간이식 환자에서 발생한 Candida tropicalis 척수골수염 1예

양성연,조용균,김백남,정두련,김양수,류지소 대한감염학회 1996 감염 Vol.28 No.1

저자들은 간이식 후 면역억제제를 투여받던 중 이식 후 초기에 일시적인 C. tropicalis 진균혈증이 있던 환자에서 수 개월 후에 발병한 C. tropicalis 척추 골수염을 외과적치료 없이 amphotericin B로 치료한 1예를 보고한다. Invasive fungal infection is a well-recognized, life-threatening complication after orthotopic liver transplantation (OLT). Most cases with invasive fungal infections occur in the first 2 months after OLT, which are most frequently caused by candida species. The majority of isolated candida infections are due to Candida albicans, and rarely to Candida tropicalis. Clinical patterns of fungal infections include disseminated infection, peritonitis, pneumonia, fungemia, and others. Although there have been a few reports of candida osteomyelitis complicating solid organ transplantations, none in OLT was found in the MEDLINE search. Moreover, osteomyelitis caused by C. tropicalis was reported only once in a renal transplant recipient. We had experienced the first case of vertebral osteomyelitis caused by C. tropicalis after transient fungemia complicating OLT, which was successfully treated with amphotericin B without surgery.

우묵사스레피(Eurya emarginata)의 플라보노이드 화합물의 분리 및 동정

양홍철,박수영,강희경,이남호 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

The extracts of Eurya emarginata showed inhibitory effect on the growth of HL-60 leukemia cells. So, 80% methanol(MeOH) extract of its leaves was partitioned to hexane, ethyl acetate, n-butanol and residual water fractions. The ethyl acetate fraction, which showed desirable activities, was further purified using SiO2 column chromatography(CC) followed by reverse phase silica gel CC, then another normal CC to give fraction 4-1-8 as a pure compound. The compound 4-1-8 was analyzed by NMR spectrometry using 1H, 13C, DEPT, HMQC and HMBC spectra, and finally proved to be well-known flavono glycoside, Quercitrin.

백혈병 및 각종 암환자에서의 Terminal Deoxynucleatidyl Transferase 활성도에 관한 연구

양수남,박종우 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

Author studied that Enzyme Immunoassay method have been used to identify the cells with Terminal Deoxynucleotidyl Transferase (TdT) activity in extracts of whole blood from 80 patients The results are as follows 1) All 20 patients with ALL were TdT positive 2) ALL 4 patients with ALL in remission were TdT negative. 3) 14 cases of 16 patients with ALL were TdT negitive. 4) 1 patient with CML in blast crisis was TdT positive. 5) All 6 patients with lymphoma were TdT negative. 6) 6 cases of 30 patients with other disease were TdT positive. As a result of above study, TdT activity has been proposed as a biological marker for confireming the diagnosis of ALL, for monitoring leuckemic activity during chemotherapy, and for diagnosis of CML in blastic crisis.

