대상포진에 대한 한방 단독 치료 치험 2례

배재룡(Jae Ryong Bae),김수진(Su Jin Kim),장상철(Sang Chul Jang),필감매(Chien Mei Pi),노주희(Ju Hee Roh) 대한의료기공학회 2016 醫療氣功 Vol.16 No.1

Objectives : The purpose of this study is to report a 67-year-old male patient with Herpes zoster(caseⅠ) and a 38-year-old female patient with Herpes zoster(caseⅡ), whose symptoms were relieved after Korean medicine treatment alone. Methods : Both patients took Yeonryeonggobondan and Pyungwee-san daily. Everytime they came to the hospital, they received acupuncture treatment, Hwidam's Su-Gi therapy and External Gigong Therapy. Acupuncture was applied by gall bladder seunggyeok(膽勝格, GB-), spleen jeonggyeok(脾正格, SP+), large intestine seunggyeok(大腸勝格, LI-) of Saam's Acupuncture Method. Hwidam's Su-Gi therapy was applied on neck. External Gigong Therapy was applied on skin lesion area. the patients' symptoms were evaluated with photographs and VAS. Results : The results were as follows: 1. In the case of a 67-year-old male patient, it took 14 days to recover the skin lesions and to reduce the pain after treatment started. And he visited 13 times during that period. 2. In the case of a 38-year-old female patient, it took 23 days to recover the skin lesions to reduce and the pain after treatment started. And she visited 10 times during that period. 3. Intensive treatment early in treating herpes zoster helped to shorten the treatment period. 4. Taking Yeonryeonggobondan and Pyungwee-san and receiving acupuncture treatment(SP+) can help to improve immunity and recover skin lesions in herpes zoster diagnosed with spleen deficiency with dampness encumbrance(脾虛濕困) and blood stasis due to qi stagnation(氣滯血瘀). 5. The combination of acupuncture treatment(GB-) and External Gigong Therapy was effective in controlling pain. 6. External Gigong Therapy is considered to be effective for the recovery of the skin as well as the pain of the herpes zoster. Conclusions : Korean medicine treatment alone has a great effect on the above two patients with herpes zoster. I hope the active research about Korean medicine treatment will be done not only for herpes zoster but also for various intractable pain diseases.

ATM망에서 실시간 연결수락제어에 관한 연구

장혁,김영훈,김용수,김희철,나상동 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1

본 논문은 이질적 버스트 트래픽을 갖는 ATM(Asynchronous Transfer Mode) 망에서 실시간 연결 수락 제어를 위한 유체 흐름 모델(fluid flow model)에 기반을 둔 실시간 알고리즘을 제안한다. 셀 손실 확률은 QOS(Quality of Service)의 기준이 되므로 제안된 실시간 알고리즘은 일정한 메모리 크기와 연결 요청의 수락 여부 즉, 연결 수락 여부의 결정을 위한 하나의 영역을 필요로 한다. 이러한 트래픽 소스 각 타입에 대한 셀 손실 확률은 트래픽 소스 타입 전체에 하나만 존재하더라도 요구를 충족 시킬 수 없으므로, 본 논문에서 제안된 실시간 알고리즘에 의해 산출되는 각각의 셀 손실확률에 충분한 상한선을 제공하는 전형적 트래픽 매개변수를 사용하여 성능을 분석한다.

Langerhans cell histiocytosis

장창덕,허준,박성환,김철훈,오수진,황희성,최설희,신상훈 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Langerhans cell histiocytosis(LCH) appears to arise from Langerhans cell and comprises a spectrum of clinical disease previously described in the literature by a variety of eponyms including histiocytosis X, eosinophilic granuloma, Hand-Christian disease, and Letterer Siwe syndrome. This rare disorder occurs in all groups, predominently affecting children & young adults. LCH has a wide spectrum of clinical features. The differentiation of several forms of this disease is primarily a clinical and not a histologic one. The radiographic characteristics include the appearance of solitary "intraosseous" lesios, the multipicity of "alveolar bone" lesions, the bone lesions, periosteal new bone formation, and slight root resorption. Prognosis of a single bone lesion, is known to be excellent. In contrast, disseminated disease has seen associated with a chronic course, a high rate of morbidity and late consequences, and possible mortality. Treatment of LCH remains problematic. Treatment of multisystem disease, where organ function is being compromised has generally been with high-dose systemic corticosteroids or multiple chemotherapy.

