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배현주,권숙희,김윤섭,박효순,박중경,최민호,채종일 대한감염학회 1998 감염 Vol.30 No.2
Despite efforts to control the spread of malaria, the disease persists in certain parts of the world. Moreover, there has been a resurgence of the disease recently. Another protozoan disease, babesiosis is a disease of animals; Humans are infected only incidentally, and when they are infected, they develop a nonspecific febrile illness. Babesia organism enters red blood cells and resembles malaria parasites, thus posing a problem in the differential diagnosis. We encountered an imported case of mixed infection of malaria and babesia. The patient was a 20-year old Korean male who had been in Saong-dume near Gabon for 3 months. We treated him with chloroquine with the diagnosis of Plasmodium malariae infection, but fever recurred after 2 weeks of the treatment. The second peripheral blood smear findings revealed specific ring forms of Babesia spp, so we changed to quinine and clindamycin. The treatment was successful and the patient was well after 4 months of follow-up period.
Thyroid Associated Ophthalomopathy in a Patient with Hashimoto’s Thyroiditis
Ho-Jun Lee,Yeo-Joo Kim,Suk-Hoe Kweon,Ah-Jeong Ryu 대한갑상선학회 2016 International Journal of Thyroidology Vol.9 No.2
A 53-year-old man consulted an ophthalmologist with a chief complaint of diplopia and bilateral eyelid swelling. He was diagnosed with hypothyroidism 2 years prior at a local clinic and had been taking levothyroxine 150 mcg daily. CT scan of the orbits showed enlargement of bilateral extraocular muscles. Laboratory findings revealed hyperthyroidism due to high dose levothyroxine. Active ophthalmopathy with Hashimoto’s hypothyroidism was diagnosed and the patient was treated with steroid pulse therapy. We reported a rare case of severe ophthalmopathy with Hashimoto’s thyroiditis that needed steroid pulse therapy.
기관지천식 환자에서 salbutamol의 분무치료에 의한 혈청 칼륨 농도의 변화
장인진,지영구,권숙회,이계영 대한알레르기학회 1998 천식 및 알레르기 Vol.18 No.4
Background and objective: The knowledge about the effects of the nebulized β₂-agonist on serum potassium is limited. We aimed to assess the possible hypokalemia following nebulization of salbutamol. Methods: Seven patients(mean age 60 ±7.1years) with acute exacerbated asthma were treated with salbutamol nebulization(5mg nebulization at 1 hour interval, 3 times) without concomitant use of steroid or other bronchodilator such as theophylline. Results: There was a significant increase in FEV1, from 46.41 ±25.91% at baseline to 62.86 ±22.38% at 3 hours after treatment. Serum potassium concentration was significantly decreased, from 3.93 ±0.58mEq/L at baseline to 3.41 ±0.62mEq/L and 3.46 ±0.53mEq/L at 1 hour and 3 hours after third nebulization, repectively. There was a significant prolongation of the QTc interval in EKG from 454.36 ±27.07msec at baseline to 479.41 ±35.64msec and 505.09 ±58. 69msec at 1 hour and 3 hours after third nebulization, respectively. Serum salbutamol concentration was 4.18 ±3.39ng/ml at baseline, and increased to 7.69 ±6.94ng/ml and 9.84 ±10.34ng/ ml at 1 hour and 3 hours after treatment, respectively. Magnitude of the hypokalemia and the degree of prolongation of the electrocardiographic QTc interval were significantly correlated with the level of serum salbutamol concenturation. Conclusion: The results suggest that cardiac complication could develop due to hypokalemia during repeated salbutamol nebulization. Caution should be done in monitoring of serum potassium concentration when using nebulized salbutamol repeatedly for the treatment of acute exacerbated bronchial asthma.