 중심으로 Focused on Traditional Costume

朴富珍,韓明淑,南基善 服飾文化學會 1999 服飾文化硏究 Vol.7 No.1

The purpose of this study was to identify the origin of diversity of costume material caused by environmental difference. For this purpose, this research involved theoretical studies and studies based on historical data obtained from previous related studies. The common truth was proved that environmental including the geographical distribution of plants and animals determines costume material. Also, It was found that the unique traditional costume styles were developed through unique combination of costume material and their culture. The major results of this study are as follows: 1. The traditional costume of North American Indian was well-developed and closely related to geographical distribution of plants and animals. Also, their costume was so diverse that it could not be categirized. 2. The traditional costume of North American Indian showed ideal har mony between nature and human being by using surrounding environment into their costume. 3. The application of plants and animal materials into their costume was one of the environment- friendly human activity and it seems to give us an important message.

심정지환자에서 epinephrine투여시 혈중 catecholamine의 변화

임경수,황성오,이부수,이강현,이진웅,임종천,김영식,김선만,김 현 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Cardiac arrest is a potent stimulus for the release of endogenous catecholamine and high plasma catecholamine concentration has been reported during cardiopulmonary resuscitation(CPR). Few data were present about the clinical effect of high plasma catecholamine and endogenous catecholamine response to exogenous epinephrine administration during CPR. Purpose : This study was designed to evaluate endogenous catecholamine response to cardiac arrest and exogenously administered epinephrine during CPR. Method : In 21 cardiac arrest victims, blood sample for epinephrine and norepinephrine was drawn before and 1 minute after each epinephrine administration during CPR. 1mg of epinephrine was administered immediately after intravenous access and 3 minute interval during CPR. Plasma catecholamines were quantitated by high-performance liquid chromatography. Result : Baseline plasma epinephrine concentraqtion was higher in patients with cardiac arrest than normal controls (985±1627 vs 194±173 pg/ml, p<0.05). Baseline plasma norepinephrine concentration was also elevated in patients with cardiac arrest than normal controls, although statistically insignificnat(1965±4915 vs 360±250 pg/ml). Plasma epinephrine concentration in cardiac arrest patients was significantly elevated after exogenous administration of epinephrine, but its response was blunted after the third does of epinephrine. Plasma norepinephrine concentration in cardiac arrest patients was also elevated, but its response was observed only after the first epinephrine administration. Plasma epinephrine concentration was persistently higher in patients with return of spontaneous circulation (ROSC) than patients without ROSC. there was no significant difference of plasma norepinephrine concentration whether spontaneous circulation was restored or not. Endogenous epinephrine response to exogenous epinephrine was not observed in patients having prolonged arrest time over 20 minutes. Conclusion : Results of this study suggests that significant amount of catecholamine is released by exogenous epinephrine administration in spite of high plasma catecholamine concentration, and degree of endogenous catecholamine response influences resuscitation outcome.

Paraquat 중독환자의 초기검사로서 sodium dithionite를 이용한 소변내 paraquat검출의 임상적 의의

윤갑준,임경수,이진웅,김영식,이부수,박덕우,김선만,이강현,황성오,안무업 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Mortality from paraquat intoxication depends upon plasma paraquat concentration. To know the severity of paraquat intoxication is important for directing therapeutic modality and predicting prognosis. Sodium dithionite test for urinary paraquat provides an easy and simple method to determine the severity of paraquat intoxication in emergency department. purpose : To determine whether the result urinary paraquat test by sodium dithionite can predict outcome in patients with paraquat intoxication in emergency department. Subjects : 48 patients(male 31, female 17, mean age 37 years) who had exposure to paraquat and presented within 24 hours after exposure. Result : Thirty five patients were positive in paraquat urine test and thirteen patients were negative. Clinical manifestations were more severe in positive patients than in negatives. Complication was much more in positives than in negatives. 28 of 35 patients(80%) in positives and 2 of 13 patients(15%) in negatives died. Conclusion : Positive test for urinary paraquat is associated with high mortality and morbidity from paraquat intoxication, and qualitative test for urinary paraquat by sodium dithionite is an useful method to determine the severity of paraquat intoxication in emergency department.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

Comparative Study of Autophagy in Oxaliplatin-Sensitive and Resistant SNU-C5 Colon Cancer Cells

Boo Sun-Jin,Piao Mei Jing,Kang Kyoung Ah,Zhen Ao Xuan,Fernando Pincha Devage Sameera Madushan,Herath Herath Mudiyanselage Udari Lakmini,Lee Seung Joo,Song Seung Eun,Hyun Jin Won 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.5