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

저소득층 중학생의 비만도에 따른 스트레스, 자아존중감 및 학교생활 적응과의 차이 분석

정성희,박수정,장현숙 이화여자대학교 교과교육연구소 2016 교과교육학연구 Vol.20 No.6

본 연구는 저소득층 중학생을 대상으로 비만도에 따른 스트레스, 자아존중감, 학교생활적응의 차이를 조사하였다. 조사 대상자는 지역주민센터 자료를 근거로 저소득층 확정을 받은 기초생활수급자, 차상위 계층 가정의 학생들을 대상으로 2015년 7월 3일부터 2015년 7월 17일까지 2주간에 걸쳐서 조사하였으며, 조사대상 인원은 총 440명이었다. 비만도 평가는 대한 비만학회의 규정에 따라 BMI<18.5은 저체중, 18.5≤BMI≤22.9은 정상, 23.0≤BMI≤24.9은 과체중, BMI≥25.0은 비만으로 분류하였다. 스트레스 조사는 가정환경, 친구, 학업, 교사/학교 등 4가지 하위 영역별로 구분하여, 총 27문항으로 구성된 도구를 활용하였으며, 청소년의 자아존중감에 대해 10문항으로 구성하였으며, 자아존중감 조사지의 신뢰도 값은 Cronbach α=.967이었다. 청소년의 학교생활적응은 5개 영역으로 구성되어 있고, 5개 영역은 교사관계적응, 교우관계적응, 학교수업적응, 학교생활적응, 학교환경적응 등 이며, 각 영역은 4문항으로 총 20문항으로 구성하였다. 본 연구의 결과, 비만군에서 스트레스 정도가 높게 나타났고, 정상체중군은 스트레스 정도가 가장 낮게 나타났으며, 비만군에서 학교생활 적응이 가장 낮게 나타났으며, 정상체중군은 학교생활 적응이 가장 높게 나타났다. 비만군에서 자아존중감이 가장 낮고, 정상체중군은 자아존중감이 가장 높게 나타났다. 비만도는 스트레스와 양의 상관관계를 나타내었으며(p<0.01), 비만도와 학교생활적응은 음의 상관관계를 나타내었으며(p<0.001), 스트레스는 자아존중감과 음의 상관관계를 나타낸다(p<0.01). 스트레스와 학교생활적응은 음의 상관관계를 나타내었고(p<0.01), 학교생활적응은 자아존중감과 양의 상관관계를 나타내었다(p<0.01). 본 연구의 결과를 종합해보면, 저소득층 학생은 비만군의 분포가 가장 높고, 비만군일수록 스트레스 정도가 높으며, 학교생활 적응이 낮고, 자아존중감이 낮게 나타났다. This study aims to investigate the differences in stress, school life adaptation and nutrient intakes according to obesity of middle school students from low income class. The subjects of the survey were selected among students from low income class, confirmed as national basic livelihood security recipients, and classified as lower income group, based on community service center data. As for measurement tools, BMI was calculated, which was used for the measurement of their obesity. For stress, the four-point Likert scale on daily stress was used, which was developed for Korean adolescents by Han (2011). For school life adaptation, the five-point Likert scale by Choi (2010) was used as a measurement tool. For self-esteem, the four-point Likert scale by Lee (2013) was used as a measurement tool. The results of this study were as follows: Most of the students from the low income class belonged to the obese group. Among the middle school students from the low income class of the Daegu area, the obese group had lower scores in all five domains of school life adaptation (teacher relationship, peer relationship, school class, school life, school environment), while the normal weight group had higher school life adaptation. Among the middle school students from the low income class of the Daegu area, the obese group had lower self-esteem, while the normal weight group had higher self-esteem.

