Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

스페이스 플래닝 手法에서 본 食事行爲空間의 規模 硏究 : 老人福祉施設을 中心으로

전진숙,김미영,김종필,김수인 朝鮮大學校 建設技術硏究所 2007 建設技術硏究 Vol.27 No.2

The resultant buildings constructed by the plans and designs of special facility construction project are showing different forms from the initial intentions. Especially, this phenomenon, which induced the conflicts in medical life of old people, caused wasting of architecture and space by various restrictions. This study assumes that proper regulations should exist for design by removing the constraints on the architecture problems which caused these conflicts to prevail in society. The purpose of this study is to investigate the current status of dining activity in medical welfare facilities for old people and to remove the factors that cause considerable financial loss and waste. For the contents of the study, it investigated the current status of dining halls and dining space for each welfare facility, examined the transportation method during dining activity, and conducted pattern analysis about dining places for each space. To this end, the study drew the calculation method for the dining activity space of the pure area, the living area, and the unit area, which is the new cultural data of the architecture planning and design about the dining space for medical old people.

유아의 성별, 연령에 따른 체력 특성

전영남,양점홍,김수진,이성민 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.2

The purpose of this study is to examine the characteristics of young children's fitness development in accordance with gheir gender and age, providing information necessary for an effective physical education instruction for young children's growth and development. For the purpose, this researcher selected total 257 young children from K Kindergarten located at K-gu in B Metropolitan City who consisted of 73 boys and 45 girls, both of were fully aged 4, and 83 boys and 56 girls, fully aged 5.......

學校周邊 道路交通 騷音과 學生 聽感反應과의 相關關係 硏究

김종수,최동훈,박진식,김석택,김장호,서정민 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.2

For my thesis I have analyzed the differences between the traffic noise level surrounding the schools and the perceived level of noise. I have used the ways of measurement and questionnaires to support my study. According to the analysis, the measured noise level was higher than the expected noise level. The equivalent noise level was proven to be higher when the windows of the classrooms were open. The noise level was also higher on the third floor than the first floor. The correlation between the measured noise level and the perceived level of noise was tested in each school. The school which had a higher expected noise level showed a high perceived level of noise. The measured noise level and the perceived level of noise became larger on the higher floors. Through the questionnaires, the traffic noises were proven to be the largest noise-making source surrounding the schools. Most of the students replied on the questionnaires that they have been consistently bothered by the noise. It interfered with their studies and concentration. Also, the sound of their voices became louder because of the noise around their schools. Therefore, I have come to the conclusion that the traffic noises that surround the schools give the students negative influences.

친환경 건축재료로써 발포알루미늄의 음향적 특성

송희수,전진용 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

In this study, the sound absorption characteristics of foam aluminum which is an environment-friendly materials for buildings is elucidated and the effect of sound absorption coefficient is measured by applying to the existing gymnasium. This experiment reports that the sound absorption coefficients by various sealing are similar and in measuring the coefficient by thickness, it results in the best efficiency at the thickness 21mm of foam aluminum and mounting depth 50mm. In the simulation of room acoustics, the reverberation time of the existing gymnasium is decreased by about 0.6sec, and the definition(D50) is improved by about 10%

老巨樹 管理實態에 關한 硏究

鄭鎭澈,田璟秀,張圭寬,崔正鎬 圓光大學校大學院 1993 論文集 Vol.12 No.-

The big trees have been keeping the relation to human's living way in various aspects, environment protection, emotion creation and tree worshiping through which they believed to be safe, happy and prosperous, and also giving more recreational opportunity to provincial particularly. This study was carried out to analyse the status of designation and management of big tree in Iri-Iksan province, Chollabuk-Do. The result are summarized as follows. 1. It was appeared that at present Big trees in the investigated area were 78 location (7 families, 9 genera, 11 species) that was identified. Among them the species appearing most frequently were Zelkova serrata(25), Salix glandulosa (20), Gingko biloba(15) and Celtis japonica(8) in that order. The order hand, designation grade of big tree classified into six categories, that is 1 botanic natural monument, 5 Si-Kun tree, 3 Eup-Myon tree, 1 maeul tree, 53 Restraint tree ad 15 Non-Designation tree. 2. In designation of nurse tree, there are key needs that are professionals in field survey. We suggested the futher designation plan stressed the importance of the value of big tree. 3. Government have to increase of the forestry staff who take sole charge of the protection of big tree, and must reach managers the technique for effective management of big tree. 4. We have to make an budget of big tree management, establish a protective facilities, control of insets and disease on time, and treat and operate on the injured big tree. Thus government should be positively concerned, and more research would need to understand the critical factors affecting the big tree.

