방사선적 물리적 특성에 의한 담석의 성분 분석

함희원,성무경,전혜정,선관우 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

In this study, gall stones from 45 patients were analyzed in vitro. Gall stones from 23 patients were cholesterol stones and the others were non-cholesterol. Correlation with each radiologic physical properties(the number of stones, shape, calcification pattern, Hounsfield units measured by computed tomography) and chemical composition(cholesterol or non-cholesterol) were analyzed. The results revealed that the numbers and size were not related to the chemical composition, but there were significant correlation with faceted stones(p=0.002) or stones with no calcification (p=0.010) and cholesterol composition, and with irregular stones(p=0.000) or stones with dense calcification(p=0.015) and non-cholesterol composition. In study of Hounsfield units, it was difficult to fix the boundary, but the difference between cholesterol composition(138.43±281.81) and non-cholesterol composition(404.32±306.06)was significant(p=0.0109).

암환자를 위한 김치의 개발 : 1. 김치레시피조절에 의한 항돌연변이효과 증진연구 1. Studies on Enhancing Antimutagenic Effect of Kimchi by Changing the Recipe

최선미,전영수,이숙희,박건영 부산대학교 김치연구소 2002 김치의 과학과 기술 Vol.8 No.-

To develop kimchi for cancer patient, we studied on enhancing antimutagenic effect of kimchi by manipulating the recipe from the result of prevalence test on kimchi by cancer patients. According to the result of prevalence test, the patients wanted to reduce the level of red pepper powder and increase some sub-ingredients such as garlic and mustard compared to the standardized kimchi. The recipe-manipulated kimchi was fermented at 15℃ for 1 day and then ripened at 5℃ for several days up to pH 4.2~4.3. The antimutagenic effect of the methanol extracts of the kimchi was evaluated by using Ames mutagenicity test with Salmonella typhimurium TA100. Among the kimchi samples, CP_2-M kimchi (2.5% red pepper powder +7.5% mustard leaf added kimchi) exhibited higher inhibitory effect on the mutagenicity induced by aflatoxin B_1 in the Ames test. In vivo supravital staining micronucleus assay, anticlastogenic effect of the CP_2-M kimchi group was higher than that of the control group. The induction of chromosome aberration by mitomycin C was significantly suppressed by CP_2-M kimchi suggesting in post-treatment.

2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15)의 돌연변이원성

김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y15 induced his+revertants of Salmonella typhimurium TA 98 and TA 1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his+revertants of Salmonella typhimurium TA 1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells. NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.

피부미용사의 스트레스와 근골격계 자각 증상과의 관련성

이은희,전선복,이무식,김남송,장문정 한국미용학회 2001 한국미용학회지 Vol.7 No.3

The purpose of this study was to examine the relationship of skin beauty artist's stress to musculoskeletal subjective symptom to identify what factors are related to skin beauty artist's musculoskeletal subjective symptom. The subjects in this study were 211 selected skin beauty artists. A survey was conducted from March 11 to 31, 2001, with standardized self-reporting questionnaire to find out the general characteristics, perceived stress level and musculoskeletal subjective symptom. The findings of this study were as below; l. All the skin beauty artists investigated were female. 110 skin beauty artists (52.1%), more than half them, were highschool graduates, 117(55,5%) were unmarried, and the mean career was 52,74 months(four years and four months). The daily mean working hours were 10.61, and the actual daily mean working hours were 7.94. 2. For health habit. 19(9.0%) skin beauty artists were smoker, which indicated that most of them didn't smoke. 136(64.5%) people, more than half them, drank alcohol, and just 72(34.1%) got exercise. 3. In regard to the relationship of general characteristics to stress, the unmarried group was more stressed as they got a score 69.25(SD 12.45), compared to the married group that got 66.30(SD 11.50). The difference between the two group was significant (p<005). The nondrinking group were more stressed out with 69.42(SD 11.50) than the drinking group with 65.87(SD 12.97). The difference between the two was significant(P<0.05). The group that didn't get exercise were more stressed with 70.17(SD 12.11) than the workout group with 64.26(SD 11.27), and the difference between the two was significant(P<0.05). By career, the group that had worked for 34 months or less were more stressed with 70.47(SD 12.38) than the other group that had worked for more than 35 months with 65.87(SD 11.48). And the difference between the two was significant. 4, As for the correlational relationship between musculoskeletal symptom to relevant variables, stress was positively correlated to musculoskeletal symptom and the pain of neck, shoulder, back, arm, hand, wrist, waist and leg. Their stress had a positive correlational relationship with the symptom in every part. The younger people made more complaint of the symptom of shoulder, back and leg, and those who had worked for less period were more stressed out. The findings of this study suggested that there was a relationship between stress and musculoskeletal subjective symptom. To prevent stress and musculoskeletal subjective symptom, there should be an attempt to ease stress. The break time should be offered regularly during working hours, and amicable human relations should be kept. The right health habit should be formed in daily living, and stretching exercise and health care should be done more thoroughly.