Factitious Fever로 밝혀진 불명열 1예

김백남,강재명,배인규,김양수,우준희,류지소 대한감염학회 2000 감염 Vol.32 No.5

세포내 물질이동기구에 관한 전자현미경적 연구

양남길,안의태,장대수 순천향대학교 1982 논문집 Vol.5 No.3

In most cell kinds, intracellular transport systems are reasonably understood at the moment. But in most neurons which have long cellular processes, i. e., more than many thousand times longer axon than the diameter of its perykaryon, intraneuronal transport system has ultimate importances for the nutrient supply and transneuronal impulse conduction. Many efforts have been focused on the membrane circulation at the nerve terminals and on the chemico-physical transduction of impulse at the synapse. But it is still complicate to understand how the fast axonal transport can meet the needs in the terminals. Even the fast axonal transport (l00∼400mm/day) is too slow to overcome the multiple demands at the cell periphery. In this experiment, we have carried 3 experiments and interrelated their results to summarize the reasonable transport system within the nerve cells. At first we have disturbed the function of fundus striati nucleus of cat by the intersect-ion of nigrostriatal input. In the second experiment all the inputs and outputs to and from the fundus striati of cat were interrupted by columnar isolation of the nucleus, and finally we have checked the autoradiographic lables in the rat fundus striati following the stereotaxic infusion of tritiated serotonin via lateral ventricle. We have scrutinized all the data to result the following summary: 1. Uptake, lysis, synthesis and transport of proteinous substances within the perykayon are depends on the similar organelles as those in the other cell kinds, i. e., pinocytotic vesicles lysosomes, ribosomes, endoplasmic reticula, transfer vesicles, Golgi complexes, carrier vesicles, etc. 2. Fast transport within the long neuronal processes depends on the smooth endoplasmic reticular tubules which are apparantly long continuous and interonnected system between perikaryon and periphery of processes. 3. Transport within the smooth reticular tubule is accomplished immediately(perhaps only-in a few second, regardless of its length) by way of the pressing of newly formed substance at the perikaryal end resulting squeeze out at the peripheral end. 4. Disturbances at the distal end or at any passageway of smooth endoplasmic reticular tubules will make swelling or edema of the tubule-system. 5. In the spiny cell that has numerous spines and spine apparati, altered synaptic condition sometimes initiate large amount of material-uptake and transport of them via spine apparati into the smooth endoplasmic tubules of dendrites, finally may result edematic tubules and dendrite. 6. Importance of speed and vesiculation of smooth endoplasmic reticular tubules in normal and pathological circumstances were discussed.

정상교하 아동의 두개안면부 성장에 관한 종적 연구

양규호,박창헌,손정수,김낙현,최남기,김선미,김기백,신혜성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

혼합치열기 정상교합 아동 24명(남:14명 여:10명 초진 시 평균 나이 9±1.3세, 평균 관찰 기간: 13±1.3개월)에 대한 성장량을 측정하여 기능적 교정장치의 순수 치료효과를 평가하는데 도움이 되기 위해 3회(5~8개월 간격) 촬영한 측모 두부 방사선 규격 사진에 대한 분석 결과 다음과 같은 결론을 얻었다. 1. 남아는 상악골은 전하방, 하악골은 전방성장하였고, 여아는 상하악골이 전하방 성장하였다(p<0.05). 2. 상하악골의 남녀간 차이에서 수평적 성장상태는 여아가 컸고(A point 여아: 2.39mm, 남아: 1.26mm, p<0.05), 수직적 성장상태는 유의한 차이가 없었다. 3. 상악 전치의 치축은 두개저에 대해서 순측 경사하였고(p<0.01) 하악 전치의 치축은 큰 변화가 없었다. The purpose of this study was to provide the reference data evaluating the treatment effect of orthopedic appliances. The skeletal and dental growth increments were measured in 24 normal mixed dentition children(boys: 14, girls: 10) by three serial lateral cephalograms: initial mean age: 9±1.3 years, mean observation period: 13±1.3 months, Cephalometric changes were analysed. The results were as follows: 1. In boys, the maxilla showed forward and downward growth pattern and the mandible showed forward growth pattern(p<0.05). In girls, the maxilla and mandible showed forward and downward growth pattern(p<0.05). 2. Horizontal growth of both maxilla and mandible in girls was superior to those in boys(A point: girls: 2.39mm, boys: 1.26mm, with p<0.05), whereas vertical growth of both maxilla and mandible in boys was similar to those in girls. 3. The change in tooth axis showed labioversion of upper incisor(p<0.01) and comparatively stable lower incisor position.

