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- 저자 : ( Suk Hwan Baek ) (검색결과 260 건)
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혈소판 농축 혈장이 임플란트 주변 골형성에 미치는 효과에 대한 연구
백명환,한석환,권종진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1
Various methods have been used to fill in the defects around the implants. Recently, researchs of developing and purifying various growth factors, and efforts to apply these growth factors in clinical situations have been carried out. Among those tries, platelet-rich plasma(PRP) containing abundant PDGF and TGF-β obtained by the sequestration and concentration of platelets by the gradient density centrifugation became one of the popular and preferred methods becuase of relatively simple procedure and abundant growth factor components. Bone morphogenic protein(BMP), platelet-derived growth factor(PDGF), and transforming growth factor-beta(TGF-β) are growth factors in the PRP that promote the bone formation. To elucidate the effects of PRP on the bone formation in peri-implant bone defects, twenty-seven Steri-Oss implants were inserted in the mandibular premolar areas of 8 adult dogs and artificial bone defects(3×4×4㎜) were prepared at the buccal side of the implants in 1st premolar, at the distal side of the implants in 3rd premolar. The control groups were filled with bovine bone grafts without PRP, and the experimental groups were filled with bovine bone grafts with PRP. Animals were sacrificed at 1, 2, 4, 8, and 12 weeks after the operation and speimens were observed by light and electron microscope. The results were as follows. first, the bone formation was observed at 1st week in the experimental groups, but at 2nd week in the control groups. second, the mature bone was observed at 4th week in the experimental groups. but 8th week in the control groups. the bone growth rate of experimental groups was more rapid than that of control groups. third, at 12th week, bone density ratio was higher in the experimental groups(71.65%) than that of the control groups(48.49%). fourth, Grafted bovine bone were almost completely absorbed at 1st week in experimental groups, but it was still present at 8th week in control groups. From the above results, PRP may accelerate the formation of new bone by promoting absorption of the graft material and increasing the growth rate of bone.
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Baek, Suk-Hwan,Chang, Hyeun-Wook 생화학분자생물학회 1992 한국생화학회지 Vol.25 No.7
Extracellular phospholipase $A_2$ was purified about 65,000-fold from human pleural fluid of patients with tuberculosis by sequential use of column chromatographies on heparin-Sepharose, butyl-Toyopearl and protein-PAK 125 HPLC. The final preparation showed a single band SDS-polyacrylamide gel, and its molecular mass was estimated to be approximately 14,500 daltons. The purified enzyme has a pH optimum of 9.0 and required $Ca^{2+}$ for maximum activity. It hydrolyzed phosphatidylethanolamine more effectively than phosphatidylserine. This enzyme was inhibited by monoclonal antiboty (HP-1) raised against phospholipase $A_2$ enzyme was inhibited by monoclonal antiboty (HP-1) raised against phospholipase $A_2$ from human synovial fluid. These observations suggested the extracellular phospholipase $A_2$ detected in human pleural fluid belongs to the "Group II" family of phopholipase $A_2$.
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Baek, Suk-Hwan,Yun, Sung-Su,Kwon, Taeg Kyu,Kim, Jae-Ryong,Chang, Hyeun-Wook,Kwak, Jong-Young,Kim, Jung-Hye,Kwun, Koing-Bo 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
Phospholipase A_(2)(PLA_(2)) regulates eicosanoid and platelet-activating factor production. It also plays an important role in the regulation of critical mediators in inflammatory diseases in which PLA_(2) activity is significantly enhanced during sepsis and multiple organ failure. Therefore, inhibitors of PLA_(2) activity offer themselves as target substances in the development of anti-inflammatory drugs. We identified 2 biflavonoids, bilobetin and ginkgetin, that can inhibit PLA_(2) activity. In experiments using 2-linol-[1-^(14)C]PE as substrate both substances potently inhibited several kinds of typeⅡ 14-kDa PLA_(2) while inhibiting typeⅠ 14-kDa PLA_(2) to a lesser extent. We tested these PLA_(2) inhibitors for their ability to inhibit the production of tumor necrosis factor α(TNFα) and 2 enzymes, inducible nitric oxide synthase (iNOS) and inducible cyclo-oxygenase(COX-2) in an assay system using lipopolysaccharide(LPS)-stimulated Raw264.7 macrophages. In Raw264.7cells, bacterial LPS induced the production of COX-2 and iNOS proteins as well as TNFα. The inhibitors consistently inhibited the production of TNFα in a dose-dependent manner. Moreover, treatment of the macrophages with bilobetin and ginkgetin shut down the production of nitrite, one of the stable end products of NO released into the culture supernatant. The decrease in NO products was accompanied by a decrease in iNOS protein level as assessed by Western blot probed with specific anti-iNOS antibody. Both inhibitors also reduced the expression of COX-2 protein in the LPS-stimulated cells, which coincided with the reduction in iNOS protein. These results, therefore, suggest that these two sPLA_(2) inhibitors may be useful for inhibiting the production of inflammatory cytokine and NO production in inflammatory diseases.