광주지역 일부 남성의 연령과 배뇨량에 따른 최고요속 정상치

윤희철,박희수,노준,장대수 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objective : The Peak or maximum uroflow rate has been useful in screening test for the diagnosis of lower urinary tract dysfunction, and is used as a parameter in the diagnosis of lower urinary tract dysfunction, such as prostatism, urethral stricture, or neurogenic bladder, and the postoperative assessment of adequate surgery in urologic patients. We need a peak uroflow rate nomogram for the adjusted peak uroflow, because uroflow in normal healthy men depends on the voided volume and decreases with age. Materials and Methods : Peak flow rates and volumes voided were measured in 315 males who were free of voiding dysfunction, ranging in age from 10 to 80. To search for the equation of age, voided volume and peak uroflow, we used the least squares method for the equation providing least residual standard deviation by SPSS program. Results : The equation of age, volume voided and peak flow rate is Q=24.383+0.413A-0.006934A2-1164.644/V (Q: peak flow rate, A: Age, V: voided volume). Means of measured age, volumes voided, and peak flow rate was 45.7, 227.6ml, and 20.7ml/sec respectively. At this point, reference peak uroflow is 23.6m1/sec. Adjusted peak uroflow was obtained by subtracting the difference between the measured and expected peak uroflow from the reference peak uroflow. According to the equation Q, We designed nomogram with adjusted peak uroflow rate used. Conclusions : In our nomogram an adjusted peak flow rate <.8ml /sec(1.2 standard deviation) should be considered suspicious for lower urinary tract obstruction. This peak uroflow rate nomogram can be used clinically to evaluate lower urinary tract obstruction and its postoperative assessment.

한국어 판 구조화 임상면담도구 개발 : 신뢰도 연구

한오수,안준호,송선희,조맹제,김장규,배재남,조성진,정범수,서동우,함봉진,이동우,박종익,홍진표 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 정신장애의 정확한 진단과 평가는 임상에서뿐만 아니라 신뢰성 있는 연구를 위해서도 매우 중요하다. Structured Clinical Interview for DSM-IV(SCID)는 임상전문가들이 사용하는 진단도구로서, 비교적 짧은 시간에 정확한 진단을 내릴 수 있다. 본 연구는 한국어판SCID를 개발하고 그 신뢰도를 평가하기 위해 수행되었다. 방법: 국문학자가 포함된 번역위원회를 통하여 연구용판 SCID를 번역한 후, 정신과 의사 2인과 임상심리학자 1인에게 한국어판SCID 실시방법을 교육시킨 뒤 한국어판SCID를 이용한 면담의 평가자간 신뢰도 (interrater reliability)를 검증하였다. 면담 대상은 1999년 2월에서 3월까지 2개 병원 정신과에 치료중인 환자 90명(남:41명, 여:29명)이었다. 결과: 현재 장애(current disorder) 평가에서 주요 우울장애, 기분부전장애, 정신분열병, 알코올 남용 및 의존, 기타 물질 남용 또는 의존, 여러 불안장애들 및 섭식장애 등과 같은 대부분 장애의 kappa값은 .70이상으로 매우 높았다. 그 이외의 양극성 장애, 망상장애, 광장공포증, 감별 불능 신체화 장애 및 건강염려증의 kappa값도 .69에서 .40사이로 수용할 수 있는 정도였다. 평생 장애(lifetime disorder)에서는 양극성 장애(k=.69)와 감별 불능 신체화장애(k=.59)를 제외한 다른 모든 장애의 kappa값이 .70이상이었다. K-SCID 면담시 Ⅰ축 질환에 대하여 흔하게 다중 진단이 내려졌으며, 평균 진단 수는 1.5∼1.7개로 나타났다. 결론: 한국어판 SCID는 신뢰도가 높은 진단도구로 생각되며, 향후 정신질환의 정확한 진단과 임상연구에 유용하게 사용될 수 있다. Objectives: Accurate diagnosis and assessment for psychiatric disorders is crucial for research, as well as for clinical practice. Structured Clinical Interview for DSM-Ⅳ(SCID-RV) is a less time-consumimg and more accurate structured diagnostic interview form. It can be used by clinical professions and is known for a reliable diagnostic tool. Present study was conducted to develop Korean version of SCID-RV and to test the inter-rater reliability. Methods: The authors have translated original SCID-RV into Korean, and revised in parallel with sociocultural background of Korea. Ninety patients from two psychiatric hospitals, both outpatient and inpatient, were interviewed and rated independently by three raters. Results: The kappa coefficients for most of illnesses, such as major depressive disorder, dysthymia, schizophrenia, alcohol abuse and dependency, anxiety disorder and eating disorder were excellent(>0.70) in the evaluation of current disorders. And the kappa coefficients for bipolar disorder, delusional disorder, agoraphobia, undifferentiated somatoform disorder, and hypochondriasis were acceptable(>0.40) in the evaluation of current disorders. In the evalua-tion of lifetime disorders, the concordant rates of all the diagnoses except bipolar disorder and undifferentiated somatoform disorder were excellent. Lack of hierarchy in DSM-Ⅳ allows for multiple Axis I diagnoses. Mean numbers of Axis I diagnoses per subject assigned by the three raters were 1.5-1.7. Conclusions: Our findings confirm that SCID-RV yields highly reliable diagnoses. SCID-RV is recommended for accurate diagnosis in clinical practice and research on psychiatric disorders.