朝鮮朝의 渾天儀 硏究

南文鉉,韓永浩,李秀雄,梁必承 건국대학교 1995 學術誌 Vol.39 No.1

Armillary spheres called honchonui is to show that during the Chosen dynasty (1392∼ 1910), Korean astronomy and technology went on its own path distinctive not only from that of the West but also from that of China, both of which had great influences on it. Our study is based upon the research of written materials and the physical investigation of some existing instruments; its findings will be used for our reconstruction of armillary spheres that were made during the middle of the dynasty. During the Choson, armillary spheres were developed to facilitate the propagation of Confucian ideology, on the one hand, to improve the knowledge of astronomy, on the other. Recognizing their importance at both aspects, the kings devoted themselves to toe making and repairing of the instruments. As time went, individuals outside of the court began to participate in making them. During the middle of the dynasty, that it from the Japanese invasion to the end of King Yongjo's rule, the Korean scientists incorporated the knowledge from the West in the making of armillary spheres. The period of King Hyonjong's reign witnessed a real innovation in making of armillary clocks. Two important scholar-officials played a major role in the renaissance of Korean technology. Upon the king's order, Yi Minch'ol cast new armillary spheres with a water-operated mechanism ; Song Iyong was also ordered to make a "self-sounding clock", that it a weight-driven armillary clock which was affected by the import of a western-style clock through China and Japan. Their joint efforts indeed led to a breakthrough not only in the history of Korean technology but also in that of mankinds. In this way, they succeeded in making armillary spheres in their own way beyond both Chinese and Western traditions of horological instrumentation. To be sure, the reconstruction of armillary spheres for which this study is to lay foundation will further stimulate the efforts at illustrating the history of Korean technology.

Corticosteroid의 全身投與가 멜라닌 및 멜라닌 細胞에 미치는 影響에 關한 實驗的 硏究

朴洋子,金秀男 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1

The hormonal control of melanin formation in the skin has aroused the attention of research workers for many decades. It is now generally accepted that endocrine factors play an important role in melanogenesis in man and animals. It is uncertain whether systemic corticosteroids, especially synthetic corticosteroids such as prednisolone, have any effect on the melanogenesis or not. Studies regarding the influence of systemic corticosteroids on the effect of ultraviolet light in melanogenesis are found rarely. The present studies were undertaken to evaluate the effect of prednisolone on melanogenesis and the influence of prednisolon is the use of ultraviolet light as noted on the skin of external ears of colored rabbits. The author observed the changes of the skin color macroscopically and microscopically after the daily intramuscular injection of prednisolone (0.5㎎/㎏/body weight) and/or daily irradiation of ultraviolet light (wave length: 2537-3660 Å, lamp to target distance: 30㎝, exposure time: 5 minutes). To observe the microscopic findings, the skin biopsy specimens which were taken at 7 day intervals for 28 days were stained with DOPA, silver nitrate and hematoxylin-eosin respectively. The results were as follows: 1. There were no macroscopic or microscopic changes of melanin or melanocytes in the animals of the control group which had been injected with blind suspension daily for 28 days. 2. In the ultraviolet irradiated group did mild increments of melanin were noticed on the 7th day of the experiment. These increased moderately or prominently on the 14th day and on the 21st day. The degree of increments decreased thereafter. Enlargement of melanocytes was paralleled with the increase in increments of melanin. Proliferation of melanocytes was observed from mild to moderate degree until the 21st day of the experiment, but these decreased after that time. 3. In the prednisolone treated group increments of melanin appeared mildly on the 7th day of the experiment, but was not changed after that. There were no changes of melanocytes either in size or number. 4. In the prednisolons treated group with the additional irradiation by ultraviolet light mild increments of melanin were noted on the 7th day of the experiment. Moderate increments were present on the 14th day with no change until the final day of experiment. Moderate enlargement was noted in the case of the increments of melanin. There was no change in the number of melanocytes. Above results suggest that systemic application of prednisolone has no effect on the synthesis of melanin and inhibit the effect of irradiation of ultraviolet light.