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Suk Hwan Baek,Hyeun Wook Chang 생화학분자생물학회 1992 BMB Reports Vol.25 No.7
Extracellular phospholipase A₂ was purified about 65,000-fold from human pleural fluid of patients with tuberculosis by sequential use of column chromatographies on heparin-Sepharose, butyl-Toyopearl and protein-PAK 125 HPLC. The final preparation showed a single band SDS-polyacrylamide gel, and its molecular mass was estimated to be approximately 14,500 daltons. The purified enzyme has a pH optimum of 9.0 and required Ca^(2+) for maximum activity. It hydrolyzed phosphatidylethanolamine more effectively than phosphatidylserine. This enzyme was inhibited by monoclonal antiboty (HP-1) raised against phospholipase A₂ enzyme was inhibited by monoclonal antiboty (HP-1) raised against phospholipase A₂ from human synovial fluid. These observations suggested the extracellular phospholipase A₂ detected in human pleural fluid belongs to the $quot;Group Ⅱ$quot; family of phopholipase A₂.
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( Seon Ha Baek ),( Hyun Suk Kim ),( Jeong Hwan Lee ),( Dong Ki Kim ),( Kook Hwan Oh ),( Yon Su Kim ),( Jin Suk Han ),( Tae Min Kim ),( Se Hoon Lee ),( Kwon Wook Joo ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1
Background/Aims: Sunitinib is an oral multitargeted tyrosine kinase inhibitor used mainly for the treatment of metastatic renal cell carcinoma. The renal ad-verse effects (RAEs) of sunitinib have not been investigated. The aim of this study was to determine the incidence and risk factors of RAEs (proteinuria [PU] and renal insuffi ciency [RI]) and to investigate the relationship between PU and anti-tumor effi cacy. Methods: We performed a retrospective review of medical records of patients who had received sunitinib for more than 3 months. Results: One hundred and fifty-five patients (mean age, 58.7 ± 12.6 years) were en-rolled, and the mean baseline creatinine level was 1.24 mg/dL. PU developed in 15 of 111 patients, and preexisting PU was aggravated in six of 111 patients. Only one patient developed typical nephrotic syndrome. Following discontinuation of sunitinib, PU was improved in 12 of 17 patients but persisted in five of 17 patients. RI occurred in 12 of 155 patients, and the maximum creatinine level was 3.31 mg/ dL. RI improved in two of 12 patients but persisted in 10 of 12 patients. Risk fac-tors for PU were hypertension, dyslipidemia, and chronic kidney disease. Older age was a risk factor for RI. The median progression-free survival was signifi-cantly better for patients who showed PU. Conclusions: The incidence of RAEs associated with sunitinib was lower than those of previous reports. The severity of RAEs was mild to moderate, and par-tially reversible after cessation of sunitinib. We suggest that blood pressure, uri-nalysis, and renal function in patients receiving sunitinib should be monitored closely.