Few studies have evaluated the role of autophagy in the development of oxaliplatin (OXT) resistance in colon cancer cells. In this study, we compared the role of autophagy between SNU-C5 colon cancer cells and OXT-resistant SNU-C5 (SNU-C5/OXTR) cells. At the same concentration of OXT, the cytotoxicity of OXT or apoptosis was significantly reduced in SNU-C5/OXTR cells compared with that in SNU-C5 cells. Compared with SNU-C5 cells, SNU-C5/OXTR cells exhibited low levels of autophagy. The expression level of important autophagy proteins, such as autophagy-related protein 5 (Atg5), beclin-1, Atg7, microtubule-associated proteins 1A/1B light chain 3B I (LC3-I), and LC3-II, was significantly lower in SNU-C5/OXTR cells than that in SNU-C5 cells. The expression level of the autophagy-essential protein p62 was also lower in SNU-C5/OXTR cells than in SNU-C5 cells. In SNUC5/ OXTR cells, the production of intracellular reactive oxygen species (ROS) was significantly higher than that in SNU-C5 cells, and treatment with the ROS scavenger N-acetylcysteine restored the reduced autophagy levels. Furthermore, the expression of antioxidant-related nuclear factor erythroid 2-related factor 2 transcription factor, heme oxygenase-1, and Cu/Zn superoxide dismutase were also significantly increased in SNU-C5/OXTR cells. These findings suggest that autophagy is significantly reduced in SNU-C5/OXTR cells compared with SNU-C5 cells, which may be related to the production of ROS in OXT-resistant cells.

Poster Session : PS 0922 ; Lower GI Tract : Synchronous Multiple Lymphomatous Polyposis and Adenocarcinoma in the Colon : A Case Report

( Sun Jin Boo ),( Chang Lim Hyun ),( Sang Hoon Han ),( Soon Jae Lee ),( Seung Uk Jeong ),( Soo Young Na ),( Hyun Joo Song ),( Yoo Kyung Cho ),( Eun Kwang Choi ),( Heung Up Kim ),( Byung Cheol Song ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Synchronous multiple lymphomatous polyposis and adenocarcinoma in the colon is very rare. We report a case in which a sporadic adenocarcinoma occurred on the lymphomatous polyp of colon was successfully resected using endoscopic submucosal dissection (ESD) technique. Case: A 69-year-old female presented with abdominal discomfort and intermittent anal bleeding for 3 months. Under the colonoscopy, there are numerous non-epithelial polyps with various size in the colon and a epithelial neoplasm larger than 4cm in the ascending colon. The biopsy of a non-epithelial polyp showed focal nodular lymphoid hyperplasia and the biopsy of the epithelial neoplasm revealed tubular adenoma with low grade dysplasia. A computed tomography demonstrated multiple tiny mural nodules in the colon and multiple homogeneous attenuated lymph node enlargement in left gastric, paraaortic, aortocaval, ileocolic, mesenteric area. A about 4.5cm sized epithelial neoplasm in the ascending colon was completely resected using ESD technique. The ESD specimen showed intraepithelial well-differentiated adenocarcinoma and extranodal marginal zone B-cell lymphoma (MALT lymphoma). A about 0.5cm sized non-epithelial polyp was resected using endoscopic mucosal resection (EMR) technique. The EMR specimen revealed diffuse large B-cell lymphoma that may arise from MALT lymphoma. She was treated with R-CHOP chemotherapy. Conclusion: We report a rare case of synchronous multiple lymphomatous polyposis and adenocarcinoma in the colon.

Production of Recombinant Miraculin Protein Using Transgenic Citrus Cell Suspension Culture System

Jin, Seong Beom,Sun, Hyeon Jin,Bachchu, Md Adnan Al,Chung, Sung Jin,Lee, Jongwoo,Han, Song-I,Yun, Jeong Hun,Boo, Kyung Whan,Lee, Dongsun,Riu, Key Zung,Kim, Jae-Hoon The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.3

Miraculin gene containing the N-terminal signal peptide was introduced into navel orange (Citrus sinensis Osb. var. brasiliensis Tanaka) callus cells by Agrobacterum-mediated transformation. Transgenic somatic embryos were screened on the shoot induction medium containing 25 mg hygromycin $L^{-1}$. Citrus callus cells were reproduced from the green color somatic embryos on the callus reproduction medium. The obtained transgenic cells were cultured in Murashige and Tucker's liquid medium containing 50 g sucrose $L^{-1}$ in a shaking incubator. Similar to the native miraculin, the secreted recombinant miraculin protein formed a disulfide-linked dimer and retained taste-modifying activity. The stability of recombinant protein expression was confirmed over nine generations of callus. This production system can be an excellent alternative for producing various recombinant proteins as well as miraculin.

A Case of Acute Myopericarditis Associated with Mycoplasma pneumoniae Infection in a Korean Adult

Jin, Young-Joo,Park, Seong Yeon,Boo, Sun-Jin,Woong, Jang Ji,Park, Kyung-Sun,Yoo, Dong-Joon,Kim, Jae Joong,Lee, Sang-Oh,Choi, Sang-Ho,Woo, Jun Hee,Kim, Yang Soo,Kim, Sung-Han 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

We report on a 45-year-old man with a confirmed diagnosis of acute myopericarditis associated with Mycoplasma pneumoniae. He visited our emergency department due to high fever (39℃) via a primary clinic. We made a diagnosis of myopericarditis based on symptoms, cardiac enzymes, electrocardiography, and transthoracic echocardiography. Serology (particle agglutination) testing for M. pneumoniae IgG antibody was also performed. The IgG antibody titer was 1:80 on the second day of admission, and increased to 1:2,560 by the 12th day of admission. Therefore, we confirmed the diagnosis of acute myopericarditis associated with M. pneumoniae and subsequently treated him with azithromycin. The symptoms and laboratory findings improved, and he recovered uneventfully.

Safeness of Endoscopic Resection in Patients with End-Stage Renal Disease on Dialysis

Sun-Jin Boo 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.4

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