港灣 시스템의 生産性 堤高를 위한 戰略的 計劃에 관한 硏究

許南秀,梁漢洙,金俊式,崔德哲 慶南大學校 産業經營硏究所 1990 産業經營 Vol.13 No.-

감염성 심내막염 진단기준(Duke Criteria: Von Reyn Criteria)의 비교 및 경식도심초음파의 유용성

김양수,김백남 대한감염학회 1997 감염 Vol.29 No.1

목적: 감염성 심내막염의 진단을 위하여 사용되는 Duke criteria의 민감도와 특이도를 알아보고 경식도 심초음파의 유용성을 검토하고자 한다. 방법: 감염성 심내막염으로 치료를 받은 99례의 임상적, 미생물학적, 그리고 심초음파 소견, 병리학적 소견을 종합하여 각각을 Duke criteria와 von Reyn criteria로 재분류하였다. 결과: 병리학적으로 증명된 27례에서 Duke criteria로 definite case는 22례(81.5%)였으며, von Reyn criteria로는 possible case가 6례(22.6%)이어, Duke criteria의 민감도가 von Reyn criteria에 비해 더 높았다(p<0.05). Duke criteria의 possible case까지 포함하면 민감도는 100%로 von Reyn criteria로 possible case까지 포함한 70.4% 보다 더 높았다(p<0.05). 병리학적으로 증명된 심내막염에서는 경식도초음파를 시행함으로써 Duke criteria의 진단적 민감도가 유의하게 증가하지는 않았다. 조직학적으로 심내막염이 아닌 7례에서 Duke criteria로 definite case는 없었지만 possible case는 6례로 85.7%의 위양성율을 보였으나 von Reyn criteria로는 모두 rejected case이어 통계적으로 유의하게 Duke criteria의 특이도가 떨어졌다. 특히 Duke criteria를 적용할 때, 경식도초음파 소견은(85.7%) 경흉부초음파에 비하여(33.3%) 위양성율이 높아 심내막염을 진단하는데 경식도초음파의 특이도는 떨어짐을 알수 있었다. Viridans streptococci 심내막염이나 S. aureus 심내막염에서도 Duke criteria가 von Reyn criteria보다 진단적 민감도 더 높았다(p<0.05). 결론: Duke criteria는 von Reyn criteria보다 진단적인 민감도는 더 높다고 할 수는 있으나 특이도는 떨어지므로 특이도를 높일수 있는 보완이 있어야 할 것으로 생각된다. 경식도초음파는 특이성이 떨어질 수 있으므로, 심내막염을 진단하는 경우에는 반드시 임상적인 증거들을 고려하여 판단하여야 한다. Background: We compared the sensitivity and specificity of the newly developed Duke criteria(D) with those of the von Reyn criteria(R), and also evaluated the usefulness of transesophageal echocardiography(TEE) for the diagnosis of infective endocarditis(IE). Methods: We retrospectively reclassified 99 cases of infective endocarditis either by the Duke criteria or by the von Reyn criteria, according to clinical, microbiologic, and echocardiographic findings. Results: Of 27 histologically-confirmed cases, the sensitivity of D(22 definite + 5 possible) was 100%, and that of R(6 probable + 13 possible) was 70.4%(p<0.05). Of 7 histologically-rejected cases, there were 6 possible cases falsely accepted as IE by D, but none were accepted by R(p<0.05). For the histologically-confirmed cases, the sensitivity of D was not improved by TEE(23/23, 100%) compared with TTE(23/23, 100%). For 7 histologically rejected cases, the false-positive rate of TEE(5/7, 85.7%) was higher than that of TTE(2/7, 33.3%). There were 2 rejected cases by R compared with 0 by D among 34 cases of IE caused by viridans streptococci(p<0.05). And there were 5 rejected cases by R compared with 0 by D among 11 cases caused by S. aureus. Conclusion: The Duke criteria was more sensitive, but less specific than the von Reyn criteria for the diagnosis of IE. TEE may be helpful, but are not specific. The usefulness of TEE should be further evaluated.