간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

The impact of pathologic differentiation (well/ poorly) and the degree of Ki-67 index in patients with metastatic WHO grade 3 GEP-NECs.

Kim, Seung Tae,Lee, Su Jin,Lee, Jeeyun,Park, Joon Oh,Park, Young Suk,Lim, Ho Yeong,Kang, Won Ki Grune & Stratton 2017 Journal of clinical oncology Vol.35 No._suppl15

<P> e15686 </P><P> Background: Herein, we investigated the impact of pathologic differentiation (well or poorly differentiated) in metastatic grade 3 GEP-NEC patients receiving etoposide and platinum-based therapy. Simultaneously, we evaluated a more exact Ki67 index cut-off point to select patients with grade 3 GEP-NEC who might benefit from etoposide plus platinum (EP)-based therapy. Methods: Among patients pathologically diagnosed with metastatic grade 3 GEP-NECs at Samsung Medical Center between June 2013 and March 2016, 31 GEP-NEC patients receiving etoposide and platinum-based therapy were included in this study. Results: Primary sites included 13 foregut-derived GEP-NECs [stomach (n = 4), duodenum (n = 4), and pancreas (n = 5)] and 2 hindgut-derived GEP-NECs of the rectum. Sixteen unclassified GEP-NECs originated from 7 gall-bladder (GB), 6 liver and 3 unknown primary sites. According to pathologic differentiation, 14 patients had well differentiated and 17 had poorly differentiated grade 3 GEP-NECs. Between well differentiated and poorly differentiated grade 3 GEP-NECs, there was a significant difference in the distribution of Ki67 index. There was no significant difference of treatment efficacy between well and poorly differentiated grade 3 GEP-NECs (RR; 35.7% vs. 41.2%, p = 0.525). Tumor response to EP occurred in 5 of 7 patients with Ki67 > 60% and 7 of 24 with Ki67≤60%, which was significantly different (RR; 71.4% vs. 29.2%, P = 0.043). There was no significant difference in PFS according to pathologic differentiation (well differentiated vs. poorly differentiated) and Ki67 index ( > 60% vs ≤60%). Conclusions: Grade 3 GEP-NECs could be morphologically classified into well and poorly differentiated NETs. Additionally, among grade 3 GEP-NECs, there was a significant difference in ranges of Ki67 index between well and poorly differentiated NECs. Higher levels ( > 60%) of Ki67 index might be a predictive marker for efficacy of EP as a standard regimen in grade 3 GEP-NECs. </P>

문학치료학 연구 서설

박기석 ( Park Ki-suk ) 한국문학치료학회 2004 문학치료연구 Vol.1 No.-

The purpose of this paper is to study Park, Ji-won朴趾源 and his works from a literary-therapy standpoint. `Literary-therapy文學治療` is a process which restores a patient from abnormal mental state to normal state through literary works. So it is a kind of psychotherapy through reading or writing. Treatment can be done by a patient himself or by an literary-therapist文學治療師. The object of treatment can be a person or a society. In this paper, I try to find out what led Park, ji-won to write his works-chinese characters short stories from a literary-therapy standpoint. In Gua-jeong-rok過庭錄 and his works, I find out that his works written in his twenties and thirties are connected with his melancholia. So Park`s chinese characters short stories can be seen as examples of self-treatment自家治療 by writing. I also find out that his works were intended for society-treatment社會治療 too.

Ki-1 임파종 1 예

김용진,김경재,박재복,이지현,안기성,강민모,최석문,황기석 대한내과학회 1993 대한내과학회지 Vol.45 No.4

A 60-year-old man was admitted to our hospital complaining of fever with chillness and anarexia for 12 weeks. Physical examination revealed supraclavicular lymphadenopathy and left inguinal lymphadenopathy. Abdominal CT scan showed the evidence of maked lymphadenopathy on retraperitoneal, external iliac, obturator, left inguinal, and celiac lymph nodes. A pathologic diagnosis of Ki-1(+) lymphoma was made by the biopsed supraclavicular lymph node because the node consisted of large cells with pleomorphic nuclei, scanty cytoplasm, large basophilic nucleoli, atypical vacuoli and large cells were positive for leukocyte common antigen, Ber-H2, marker, and B-cell marker.

