홍난파의 자필악보와 해제 : 나운영 음악자료(2) / 제공 : 나운영 기념사업회 : 홍난파 자료2 : 악보편

홍정수(Jung Soo Hong) 민족음악학회 1999 음악과 민족 Vol.18 No.-

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

Critical role of bile acid (BA) in the cellular entry and permissiveness of Hepatitis B virus in vitro

Hong‑Jai Lee,Bo‑Young Shin,Jae‑Seung Moon,Ailyn Fadriquela,Selikem Abla Nuwormegbe,Chun‑Chang Ho,Jin‑Su Shin,Jee‑Sang Yoon,Sang‑Kyou Lee,Soo‑Ki Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Lack of universal replication system for hepatitis B virus with narrow host range and organ tropism has hampered to uncover the pathogenesis of HBV. Previously, we reported the essentiality of humoral milieu and its components toward HBV and hepatitis C virus survival/viability in vitro. Of these components, the precise role of enterohepatic humoral milieu such as bile acid (BA) on HBV cultivation in vitro and in vivo is unknown. Objective We explored whether BA, specifically taurochenodeoxycholic acid (tCDCA) would directly regulate the viral DNA and surface antigen expression of HBV in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. Result We found that higher concentration of taurochenodeoxycholic acid (tCDCA) is able to preserve the genomic stability of HBV in cell-free DMEM, showing higher the surface antigenicity than taurocholic acid (tCA). In line, we found that in vitro cell culture condition (100 μmol/L of tCDCA coupled with 1 × 108 g e/mL HBV) would be optimal for HBV entry into target cells. Using this, human (HepG2, Huh7), and rodent (Hepa1c1c7, H4-II-E) hepatoma cell lines were infected by HBV, as evidenced by the presence of HBV biomarkers (HBsAg, and HBV DNA in culture supernatant, as well as HBcAg in cell). Further, cellular entry test revealed that HBV is able to infect 12 different non-hepatic cell lines regardless of species, and organ/tissue, consequently reproducing progeny as confirmed by HBV biomarkers. Last, reinfection test showed that the progenies of HBV from immortalized HepG2, and Hepa1c1c7 cells are able to enter into each or vice versa naïve HepG2, and Hepa1c1c7 cells with or without BA. Conclusion This study demonstrates that enterohepatic humoral milieu such as BA, specifically tCDCA would directly regulate HBV DNA and its surface antigen expression in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. This is the first note to render HBV permissive to human or rodent hepatic and non-hepatic cells via sole manipulation of humoral milieu, thus establishing the platform for in vitro robust replication system of HBV.

야쿠트어 폐쇄자음 연구-러시아어 차용어휘 분석-

강덕수 ( Duck Soo Kang ),김지선 ( Jee Sun Kim ),홍준희 ( Jun Hee Hong ) 한국외국어대학교 언어연구소 2007 언어와 언어학 Vol.0 No.39

Duck-soo Kang.Jee-sun Kim.Jun-hee Hong. 2007. A Study of Obstruents in Yakut through Analysis of Borrowed Words from Russian. Language and Linguistics 39, 1-16. One of the most important constraints in Yakut is connected with syllabic structure. Its syllabic structure is based on CV. So the constraint of "NoGeminates" is strictly applied. And the harmony between features is also considered important. Yakut has the strict constraint on the phonotactical relations. In Yakut a feature [constricted glottis] works more vigorously than [voiced]. This feature is combined with a feature [+back] or [+lab], making new constraints on the initial place: *#[+back, -CG], *# [+lab,+CG]. Finally, consonantal assimilation in obstruents of Yakut is dominated by 2 lows of constraints. VowelHarmony >> Ident-CV[pl] >> NCP >> *[+palatal]# >> Ident-IO; *#[+back, -cont][+back,-high] >> *#[+back,-CG], *# [+lab,+CG] >> [+cont] >> NoGem >> Ident-IO >> *[+voiced]#

Studies on the Activation Mechanism of c-src Protein Tyrosine Kinase by Ginsenoside-Rg1

Hong, Hee Youn,Yoo, Gyurng Soo,Choi, Jung Kap 전남대학교 약품개발연구소 1998 약품개발연구지 Vol.7 No.1