김치저장성 향상을 위한 동결방법이 배추조직의 물성변화에 미치는 영향

양진한,박소희,유진현,임호수,조재선,황성연 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.2

김치를 10˚C에서 8일간 숙성시켜 산도 0.6~0.7%로 숙성된 김치를 -70˚C와 -20˚C로 냉동하며 -20˚C에서 저장하면서 배추 조직의 elasticity, hardness, 세포 조직의 변화, 드립양을 실험한 결과는 다음과 같다. -70˚C에서 급속 동결한 것과 -20˚C에서 완만 동결한 냉동 김치 중 배추조직의 elasticity는 냉동 저장 15일까지 감소하다 일정하게 유지되었고 hardness는 거의 변화가 없었으며 냉동 방법에 따른 변화도 거의 나타나지 않았다. 투과 전자현미경으로 관찰한 결과 control의 경우 세포벽이 매우 두꺼우며 세포의 모양들이 잘 보존되어 잇는 것을 볼 수 있었고 -20˚C로 냉동 처리하여 해동시킨 세포벽들은 많이 손상되어 있음을 볼 수 있었으며 -70˚C로 급속 냉동시료의 경우 세포벽의 손상 정도가 -20˚C로 냉동 처리한 시료보다 덜 파괴되어 있음을 볼 수 있었다.한편 냉동 저장기간 동안 드립의 손실량의 변화는 -70˚C로 냉동 처리한 시료의 드립양은 3~4%정도로 -20˚C로 냉동 처리한 시료의 5~6%에 비해 적은 것을 알 수 있었다. This study was conducted to investigate the effect of freezing methods, show freezing at -20℃ and rapid freezing at -70℃, on physical properties of Chinese cabbage in frozen Kimchi during storage at -20℃. Elasticity of midrib of Chinese cabbage in frozen Kimchi was decreased until 15 days and did not changed thereafter during storage at -20℃, Hardness of that was not changed during storage. Those results of elasticity and hardness of slow frozen sample are similar to rapid frozen sample. By the morphological observation through transmission electron microscope, more of cellular structure of Chinese cabbage in slow frozen was destructed than that of rapid frozen sample. Drip loss was more in slow frozen sample than that in rapid one.

중학교 학생들의 체조수업에 대한 관심도 조사 연구

김진수,전정균 경희대학교 체육과학연구소 2001 體育學論文集 Vol.29 No.-

The results of the study on the degree of interest in gymnastics classes of 475 middle school students in Kyungkido is as follows. The first, the degrees of motive endowment and interest in gymnastics classes of students before classes were low. The second, the students who are participating the classes show the high significant level of P〈0.001 over the questions about the degree of satisfaction for class contents, the degree of satisfaction when their skills improve, class time assignment, and the joint class of boy and girl students, that the degree of satisfaction of the students who participate the classes pleasantly marked high. The third, Students don't content themselves with the field and equipment. The forth, the result indicates the positive tendencies of students over the impact of gymnastic classes on the body is very high. The fifth, the demand of teacher's exhibition is very high.

전립선 기질세포의 증식과 COX-2 발현에 대한 프로게스테론의 영향

정수련,김성한,최이화,박지은,전은미,강영진,이광윤,최형철 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

전립선비대증은 노인 남성에서 흔히 유발되는 질환이며, 노화가 진행될 수록 빈도가 높아지는 특징을 가진다. 이 질환의 원인은 전립선기질세표의 과도한 증식으로 유발된다고 알려져 있지만 그 자세한 기전에 대해서는 잘 알려져 있지 않다. 전립선비대증에서 progesterone 수용체 양성 세포가 다른 전립선 종양에 비해서 많고, progesterone은 testosterone에서 DHT로 전환되는 것을 감소시키는 역할을 가진다고 알려졋다. 또한 남성 전립선 평활근의 과증식에 의한 질환이므로 평활근 세포의 증식과 관련성이 있다고 보고된 COX-2의 전립선비대증에 대한 영향에 대한 연구가 필요하다. 전립선 기질세포에 progesterone을 3일간 투여하여 배양한 경우 기질세포 증식은 차이가 없었다. Progesterone을 단독 또는 DHT와 같이 투여한 기질세포에서 남성호르몬 수용체 mRNA 발현은 비처리군과 비교하여 유의한 차이가 없었다. 또한 progesterone과 DHT 동시 투여에 의한 COX-2 mRNA 발현에도 차이가 없었다. 그러나 progesterone에 의한 남성 호르몬 수용체와 COX-2 단백 발현에서는 대조군과 비교하여 유의하게 감소시켰다. 이상의 결과는 progesterone은 남성호르몬 수용체에 대해 전사 후 반응 (post-transcriptional response)에 효과를 나타내어 남성호르몬 수용체 발현을 감소시키는 작용은 가지며, COX-2 발현 억제효과를 나타내므로 전립선비대증의 치료에 이용될 수 있을 것으로 사료된다. Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5α-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. Materials and Methods: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. Results: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. Conclusion: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

성균관대학교 멀티미디어 원격교육 시스템(배움 한마당) 개발에 관한 연구

김석수,권해문,이상권,김상진,전진호,황대준 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1

We propose SKKU Multimedia Distance Education System for distance education between nature science campus(Suwon) and social science campus(Seoul) in Sung Kyun Kwan University on DooRae (Distributed Object Oriented Multimedia Application Crafting Environment for Collaboration) framework (or platform). We support ONE : N study mode for a group lecture and discussion between two campus, and also we support mediation for floor mode of a group lecture and brain storming for floor mode of discussion. The communication portocol of this system is composed of TCP/IP and UDP, and the network type is composed of WAN(El line)for between the Suwon campus and Seoul campus, ATM LAN for each campus(local site). And, this system supports the application development of the collaborative multimedia environment connected with the various network in the CBM (Computer based Multimedia) based. Also, it does not restrict on space between a teacher(s) and a student(s) into cyberspace which made by network. This system has an interaction, late comer, a question and an answer, multi-session, application sharing and whiteboard which resembles chalkboard. Also, various supplementary functions such as video conference and voice conference for this system are what makes face-to-face education effective. Also it supports real or non-real type. The operation system developed on windows 95.