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Mi-Ran Lee,Sang-Hoon Park,Tae-Suk Kim,Sang-Ki Baek,Sang-Jin Jin,Yeoung-Gyu Ko,Hwan-Hwoo Sung,Ho-Baek Yoon,Jin-Wook Kim,Joon-Hee Lee 경상대학교 농업생명과학연구원 2014 농업생명과학연구 Vol.48 No.6
The cloning efficiency is extremely low despite successful somatic cell nuclear transfer (SCNT) method producing cloned animals in several mammals. In general, faulty epigenetic modifications underlying the incomplete reprogramming of donor cell nuclei after SCNT mainly results in low cloning efficiency. The nuclear reprogramming process involves epigenetic modifications, such as DNA demethylation and histone acetylation, which may be an important factor in enhancing the cloning efficiency. Recently, the histone deacetylase inhibitors (HDACi), such as trichosatin A (TSA) and m-carboxycinnamic acid bishydroxamide (CBHA), to increase histone acetylation have been used to improve the developmental competence of SCNT embryos. Therefore, we compared the effects of TSA with CBHA on the in vitro developmental competence and pluripotency-related gene expression (Oct4, Nanog and Sox2) in porcine cloned blastocysts and histone acetylation pattern (H3K9ac). The porcine cloned embryos were treated with a 50nM concentration of TSA and 100μM concentration of CBHA during the in vitro early culture (10h) after cell fusion and then were assessed to cleavage rate, development to the blastocyst stage and pluripotency-related gene expression in NT blastocyst also, level of histone acetylation in zygote, 2cell, 4cell stage. As results, Although NT, TSA and CBHA treated NT embryos were not different between all groups for cleavage rates, the developmental competence to the blastocyst stage was significantly increased in CBHA treated embryos (22.7%) compared to that of normal NT and TSA treated NT embryos (8.1% and 15.4%)(p<0.05). In addition, all of pluripotent transcription factors (Oct4, Nanog and Sox2) were expressed in the CBHA treated NT embryos, however, Sox2 and Oct4 were expressed in TSA treated NT embryos and expression pattern of CBHA treated NT embryos is particularly similar to that of IVF embryos. Also, CBHA treated NT embryos were increased in level of histone acetylation (H3K9ac) at the zygote, 2-cell, 4-cell stage compared to those of NT and TSA treated NT embryos. In conclusion, the treatment of CBHA as a histone deacetylase inhibitor significantly increased the developmental competence of porcine NT embryos and pluripotency-related gene expressions(Oct4, Nanog and Sox2) in NT blastocysts and level of histone acetylation (H3K9ac).
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Hwan-Hyung Park,Suk-Hwan Jung,Juil Yoon,Kwang Koo Jee,Jun Hyun Han,Seung-Hak Baek 대한치과교정학회 2019 대한치과교정학회지 Vol.49 No.4
Objective: To investigate the effects of reversing the coiling direction of nickeltitanium closed-coil springs (NiTi-CCSs) on the force-deflection characteristics. Methods: The samples consisted of two commercially available conventional NiTi-CCS groups and two reverse-wound NiTi-CCS groups (Ormco-Conventional vs. Ormco-Reverse; GAC-Conventional vs. GAC-Reverse; n = 20 per group). The reverse-wound NiTi-CCSs were directly made from the corresponding conventional NiTi-CCSs by reversing the coiling direction. Tensile tests were performed for each group in a temperature-controlled acrylic chamber (37 ± 1oC). After measuring the force level, the range of the deactivation force plateau (DFP) and the amount of mechanical hysteresis (MH), statistical analyses were performed. Results: The Ormco-Reverse group exhibited a significant shift of the DFP end point toward the origin point (2.3 to 0.6 mm), an increase in the force level (1.2 to 1.3 N) and amount of MH (1.0 to 1.5 N) compared to the Ormco-Conventional group (all p < 0.001), which indicated that force could be constantly maintained until the end of the deactivation curve. In contrast, the GAC-Reverse group exhibited a significant shift of the DFP-end point away from the origin point (0.2 to 3.3 mm), a decrease in the force level (1.1 to 0.9 N) and amount of MH (0.6 to 0.4 N) compared to the GAC-Conventional group (all p < 0.001), which may hinder the maintenance of force until the end of the deactivation curve. Conclusions: The two commercially available NiTi-CCS groups exhibited different patterns of change in the force-deflection characteristics when the coiling direction was reversed.
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