We have studied an activation mechanism of pp60^(c-src) protein tyrosine kinase (PTK) by ginsenoside-Rg₁ (G-Rg₁) in NIH(pMcsrc/foc)B c-src overexpressor cells. It was previously reported that G-Rg₁ stimulated the activation of c-src kinase at 20 μM with a 18 hr-incubation, increasing the activity by 2-4-fold over that of untreated control, and this effect was blocked by treatments of inhibitors of either protein synthesis (cycloheximide) or RNA synthesis (actinomycin D) (Hong. H.Y. et al. Arch. Pharm. Res. 16, 114 (1993)). However, an amount of c-src protein itself in wild-type cells was not changed by G-Rg₁. When the cells mutated at one or two tyrosine residue(s) (Y416/527) that are important sites to regulate the kinase activity were treated with G-Rg₁, increases both in the activity of c-src kinase and in the expression of the protein were not observed. In addition, removal of extracellular calcium ion by EGTA or inhibition of PKC by H-7 canceled the G-Rg₁-induced activation of the kinase. Although the activation was little affected by G-Rg₁ with a calcium ionophore A23187, it was synergistically stimulated by treatment of G-Rg₁ and PMA, a PKC activator. Taken together, these results suggest that the activation of c-src kinase by G-Rg₁ is caused by an increase in the specific activity of the kinase, but not in amount of it, and is involved with both cellular calcium ion and PKC. Further the increase in the specific activity of c-src kinase may result from altered phosphorylation at tyr-416 and -527.

혈소판 감소증 환자에서 대마비와 전신 상태의 급격한 악화 : 급성 대동맥 혈전증 A Case Report of Acute Aortic Thrombosis 증례 보고

이홍기,박훤겸,백홍규,남영수,김영선,김용수 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2

Acute aortic occlusion is rare but poses a high mortality and morbidity. Prompt diagnosis and treatment is essential. Typical presentation is rest pain with bilateral absent femoral pulse. When the non-typical symptoms predominate such as paraplegia, acute abdomen or sudden-onset hypertension, diagnosis may be difficult. We experienced a case of acute aortic thrombosis who suddenly developed paraplegia and rapidly deteriorated within several hours. When the paraplegia developed, he was under treatment with heparin and urokinase, was thrombocytopenic, and the femoral arteries were pulsatile. Spinal cord compression due to bleeding complication had to be ruled out. Duplex sonography and lumbar CT scan were not diagnostic. Aortic thrombosis was diagnosed by abdominal CT scan. This case illustrates the need for high suspicion of acute aortic occlusion presenting with paraplegia especially in patients with associated atherosclerotic disease.

고호모시스테인증과 동반된 소뇌출혈 1예

홍석찬,안재영,조수진,정진상,이광호,홍승철,변홍식 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

논문 : 1920년대 초기 『조선일보』 「문예란」 연구 -발굴과 위상의 구명

박현수 ( Hyun Soo Park ),홍현영 ( Hyun Young Hong ) 민족문학사학회·민족문학사연구소 2015 민족문학사연구 Vol.57 No.-