『일신수필』에 나타난 연암의 관심사 : 북학을 중심으로

박기석(Park, Ki-suk) 서울여자대학교 인문과학연구소 2012 인문논총 Vol.24 No.-

This paper is a research of a matter of Yeonam' s interest in Ilsin-Supil(馹汛隨筆). Ilsin-Supil is the third chapter of Yeonam(燕巖) Park-jiwon' s(朴趾源) Yeolha-ilgi(熱河日記). In this paper, I focused on yeonam's interest about the idea of Buk-hak(北學). First chapter is about Yeon-am' s thinking of learning at the preface of Ilsin-Supil-seo(馹汛隨筆序). In Ilsin-Supil-seo(馹汛隨筆序), Yeonam criticized about the learning that depends on mouth and ear and expressed his view that learning should have an open mind and deep thought. in addition, he said that keeping records is very important for learning. Second chapter is the idea about 'the argument of grand sight of Ch'ing Dynasty'. In this chapter, I talked about 'the thought toward Ch'ing Dynasty' of Chosun Dynasty' scholar who indulged in 'the justification and the expedition to conquer the north'. Moreover, I discussed about the scholar who persist practical science- Iyong-husaeng(利用厚生)-, his opinion is to learn Ch'ing Dynasty'culture-that is to say Buk-hak(北學). Last chapter was the discussion about a system of wheel(車制) Especially system of vehicle. Yeon-am observed the system of vehicle minutely and persists in using that system of vehicle in Chosun Dynasty. Because he thought that if using a vehicle, the commons of Chosun Dynasty would escape from affected by poverty.

人口政策에 따른 諸課題

朴聖根(Park Seong Kun),Koh Kap Suk(토론자),Chang Man-Ki(토론자) 한국인구학회 1979 한국인구학 Vol.2 No.1

There are two main problems in formulating population policies. First, is it reasonable to formulate population policy in isolation from other social and economic policies? It is the personal belief of Mr. S. Park that a population policy should be regarded as a part of other social and economic policies. Second, there appears to be no clearly formulated long range objectives in conducting the current population redistribution policy; 1) Community development program should be based on the recognition of the special characteristics of the area. And the re-location program for industries should be strongly supported with special tax and loan consideration. 2) The policy aimed at the dispersion of population should be conducted with the program of providing an equal educational opportunity regardless of geographical location, and family planning. Discussants: Koh, Kap Suk and Chang, Man-Ki. 1. Urbanization may be considered as an inevitable result of industrialization. In order to regulate effectively the population movements into urban centers, there should be a clearly formulated population policy in co-ordination with other social and economic policies. 2. Let us assume that Korea will achieve the zero population growth rate by the year 2,000. The fact that currently there are no long range "visional" proposals to deal with the population composition and distributional problems indicates that there has been no comprehensive research about population planning. 3. The optimal population size for Korea should not be thought of in terms of a static concept but a dynamic concept which is related to manpower supply and housing problems. 4. The problem of aging should not be looked at solely as an economic issue. Instead, it should be examined from a humanistic point of view where high priority is placed on restoring human dignity for the older citizens. Response of Mr. Park: 1. There is a tendency to over-emphasize the economic side of population issues. It should be pointed out that a man not only provides labor which is an input for the production of economic goods, but also he is a consumer for whose welfare economic goods are produced in the first place. It should be remembered that economic growth has beneficial impacts on the population but it also has harmful effects. 2. In order to make the government officials aware of population issues, it has been proposed to the Population Policy Evaluation Committee that the courses in population studies be included in the study program for the re-education of government employees. 3. Issues involved in population dispersion: Urbanization is an inevitable process of economic development. Problems arising from urbanization should be solved not by forcefully preventing the migration of population from rural areas to urban centers but by reducing the rural-urban gap in the living conditions. This policy has already been implemented to some extent as indicated by the government's policy of decentralization of industries and Saemaul Movement. In summary, the basic policy of government is to slow down the rural-urban migration by providing incentives to stay in farms in the rural area rather than by the strong-handed method of preventing the internal migration.