수술로 호전되지 않은 췌장 농양을 내시경 치료로 완치한 1 예

서희영;전태주;김선영;강미선;허란;박지영;서동대;오태훈 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Necrotizing pancreatitis develops in about 10-20% of patients with acute pancreatitis, and pancreatic abscesses develop in 3% of them. The mortality of pancreatic abscess has been reported up to 40% in one study. Recently, there are several reports that show good results with n on-surgical therapy, such as percutaneous drainage and endoscopic drainage, but if the non-surgical drainage fails, surgical therapy are recommended. However, there is no definite therapeutic method which is suggested yet so far after the failure of the surgical drainage. So we report the case in which we experienced successful treatment of pancreatic abscess by endoscopic removal of necrotic tissue through the gastrocystostomy, after the failure of the surgical debridement and internal drainage through gastrocystostomy.

고춧가루내의 고추씨 함량이 김치발효와 항돌연변이 활성에 미치는 영향

최선미,전영수,이숙희,박건영 부산대학교 김치연구소 2002 김치의 과학과 기술 Vol.8 No.-

The fermentation characteristics such as pH, acidity, lactic acid bacterial counts and panel taste of kimchi, and antimutagenic activity of kimchi were studied when the kimchi prepared with different ratio of seed (S) pericarp (P) in red pepper powder and fermented at 15℃. The pHs of P:S = 9:1 kimchi and P:S = 7:3 kimchi decreased gradually during the kimchi fermentation, however, pHs of P:S = 5:5 kimchi and P:S = 3:7 kimchi decreased very fast during the fermentation. The counts of Leuconostoc sp were high in P:S = 9:1 kimchi and P:S = 7:3 kimchi but the levels were low in P:S = 5:5 kimchi and P:S = 3:7 kimchi. Whereas Lactobacillus sp counts were low in P:S = 9:1 kimchi and P:S = 7:3 kimchi, but the counts were high in P:S = 5:5 kimchi and P:S = 3:7 kimchi during the fermentation. P:S = 3:7 kimchi showed the highest prevalence in the panel taste of the kimchis and the P:S = 3:7 kimchi resulted in the lowest prevalence. The antimutagenic activities of the kimchi juices were studied by Ames test using Salmonella typhimurium TA100 and SOS chromotest using E. coil PQ37. As the ratio of the seed increased, the antimutagenicities increased. Among the kimchi samples, P:S = 5:5 kimchi significantly reduced (p<0.05) the mutagenicities induced by aflatoxin B_1(AFB_1) in Ames test and SOS response against N-methy1-N'-nitro-N-nitrosoguanidine (MNNG) in SOS chromotest. From the results of the experiments, the P:S = 7:3 kimchi seems to be the best seed ratio of red pepper powder for the preparation of kimchi in terms of fermentation characteristics and antimutagenicity of the kimchi.

2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione(NQ-Y15)의 돌연변이원성

김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.4

2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y 15 induced his+ revertants of Salmonella typhimurium TA 98 and TA1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his^(+) revertants of Salmonella typhimurium TA1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells, NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.

Hydantoin환의 가수분해반응 및 O-알킬화반응을 이용한 새로운 A1ky1 α-Anilinophenylacetate 유도체의 합성

박명숙,최희전,박해선,권순경 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1

For the development of new synthetic method for unnatural amino acid esters, alkyl α-anilinophenylacetates 4a-i were synthesized through base-catalyzed hydrolysis of 1,5-diphenylhydantoins 1a-b in methanol and O-alkylation of sodium α-anilinophenylacetate 3 with alkyl halides in DMF. Even though hydrolysis of hydantoin ring was undertaken under about 30-40℃ in methanol, the hydantoic acid sodium salt 2 was continuously converted to the sodium α-anilinophenylacetate 3. All synthetic process from hydantoin to alkyl α-anilinopheny lacetates could be carried out in one-pot without isolation of intermediates.

포사맥스 정(알렌드론산나트륨 70mg)에 대한 대웅 알렌드로네이트 정 70mg의 생물학적 동등성

이예리,정선경,양승권,최기호,신용철,전형규,강승우,이희주 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.2

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.