『조선일보』의 「문예란」은 1921년 7월 4일부터 같은 해 8월 27일까지 『조선일보』1면에 개설되었다. 이 글의 목적은 『조선일보』 「문예란」에 실린 작품들을 발굴, 소개하고, 그 위상을 구명하는 것이다. 「문예란」이 개설되었던 때는 『조선일보』가 23회에 이르는 발매반포금지와 2차례의 정간을 겪고 점차 운영에서 정상을 찾아가던 즈음이었다. 「문예란」은 총 38회 개설되었는데, 시가 21편, 평론이 3편, 기행문이 1편, 수필이 1편 등 모두 26편의 작품이 실렸다. 「문예란」에 글을 수록한 작가는 변영로, 남궁벽, 김억, 박종화, 오상순, 오천석, 김찬영, 현진건 등이다. 변영로는 「문예란」에서 가장 활발한 작품 활동을 했으며 필자들의 교류에서도 중심에 있었다. 그는 진리가 확정된 세계에서 벗어나 불확실성에 투신하는 자세를 새롭게 창출될 문학의 핵심이라고 주장했다. 이 글은 남궁벽이 스스로 ``∼다``체로 번역해 발표한 「별의압흠」, 「말」 등을 소개하는 것을 통해 정본 확정의 문제를 제기했다. 또 작가의 과작을 고려할 때 새롭게 발굴, 소개하는 남궁벽의 시 5편이 지니는 무게 역시 가볍지 않다. 박종화의 시 가운데 「廢園에누어셔」는 「黑房秘曲」에 실린 시와 달리 3장으로 되어 있다. 특히 3장이 당시 박종화의 지우였던 정백, 홍사용 등의 갈등과 관련되어 주목을 필요로 한다. 이 글에서 소개하는 오상순의 두 시 역시 처음 발굴, 소개하는 시들이다. 이들은 어린 시절의 상상력이 깃든 언어를 가장 본질적인 것으로 파악하는 당시 오상순의 문학관을 드러내고 있다. 「문예란」의 필자들은 이미 문단의 승인을 받은 존재들이었다는 점에서 작품들 역시 문학청년 시기의 습작이나 투고작과는 다르다. 또 「문예란」의 필자는 각각의 동인지에 얽매이지 않는 문인들의 네트워크와 문학 활동을 파악할 수 있는 대상이기도 하다. 「문예란」이 지닌 가장 두드러진 의미는 『조선일보』를 비롯해 『동아일보』 『매일일보』 등 당시 신문 미디어에 같은 성격의 지면이 존재하지 않았다는 점에 있다. Literary section in Chosun Ilbo was first open on July 4, 1921 and lasted until on August 27 in the same year. The section was reported on the first page of Chosun Ilbo. The purpose of this article was to discover and introduce the pieces of literary work reported in Chosun Ilbo, and to bring light on the status of its literary section. The time when literary section was established was the moment Chosun Ilbo was returning to normal condition of running business after having twenty three times of prohibition of release and two times of suspension. The number of reported literary section was thirty eight, which included twenty one pieces of poem, three pieces of critique, one piece of travel essay, and one piece of essay. Thus, the total number of reported literary work was twenty six. Writers who participated in the section were as followed : Young-Roh Byun, Byuk Namgung, Uk Kim, Jong-Hwa Park, Sang-Soon Oh, Chun-Seok Oh, Chan-Young Kim and Jin-Gun Hyun. Among them, Young-Roh Byun was the most active writer in the literary section and was in the center of mutual exchange of opinion among the writers. He sought the core of literature in the attitude that was devoted to the uncertainty, which was off the world of concrete truth. This article supposed a question on determination of the formal copies by discovering and introducing the Byul-eui-ap-hem(별의압흠), and Mal(말) which were reported by Byuk. He translated these pieces for himself using style of writing, "∼ da". Moreover, as Namgung was not a prolific writer, the importance of five pieces of poem by Byuk Namgung should not be overlooked. Park`s poem, Lying in the closed garden(廢 園에누어셔), consisted of three chapters compared to that of his, which were issued in Secret songs in a black room(黑房秘曲). Especially, the third chapter of it was related to conflict among his companions, Baek Jung and Sah-Yong Hong. Therefore, it needs to be focused on that chapter. Two pieces of poem by Sang-Soon Oh were introduced for the first time. These represented Oh`s literary view at the moment, which the writer understood the language with childhood imagination as the most essential one. Writers of the literary section had already been approve by the literary circle. For this reason, the pieces reported in the literary section had a different character from their studies or submission before starting their literature career. In addition, the writers were the subject of the network and career activities among the writers who were not bound by literary coterie magazines. The most significant meaning of literary section was that the section with the same character did not exist in Dong-A Ilbo, Maeil Shinbo, or Chosun Ilbo itself. To prove this point, relation between news media and literature in early 1920s was discussed.

특집 1 : 한국 작곡가 연구 6 / 나운영 음악자료 ( 3 ) 제공 : 나운영 기념사업회

홍정수(Jung Soo Hong) 민족음악학회 2000 음악과 민족 Vol.19 No.-

말기 위암 외래 환자에게 제공된 통증관리의 염려 및 주저정도에 미치는 효과

공성화,이상홍,정자현,김지영,이수연,김순애 임상간호사회 2004 임상간호연구 Vol.10 No.1

Purpose: This study was designed to evaluate the effect of cancer pain-management-education on the concerns and hesitancy of pain-management in out-patient of terminal gastric cancer. Method: 24 terminal gastric cancer patients who had not surgery, were assigned to the control group and 24 were assigned to the experimental group receiving pain-management-education. As Measurement-instrument of concern on pain-management and questionnaire on degrees of hesitancy were used the questionnaire developed by Ward( 1993) and translated by Kim Hong-Soo(1998). Data were analyzed per descriptive analysis, x²-test and t-test with the SPSS 10.0 program. Result: Degrees of concern of cancer-patient on pain-management between experimental-group and control-group showed significant difference: Experimental-group changed from 2.52 to 1.13 point(maximum 5 point) and control-group from 2.59 to 2.40 point(p=.000). Degrees of hesitancy of cancer-patient on pain-management between two groups showed significant difference. Experimental-group changed from 2.33 to 1.35 point and control-group from 2.77 to 2.52 point(p=.000). Conclusion: Above findings showed that pain-management-education reduces the concern and hesitancy on pain-management in out-patient of terminal gastric cancer. We conclude that the pain-management-education in this study was identified the effective nursing program.