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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
분지각이 작고 일시 개화성이 우수한 숙근 안개초 ‘드림송’ 육성
정동춘(Dong-Chun Cheong),최창학(Chang-Hak Choi),송영주(Young-Ju Song),김정만(Jeong-Man Kim),이진재(Jin-Je Lee) 한국원예학회 2014 원예과학기술지 Vol.32 No.4
‘Bristol Fairy’ 유래의 결실되는 아조변이체인 ‘Gyp99’의 실생계통으로 밝은 백색 겹꽃에 소화가 큰 ‘Gyp06-11’로부터 2008년 특성이 우수한 ‘Gyp08-2’ 계통을 선발하여 2009-2010년 2년 동안 특성평가 및 특성검정을 통해 ‘Dream Song’을 육성하였다. ‘Dream Song’의 초형은 직립형이고, 잎 모양은 피침형, 소화는 꽃잎수가 많고 암술이 2개인 백색겹꽃으로 꽃잎은 도란형, 꽃잎 끝 모양은 약간 둥근형, 꽃받침 모양은 컵형인 ‘Dream Song’ 고유의 특성을 가진다. 또한 소화의 일시개화성이 우수하고 절화수명이 매우 길며, 분지각이 작고 흰가루병에 강하고 총체벌레와 잎굴파리 등 충해에도 강해 재배적 가치가 높은 특성을 가진다. 준고냉지 여름절화 작형에서 ‘Dream Song’ 개화는 ‘Bristol Fairy’보다 17일 늦고 절간장과 화경장이 길었으며, 측지 분화가 많고 줄기가 굵었다. 또한 소화가 크고 야간 기온 22℃, 7일 이상의 고온조건에서도 기형화 발생이 없었다. ‘Dream Song’ is a cultivar of Gypsophila paniculata developed by the Jeollabuk-do Agricultural Research & Extension Services in 2010 for cut-flower production. This hybrid was bred from 121 seedlings collected from an open-pollinated population of ‘Gyp06-11’. It has novel morphological characteristics of upright plant type, lanceolate leaves, double florets with a few bright white-colored petals of obovate shape, truncate petal tips, and cup-shaped calyces. Furthermore ‘Dream Song’ has desirable cultivation characteristics including narrow branching angle, and moderate resistance to powdery mildew, thrips and leaf miners. Moreover it produces more primary branches, and longer internodes and flower stalks than reference cultivar ‘Bristol Fairy’ during summer cultivation in a subalpine area (500 m over the sea level). Flowering in ‘Dream Song’ is delayed by about 17 days as compared to ‘Bristol Fairy’. ‘Dream Song’ produces normal flowers with 2 pistils and an average of 10.4 stamens, with fewer malformed flowers than ‘Bristol Fairy’.
Ji Chang Woo,Kim Nam-Jung,Lee Sang-Guei,Hwang-Yong Kim,Choi Hoon-Sik,Song In-Sun,Ko Jee Sun 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
We analyzed the chirp sound and behavior of Teleogryllus emma with observation system, which was consisted of computer, ccd-camera and microphone. Computational methods of wavelet transformation and Self-Organizing Maps (SOM) were utilized to characterized the chirp sound of insect species for automatic counting in this study. Wavelets were initially applied to feature extraction of the chirp sound. Wavelet coefficients were accordingly calculated based on the basis function (e.g., Morlet). The obtained coefficients were subsequently provided to count number of chirps in each song. Sound structure of insect specimens consisted with long chirp and short chirp and the patterns of song were grouped by frequency of long chirp and short chirp. The song patterns of insect specimens were divided by Self-Organizing Map (SOM) that was used number of chirp as input data. Application of computational methods to automatic detection of chirp sound was further discussed for obtaining objective assessment in behavior science.
Lee,Jang-Soo,Lee,Keun-Hyang,Kim,Yeo-Song,Kang,Kwon-Kyoo,Nou,Ill-Sup,Hirata,Yutaka 한국자원식물학회 2004 Plant Resources Vol.7 No.2
Co-segregation of male fertility with DNA markers selected by RAPD analysis as being potentially linked to the restorer gene (Rf) for Cytoplasmic male sterility (CMS) was analyzed using segregating F2 population. One RAPD marker directly linked to the Rf locus was identified. Amplification of OPT-02/570 using the STS primers generated a monomorphic band of each fertile plants randomly selected F2 progenies. From these results, this specific marker would be strongly linked to be restoring gene. The use of STS marker is effective in overcoming the reliability of the RAPD phenotype and improving their utility for MAS, co-dominant STS markers are especially very useful.