입원 환자 영양검색 전산 프로그램 개발

안수미,윤기영,신연명,최경현,임근승,장문경,송윤미,공은희 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : About 30% of patients in the hospital are under nourishment. A large portion of people are undernourished when they are admitted to the hospital and in the majority of these, undernutrition develops further while in hospital. Patient-Generated subjective global assessment(PG-SGA), a method of nutritional assessment based on clinical judgment, has been widely used to assess the nutritional status of adults for both clinical and research purposes. Modified PG-SGA can be used as a nutrition screening tool, and a comprehensive nutrition assessment is desirable for those who are malnourished. The purpose of this study is to develop a simple, reliable and valid nutrition screening program(NSP). Methods : We applied the nutrition screening program(NSP) to adult inpatients who are at risk of malnutrition using the Modified Patient-Generated subjective global assessment(PG-SGA) and objective assessment(electrical medical record data). Results : Therefore simple and beneficial NSP is developed for patients with severe malnutrition. Using NSP. nutritional information of the severe malnutrition patient should be shared with the physicians and they should be taken care of by clinical dietitians to improve their nutritional status. Conclusion : The Modified PG-SGA and nutrition screening tool are simple, reliable and valid nutrition screening program(NSP).

Neuropeptide γ의 구조 및 생리활성

구희정,서정길,김은희,허민도,정준기,박장수,강신원,박남규 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

생리활성을 지닌 신경펩타이드의 구조와 활성간의 관계를 규명하기 위하여 고상법으로 합성한 세종류의 neuropeptide γ(mammalian-,trout- 그리고 goldfish-neuropeptide γ)를 사용하여 연구하였다. Circular dichroism spectra에 의하면 mammalian-,trout- 와 goldfish-neuropeptide γ는 완충액 조건하에 모두 random한 구조를 나타내었다. 중성 및 산성 지질 존재 하에서, mammalian-과 trout- neuropeptide γ는 여전히 random한 구조를 취하였다. 그러나, goldfish-neuropeptide γ는 중성 및 산성지질하에서 부분적으로 α-helix구조를 나타내었다. 장관 수축활성에 있어서는 carp 장관, guinea-pig 회장 그리고 rat십이지장에 대하여 비교하였다. Carp에 대해서는 goldfish-neuropeptide γ= trout- neuropeptide γ>mammalian-neuropeptide γ순으로 활서이 나타났다. 그러나, guinea-pig 회장과 rat십이지장에 대해서 mammalian-neuropeptide γ는 어류 유래성 neuropeptide g들 보다 높은 수축활성을 나타내었다. 이러한 결과들은 neuropeptide γ들이 종-특이적인 활성을 나타낸다는 것을 제시한다. The relationship between structure and biological activity was studied on the three neuropeptides(mammalian-,trout- and goldfish-neuropeptide γ)that were syntheized by the solid-phase method. Circular dichroism spectra showed that mammalian-,trout- and goldfish-neuropeptide γadopted an undered structure in buffer solution. In the presence od neutral and acidic liposomes, mammalian-and trout- neuropeptide γ also took a random structure. However, goldfish-neuropeptide γ took an α-helical structure in acidic liposomes. The intestinal motility response was investigated with carp interstines, guinea-pig ileums and rat duodenums. In case of carp intestine, contractine activity was as follows:goldfish-neuropeptide γ= trout- neuropeptide γ> mammalian-neuropeptide γ. On the other hand, the contracile activity of mammalian-neuropeptide γ was more potent than trout- and goldfish-neuropeptide γ in the guinea-pig ileums and rat duodenums. these results suggest that neuropeptide γs showed the species-specific activity.