「도강록」에 나타난 연암의 관심사

박기석 ( Park Ki-suk ) 한국고전문학교육학회 2011 고전문학과 교육 Vol.21 No.-

「도강록」은 연암 박지원의 _열하일기_ 중에서 일기체로 기술된 일곱 편의 글 중, 의주에서 압록강을 건너 요양에 이르는 15일간의 여행기록이다. 압록강을 건너기전부터 청국 변경인 책문에 이르기까지의 여행기록에서 우리는 미지의 세계 청나라로 들어가는 연암의 착잡한 심경을 읽을 수 있다. 압록강을 건너 요동지방을 지나면서는 옛 고구려 강역을 떠올리고, 우리나라 영토에 대한 역사의식을 강하게 표출하였다. 봉황성을 지나면서 연암은 봉황성이 그 옛날 고구려 양만춘이 당 태종을 상대로 싸웠던 안시성이라는 주장에 대해 강한 의문을 제기하고는 역사, 지리학적 전고를 바탕으로 안시성의 위치를 추정하여 봉황성과는 다름을 밝히고자 했다. 또한 평양과 패수의 위치가 시대에 따라 바뀌었음을 전고를 바탕으로 고증하고, 옛 고구려 영토였던 압록강 북쪽의 요동 땅이 선조들의 잘못으로 줄어들어 지금은 청나라 영토가 되어 있음을 안타깝게 여겼다. 「도강록」에서 연암은 청인들의 삶의 모습을 관심 있게 관찰하였다. 특히 집의 구조, 건축 재료, 건축방식 등 가옥에 대해 세심하게 관찰하였다. 우물과 물 깃는 방식, 방구들 놓는 제도, 벽돌사용법, 기와 이는 법 등에 대해서도 관심을 가지고 유심히 살피고 우리 것과 비교하여 그 장점을 배우고자 했다. 또한 청인들의 벽돌 굽는 가마와 우리나라의 옹기가마를 비교하였고, 청조의 농업보호정책에 대해서도 직접 목격한 바를 바탕으로 기술하였다. 이와 같은 내용은 이용후생에 대한 관심에서 비롯된 것이다. This paper is the research of a matter of Yeon-am's interest in Do-gang-rok(渡江錄). Do-gang-rok is the first chapter of Yeon-am Park-jiwon's Yeol-ha-il-gi(熱河日記). In this paper, I examined the Yeon-am's mind of mixed feelings that across Ap-rok river(鴨綠江) and enter the unknown world, Ch'ing dynasty(淸國). In the next, I have selected out Yeon-am's two importance interest in Do-gang-rok(渡江錄). The one is Yeon-am's interest in historical consciousness of Go-gu-ro(高句麗) territory. He investigated that the Manchu(滿洲) districts is originally, historically our territory. The another is Yeon-am's interest in I-yong-hu-saeng(利用厚生). He observed the Ch'ing's live well carefully. Above all he had an interest in housing culture and compared with ours. An example housing structure, a way of construction, a way of make brick and roofing tile, structure of chimney and kang, ondol etc.

『성경잡지』에 나타난 연암의 관심사

박기석(Park, ki-suk) 서울여자대학교 인문과학연구소 2011 인문논총 Vol.22 No.-

Seong-kyong-chap-ji is the second chapter of yeon-am Park-jiwon’s Yeol-ha-il-gi(熱河日記). The purpose of this study is to examine for a matter of yeon-am’s interest in Seong-kyong-chap-ji(盛京雜識). In this paper, I studied yeon-am’s interest at three point of view. The results are as follows. First, examined carefully yeon-am’s historical consciousness of the old territory in Manchuria(滿洲). Leave for Seong-kyong(盛京), yeon-am turn the head back looking Yoya-plain(遼野), and looked back on the past wars of the Ming(明) and Ch’ing(淸) Dynasty and others. Arrive in Seong-kyong(盛京), as he entered the castle gate of Sim-yang(瀋陽), he thought out this land is our territory. But after that he no more mentioned our old territory. He wondered at the busy street with many carriages and people and abundance of products and concentrated in reality before his face. Second, through the conversation by writing with Chinese traders, yeon-am knew about their personality and view of life. Sok-jae-pil-dam(粟齋筆談) and Sang-lu-pil-dam(商樓筆談) is the writings of conversation by writing of yeon-am and Chinese traders. In that writings, Chinese traders culture is expressed well. Third, yeon-am wrote the experience of an awkward situations by culture difference. Through ‘Ki-sang-sae-sol (欺霜賽雪)’ yeon-am knew that even if Chosun and China use same letters, meaning is difference owing to the culture. And also the ceremonies of funeral is held difference although tow people respect for Ju-ja-ga-lye(朱子家禮).

重化學工業機械의 國産化方案에 關한 硏究 : 特히 窯業에 있어서의 燒成爐, 粉碎機, 排風機, 冷却機, 電氣集마器 自動枰量供給器 等의 製作을 目的으로

趙哲衡,朴碩喆,丁太權,宋鐵,桭達福,金基玉,朴煥奎,趙煥從,朴善鐘,金種一,李茂錫 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

This is to investigate the posibility of home manufacturing of heavy chemical industry machines, such as rotary kiln, crusher, blower, cooler, electrostatic precipitator and weighing feeder of cement plant. It is concluded that even though we can not make all of them (some of them are made now and some others are going to be made in the near future, some of them are made whole and some others are made partially), we can build or export the cement plant by importing the important machines which we can not make now and by substituting them with ours gradually.

간경변증 환자에서 Escherichia colli 균혈증 합병 시 간기능 장애에 따른 C-reactive protein 생성 능력에의 영향

박완범,강철인,김동민,이기덕,장희창,김흥빈,오명돈,이효석,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5