Kim, Kyeong Seok,Yang, Hun Yong,Song, Hosup,Kang, Ye Rim,Kwon, JiHoon,An, JiHye,Son, Ji Yeon,Kwack, Seung Jun,Kim, Young-Mi,Bae, Ok-Nam,Ahn, Mee-Young,Lee, Jaewon,Yoon, Sungpil,Lee, Byung μ,Kim, Hyung TAYLOR & FRANCIS 2017 Journal of Toxicology and Environmental Health Vol.80 No.9
<P>Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically available biomarkers for disease detection are currently not available. Recently, a new biomarker, selenium-binding protein 1 (SBP1), was identified for detection of nephrotoxicity using proteomic analysis. The aim of this study was to assess the sensitivity of urinary SBP1 levels as an early detection of AKI using animal models such as cisplatin or ischemia/reperfusion (I/R). Sprague-Dawley rats were injected with cisplatin (6 mg/kg, once i.p.) and sacrificed at 1, 3, or 5 days after treatment. Ischemia was achieved by bilaterally occluding both kidneys with a microvascular clamp for 45 min and verified visually by a change in tissue color. After post-reperfusion, urine samples were collected at 9, 24, and 48 hr intervals. Urinary excretion of protein-based biomarkers was measured by Western blot analysis. In cisplatin-treated rats, mild histopathologic alterations were noted at day 1 which became severe at day 3. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were significantly increased at day 3. Levels of urinary excretion of SBP1, neutrophil gelatinase-associated lipocalin (NGAL), and a tissue inhibitor of metalloproteinase-1 (TIMP-1) were markedly elevated at day 3 and 5 following drug treatment. In the vehicle-treated I/R group, serum levels of BUN and SCr and AST activity were significantly increased compared to sham. Urinary excretion of SBP1 and NGAL rose markedly following I/R. The urinary levels of SBP1, NGAL, TIMP-1, and KIM-1 proteins excreted by AKI patients and normal subjects were compared. Among these proteins, a marked rise in SBP1 was observed in urine of patients with AKI compared to normal subjects. Based upon receiver-operator curves (ROC), SBP1 displayed a higher area under the curve (AUC) scores than levels of SCr, BUN, total protein, and glucose. In particular, SBP1 protein was readily detected in small amounts of urine without purification. Data thus indicate that urinary excretion of SBP1 may be useful as a reliable biomarker for early diagnosis of AKI in patients.</P>
A STUDY on FOREST FIRE SPREADING ALGORITHM with CALCULATED WIND DISTRIBUTION
Song,J,H,Kim,E,S,Lim,H,J,Kim,H,Kim,H,S,Lee,S,Y 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-
There are many parameters in prediction of forest fire spread. The variables such as fuel moisture, fuel loading, wind velocity, wind direction, relative humidity, slope, and solar aspect have important effects on fire. Particularly, wind and slope factors are considered to be the most important parameters in propagation of forest fire. Generally, slope effect cause different wind distribution in mountain area. However, this effect is disregarded in complex geometry. In this paper, wind is estimated by applying computational fluid dynamics to the forest geometry. Wind velocity data is obtained by using CFD code with Newtonian model and slope is calculated with geometrical data. These data are applied fer 2-dimentional forest fire spreading algorithm with Korean ROS(Rate Of Spread). Finally, the comparison between the simulation and the real forest fire is made. The algorithm spread of forest fire will help fire fighter to get the basic data far fire suppression and the prediction to behavior of forest fire.
수정 Cam-clay 이론을 이용한 점토의 비배수 강도 예측에 관한 연구
이송 ( Lee¸ Song ),이규환 ( Lee¸ Kyu-hwan ),김태훈 ( Kim¸ Tae-hwoon ) 한국구조물진단유지관리공학회 2002 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.6 No.2
국내 지역에서 대부분의 자연 연약점토는 약간 또는 매우 과압밀된 상태를 갖고 있다. 이러한 연약한 지반에 제방을 건설하기 위해서는 지반의 지지력이 결정되어야 하며, 응력이력에 따른 비배수 전단강도는 단계하중재하시 재방의 단계성토고와 안정성을 분석함에 매우 중요하게 하다. 이러한 점에서 한계상태이론의 Cam-clay 이론은 정규압밀과 과압밀된 점토지반의 비배 수 전단강도를 예측함에 있어 합리적인 결과를 주며, 비등방조건에서 비배수 전단강도의 예측 은 실내삼축시험과 잘일치하고 있다. 따라서, 본 논문에서는 MCCM 이론의 적용성을 국내 저소성 실트질 점토를 블록 샘플링하여 실내 등방 및 비등방 시험을 실시하여 검증하였으며, 과거 여러 지역에서 연구된 결과들과 비교하여 재분석하였다.
기체크로마토그래피를 이용한 산양삼,백삼,홍삼중의 농약잔류 분석
맹주양;이용구;이숙재;정진아;김정미;김선화;김송아 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2
Commercial Korean ginseng-Ginseng cultivated in mountains(GCM), White Ginseng (WG), and Red Ginseng (RG) - were used, respectively, to analyze the pesticide residues in them. The selected pesticides for the analysis of residue were procymidone and tolclofos-methyl. Procymidone residue was no detected in all of them and tolclofos-methy residue was shown as follows: RG(0.270ppm)>GCM(0.0541ppm)>WG(0.007ppm).
( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.