기업에서 효과적인 위기관리 시스템 구축 방안에 관한 연구 - 식품업체 이물 사고 중심으로

이장희, 강수진 충북대학교 국가위기관리연구소 2011 국가위기관리연구 Vol.5 No.1

위기관리시스템의 목적은 위기관리의 구체적인 내용을 시스템화하여 체계적으로 운영하는데 목적이 있다. 본 연구는 2000년 식중독 사고를 은폐한 유키지루시 유업의 사례를 통해 2008년 1월부터 2009년 12월까지 식품의약안전청을 통해 보도된 국내 식품관련 이물(異物) 사고들이 기업의 주가에 미치는 영향을 토대로 위기관리의 필요 성을 제안하였다. 주요 이물사고 조사 및 조치결과에 따르면 6개사 11건의 사고가 발 생하였으며 주식 시장 개장일을 기준하여 사건이 발생되기 전 주가가 회복되는 기간 이 최대 54일이 소요되었다. 11개 사고내용을 기준으로 평균 14일이 주가회복에 필요 한 시간이었으며 중복사고를 제거한 6개 업체는 28일로 1달 이상의 시간이 필요했다. 이에 기업들에게는 표준화된 ERM 체계를 다음과 같이 제안하였다. 제안한 ERM 프 로세스는 1단계 Risk SWOT를 작성하여 잠재적인 위기(Risk)를 파악하는 위기(Risk) 의 식별, 2단계 전략적 중요도 및 운영차원의 평가를 통해 관리가 필요한 중점 관리 대상 위기를 도출하는 위기(Risk)의 평가, 3단계 관리 중요성, 조기 경보 가능성, 측 정 가능성을 기준으로 KRI를 선정하는 KRI의 도출, 4단계 위기(Risk) 관리를 위한 대응 체제 및 관리 방식 구체화와 위기(Risk) 관리 조직 설계의 대응 방안 수립으로 구성을 할 수 있다. 본 연구는 공공분야의 개별 조직들이 자체적인 위기관리 프레임 을 운영하는 것과 같이 개별기업들이 보편적으로 적용할 수 있는 위기(Risk)관리 기 본 프레임워크를 제시한데 의의가 있다. 이러한 기본 프레임워크를 활용한다면 실제 기업에서 위기(Risk)관리 체계를 수립하는 작업이 훨씬 용이할 것이다. The goal of crisis management system the contents which crisis management is concrete about low of system is operates systematically. The study which sees base is doing in MEGMILK SNOW BRAND instances which conceal a food poisoning accident. From 2008 January until 2009 December Korean Food and Drug Administration(KFDA) led and are reported foodstuffs relation foreign body accident enterprise domestically in the sample. The study which sees proposed the necessity the foreign body accident affects in stock price of the enterprise and crisis management. Analytical result 11 proposal accidents occurred from 6 enterprises. After foreign body accident occurring the stock price recovery time is 54th(about 2months). So, the proposed ERM systems which are standardized at the enterprises. ERM processes which proposes draw up 1 phase Risk SWOT and Risk identifications which grasp Risk where is latent, 2 phased strategy the importance leads and evaluation of operation dimension and the important management objective crisis where the management is necessary the low of escape Risk evaluation, 3 phased management importance, early warning possibility and measurement possibility is a possibility of composing with confrontation plan establishment of the countermeasure systems for KRI escape which selects KRI in standard and 4 phased Risk management and management style materializations and Risk organization for management plans. The study like operating the crisis management frame where the individual organizations of public field are oneself and there is a questionable matter which presents Risk managements Framework the individual enterprises will be able to apply universally. If applies a basic frame work, the work which establishes Risk management systems from the actual enterprise far will be easy.